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1. 发明申请

WO2019108641A1 ANALYTE INDICATOR INTEGRATED WITH A CATALYTICALLY ACTIVE MATERIAL 审中-公开
公开(公告)号：WO2019108641A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/062831
申请日：2018-11-28
申请人： SENSEONICS, INCORPORATED
发明人： MORTELLARO, Mark , HUFFSTETLER, Philip , KIM, Tina HyunJung , MOHANTY, Sanat
IPC分类号： A61B5/145 , A61B5/00 , G01N31/22
CPC分类号： A61B5/14865 , A61B5/076 , A61B5/14532 , A61B5/1459 , A61B2562/125 , A61B2562/162
摘要： An analyte sensor may include a sensor housing and an analyte indicator element embedded within and/or covering at least a portion of the sensor housing. The analyte indicator element may include a porous base having an interior surface and an exterior surface. The analyte indicator may include a catalytically active material disposed on at least one of the interior and exterior surfaces of the porous base, in which the catalytically active material catalyzes the degradation of reactive oxygen species. The analyte indicator may include a polymer unit polymerized onto or out of the porous base and an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit.

2. 发明申请

WO2014186727A1 OPACITY CONSISTENT POLYMER GRAFT FOR OPTICAL SENSOR 审中-公开
标题翻译：光学传感器的一致性聚合物光栅
公开(公告)号：WO2014186727A1
公开(公告)日：2014-11-20
申请号：PCT/US2014/038432
申请日：2014-05-16
申请人： SENSEONICS, INCORPORATED
发明人： WHITEHURST, Todd , HUFFSTETLER, Philip
IPC分类号： G01N33/48 , G01N21/64
CPC分类号： A61B5/1455 , A61B5/0031 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B2562/162
摘要： A sensor ( e.g. , an optical sensor) that may be placed within a living animal ( e.g ., a human) and may be used to measure an analyte ( e.g ., glucose or oxygen) in a medium ( e.g. , interstitial fluid) within the animal. The sensor may include a sensor housing and a polymer graft including indicator molecules and covering at least a portion of the sensor housing. The opacity of the polymer graft may remain substantially the same ( i. e ., may have little or no variation) over time. The sensor may include a photodetector, and variation in the opacity of the polymer graft does not cause a significant change in a measurement signal output by the photodetector. The polymer hydrogel may be made of polymers including acrylic acid and/or polyethylene glycol.
摘要翻译：可以放置在活的动物（例如人）内的传感器（例如，光学传感器），并且可以用于测量动物中的介质（例如，间质液）中的分析物（例如，葡萄糖或氧）。传感器可以包括传感器外壳和聚合物移植物，其包括指示剂分子并且覆盖传感器外壳的至少一部分。随着时间的推移，聚合物移植物的不透明度可以保持基本上相同（即，可能具有很小或没有变化）。传感器可以包括光电检测器，并且聚合物移植物的不透明度的变化不会导致由光电检测器输出的测量信号的显着变化。聚合物水凝胶可以由包括丙烯酸和/或聚乙二醇的聚合物制成。

3. 发明申请

WO2016014800A1 FABRICATION OF A FLUORESCENT MATERIAL FOR SENSING AN ANALYTE 审中-公开
标题翻译：用于感应分析仪的荧光材料的制造
公开(公告)号：WO2016014800A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/041739
申请日：2015-07-23
申请人： SENSEONICS, INCORPORATED
发明人： HUFFSTETLER, Philip , EMKEN, Jeremy , WHITEHURST, Todd
IPC分类号： C12M1/30 , C12M3/00
CPC分类号： G01N21/6428 , G01N21/77 , G01N31/22 , G01N33/544 , G01N33/582 , G01N2021/773 , G01N2021/7786
摘要： An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.
摘要翻译：分析物指示剂可以包括多孔基底，并且可以包括在分析物传感器中。分析物指示剂可在压缩存在的情况下保持其物理，化学和光学性质。多孔基底可以不透明度变化。分析物指示剂可以包括（i）在多孔基底上连接或聚合的聚合物单元和（ii）附着到聚合物单元上或与聚合物单元共聚的分析物感测元件。分析物感测元件可以包括一个或多个指示剂分子。分析物感测元件可以包括一个或多个指示剂聚合物链。分析物指示剂可以包括（i）在多孔基底上连接或聚合的指示剂聚合物链，和（ii）附着于指示剂聚合物链的指示剂分子。

4. 发明申请

WO2023028572A1 MEDIATION OF IN VIVO ANALYTE SIGNAL DEGRADATION 审中-公开
公开(公告)号：WO2023028572A1
公开(公告)日：2023-03-02
申请号：PCT/US2022/075489
申请日：2022-08-26
申请人： SENSEONICS, INCORPORATED
发明人： CHATTERJEE, Joon , MOHANTY, Sanat , HUFFSTETLER, Philip , VELVADAPU, Venkata , TORRES JR, Leopoldo
IPC分类号： A61B5/1473 , A61B5/145 , G01N27/26 , G01N27/327
摘要： A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator.

5. 发明申请

WO2022251427A1 DETECTING AND CORRECTING FOR INTERFERENCE IN AN ANALYTE MONITORING SYSTEM 审中-公开
公开(公告)号：WO2022251427A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/031035
申请日：2022-05-26
申请人： SENSEONICS, INCORPORATED
发明人： DEHENNIS, Andrew , MORTELLARO, Mark , CHAVAN, Abhi , VELVADAPU, Venkata , HUFFSTETLER, Philip , MASCIOTTI, James , SANCHEZ, Patricia
IPC分类号： G01N35/00 , G01N33/66 , A61B5/1495 , A61B5/145 , A61B5/1455 , A61B5/1459 , G01N21/27
摘要： A sensor, system, and method for detecting and correcting for an effect on an analyte indicator of an analyte sensor. The analyte indicator may be configured to exhibit a first detectable property that varies in accordance with an analyte concentration and an effect on (e.g., degradation of) the analyte indicator. The analyte sensor may also include an interferent indicator configured to exhibit a second detectable property (e.g., absorption) that varies in accordance the effect on the analyte indicator. The analyte sensor may generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) an interferent measurement based on the second detectable property exhibited by the interferent indicator. The analyte sensor may be part of a system that also includes a transceiver. The transceiver may use the analyte and interferent measurements to calculate an analyte level.

6. 发明申请

WO2020172540A1 MEDIATION OF IN VIVO ANALYTE SIGNAL DEGRADATION 审中-公开
公开(公告)号：WO2020172540A1
公开(公告)日：2020-08-27
申请号：PCT/US2020/019238
申请日：2020-02-21
申请人： SENSEONICS, INCORPORATED
发明人： CHATTERJEE, Joon , MOHANTY, Sanat , HUFFSTETLER, Philip , VELVADAPU, Venkata
IPC分类号： A61B5/145 , G01N33/52 , G01N33/50
摘要： A sensor ( e.g. , an optical sensor) that may be implanted within a living animal ( e.g. , a human) and may be used to measure an analyte ( e.g. , glucose or oxygen) in a medium ( e.g. , interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator.

7. 发明申请

WO2020092897A1 DRUG ELUTING MATRIX ON ANALYTE INDICATOR 审中-公开
公开(公告)号：WO2020092897A1
公开(公告)日：2020-05-07
申请号：PCT/US2019/059384
申请日：2019-11-01
申请人： SENSEONICS, INCORPORATED
发明人： HUFFSTETLER, Philip , MOHANTY, Sanat , ATTWOOD, Robert
IPC分类号： A61B5/145 , A61B5/1473 , A61M37/00
摘要： A sensor that may be implanted within a living animal ( e.g. , a human) and may be used to measure an analyte ( e.g. , glucose or oxygen) in a medium ( e.g. , interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing and an analyte indicator covering at least a portion of the sensor housing. The sensor may include a drug-eluting matrix that covers at least a portion of the analyte indicator. The drug-eluting matrix may include one or more openings configured to allow the medium to pass through the drug-eluting matrix and come into contact with the analyte indicator. The sensor may include one or more therapeutic agents. The one or more therapeutic agents may reduce deterioration of the analyte indicator. The one or more therapeutic agents may be incorporated within the drug-eluting matrix.

8. 发明申请

WO2015073876A1 FLUORESCENCE-BASED SENSOR WITH MULTIPLE INDICATOR GRAFTS 审中-公开
标题翻译：基于荧光的传感器与多个指示器
公开(公告)号：WO2015073876A1
公开(公告)日：2015-05-21
申请号：PCT/US2014/065782
申请日：2014-11-14
申请人： SENSEONICS, INCORPORATED
发明人： EMKEN, Jeremy , HUFFSTETLER, Philip , WHITEHURST, Todd
IPC分类号： A61B5/145 , G01N21/63 , G01N21/64
CPC分类号： A61B5/14503 , A61B5/0031 , A61B5/1451 , A61B5/14532 , A61B5/14556 , A61B5/1459 , A61B5/1473 , A61B5/14735 , A61B5/6861 , A61B2560/0219 , A61B2560/0247 , G01N21/27 , G01N21/645 , G01N2021/6421 , G01N2021/6441
摘要： A system including a sensor and a transceiver and configured to determine a concentration of an analyte in a medium of a living animal. The sensor may include first and second signal photodetectors and first and second reference photodetectors, which may each be covered by an associate filter. The first photodetector may receive light emitted from first and second grafts, respectively. The grafts may receive excitation light from one or more light sources. The transceiver may receive signals from the photodetectors of the sensor and may determine the analyte concentration based on the received signals.
摘要翻译：一种包括传感器和收发器并且被配置为确定活动物体的介质中的分析物的浓度的系统。传感器可以包括第一和第二信号光电检测器以及可以由关联滤波器覆盖的第一和第二参考光电探测器。第一光电检测器可以分别接收从第一和第二移植物发射的光。移植物可以接收来自一个或多个光源的激发光。收发器可以从传感器的光电检测器接收信号，并且可以基于接收到的信号来确定分析物浓度。

9. 发明申请

WO2015027018A1 DRUG ELUTION FOR IN VIVO PROTECTION OF BIO-SENSING ANALYTES 审中-公开
标题翻译：生物感测分析仪的生物降解药物
公开(公告)号：WO2015027018A1
公开(公告)日：2015-02-26
申请号：PCT/US2014/052010
申请日：2014-08-21
申请人： SENSEONICS, INCORPORATED
发明人： HUFFSTETLER, Philip , EMKEN, Jeremy , WHITEHURST, Todd
IPC分类号： A61B5/1473
CPC分类号： A61B5/1459 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14542 , A61B5/14546 , A61B5/14556 , A61B5/1473 , A61B5/4839 , A61B5/6847 , A61M37/00 , A61M2205/3303 , A61M2205/3306 , A61M2230/005
摘要： A sensor ( e.g. , an optical sensor) that may be implanted within a living animal ( e.g. , a human) and may be used to measure an analyte ( e.g. , glucose or oxygen) in a medium ( e.g. , interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more therapeutic agents. The one or more therapeutic agents may reduce deterioration of the analyte indicator. The one or more therapeutic agents may be incorporated within the analyte indicator, a membrane covering at least a portion of the analyte indicator, and/or one or more drug eluting polymer matrices, which may be external to or within the sensor housing.
摘要翻译：可以植入活体动物（例如人）中的传感器（例如，光学传感器），并可用于测量介质中的分析物（例如，葡萄糖或氧气）（例如，间质液，血液或腹膜内液）。传感器可以包括传感器外壳，覆盖传感器外壳的至少一部分的分析物指示器和一种或多种治疗剂。一种或多种治疗剂可以减少分析物指示剂的劣化。一种或多种治疗剂可以并入分析物指示剂内，覆盖至少一部分分析物指示剂的膜，和/或一种或多种药物洗脱聚合物基质，其可以在传感器壳体的外部或内部。

10. 发明申请

WO2014106117A2 ANALYTE PERMEABLE MEMBRANE SYSTEMS FOR OXIDATIVE AND OPTICAL STABILITY 审中-公开
标题翻译：分析渗透膜系统的氧化和光稳定性
公开(公告)号：WO2014106117A2
公开(公告)日：2014-07-03
申请号：PCT/US2013/078103
申请日：2013-12-27
申请人： SENSEONICS, INCORPORATED
发明人： EMKEN, Jeremy , HUFFSTETLER, Philip , WHITEHURST, Todd
IPC分类号： A61B5/1459 , A61B5/145
CPC分类号： A61B5/14532 , A61B5/0031 , A61B5/1459 , A61B2562/162
摘要： A sensor that may be used to detect the presence, amount, and/or concentration of an analyte in a medium within an animal. The sensor may include a sensor housing, an indicator element embedded within and/or covering at least a portion of the sensor housing, and a membrane over the indicator element. The membrane may reduce indicator element deterioration by preventing immune cells, such as white blood cells, from contacting the indicator element, substantially prevent transmission of light of at least a specified wavelength or range of wavelengths through the membrane, and/or permit the analyte to pass through to the indicator element. The membrane may be an opaque diffusion membrane. The sensor may include a foil. The foil may block light and/or reduce indicator element deterioration. The membrane may reduce oxidation of the indicator element.
摘要翻译：可用于检测动物中的介质中分析物的存在，量和/或浓度的传感器。传感器可以包括传感器壳体，嵌入在传感器壳体的至少一部分内和/或覆盖传感器壳体的至少一部分的指示器元件以及指示器元件上的膜。膜可以通过防止诸如白细胞的免疫细胞接触指示剂元件来减少指示剂元件的劣化，从而基本上防止透过膜的至少一定波长或波长范围的光的透过，和/或允许分析物传递到指示元素。膜可以是不透明扩散膜。传感器可以包括箔。箔可能阻挡光和/或降低指示元件的劣化。膜可以减少指示元件的氧化。

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