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1. 发明申请

WO2014186727A1 OPACITY CONSISTENT POLYMER GRAFT FOR OPTICAL SENSOR 审中-公开
标题翻译：光学传感器的一致性聚合物光栅
公开(公告)号：WO2014186727A1
公开(公告)日：2014-11-20
申请号：PCT/US2014/038432
申请日：2014-05-16
申请人： SENSEONICS, INCORPORATED
发明人： WHITEHURST, Todd , HUFFSTETLER, Philip
IPC分类号： G01N33/48 , G01N21/64
CPC分类号： A61B5/1455 , A61B5/0031 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B2562/162
摘要： A sensor ( e.g. , an optical sensor) that may be placed within a living animal ( e.g ., a human) and may be used to measure an analyte ( e.g ., glucose or oxygen) in a medium ( e.g. , interstitial fluid) within the animal. The sensor may include a sensor housing and a polymer graft including indicator molecules and covering at least a portion of the sensor housing. The opacity of the polymer graft may remain substantially the same ( i. e ., may have little or no variation) over time. The sensor may include a photodetector, and variation in the opacity of the polymer graft does not cause a significant change in a measurement signal output by the photodetector. The polymer hydrogel may be made of polymers including acrylic acid and/or polyethylene glycol.
摘要翻译：可以放置在活的动物（例如人）内的传感器（例如，光学传感器），并且可以用于测量动物中的介质（例如，间质液）中的分析物（例如，葡萄糖或氧）。传感器可以包括传感器外壳和聚合物移植物，其包括指示剂分子并且覆盖传感器外壳的至少一部分。随着时间的推移，聚合物移植物的不透明度可以保持基本上相同（即，可能具有很小或没有变化）。传感器可以包括光电检测器，并且聚合物移植物的不透明度的变化不会导致由光电检测器输出的测量信号的显着变化。聚合物水凝胶可以由包括丙烯酸和/或聚乙二醇的聚合物制成。

2. 发明申请

WO2016191715A1 WIRELESS ANALYTE MONITORING 审中-公开
公开(公告)号：WO2016191715A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/034730
申请日：2016-05-27
申请人： SENSEONICS, INCORPORATED
发明人： RAISONI, Barkha , WHITEHURST, Todd , LONG, Christina , WALTERS, Steven , DEHENNIS, Andrew
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1459 , A61B5/155 , A61B5/157
CPC分类号： A61B5/002 , A61B5/0022 , A61B5/14503 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/6898 , A61B5/7221 , A61B5/7435 , A61B5/746 , A61B5/7475 , A61B5/749 , A61B5/7495 , A61B2562/0219 , A61M5/142 , A61M5/1723 , G06F19/00 , G16H40/67
摘要： A computing device receives analyte data produced by an analyte monitoring sensor over a communications link from at least one first device. Health data, comprising at least part of the analyte data, may be communicated over a communications link to at least one second device in response to a request. The first device may be positioned over the analyte monitoring sensor using signal strength and location information. External analyte data may be employed to calibrate the analyte monitoring sensor.

3. 发明申请

WO2016191710A1 WIRELESS ANALYTE MONITORING 审中-公开
标题翻译：无线分析监测
公开(公告)号：WO2016191710A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/034714
申请日：2016-05-27
申请人： SENSEONICS, INCORPORATED
发明人： RAISONI, Barkha , LERNER, David , LONG, Christina , CHEN, Oliver , WHITEHURST, Todd , RASTOGI, Ravi , DEHENNIS, Andrew
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1495 , G01N27/26 , G06F19/00
CPC分类号： A61B5/002 , A61B5/0022 , A61B5/14503 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/6898 , A61B5/7221 , A61B5/7435 , A61B5/746 , A61B5/7475 , A61B5/749 , A61B5/7495 , A61B2562/0219 , A61M5/142 , A61M5/1723 , G06F19/00 , G16H40/67
摘要： A computing device receives analyte data produced by an analyte monitoring sensor over a communications link from at least one first device. Health data, comprising at least part of the analyte data, may be communicated over a communications link to at least one second device in response to a request. The first device may be positioned over the analyte monitoring sensor using signal strength and location information. External analyte data may be employed to calibrate the analyte monitoring sensor.
摘要翻译：计算设备通过通信链路从至少一个第一设备接收由分析物监测传感器产生的分析物数据。包括分析物数据的至少一部分的健康数据可以响应于请求而通过通信链路传送到至少一个第二设备。可以使用信号强度和位置信息将第一装置定位在分析物监测传感器上方。外部分析物数据可用于校准分析物监测传感器。

4. 发明申请

WO2016191706A1 WIRELESS ANALYTE MONITORING 审中-公开
标题翻译：无线分析监控
公开(公告)号：WO2016191706A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/034708
申请日：2016-05-27
申请人： SENSEONICS, INCORPORATED
发明人： RAISONI, Barkha , MONTGOMERY, Barbara , WHITEHURST, Todd , ZHAO, Shang , PANLILIO, Mirasol , DEHENNIS, Andrew
IPC分类号： A61B5/145 , A61B5/1468 , A61B5/1473 , A61B5/1477
CPC分类号： A61B5/002 , A61B5/0022 , A61B5/14503 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/6898 , A61B5/7221 , A61B5/7435 , A61B5/746 , A61B5/7475 , A61B5/749 , A61B5/7495 , A61B2562/0219 , A61M5/142 , A61M5/1723 , G06F19/00 , G16H40/67
摘要： A computing device receives analyte data produced by an analyte monitoring sensor over a communications link from at least one first device. Health data, comprising at least part of the analyte data, may be communicated over a communications link to at least one second device in response to a request. The first device may be positioned over the analyte monitoring sensor using signal strength and location information. External analyte data may be employed to calibrate the analyte monitoring sensor.
摘要翻译：计算设备从至少一个第一设备通过通信链路接收由分析物监测传感器产生的分析物数据。包括至少部分分析物数据的健康数据可以响应于请求通过通信链路传送到至少一个第二设备。可以使用信号强度和位置信息将第一装置定位在分析物监测传感器上方。可以使用外部分析物数据来校准分析物监测传感器。

5. 发明申请

WO2014205205A1 A REMOTELY POWERED SENSOR WITH ANTENNA LOCATION INDEPENDENT OF SENSING SITE 审中-公开
标题翻译：遥感动力传感器，天线位置独立于感测现场
公开(公告)号：WO2014205205A1
公开(公告)日：2014-12-24
申请号：PCT/US2014/043165
申请日：2014-06-19
申请人： SENSEONICS, INCORPORATED
发明人： DEHENNIS, Andrew , WHITEHURST, Todd
IPC分类号： A61B5/145 , G01N21/64
CPC分类号： A61B5/0015 , A61B5/0031 , A61B5/14532 , A61B5/1455 , A61B5/1459 , A61B2560/0219 , A61B2562/162
摘要： A system and method for detecting the amount or concentration of an analyte in a medium in living organism. The system may include an analyte sensor module and a transmitter module, which may be separate and distinct components. The analyte sensor module and transmitter module may be at different locations but connected by one or more transmission elements. The analyte sensor may include indicator elements configured to exhibit a detectable property based on the amount or concentration of the analyte in proximity to the indicator elements. The analyte sensor may include sensor elements configured to generate a data signal based on the detectable property exhibited by the indicator elements. The transmission elements may be configured to convey data signals generated by the sensor elements from the analyte sensor module to the transmitter module. The transmitter module may include an antenna.
摘要翻译：用于检测活体中介质中分析物的量或浓度的系统和方法。该系统可以包括分析物传感器模块和发射器模块，其可以是分离的和不同的组件。分析物传感器模块和发射器模块可以在不同的位置处，而是由一个或多个传输元件连接。分析物传感器可以包括指示元件，其被配置为基于在指示元件附近的分析物的量或浓度来显示可检测的特性。分析物传感器可以包括被配置为基于由指示元件显示的可检测特性产生数据信号的传感器元件。传输元件可以被配置为将由传感器元件产生的数据信号从分析物传感器模块传送到发射器模块。发射机模块可以包括天线。

6. 发明申请

WO2016014800A1 FABRICATION OF A FLUORESCENT MATERIAL FOR SENSING AN ANALYTE 审中-公开
标题翻译：用于感应分析仪的荧光材料的制造
公开(公告)号：WO2016014800A1
公开(公告)日：2016-01-28
申请号：PCT/US2015/041739
申请日：2015-07-23
申请人： SENSEONICS, INCORPORATED
发明人： HUFFSTETLER, Philip , EMKEN, Jeremy , WHITEHURST, Todd
IPC分类号： C12M1/30 , C12M3/00
CPC分类号： G01N21/6428 , G01N21/77 , G01N31/22 , G01N33/544 , G01N33/582 , G01N2021/773 , G01N2021/7786
摘要： An analyte indicator may include a porous base and may be included in an analyte sensor. The analyte indicator may retain its physical, chemical, and optical properties in the presence of compression. The porous base may not vary in opacity. The analyte indicator may include (i) a polymer unit attached or polymerized onto or out of the porous base and (ii) an analyte sensing element attached to the polymer unit or copolymerized with the polymer unit. The analyte sensing element may include one or more indicator molecule. The analyte sensing element may include one or more indicator polymer chains. The analyte indicator may include (i) an indicator polymer chain attached or polymerized onto or out of the porous base and (ii) indicator molecules attached to the indicator polymer chain.
摘要翻译：分析物指示剂可以包括多孔基底，并且可以包括在分析物传感器中。分析物指示剂可在压缩存在的情况下保持其物理，化学和光学性质。多孔基底可以不透明度变化。分析物指示剂可以包括（i）在多孔基底上连接或聚合的聚合物单元和（ii）附着到聚合物单元上或与聚合物单元共聚的分析物感测元件。分析物感测元件可以包括一个或多个指示剂分子。分析物感测元件可以包括一个或多个指示剂聚合物链。分析物指示剂可以包括（i）在多孔基底上连接或聚合的指示剂聚合物链，和（ii）附着于指示剂聚合物链的指示剂分子。

7. 发明申请

WO2015021273A1 ANALYTE SENSOR TRANSCEIVER CONFIGURED TO PROVIDE TACTILE, VISUAL, AND / OR AURAL FEEDBACK 审中-公开
标题翻译：分析传感器收发器配置为提供触觉，视觉和/或AURAL反馈
公开(公告)号：WO2015021273A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/050141
申请日：2014-08-07
申请人： SENSEONICS INCORPORATED
发明人： TANKIEWICZ, Szymon , EMKEN, Jeremy , DEHENNIS, Andrew , WHITEHURST, Todd
IPC分类号： A61B5/145
CPC分类号： A61B5/14503 , A61B5/0031 , A61B5/14532 , A61B5/7455 , A61B5/746
摘要： A transceiver for interfacing with an analyte sensor. The transceiver may include an interface device and a notification device. The interface device may be configured to convey a power signal to the analyte sensor and to receive data signals from the analyte sensor. The notification device may be configured to generate one or more of a vibrational, aural, and visual signal based on one or more data signals received from the analyte sensor. The interface device of the transceiver may receive analyte data from the analyte sensor, and the transceiver may comprise a processor configured to calculate an analyte concentration value based on the received analyte data. The notification device may be configured to generate one or more of aural, visual, or vibrational alarm when the calculated analyte concentration value exceeds or falls below a threshold value.
摘要翻译：用于与分析物传感器接口的收发器。收发器可以包括接口设备和通知设备。接口装置可以被配置为将功率信号传送到分析物传感器并且从分析物传感器接收数据信号。通知装置可以被配置为基于从分析物传感器接收的一个或多个数据信号来生成振动，听觉和视觉信号中的一个或多个。收发器的接口设备可以从分析物传感器接收分析物数据，并且收发器可以包括被配置为基于接收的分析物数据计算分析物浓度值的处理器。通知装置可以被配置为当所计算的分析物浓度值超过或低于阈值时产生听觉，视觉或振动报警中的一个或多个。

8. 发明申请

WO2015021269A1 A CO-PLANAR, NEAR FIELD COMMUNICATION TELEMETRY LINK FOR AN ANALYTE SENSOR 审中-公开
标题翻译：一个CO-PLANAR，用于分析仪传感器的近场通信电话链路
公开(公告)号：WO2015021269A1
公开(公告)日：2015-02-12
申请号：PCT/US2014/050136
申请日：2014-08-07
申请人： SENSEONICS, INCORPORATED
发明人： TANKIEWICZ, Szymon , SCHAEFER, Joshua , DEHENNIS, Andrew , WHITEHURST, Todd
IPC分类号： A61B5/145
CPC分类号： A61B5/0031 , A61B5/0004 , A61B5/002 , A61B5/14503 , A61B5/14532 , A61B5/14556 , A61B5/1459
摘要： An inductive sensor system for remote powering and communication with an analyte sensor (e.g., a fully implantable analyte sensor). The system may include an analyte sensor and transceiver. The system may be ferrite-enhanced. The transceiver may implement a passive telemetry for communicating with the analyte sensor via an inductive magnetic link for both power and data transfer. The link may be a co-planar, near field communication telemetry link. The transceiver may include a reflection plate configured to focus flux lines linking the transceiver and the sensor uniformly beneath the transceiver. The transceiver may include an amplifier configured to amplify battery power and provide radio frequency (RF) power to a transceiver antenna.
摘要翻译：用于远程供电和与分析物传感器（例如，完全可植入的分析物传感器）通信的感应传感器系统。该系统可以包括分析物传感器和收发器。该系统可以是铁氧体增强的。收发器可以实现用于通过用于电力和数据传输的感应磁链路与分析物传感器通信的无源遥测。链路可以是共面的近场通信遥测链路。收发器可以包括反射板，该反射板被配置为将收发器和传感器均匀地聚集在收发器之下的磁通线。收发器可以包括被配置为放大电池功率并且向收发器天线提供射频（RF）功率的放大器。

9. 发明申请

WO2014144514A2 IMPROVED IMPLANTATION AND ANTENNA ORIENTATION OF AN IMPLANTABLE SENSOR 审中-公开
标题翻译：改进可植入传感器的植入和天线方向
公开(公告)号：WO2014144514A2
公开(公告)日：2014-09-18
申请号：PCT/US2014/028956
申请日：2014-03-14
申请人： SENSEONICS, INCORPORATED
发明人： TANKIEWICZ, Szymon , WHITEHURST, Todd
IPC分类号： B29C67/00
CPC分类号： A61B5/686 , A61B5/0015 , A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/1459 , H04B5/00 , H04B5/0043 , H04B5/0087
摘要： A sensor system including an implantable sensor and an external transceiver. Aspects of the sensor system may provide improved implantation and antenna orientation of the implanted sensor. The sensor may include a sensor antenna, the transceiver may include a transceiver antenna. In some embodiments, the sensor antenna and/or transceiver antenna may include a first set of coils oriented in a first plane and a second set of coils oriented in a second plane that is different than the first plane. In some embodiments, the sensor may have a geometry that will prevent or reduce movement and/or rotation of the implanted sensor. For instance, in some embodiments, the sensor may be enclosed in silicon that contains antenna coils and/or include wings, a fluid filled sack, a swelling material, an expansion material, and/or arms.
摘要翻译：包括可植入传感器和外部收发器的传感器系统。传感器系统的各方面可以提供植入传感器的改进的注入和天线取向。传感器可以包括传感器天线，收发器可以包括收发器天线。在一些实施例中，传感器天线和/或收发器天线可以包括定向在第一平面中的第一组线圈和定向成不同于第一平面的第二平面中的第二组线圈。在一些实施例中，传感器可以具有将防止或减少植入传感器的移动和/或旋转的几何形状。例如，在一些实施例中，传感器可以被封装在包含天线线圈和/或包括翅膀，流体填充袋，膨胀材料，膨胀材料和/或臂的硅中。

10. 发明申请

WO2016137444A1 ANALYTE SENSOR 审中-公开
标题翻译：分析传感器
公开(公告)号：WO2016137444A1
公开(公告)日：2016-09-01
申请号：PCT/US2015/017299
申请日：2015-02-24
申请人： SENSEONICS, INCORPORATED
发明人： DEHENNIS, Andrew , TANKIEWICZ, Szymon , WHITEHURST, Todd
IPC分类号： A61B5/04 , A61N1/05 , H04B7/24 , G05F5/04
CPC分类号： A61B5/14503 , A61B5/0031 , A61B5/14532 , A61B5/14552 , A61B2560/0219
摘要： Sensors and methods for measurement of an analyte in a medium within a living animal are described. The sensor may include an inductive element that may receive power from an external device. The sensor may also include a charge storage device (CSD) and a memory. The sensor may perform analyte measurements initiated by the external device using power received from the external device and convey the analyte measurements to the external device using the inductive element. The sensor also may perform autonomous analyte measurements using the on board charge device's power and store the autonomous analyte measurements in the memory. The sensor may convey one or more stored analyte measurements to the external device using the inductive element using power received from the external device. The sensor may include a CSD-powered clock and a CSD-powered measurement scheduler that initiate the autonomous analyte measurements.
摘要翻译：描述了用于测量活体动物中的介质中的分析物的传感器和方法。传感器可以包括可以从外部设备接收电力的感应元件。传感器还可以包括电荷存储装置（CSD）和存储器。传感器可以使用从外部设备接收的功率来执行由外部设备发起的分析物测量，并使用电感元件将分析物测量值传送到外部设备。传感器还可以使用车载充电装置的功率执行自主的分析物测量，并将自主分析物测量存储在存储器中。传感器可以使用从外部设备接收的功率使用电感元件将一个或多个存储的分析物测量值传送到外部设备。传感器可以包括CSD供电的时钟和启动自主分析物测量的CSD供电的测量调度器。

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