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    • 1. 发明申请
    • Automated non-invasive real-time acute renal failure detection system
    • 自动非侵入性实时急性肾功能衰竭检测系统
    • US20060100743A1
    • 2006-05-11
    • US11113212
    • 2005-04-22
    • Seth TownsendChristopher KomanskiRichard BoyerNathan TedfordDerek FineRobert Star
    • Seth TownsendChristopher KomanskiRichard BoyerNathan TedfordDerek FineRobert Star
    • G05D21/00
    • A61B5/201A61B5/14507A61B5/208A61B5/412
    • A real-time, non-invasive system and method for determining the level of an analyte of interest in the urine of a patient is disclosed. The system and method uses the measured level of an analyte of interest to detect the onset of acute renal failure (ARF) as early as possible to prevent that patient from developing the disease or mitigating the effects of the disease. The system and method may be used to monitor the recovery of a patient after an ARF diagnosis. Preferably, the analyte of interest is creatinine or urea. The system may be placed in the urine drain line of a patient between a Foley catheter or other urinary drain and a urine collection bag. The system makes substantially continuous measurements of the urine flow rate and the concentration of the analyte of interest to determine the mass excretion rate of the analyte so it may be monitored to detect if the patient experiences a delta change in the mass excretion rate of an analyte that is indicative of the onset of ARF or a change in renal function.
    • 公开了一种用于确定患者尿液中感兴趣的分析物的水平的实时非侵入性系统和方法。 系统和方法使用目标分析物的测量水平尽可能早地检测急性肾功能衰竭(ARF)的发作,以防止该患者发展疾病或减轻疾病的影响。 该系统和方法可以用于在ARF诊断之后监视患者的恢复。 优选地,感兴趣的分析物是肌酸酐或尿素。 该系统可以放置在患有Foley导尿管或其它排尿管和尿液收集袋之间的尿液排泄管线中。 该系统基本上连续地测量尿液流速和感兴趣的分析物的浓度,以确定分析物的质量排泄速率,以便可以对其进行监测,以检测患者是否经历分析物质量排泄速率的δ变化 这表明ARF的发生或肾功能的变化。