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1. 发明授权

US07473342B2 Capillary array and capillary electrophoresis apparatus 有权
标题翻译：毛细管阵列和毛细管电泳仪
公开(公告)号：US07473342B2
公开(公告)日：2009-01-06
申请号：US11395158
申请日：2006-04-03
申请人： Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
发明人： Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
IPC分类号： G01N27/00
CPC分类号： G01N27/44708
摘要： In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.
摘要翻译：在毛细管的温度不能根据毛细管产生的热量的变化而不能快速控制的情况下，不将样品的凝胶速度控制在一定程度以降低样品的分析性能。本发明旨在稳定电泳速度。其上布置有多个毛细管的基板的表面与能够进行温度控制的构件接触，从而控制毛细管的温度。由于根据本发明能够控制温度和毛细管的构件彼此直接接触，所以可以高精度地快速地控制毛细管的温度，使得电泳速度稳定。

2. 发明申请

US20060219559A1 Capillary array and capillary electrophoresis apparatus 有权
公开(公告)号：US20060219559A1
公开(公告)日：2006-10-05
申请号：US11395158
申请日：2006-04-03
申请人： Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
发明人： Seiichi Ugai , Tomonari Morioka , Ryoji Inaba , Akihiro Suzuki , Yoshinori Ookoshi , Yoshiyuki Okishima , Tsukasa Ohira , Motohiro Yamazaki , Takashi Gomi
IPC分类号： G01N27/00
CPC分类号： G01N27/44708
摘要： In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.

3. 发明申请

US20060076239A1 Electrophoresis apparatus 审中-公开
标题翻译：电泳仪
公开(公告)号：US20060076239A1
公开(公告)日：2006-04-13
申请号：US11245491
申请日：2005-10-07
申请人： Ryoji Inaba , Motohiro Yamazaki , Akihiro Suzuki , Miho Ozawa , Daizo Tokinaga , Tomonari Morioka , Seiichi Ugai
发明人： Ryoji Inaba , Motohiro Yamazaki , Akihiro Suzuki , Miho Ozawa , Daizo Tokinaga , Tomonari Morioka , Seiichi Ugai
IPC分类号： G01N27/447
CPC分类号： G01N27/447
摘要： In an electrophoresis apparatus comprising capillaries for containing therein fluorescence-labeled substances, and a sensor for irradiating the capillaries with exciting light and detecting fluorescences, the sensor has a substrate including a datum surface for holding thereon the capillaries, and a groove sinking from the datum surface, and the groove has a plurality of reflecting surfaces for reflecting thereon the fluorescences emitted from the capillaries by a plurality of times.
摘要翻译：在包括用于在其中含有荧光标记物质的毛细管的电泳装置和用于用激发光照射毛细管并检测荧光的传感器中，传感器具有包括用于保持毛细管的基准表面的基底和从基准面凹下的凹槽表面，并且凹槽具有多个反射表面，用于在其上反射从毛细管发射的荧光多次。

4. 发明授权

US07883613B2 Capillary electrophoresis apparatus 有权
标题翻译：毛细管电泳仪
公开(公告)号：US07883613B2
公开(公告)日：2011-02-08
申请号：US11806889
申请日：2007-06-05
申请人： Takashi Gomi , Ryoji Inaba , Motohiro Yamazaki , Hidenori Namba , Jin Matsumura , Hiromi Yamashita , Seiichi Ugai , Kazumichi Imai
发明人： Takashi Gomi , Ryoji Inaba , Motohiro Yamazaki , Hidenori Namba , Jin Matsumura , Hiromi Yamashita , Seiichi Ugai , Kazumichi Imai
IPC分类号： G01N27/453
CPC分类号： G01N27/44721
摘要： The present invention provides a capillary electrophoresis apparatus in which a capillary is easily attached to and detached from a migration medium filling unit without mixing impurities into the capillary. Mixture of impurities such as dust is also prevented when a capillary negative-electrode end is brought into contact with a sample stored in a vessel. Furthermore, temperature control is efficiently performed in the capillary. In the capillary electrophoresis apparatus, the whole of capillary array can be supported by grasping a grip portion by hand. A migration medium filling mechanism includes a slide mechanism which moves a polymer block with respect to a capillary head. The capillary electrophoresis apparatus includes a vessel in which a sample and a buffer can simultaneously be stored. Temperatures of the capillary and an irradiation and detection unit are controlled by a temperature control function provided in a thermostatic device.
摘要翻译：本发明提供了一种毛细管电泳装置，其中毛细管容易地连接到迁移介质填充单元并从迁移介质填充单元中分离而不将杂质混入毛细管中。当毛细管负极端与存储在容器中的样品接触时，也可以防止诸如灰尘等杂质的混合物。此外，在毛细管中有效地进行温度控制。在毛细管电泳装置中，通过用手抓握把手部分可以支撑整个毛细管阵列。迁移介质填充机构包括相对于毛细管头移动聚合物嵌段的滑动机构。毛细管电泳装置包括可以同时存储样品和缓冲液的容器。毛细管和照射和检测单元的温度由恒温装置中提供的温度控制功能控制。

5. 发明申请

US20070278101A1 Capillary electrophoresis apparatus 有权
标题翻译：毛细管电泳仪
公开(公告)号：US20070278101A1
公开(公告)日：2007-12-06
申请号：US11806889
申请日：2007-06-05
申请人： Takashi Gomi , Ryoji Inaba , Motohiro Yamazaki , Hidenori Namba , Jin Matsumura , Hiromi Yamashita , Seiichi Ugai , Kazumichi Imai
发明人： Takashi Gomi , Ryoji Inaba , Motohiro Yamazaki , Hidenori Namba , Jin Matsumura , Hiromi Yamashita , Seiichi Ugai , Kazumichi Imai
IPC分类号： G01N27/00
CPC分类号： G01N27/44721
摘要： The present invention provides a capillary electrophoresis apparatus in which a capillary is easily attached to and detached from a migration medium filling unit without mixing impurities into the capillary. Mixture of impurities such as dust is also prevented when a capillary negative-electrode end is brought into contact with a sample stored in a vessel. Furthermore, temperature control is efficiently performed in the capillary. In the capillary electrophoresis apparatus, the whole of capillary array can be supported by grasping a grip portion by hand. A migration medium filling mechanism includes a slide mechanism which moves a polymer block with respect to a capillary head. The capillary electrophoresis apparatus includes a vessel in which a sample and a buffer can simultaneously be stored. Temperatures of the capillary and an irradiation and detection unit are controlled by a temperature control function provided in a thermostatic device.
摘要翻译：本发明提供了一种毛细管电泳装置，其中毛细管容易地附着到迁移介质填充单元上并从迁移介质填充单元中分离而不将杂质混入毛细管中。当毛细管负极端与存储在容器中的样品接触时，也可以防止诸如灰尘等杂质的混合物。此外，在毛细管中有效地进行温度控制。在毛细管电泳装置中，通过用手抓握把手部分可以支撑整个毛细管阵列。迁移介质填充机构包括相对于毛细管头移动聚合物嵌段的滑动机构。毛细管电泳装置包括可以同时存储样品和缓冲液的容器。毛细管和照射和检测单元的温度由恒温装置中提供的温度控制功能控制。

6. 发明授权

US06878256B2 Capillary array device 有权
标题翻译：毛细管阵列器件
公开(公告)号：US06878256B2
公开(公告)日：2005-04-12
申请号：US10100009
申请日：2002-03-19
申请人： Syouzou Kasai , Yoshiyuki Okishima , Tomonari Morioka , Yasushi Shimizu , Hiroyuki Tanaka , Takayasu Furukawa , Noriyuki Shimoda , Seiichi Ugai
发明人： Syouzou Kasai , Yoshiyuki Okishima , Tomonari Morioka , Yasushi Shimizu , Hiroyuki Tanaka , Takayasu Furukawa , Noriyuki Shimoda , Seiichi Ugai
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44704 , G01N27/44743 , G01N27/44782
摘要： The present invention easies a connection between electrodes of a capillary array device and a connection plate for supplying a high voltage to the electrodes.According to the present invention, a connection plate 23 and hollow electrodes 20 are connected without solder but via a spring force. Alternatively, the hollow electrodes 20 can be connected to the connection plate 23 by utilizing volume elasticity of the connection plate.
摘要翻译：本发明简化了毛细管阵列器件的电极和用于向电极提供高电压的连接板之间的连接。根据本发明，连接板23和中空电极20没有焊料而是通过弹簧力连接。或者，中空电极20可以通过利用连接板的体积弹性而连接到连接板23。

7. 发明授权

US06881316B2 Capillary array device 有权
标题翻译：毛细管阵列器件
公开(公告)号：US06881316B2
公开(公告)日：2005-04-19
申请号：US10190481
申请日：2002-07-09
申请人： Syouzou Kasai , Yoshiyuki Okishima , Tomonari Morioka , Yasushi Shimizu , Hiroyuki Tanaka , Takayasu Furukawa , Noriyuki Shimoda , Seiichi Ugai
发明人： Syouzou Kasai , Yoshiyuki Okishima , Tomonari Morioka , Yasushi Shimizu , Hiroyuki Tanaka , Takayasu Furukawa , Noriyuki Shimoda , Seiichi Ugai
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44704 , G01N27/44743 , G01N27/44782
摘要： The present invention easies a connection between electrodes of a capillary array device and a connection plate for supplying a high voltage to the electrodes.According to the present invention, a connection plate 23 and hollow electrodes 20 are connected without solder but via a spring force. Alternatively, the hollow electrodes 20 can be connected to the connection plate 23 by utilizing volume elasticity of the connection plate.
摘要翻译：本发明简化了毛细管阵列器件的电极和用于向电极提供高电压的连接板之间的连接。根据本发明，连接板23和中空电极20没有焊接而是通过弹簧力连接。或者，中空电极20可以通过利用连接板的体积弹性而连接到连接板23。

8. 发明授权

US06977034B2 Capillary array and electrophoresis apparatus 有权
标题翻译：毛细管阵列和电泳仪
公开(公告)号：US06977034B2
公开(公告)日：2005-12-20
申请号：US10239765
申请日：2000-12-04
申请人： Tomonari Morioka , Yasushi Shimizu , Seiichi Ugai , Toshiaki Kita , Kiyoshi Tsukada
发明人： Tomonari Morioka , Yasushi Shimizu , Seiichi Ugai , Toshiaki Kita , Kiyoshi Tsukada
IPC分类号： G01N27/447 , G01N27/453 , G01N30/02
CPC分类号： G01N27/44782 , G01N27/44721
摘要： A capillary array comprising multiple capillaries and two holding substrates for arranging the aforementioned multiple capillaries in a substantially plane surface by sandwiching at least some of these capillaries mutually. One of the holding substrates has a detection window for transmitting the detected light emitted by a test sample by irradiation of light. Especially, this detection window comprises multiple light transmission areas provided to correspond to each capillary to transmit the detected light, and light cut-off areas provided between these light transmission areas to cut off the detected light. These light cut-off areas cut off light reflected from the surface of capillaries and hence improve the SN ratio, thereby ensuring high-precision detection.
摘要翻译：毛细管阵列，其包括多个毛细管和两个保持基板，用于通过相互夹住这些毛细管中的至少一些来将上述多个毛细管布置在基本上平面的表面中。保持基板中的一个具有用于通过照射光透射由测试样品发射的检测到的光的检测窗口。特别地，该检测窗口包括多个透光区域，其设置为对应于每个毛细管以透射检测到的光，以及设置在这些光透射区域之间的遮光区域以切断检测到的光。这些遮光区域切断从毛细管表面反射的光，从而提高SN比，从而确保高精度检测。

9. 发明授权

US07445701B2 Capillary array unit and electrophoresis based thereon 有权
标题翻译：基于毛细管阵列单元和电泳
公开(公告)号：US07445701B2
公开(公告)日：2008-11-04
申请号：US11204116
申请日：2005-08-16
申请人： Tomonari Morioka , Yasushi Shimizu , Seiichi Ugai , Toshiaki Kita , Kiyoshi Tsukada
发明人： Tomonari Morioka , Yasushi Shimizu , Seiichi Ugai , Toshiaki Kita , Kiyoshi Tsukada
IPC分类号： G01N27/453
CPC分类号： G01N27/44782 , G01N27/44721
摘要： A capillary array includes multiple capillaries and two holding substrates for arranging the aforementioned multiple capillaries in a substantially plane surface by sandwiching at least some of these capillaries mutually. One of the holding substrates has a detection window for transmitting the detected light emitted by a test sample by irradiation of light. Especially, this detection window includes multiple light transmission areas provided to correspond to each capillary to transmit the detected light, and light cut-off areas provided between these light transmission areas to cut off the detected light. These light cut-off areas cut off light reflected from the surface of capillaries and hence improve the SN ratio, thereby ensuring high-precision detection.
摘要翻译：毛细管阵列包括多个毛细管和两个保持基板，用于通过相互夹住这些毛细管中的至少一些来将上述多个毛细管布置在基本上平面的表面中。保持基板中的一个具有用于通过照射光透射由测试样品发射的检测到的光的检测窗口。特别地，该检测窗口包括多个透光区域，其设置为对应于每个毛细管以透射检测到的光，以及设置在这些光透射区域之间的遮光区域，以切断检测到的光。这些遮光区域切断从毛细管表面反射的光，从而提高SN比，从而确保高精度检测。

10. 发明申请

US20060049053A1 Capillary array unit and electrophoresis based thereon 有权
标题翻译：基于毛细管阵列单元和电泳
公开(公告)号：US20060049053A1
公开(公告)日：2006-03-09
申请号：US11204116
申请日：2005-08-16
申请人： Tomonari Morioka , Yasushi Shimizu , Seiichi Ugai , Toshiaki Kita , Kiyoshi Tsukada
发明人： Tomonari Morioka , Yasushi Shimizu , Seiichi Ugai , Toshiaki Kita , Kiyoshi Tsukada
IPC分类号： C07K1/26 , G01N27/447
CPC分类号： G01N27/44782 , G01N27/44721
摘要： A capillary array includes multiple capillaries and two holding substrates for arranging the aforementioned multiple capillaries in a substantially plane surface by sandwiching at least some of these capillaries mutually. One of the holding substrates has a detection window for transmitting the detected light emitted by a test sample by irradiation of light. Especially, this detection window includes multiple light transmission areas provided to correspond to each capillary to transmit the detected light, and light cut-off areas provided between these light transmission areas to cut off the detected light. These light cut-off areas cut off light reflected from the surface of capillaries and hence improve the SN ratio, thereby ensuring high-precision detection.
摘要翻译：毛细管阵列包括多个毛细管和两个保持基板，用于通过相互夹住这些毛细管中的至少一些来将上述多个毛细管布置在基本上平面的表面中。保持基板中的一个具有用于通过照射光透射由测试样品发射的检测到的光的检测窗口。特别地，该检测窗口包括多个透光区域，其设置为对应于每个毛细管以透射检测到的光，以及设置在这些光透射区域之间的遮光区域，以切断检测到的光。这些遮光区域切断从毛细管表面反射的光，从而提高SN比，从而确保高精度检测。

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