专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5062995A Polymeric carbamate detergent builders 失效
公开(公告)号：US5062995A
公开(公告)日：1991-11-05
申请号：US475660
申请日：1990-02-06
申请人： Shang-Ren Wu , Albert Garofalo
发明人： Shang-Ren Wu , Albert Garofalo
IPC分类号： C07C271/22 , C08F18/00 , C11D3/37
CPC分类号： C11D3/3773 , C07C271/22 , C08F18/00 , C11D3/3769
摘要： Novel vinyl carbamates, prepared from vinyl chloroformate and amino acids and polymers containing from 5-100% of these novel vinyl carbamates are disclosed. These polymers act as sequestering agents and are useful as detergency builders. Detergent compositions incorporating the polymers can be prepared without use of phosphorus-containing detergent builders.Formulas for the novel carbamates and polymers are as follows:Vinyl carbamate compounds of the Formula: ##STR1## wherein a and b are independently 0, 1, or 2, or even greater; R is hydrogen methyl, ethyl or long chain alkyl, alkenyl or aryl and M is C.sub.1-4 alkyl, hydrogen, or a cation which forms a substantially water soluble salt with said compound at ambient temperatures; andPolymeric compounds of the formula: ##STR2## wherein a and b are independently 0, 1 or 2 or even greater; m is at least one; R is hydrogen, methyl, ethyl, or long chain alkyl, alkenyl or aryl and M is C.sub. 1-4 alkyl, hydrogen, or a cation which forms a substantially water soluble salt with said polymeric compound at ambient temperatures; andPolymeric compounds with repeating units of the structure: ##STR3## wherein a and b are independently 0, 1 or 2 or even greater; wherein m and n are at least one; R is hydrogen, methyl, ethyl, or long chain alkyl, alkenyl or aryl and M is hydrogen or a cation which forms a substantially water soluble salt with said polymeric compound at ambient temperatures or C.sub.1-4 alkyl and wherein A is a repeating unit having at least one copolymerized comonomer, said comonomers being selected from the group consisting of unsaturated carboxylic acids and their salts, esters and derivatives, unsaturated dicarboxylic acids and their salts, esters, and derivatives, unsaturated alcohols, unsaturated amines, unsaturated pyrrols, vinyl ethers, alkyl acrylates, alkenyl carboxylalkyl ethers, vinyl esters of carboxylic acids, olefins and furans.

2. 发明申请

US20060281733A1 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases 失效
标题翻译： 4-溴-5-（2-氯 - 苯甲酰基氨基）-1H-吡唑-3-羧酸酰胺衍生物和相关化合物作为缓激肽b1受体拮抗剂，用于治疗炎性疾病
公开(公告)号：US20060281733A1
公开(公告)日：2006-12-14
申请号：US10555519
申请日：2004-04-30
申请人： Jay Tung , Albert Garofalo , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , R. Jeffrey Neitz , Jennifer Marugg , Martin Neitzel
发明人： Jay Tung , Albert Garofalo , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , R. Jeffrey Neitz , Jennifer Marugg , Martin Neitzel
IPC分类号： A61K31/5377 , A61K31/5513 , A61K31/55 , A61K31/496 , A61K31/4545 , A61K31/454 , A61K31/4152 , C07D403/02
CPC分类号： C07D401/14 , C07D231/16 , C07D231/40 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08
摘要： Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
摘要翻译：公开了作为缓激肽B 1受体拮抗剂的式I和II化合物，并且可用于治疗由缓激肽B 1介导的哺乳动物中疾病或与疾病相关的不良症状， SUB>受体。某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。

3. 发明申请

US20080090817A1 Bridged N-Cyclic Sulfonamido Inhibitors of Gamma Secretase 失效
标题翻译：桥联N环磺酰胺抑制剂的γ分泌酶
公开(公告)号：US20080090817A1
公开(公告)日：2008-04-17
申请号：US11951097
申请日：2007-12-05
申请人： Simeon Bowers , Albert Garofalo , Roy Hom , Andrei Konradi , Matthew Mattson , Martin Neitzel , Christopher Semko , Anh Truong , Jing Wu , Ying-zi Xu
发明人： Simeon Bowers , Albert Garofalo , Roy Hom , Andrei Konradi , Matthew Mattson , Martin Neitzel , Christopher Semko , Anh Truong , Jing Wu , Ying-zi Xu
IPC分类号： A61K31/5365 , A61K31/437 , A61P25/28 , C07D497/04 , C07D497/14 , C07D471/14 , A61K31/4985
CPC分类号： C07D451/14 , C07D471/08 , C07D471/18 , C07D471/22 , C07D498/08
摘要： The invention provides N-cyclic sulfonamido compounds and salts of Formula I: wherein A is as described in the specification and R1 and R2 combine to form a [3.3.1] or a [3.2.1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3.3.1] or [3.2.1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula I.
摘要翻译：本发明提供N-环磺酰氨基化合物和式I的盐：其中A如说明书中所述，R 1和R 2 2结合形成[3.3.1 ]或[3.2.1]环体系，其中氮连接到两个桥头堡碳上，并且[3.3.1]或[3.2.1]环体系任选地与杂芳基或杂环烷基环稠合。式I的化合物可用于治疗或预防认知障碍，例如阿尔茨海默病。本发明还包括含有式I化合物的药物组合物，治疗认知障碍的方法，例如阿尔茨海默氏病，以及可用于制备式I化合物的中间体。

4. 发明申请

US20080021056A1 Fused, Tricyclic Sulfonamide Inhibitors of Gamma Secretase 审中-公开
标题翻译：融合，三环磺酰胺抑制剂的γ分泌酶
公开(公告)号：US20080021056A1
公开(公告)日：2008-01-24
申请号：US11757140
申请日：2007-06-01
申请人： Andrei Konradi , Gary Probst , Danielle Aubele , Albert Garofalo , Roy Hom , Martin Neitzel , Christopher Semko , Anh Truong
发明人： Andrei Konradi , Gary Probst , Danielle Aubele , Albert Garofalo , Roy Hom , Martin Neitzel , Christopher Semko , Anh Truong
IPC分类号： A61K31/435 , A61P25/00 , C07D471/00
CPC分类号： C07D471/04 , C07D471/14 , C07D487/14 , C07D495/14 , C07D513/14
摘要： The invention provides compounds of formula I: or pharmaceutically salts thereof where R1, R2, and the A, B, and C-rings are as defined herein. Compounds of formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's disease. The invention also encompasses pharmaceutical compositions comprising compounds or salts of formula I, methods of preparing the desired compounds, and methods of treating cognitive disorders, such as Alzheimer's disease, using the compounds or salts of formula I.
摘要翻译：本发明提供式I化合物或其药学上可接受的盐，其中R 1，R 2和A，B和C - 环如本文所定义。式I化合物可用于治疗或预防认知障碍，如阿尔茨海默病。本发明还包括使用式I化合物或其盐的药物组合物，其包含式I化合物或盐，制备所需化合物的方法，以及治疗认知障碍如阿尔茨海默氏病的方法。

5. 发明申请

US20070155753A1 5-(Arylsulfonyl)-Pyrazolopiperidines 失效
标题翻译： 5-（芳基磺酰基） - 吡唑并哌啶
公开(公告)号：US20070155753A1
公开(公告)日：2007-07-05
申请号：US11566070
申请日：2006-12-01
申请人： Xiaocong Ye , Albert Garofalo , Jacek Jagodzinski , Andrei Konradi , Christopher Semko , Jenifer Smith , Ying-zi Xu
发明人： Xiaocong Ye , Albert Garofalo , Jacek Jagodzinski , Andrei Konradi , Christopher Semko , Jenifer Smith , Ying-zi Xu
IPC分类号： A61K31/513 , A61K31/501 , A61K31/497 , A61K31/4745
CPC分类号： C07D491/04 , C07D211/96 , C07D471/04
摘要： The invention provides N-cyclic sulfonamido compounds of Formula I wherein A, B, R1, R1a, R2, R2a, R3 and R3a are as described in the specification. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of preparing compounds of formula I, and methods of treating cognitive disorders, such as Alzheimer's disease.
摘要翻译：本发明提供式I的N-环磺酰氨基化合物，其中A，B，R 1，R 1a，R 2，R 2， 2a，R 3和R 3a如说明书中所述。式I的化合物可用于治疗或预防认知障碍，例如阿尔茨海默病。本发明还包括包含式I化合物，制备式I化合物的方法和治疗认知障碍如阿尔茨海默氏病的方法的药物组合物。

6. 发明申请

US20070123531A1 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic acid (phenyl) amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases 审中-公开
标题翻译： 4-溴-5-（2-氯 - 苯甲酰基氨基）-1 - 吡唑-3-羧酸（苯基）酰胺衍生物和相关化合物作为缓激肽b1受体拮抗剂，用于治疗炎性疾病
公开(公告)号：US20070123531A1
公开(公告)日：2007-05-31
申请号：US10555508
申请日：2004-04-30
申请人： Albert Garofalo , Jay Tung , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , Jennifer Marugg , Martin Neitzel
发明人： Albert Garofalo , Jay Tung , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , Jennifer Marugg , Martin Neitzel
IPC分类号： A61K31/5377 , A61K31/4709 , A61K31/4439 , A61K31/416 , A61K31/4178 , A61K31/427 , A61K31/423 , C07D413/02 , C07D417/02 , C07D405/02 , C07D403/02
CPC分类号： C07D401/12 , C07D231/16 , C07D231/40 , C07D403/12 , C07D417/12
摘要： Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
摘要翻译：公开了缓激肽B1受体拮抗剂的化合物，可用于治疗由缓激肽B1受体介导的哺乳动物中疾病或与疾病状况相关的不良症状。某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。

7. 发明授权

US07759382B2 Acylated amino acid amidyl pyrazoles and related compounds 失效
标题翻译：酰化氨基酸氨基吡唑和相关化合物
公开(公告)号：US07759382B2
公开(公告)日：2010-07-20
申请号：US10559823
申请日：2004-06-04
申请人： Jay S. Tung , Lee H. Latimer , Jing Wu , Albert Garofalo , Michael A. Pleiss , Darren Dressen , Ashley Guinn , Scott A. Jenkins , Jennifer Sealy , John Tucker , David W. G. Wone
发明人： Jay S. Tung , Lee H. Latimer , Jing Wu , Albert Garofalo , Michael A. Pleiss , Darren Dressen , Ashley Guinn , Scott A. Jenkins , Jennifer Sealy , John Tucker , David W. G. Wone
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D231/40 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/12
摘要： This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula I. The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhibiting β-amyloid peptide release and/or synthesis, a method for inhibiting γ-secretase activity, and a method for treating neurological disorders associated with β-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula I. The compounds of Formula I are useful in the prevention and treatment of Alzheimer's disease.
摘要翻译：本发明涉及酰化氨基酸酰氨基吡唑和式I的相关化合物。本发明还涉及包含这种化合物或其药学上可接受的盐形式的药物组合物。本发明进一步涉及一种抑制β-淀粉样蛋白肽释放和/或合成的方法，一种抑制γ-分泌酶活性的方法，以及用于治疗与β-淀粉样蛋白肽生产相关的神经障碍的方法。该方法包括向宿主施用包含有效量的式I化合物的药物制剂。式I化合物可用于预防和治疗阿尔茨海默氏病。

8. 发明申请

US20070049612A1 Bridged N-Cyclic Sulfonamido Inhibitors of Gamma Secretase 失效
标题翻译：桥联N环磺酰胺抑制剂的γ分泌酶
公开(公告)号：US20070049612A1
公开(公告)日：2007-03-01
申请号：US11465726
申请日：2006-08-18
申请人： Simeon Bowers , Albert Garofalo , Roy Hom , Andrei Konradi , Matthew Mattson , Martin Neitzel , Christopher Semko , Anh Truong , Jing Wu , Ying-zi Xu
发明人： Simeon Bowers , Albert Garofalo , Roy Hom , Andrei Konradi , Matthew Mattson , Martin Neitzel , Christopher Semko , Anh Truong , Jing Wu , Ying-zi Xu
IPC分类号： A61K31/4745 , A61K31/46 , C07D451/02
CPC分类号： C07D451/14 , C07D471/08 , C07D471/18 , C07D471/22 , C07D498/08
摘要： The invention provides N-cyclic sulfonamido compounds and salts of Formula I: wherein A is as described in the specification and R1 and R2 combine to form a [3.3.1] or a [3.2.1] ring system, where the nitrogen is attached to the two bridgehead carbons, and the [3.3.1] or [3.2.1] ring systems are optionally fused with an heteroaryl or heterocycloalkyl ring. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's Disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of treating cognitive disorders, such as Alzheimer's disease, and the intermediates useful in preparing the compounds of Formula I.
摘要翻译：本发明提供N-环磺酰氨基化合物和式I的盐：其中A如说明书中所述，R 1和R 2 2结合形成[3.3.1 ]或[3.2.1]环体系，其中氮连接到两个桥头堡碳上，并且[3.3.1]或[3.2.1]环体系任选地与杂芳基或杂环烷基环稠合。式I的化合物可用于治疗或预防认知障碍，例如阿尔茨海默病。本发明还包括含有式I化合物的药物组合物，治疗认知障碍的方法，例如阿尔茨海默氏病，以及可用于制备式I化合物的中间体。

9. 发明申请

US20070161633A1 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carboxylic acid (1-aminocarbonyl)eth-1-yl) amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases 审中-公开
标题翻译： 4-溴-5-（2-氯 - 苯甲酰基氨基）-1 - 吡唑-3-羧酸（1-氨基羰基）乙-1-基）酰胺衍生物和相关化合物作为缓激肽b1受体拮抗剂，用于治疗炎性疾病
公开(公告)号：US20070161633A1
公开(公告)日：2007-07-12
申请号：US10555515
申请日：2004-04-30
申请人： Jay Tung , Albert Garofalo , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , Jennifer Marugg , Martin Neitzel
发明人： Jay Tung , Albert Garofalo , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , Jennifer Marugg , Martin Neitzel
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/454 , A61K31/4152 , C07D413/02 , C07D403/02
CPC分类号： C07D401/14 , C07D231/16 , C07D231/40 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08
摘要： Disclosed are compounds of formulae (I) and (II) that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action. Wherein Z is selected from O, S and NH; Q of formula (III) and the other substituents are as defined in claim 1.
摘要翻译：公开了缓激肽B 1受体拮抗剂的式（I）和（II）化合物，并且可用于治疗由缓激肽B介导的哺乳动物中的疾病或减轻与疾病相关的不良症状B _{1 受体。某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。其中Z选自O，S和NH; 式（III）的Q和其它取代基如权利要求1中所定义。}

10. 发明申请

US20050038099A1 Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists 审中-公开
标题翻译：取代的吡唑衍生物和相关化合物作为缓激肽B1受体拮抗剂
公开(公告)号：US20050038099A1
公开(公告)日：2005-02-17
申请号：US10836929
申请日：2004-04-30
申请人： Jay Tung , Albert Garofalo , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , Jennifer Marugg , Martin Neitzel
发明人： Jay Tung , Albert Garofalo , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , Jennifer Marugg , Martin Neitzel
IPC分类号： A61P29/00 , C07D231/16 , C07D231/40 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08 , A61K31/416 , A61K31/4152
CPC分类号： C07D401/14 , C07D231/16 , C07D231/40 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D487/08
摘要： Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
摘要翻译：公开了缓激肽B1受体拮抗剂的化合物，可用于治疗由缓激肽B1受体介导的哺乳动物中疾病或与疾病状况相关的不良症状。某些化合物表现出增加的效力，并且还预期表现出增加的作用持续时间。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式