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    • 8. 发明授权
    • 1,2 Dihydro- and 1,2,3,4-tetrahydro quinolylacetic acids and analgesic
use thereof
    • 1,2二氢 - 和1,2,3,4-四氢喹啉基乙酸及其止痛用途
    • US4555513A
    • 1985-11-26
    • US452146
    • 1982-12-22
    • Masaaki HamadaKaoru OkamaotoTeikichi Kurosaki
    • Masaaki HamadaKaoru OkamaotoTeikichi Kurosaki
    • C07D215/14A61K31/47A61P25/04A61P29/00C07D215/06C07D215/08C07D215/12C07D215/18C07D215/22C07D215/233
    • C07D215/233C07D215/06C07D215/08C07D215/12C07D215/18
    • Novel quinolylacetic acid compounds of the formula (I): ##STR1## wherein R.sub.1 is a member selected from the group consisting of hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms, and a lower alkyl group having 1 to 4 carbon atoms substituted with an aromatic group having a substituent;R.sub.2 is a member selected from the group consisting of hydrogen atom and a lower alkyl group having 1 to 4 carbon atoms;R.sub.3 is a member selected from the group consisting of hydrogen, a halogen atom, an alkyl group having 1 to 8 carbon atoms, and an alkenyl group having 2 to 8 carbon atoms;R.sub.4 and R.sub.5, carpable of cyclization, are each a member selected from the group consisting of hydrogen atom and a lower alkyl group having 1 to 4 carbon atoms;R.sub.6 is a member selected from the group consisting of hydrogen atom an alkyl group having 1 to 8 carbon atoms, an alkenyl group having 2 to 5 carbon atoms, an alkynyl group having 3 to 8 carbon atoms, an aralkyl group, a substituted aralkyl group, an aliphatic or aromatic acyl group, and a substituted aliphatic or aromatic acyl group; andA is a member selected from the group consisting of hydrogen atom and an oxo group;the broken line denoting a second bond or no bond when A is a hydrogen atom and denoting no bond when A is an oxo group, and pharmaceutically acceptable salts thereof.
    • 式(I)的新型喹啉基乙酸化合物:其中R 1是选自氢原子,具有1至4个碳原子的低级烷基和具有1至4个碳原子的低级烷基的成员 4个碳原子被具有取代基的芳基取代; R2为选自氢原子和碳原子数为1〜4的低级烷基的成员; R3为选自氢,卤素原子,碳原子数为1〜8的烷基和碳原子数为2〜8的烯基的成员; 可环化的R 4和R 5各自是选自氢原子和具有1至4个碳原子的低级烷基的成员; R6为选自氢原子,碳原子数1〜8的烷基,碳原子数2〜5的烯基,碳原子数3〜8的炔基,芳烷基,取代芳烷基 脂族或芳族酰基,和取代的脂族或芳族酰基; A为选自氢原子和氧代基的成员; 当A是氢原子并且当A是氧代基时不表示键时,表示第二个键或无键的虚线及其药学上可接受的盐。
    • 10. 发明申请
    • FLUID FILLED TYPE VIBRATION DAMPING DEVICE
    • 流体填充型振动阻尼装置
    • US20110001281A1
    • 2011-01-06
    • US12733554
    • 2009-07-29
    • Tomohiro KanayaMasaaki HamadaMasahiro Ohnishi
    • Tomohiro KanayaMasaaki HamadaMasahiro Ohnishi
    • F16F13/10F16F13/14F16F13/16B60K5/12
    • F16F13/107F16F13/18
    • A fluid-filled type vibration damping device wherein a second mounting member is secured to a vehicle body; an opening of the second mounting member is closed off to define a pressure-receiving chamber a flexible film is arranged covering an outside of a main rubber elastic body to define an equilibrium chamber; a low-frequency orifice passage and a high-frequency orifice passage connect the pressure-receiving chamber and the equilibrium chamber a first moveable member is disposed on a fluid channel through the high-frequency orifice passage; the first moveable member being supported by a first support member that is linked to the second mounting member via the main rubber elastic body; and a fluid channel through the low-frequency orifice passage is situated away from the placement location of the first moveable member.
    • 一种流体填充式减震装置,其中第二安装构件固定到车体; 封闭第二安装构件的开口以限定受压室,柔性膜被布置成覆盖主橡胶弹性体的外侧以限定平衡室; 一个低频孔通道和一个高频孔通道将压力接收室和平衡室连接起来,第一可移动构件设置在通过高频孔通道的流体通道上; 所述第一可移动构件由经由所述主橡胶弹性体连接到所述第二安装构件的第一支撑构件支撑; 并且穿过低频孔通道的流体通道远离第一可移动构件的放置位置。