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1. 发明授权

US06828091B2 Method of identifying immunosuppressive agents 失效
标题翻译：识别免疫抑制剂的方法
公开(公告)号：US06828091B2
公开(公告)日：2004-12-07
申请号：US09920332
申请日：2001-08-02
申请人： Shailaja Kasibhatla , Douglas R. Green , Ben Tseng
发明人： Shailaja Kasibhatla , Douglas R. Green , Ben Tseng
IPC分类号： C12Q125
CPC分类号： G01N33/505
摘要： A method for identifying therapeutically effective immunosuppressive agents by screening such agents for those which induce apoptosis in activated T cells is disclosed. T cells were isolated then activated and treating with various test compounds. A caspase substrate is added to detect caspase activation and apoptosis in the cells. Compounds which stimulate caspase activation and apoptosis are also tested against resting T cells to determine those agents which are more effective in activated T cells compared to resting T cells. Compounds with this selectivity are effective in treating immunopathological disorders such as arthritis, graft rejection, graft versus host disease, inflammatory bowel syndrome and the like.
摘要翻译：公开了通过筛选诱导活化的T细胞凋亡的那些试剂来鉴定治疗有效的免疫抑制剂的方法。分离T细胞，然后活化并用各种试验化合物处理。加入半胱天冬酶底物以检测细胞中的半胱天冬酶活化和细胞凋亡。还针对静息T细胞测试刺激半胱天冬酶活化和凋亡的化合物，以确定与静息T细胞相比在活化的T细胞中更有效的那些试剂。具有这种选择性的化合物在治疗免疫病理学疾病如关节炎，移植排斥反应，移植物抗宿主病，炎性肠综合征等方面是有效的。

2. 发明授权

US08718678B2 Selective delivery of presence messages for wireless communication devices 有权
标题翻译：无线通信设备的存在消息的选择性传递
公开(公告)号：US08718678B2
公开(公告)日：2014-05-06
申请号：US12389448
申请日：2009-02-20
申请人： Douglas R. Green , Jeremy R. Breau
发明人： Douglas R. Green , Jeremy R. Breau
IPC分类号： H04W24/00
CPC分类号： H04W4/02 , H04L67/24 , H04L67/28 , H04W4/12
摘要： What is disclosed is a method for communicating a presence message from a presence server to a monitoring wireless communication device, wherein the presence message indicates a location-oriented status of a monitored wireless communication device. The method includes receiving the presence message from the presence server and determining if the monitoring wireless communication device is in an active mode. If the monitoring wireless communication device is in the active mode, the method includes transferring the presence message for delivery to the monitoring wireless communication device. If the monitoring wireless communication device is not in the active mode, the method includes applying filtering characteristics to the presence message, creating summary data of the presence message, and transferring the summary data of the presence message for delivery to the monitoring wireless communication device once the monitoring wireless communication device enters the active mode.
摘要翻译：所公开的是一种用于将存在消息从存在服务器传送到监控无线通信设备的方法，其中所述存在消息指示所监视的无线通信设备的面向位置的状态。该方法包括从存在服务器接收存在消息并确定监控无线通信设备是否处于活动模式。如果监视无线通信设备处于活动模式，则该方法包括传送用于传送到监视无线通信设备的存在消息。如果监控无线通信设备不处于活动模式，则该方法包括对存在消息应用过滤特征，创建存在消息的汇总数据，以及将存在消息的汇总数据传送给监控无线通信设备一次监控无线通信设备进入活动模式。

3. 发明授权

US08463896B2 Dynamic portal creation based on personal usage 有权
标题翻译：基于个人使用的动态门户创建
公开(公告)号：US08463896B2
公开(公告)日：2013-06-11
申请号：US12188659
申请日：2008-08-08
申请人： Jeremy R. Breau , Robert Pippert , Douglas R. Green , Lyle W. Paczkowski , Samuel M. Woleben
发明人： Jeremy R. Breau , Robert Pippert , Douglas R. Green , Lyle W. Paczkowski , Samuel M. Woleben
IPC分类号： G06F15/173 , G06F15/16 , G06F3/048 , G06Q30/00
CPC分类号： G06F17/30864 , G06F17/30873
摘要： Methods, media and systems are provided for generating a dynamic web portal in a wireless network, and the portal is based on personal usage. An initialized portal contains no web content. Systems include one or more network elements configured to monitor requests for resource components, to generate web portals, and to dynamically update the portals based on the requests for resource components. Data structures embodied on a computer-readable media are included for storing numerical data regarding the requests and for storing a plurality of portals. The dynamic web portal is updated to contain component resources from visited web pages, each having a respective universal resource locator (URL) or portion of code with which it is associated. Requests for resources are monitored and added to a web portal when a specified threshold is surpassed so that an updated web portal can be presented.
摘要翻译：提供方法，媒体和系统用于在无线网络中生成动态门户网站，门户网站基于个人使用。初始化的门户不包含Web内容。系统包括被配置为监视对资源组件的请求，生成web门户以及基于对资源组件的请求来动态地更新门户的一个或多个网络元件。包括体现在计算机可读介质上的数据结构被包括用于存储有关请求的数字数据和用于存储多个门户。动态门户网站被更新为包含来自访问网页的组件资源，每个都具有相应的通用资源定位符（URL）或与其相关联的代码部分。监视资源请求，并在超过指定的阈值时添加到门户网站，以便可以呈现更新的门户网站。

4. 发明授权

US08135382B1 Billing and OAM function integration in a mixed-switching environment 有权
标题翻译：计费和OAM功能集成在混合交换环境中
公开(公告)号：US08135382B1
公开(公告)日：2012-03-13
申请号：US12132599
申请日：2008-06-03
申请人： Douglas R. Green , Bejoy Pankajakshan , Randy Hiser
发明人： Douglas R. Green , Bejoy Pankajakshan , Randy Hiser
IPC分类号： H04M11/00 , H04W4/00
CPC分类号： H04L12/1403 , H04M15/41 , H04M15/43 , H04M15/44 , H04M15/55 , H04M15/62
摘要： Methods, systems, and media are provided for interfacing components in a wireless telecommunications network. An interface allows for the efficient transfer of data that facilitates billing and operations functions. This data is transferred from proxy gateways to application servers to servers that provide billing functions and operations, administration, and management (OAM) functions. The interface enables the transmission by communicating a mobile switching center code, a proxy identifier, a traffic restriction flag, and a packet data unit type. By aggregating this information at the application server into a useful form for devices used in billing and operations, information technology (IT) overhead for billing and operations systems support is reduced. Also lowered is the congestion present on the network, as fewer links are necessary between servers and proxies. The proxy gateway is situated between a circuit-switched network providing access services and a packet-switched network providing connectivity services. The gateway also is coupled to an application server on the packet-switched network.
摘要翻译：提供了用于在无线电信网络中对接组件的方法，系统和媒体。一个接口允许有效传输数据，便于计费和操作功能。该数据从代理网关传输到应用程序服务器，提供计费功能和操作，管理和管理（OAM）功能的服务器。该接口通过传送移动交换中心码，代理标识符，交通限制标志和分组数据单元类型来实现发送。通过将应用服务器上的此信息聚合成用于计费和操作的设备的有用形式，减少了用于计费和操作系统支持的信息技术（IT）开销。网络上的拥塞也降低了，因为服务器和代理之间链路的需求较少。代理网关位于提供接入服务的电路交换网络和提供连接服务的分组交换网络之间。网关还耦合到分组交换网络上的应用服务器。

5. 发明申请

US20110038855A1 TRAIL AND METHODS OF MODULATING T CELL ACTIVITY AND ADAPTIVE IMMUNE RESPONSES USING TRAIL 审中-公开
标题翻译： TRAIL和调节细胞活性的方法和使用TRAIL的自适应免疫应答
公开(公告)号：US20110038855A1
公开(公告)日：2011-02-17
申请号：US12417487
申请日：2009-04-02
申请人： Stephen P. Schoenberger , Douglas R. Green , Edith M. Janssen , Nathalie M. Droin
发明人： Stephen P. Schoenberger , Douglas R. Green , Edith M. Janssen , Nathalie M. Droin
IPC分类号： A61K39/395 , C12N5/0783 , A61P37/00 , A61P25/00
CPC分类号： C07K16/2875 , C07K16/2878
摘要： Methods of modulating a T cell response are provided. Methods include, among other things, contacting a T cell that expresses TNF-related apoptosis-inducing ligand (TRAIL, Apo-2L) or TRAIL receptor (DR4 or DR5) with a molecule that binds to TRAIL (Apo-2L), a molecule that binds to TRAIL receptor (DR4 or DR5), or with a soluble TRAIL (Apo-2L) reagent.
摘要翻译：提供调节T细胞应答的方法。方法包括使表达TNF相关凋亡诱导配体（TRAIL，Apo-2L）或TRAIL受体（DR4或DR5）的T细胞与结合TRAIL（Apo-2L）的分子，分子其结合TRAIL受体（DR4或DR5）或可溶性TRAIL（Apo-2L）试剂。

6. 发明授权

US09373091B1 Method and system of providing vending service 有权
标题翻译：提供售货服务的方法和系统
公开(公告)号：US09373091B1
公开(公告)日：2016-06-21
申请号：US12054005
申请日：2008-03-24
申请人： John E. Belser , David U. McKinney , Timothy L. Swan , Douglas R. Green
发明人： John E. Belser , David U. McKinney , Timothy L. Swan , Douglas R. Green
IPC分类号： G06F7/08 , G06Q10/00
CPC分类号： G06Q10/00 , G06Q20/00 , G06Q20/32 , G06Q20/322 , G06Q20/3224 , G06Q20/3278 , G06Q30/0601
摘要： A method and system for providing a user of a wireless communication device (WCD) with vending service. The WCD may present the user with data indicating items available for purchase from a vendor. The WCD may then receive the user's directive to order an item from the vendor. In response, the WCD may obtain data stored at a transponder in proximity to the WCD that indicates a location of the WCD. In one example, the transponder may be at a fixed location, such as by being affixed to a fixed object at a venue (e.g., a stadium seat), in which case the stored data may indicate the fixed location. The WCD may then send an order for the item and the obtained data to the vendor. In turn, the vendor may use the data to determine a location of the WCD and then deliver the item to the determined location.
摘要翻译：一种用于向无线通信设备（WCD）的用户提供自动售货服务的方法和系统。 WCD可向用户呈现指示可从供应商购买的物品的数据。然后，WCD可以接收用户的指令以从供应商订购料品。作为响应，WCD可以获得存储在指示WCD的位置的WCD附近的应答器处的数据。在一个示例中，应答器可以处于固定位置，例如通过在场地（例如，体育场座椅）上固定到固定对象，在这种情况下，存储的数据可以指示固定位置。然后，WCD可以向该供应商发送该项目的订单和所获得的数据。反过来，供应商可以使用数据来确定WCD的位置，然后将该物品交付到确定的位置。

7. 发明授权

US08175614B1 Method and system for associating a location with a wireless modem 有权
标题翻译：将位置与无线调制解调器相关联的方法和系统
公开(公告)号：US08175614B1
公开(公告)日：2012-05-08
申请号：US12247285
申请日：2008-10-08
申请人： Douglas R. Green , Stevan A. Klesper , Manoj Monga , Lei Zhu , Wen Xue
发明人： Douglas R. Green , Stevan A. Klesper , Manoj Monga , Lei Zhu , Wen Xue
IPC分类号： H04W4/00 , H04M1/00 , H04M3/42 , H04B7/00 , H04J1/02
CPC分类号： H04W64/00 , H04M3/42348 , H04W4/90
摘要： There is disclosed herein a method, system and computer software product for associating a location with a wireless modem, wherein the modem has a modem identifier and a registered address associated therewith and wherein the method comprises: receiving a communication transmitted by the modem wherein the communication includes the modem identifier; determining whether the base station first receiving the communication is located within a predetermined proximity of the registered address; associating with the communication a receiving base station identifier of the base station that first received the communication; associating with the registered address a registered address base station identifier associated therewith; and comparing the registered address base station identifier with the receiving base station identifier.
摘要翻译：这里公开了一种用于将位置与无线调制解调器相关联的方法，系统和计算机软件产品，其中调制解调器具有调制解调器标识符和与其相关联的注册地址，并且其中该方法包括：接收由调制解调器发送的通信，其中通信包括调制解调器标识符; 确定所述基站首先接收所述通信是否位于所述注册地址的预定接近度内; 与所述通信相关联的是首先接收到所述通信的所述基站的接收基站标识符; 与注册地址相关联的与其相关联的注册地址基站标识符; 以及将注册的地址基站标识符与接收基站标识符进行比较。

8. 发明授权

US08060121B1 Mobile network presence service with load-based notification throttling 有权
标题翻译：移动网络存在服务与基于负载的通知限制
公开(公告)号：US08060121B1
公开(公告)日：2011-11-15
申请号：US11935983
申请日：2007-11-06
申请人： Yaojun Sun , Jing Qu , Joseph Schaedler , Wei-Ming Lan , Douglas R. Green
发明人： Yaojun Sun , Jing Qu , Joseph Schaedler , Wei-Ming Lan , Douglas R. Green
IPC分类号： H04W68/00
CPC分类号： H04L67/24 , H04W4/00 , H04W28/18 , H04W68/00
摘要： Methods and systems are described for providing a presence service that is particularly useful for mobile telecommunications devices. A plurality of outgoing presence updates are sent to a presence client. The system monitors the level of network traffic and determines whether the client is in a region of high network load. If the client is in a region experiencing a condition of high network load, the system throttles the outgoing presence updates during the condition of high network load. The level of throttling may depend at least in part on the amount of time that has elapsed since the presence client began a presence session, and/or the amount of time that has elapsed since an incoming presence update was received from the presence client. In determining the latter amount of elapsed time, the system may consider only the amount of time elapsed since an incoming non-automatic presence update was received from the presence client. When presence updates are throttled, the may schedule presence updates such that at least a minimum delay period elapses between consecutive updates to a particular client.
摘要翻译：描述了用于提供对移动电信设备特别有用的在线服务的方法和系统。多个出站存在更新被发送到存在客户端。系统监控网络流量级别，并确定客户端是否处于网络负载高的区域。如果客户端处于遇到高网络负载状况的区域，系统会在高网络负载的情况下阻止外出存在更新。节流等级至少部分地取决于从出席客户端开始呈现会话以来经过的时间量和/或从存在客户端接收到入场存在更新以来经过的时间量。在确定经过时间的后一个量时，系统可以仅考虑从存在客户端接收到进入的非自动存在更新所经过的时间量。当存在更新被限制时，可以调度存在更新，使得在对特定客户端的连续更新之间经过至少最小延迟时间段。

9. 发明授权

US07864048B1 Device location transition awareness in a wireless modem 有权
标题翻译：无线调制解调器中的设备位置转换意识
公开(公告)号：US07864048B1
公开(公告)日：2011-01-04
申请号：US11862768
申请日：2007-09-27
申请人： Warren B. Cope , Douglas R. Green
发明人： Warren B. Cope , Douglas R. Green
IPC分类号： G08B13/14
CPC分类号： H04M7/0069 , H04L67/18 , H04M2242/04 , H04M2242/30 , H04W4/02 , H04W4/023 , H04W4/20 , H04W4/90 , H04W64/00 , H04W76/50
摘要： A method is provided in a communication system for determining a relative position change of a wireless modem. The first location of the wireless modem is determined, and then the wireless modem reports the first location to a service node. A dead reckoning device within the wireless modem then determines a second location of the wireless modem. If the second location is greater than a predetermined distance from the first location, then the wireless modem reports the second location to the service node.
摘要翻译：在用于确定无线调制解调器的相对位置变化的通信系统中提供了一种方法。确定无线调制解调器的第一位置，然后无线调制解调器向服务节点报告第一位置。无线调制解调器内的航位推算装置然后确定无线调制解调器的第二位置。如果第二位置大于距离第一位置的预定距离，则无线调制解调器向服务节点报告第二位置。

10. 发明申请

US20100036933A1 Dynamic Portal Creation Based on Personal Usage 有权
标题翻译：基于个人使用的动态门户创建
公开(公告)号：US20100036933A1
公开(公告)日：2010-02-11
申请号：US12188659
申请日：2008-08-08
申请人： Jeremy R. Breau , Robert Pippert , Douglas R. Green , Lyle W. Paczkowski , Samuel M. Woleben
发明人： Jeremy R. Breau , Robert Pippert , Douglas R. Green , Lyle W. Paczkowski , Samuel M. Woleben
IPC分类号： G06F15/16
CPC分类号： G06F17/30864 , G06F17/30873
摘要： Methods, media and systems are provided for generating a dynamic web portal in a wireless network, and the portal is based on personal usage. An initialized portal contains no web content. Systems include one or more network elements configured to monitor requests for resource components, to generate web portals, and to dynamically update the portals based on the requests for resource components. Data structures embodied on a computer-readable media are included for storing numerical data regarding the requests and for storing a plurality of portals. The dynamic web portal is updated to contain component resources from visited web pages, each having a respective universal resource locator (URL) or portion of code with which it is associated. Requests for resources are monitored and added to a web portal when a specified threshold is surpassed so that an updated web portal can be presented.
摘要翻译：提供方法，媒体和系统用于在无线网络中生成动态门户网站，门户网站基于个人使用。初始化的门户不包含Web内容。系统包括被配置为监视对资源组件的请求，生成web门户以及基于对资源组件的请求来动态地更新门户的一个或多个网络元件。包括体现在计算机可读介质上的数据结构被包括用于存储有关请求的数字数据和用于存储多个门户。动态门户网站被更新为包含来自访问网页的组件资源，每个都具有相应的通用资源定位符（URL）或与其相关联的代码部分。监视资源请求，并在超过指定的阈值时添加到门户网站，以便可以呈现更新的门户网站。

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