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    • 6. 发明申请
    • MEDICAL GLUES FOR SURGERY COMPRISING BIOACTIVE COMPOUNDS
    • 包含生物化合物的手术用药物
    • US20110003898A1
    • 2011-01-06
    • US12920680
    • 2009-02-21
    • Heike HeckrothBurkhard KöhlerSebastian Dörr
    • Heike HeckrothBurkhard KöhlerSebastian Dörr
    • A61K47/00A61P17/02A61P31/00A61P23/02
    • A61L24/046A61L24/0015A61L2300/402A61L2300/408A61L2300/41C08G18/10C09J175/04C08G18/48C08G18/3821C08G18/3206
    • The present invention relates to novel, rapidly curing adhesives based on hydrophilic polyisocyanate prepolymers for use in surgery, which contain pharmacologically active ingredients. The adhesive system contains A) isocyanate group-containing prepolymers obtainable from A1) aliphatic isocyanates and A2) polyols with number-averaged molecular weights of ≧400 g/mol and average OH group contents of from 2 to 6 B) a curing component comprising B1) amino group-containing aspartate esters of the general formula (I) wherein X is an n-valent organic radical, which is obtained by removal of the primary amino groups of an n-functional amine, R1 and R2 are the same or different organic radicals, which contain no Zerevitinov active hydrogen and n is a whole number of at least 2 and B2) organic fillers which have a viscosity at 23° C. measured to DIN 53019 in the range from 10 to 6000 mPas and C) optionally reaction products of isocyanate group-containing prepolymers according to the definition of component A) with aspartate esters according to component B1) and/or organic fillers according to component B2) and D) at least one pharmacologically active compound.
    • 本发明涉及基于含有药理学活性成分的用于手术的亲水性多异氰酸酯预聚物的新型快速固化粘合剂。 该粘合剂体系含有A)含异氰酸酯基的预聚物,其可由A1)脂族异氰酸酯和A2)数均分子量为≥400g/ mol,平均OH基含量为2-6的多元醇组成)包含B1 )通式(I)的含氨基的天冬氨酸酯,其中X为n价有机基团,其通过除去正官能胺的伯氨基而得到,R1和R2是相同或不同的有机物 基团,其不含泽雷维诺诺活性氢,n是至少为2和B2的整数)有机填料,其在23℃下具有粘度,根据DIN 53019测量为10至6000mPas,C)任选的反应产物 根据组分A)的定义的含异氰酸酯基的预聚物与根据组分B1)的天冬氨酸酯和/或根据组分B2的有机填料)和D)至少一种药理活性化合物。