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1. 发明授权

US07276359B1 Polynucleotide composition, method of preparation, and use thereof 失效
标题翻译：多核苷酸组合物，制备方法及其用途
公开(公告)号：US07276359B1
公开(公告)日：2007-10-02
申请号：US09622235
申请日：1999-03-12
申请人： Shankar Musunuri , Patrick P. DeLuca
发明人： Shankar Musunuri , Patrick P. DeLuca
IPC分类号： C12N15/64 , A61K31/70
CPC分类号： C12N15/10
摘要： A lyophilized polynucleotide composition contains at least one polynucleotide and at least one cryoprotectant, wherein the ratio of the polynucleotide to cryoprotectant is from about 0.001 to about 1.0 part by weight polynucleotide per 1.0 part by weight of the cryoprotectant. This composition also contains from about 0.5 weight percent to about (6) weight percent water, based on the total weight of the final lyophilized polynucleotide composition. The polynucleotide composition of this invention is characterized by enhanced stability, in that it retains at least 90% supercoil over a time period of at least (10) days at a temperature of about 37° C. The lyophilized polynucleotide composition also has improved solubility. An improved process for lyophilization of polynucleotides employs a specific primary drying cycle, that results in the above-described stable, lyophilized polynucleotide composition.
摘要翻译：冻干的多核苷酸组合物含有至少一种多核苷酸和至少一种冷冻保护剂，其中多核苷酸与冷冻保护剂的比例为每1.0重量份冷冻保护剂约0.001至约1.0重量份的多核苷酸。基于最终冻干的多核苷酸组合物的总重量，该组合物还含有约0.5重量％至约（6）重量百分比的水。本发明的多核苷酸组合物的特征在于增强的稳定性，因为其在约37℃的温度下在至少（10）天的时间内保留至少90％的超螺旋。冻干的多核苷酸组合物也具有改善的溶解度。用于冻干多核苷酸的改进方法采用特定的初级干燥循环，其导致上述稳定的冻干多核苷酸组合物。

2. 发明申请

US20090253754A1 Fast dissolving films and coatings for controlled release of flavors, active pharmaceutical ingredients, food substances, and nicotine 审中-公开
标题翻译：用于控释香料，活性药物成分，食物和尼古丁的快速溶解薄膜和涂层
公开(公告)号：US20090253754A1
公开(公告)日：2009-10-08
申请号：US12315603
申请日：2008-12-04
申请人： Francesca Selmin , Paolo Blasi , David R. Worthen , David Johnson , Patrick P. DeLuca
发明人： Francesca Selmin , Paolo Blasi , David R. Worthen , David Johnson , Patrick P. DeLuca
IPC分类号： A61K31/44 , A24B15/36 , B05D3/02 , A61K47/30 , A61P43/00 , C08L1/00 , C08L1/26 , A23L1/226
CPC分类号： A61K9/006 , A61K9/7007
摘要： A fast-dissolving film for use as a platform for the delivery of material to the oral cavity, comprising a film forming agent; a plasticizing agent; and a fast-dissolving, water-soluble agent; and methods for producing same.
摘要翻译：一种用作将材料输送到口腔的平台的快速溶解膜，包括成膜剂; 增塑剂; 和一种快速溶解的水溶性剂; 及其制造方法。

3. 发明授权

US4267449A Testing the integrity of liquid containing hermetically sealed containers by the use of radioactive markers 失效
标题翻译：通过使用放射性标记测试含有密封容器的液体的完整性
公开(公告)号：US4267449A
公开(公告)日：1981-05-12
申请号：US66390
申请日：1979-08-14
申请人： Patrick P. DeLuca , L. David Butler
发明人： Patrick P. DeLuca , L. David Butler
IPC分类号： G01M3/22 , G01T1/161
CPC分类号： G01M3/226
摘要： A method for detecting leaky ampules filled with a liquid such as a parenteral solution. The ampules to be tested are immersed in a solution containing a short-lived radionuclide, and a pressure differential is imposed between the solution containing the radionuclide and the parenteral solution or other liquid contained in the ampules. The ampules are then removed from solution, decontaminated to remove any solution adhering to the outer surface and pores thereof, dried, and finally examined for electromagnetic radiation, preferably gamma radiation, emanating from the interior of the ampules which would indicate a leaky condition thereof.
摘要翻译：用于检测填充有诸如肠胃外溶液的液体的泄漏安瓿的方法。将待测试的安瓿浸入含有短寿命放射性核素的溶液中，并且在包含放射性核素的溶液和肠胃外溶液或安瓿中包含的其它液体之间施加压力差。然后从溶液中取出安瓿，去除污垢以除去附着在外表面和孔上的任何溶液，干燥，最后检查从安瓿内部发出的电磁辐射，优选γ辐射，这些辐射将表示其泄漏状况。

4. 发明申请

US20090301504A1 Method for producing flavored particulate solid dispersions 审中-公开
标题翻译：生产调味颗粒固体分散体的方法
公开(公告)号：US20090301504A1
公开(公告)日：2009-12-10
申请号：US12290575
申请日：2008-10-31
申请人： David R. Worthen , David Johnson , Patrick P. DeLuca , Paolo Blasl
发明人： David R. Worthen , David Johnson , Patrick P. DeLuca , Paolo Blasl
IPC分类号： A24B15/00
CPC分类号： A24B13/00 , A23L27/70 , A23L27/74 , A23L27/79 , A24B15/283
摘要： A method for producing flavoring materials consisting of a flavor and a simple matrix material that are GRAS or approved for use in food, and that will be stable under extremely adverse conditions, greater than 50% moisture, high pH, high temperature stability (60° C.), yet be released in the oral cavity; without the use of organic solvents, and with the use of inexpensive materials and unsophisticated equipment.
摘要翻译：一种生产调味料的方法，由风味和简单的基质材料组成，GRAS或批准用于食品，并且在非常不利条件下稳定，大于50％的水分，高pH，高温稳定性（60°） C.），但在口腔释放; 不使用有机溶剂，并且使用廉价的材料和不成熟的设备。

5. 发明授权

US5160745A Biodegradable microspheres as a carrier for macromolecules 失效
标题翻译：可生物降解的微球作为大分子的载体
公开(公告)号：US5160745A
公开(公告)日：1992-11-03
申请号：US463008
申请日：1990-01-09
申请人： Patrick P. DeLuca , Frantisek Rypacek
发明人： Patrick P. DeLuca , Frantisek Rypacek
IPC分类号： A61K9/16
CPC分类号： A61K9/1652 , A61K9/1641 , A61K9/1694 , Y10S514/885 , Y10S514/963 , Y10S514/965 , Y10T428/2987
摘要： A method for preparing biodegradable microspheres having a three-dimensional network in which biologically active macromolecular agents are physically entrapped therein. The microsphere is able to degrade and release the macromolecular agent at a controlled rate. The method involves emulsifying a vinyl derivative of a biodegradable hydrophilic polymer, a water-soluble monovinyl monomer and a biologically active macromolecule in water, and copolymerizing the biodegradable hydrophilic polymer and the water-soluble monovinyl monomer such that the biologically active macromolecule is entrapped therein.
摘要翻译：一种制备具有三维网络的可生物降解的微球的方法，其中生物活性大分子物质被物理捕获在其中。微球能够以受控的速率降解和释放大分子试剂。该方法包括将可生物降解的亲水聚合物的乙烯基衍生物，水溶性单乙烯基单体和生物活性大分子乳化在水中，并使生物降解的亲水聚合物和水溶性单乙烯基单体共聚，使生物活性大分子被捕获在其中。

6. 发明授权

US4818542A Porous microspheres for drug delivery and methods for making same 失效
标题翻译：用于药物递送的多孔微球及其制备方法
公开(公告)号：US4818542A
公开(公告)日：1989-04-04
申请号：US846513
申请日：1986-03-31
申请人： Patrick P. DeLuca , Motoko Kanke , Toyomi Sato , Hans G. Schroeder
发明人： Patrick P. DeLuca , Motoko Kanke , Toyomi Sato , Hans G. Schroeder
IPC分类号： A61K9/16 , A61K9/19 , A61K9/50 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/42 , A61K9/52 , B01J13/02
CPC分类号： A61K9/1694 , Y10S424/07 , Y10S514/965 , Y10T428/2989
摘要： Controlled release drug delivery systems comprised of spherical microporous polymeric network of interconnecting channels containing pore incorporated drugs or other agents wherein the drugs or agents are confined within the pore channel are described. Also disclosed are processing parameters in connection with the novel method of the invention for obtaining drug delivery systems especially suited for parenteral as well as oral administration.
摘要翻译：描述了由包含孔结合药物或其他药物的互连通道的球形微孔聚合物网络组成的控释药物递送系统，其中药物或药剂被限制在孔通道内。还公开了与本发明的新颖方法相关的用于获得特别适合于肠胃外和口服给药的药物递送系统的加工参数。

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