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1. 发明申请

US20060266372A1 High pressure delivery system 有权
标题翻译：高压输送系统
公开(公告)号：US20060266372A1
公开(公告)日：2006-11-30
申请号：US11369662
申请日：2006-03-06
申请人： Scott Miller , Howard Preissman
发明人： Scott Miller , Howard Preissman
IPC分类号： A61B19/00
CPC分类号： A61B17/8822
摘要： This relates to an improved delivery system for accurately loading and controlling the delivery of flowable material to a patient. Particularly, the system may be used in the injection of hard tissue implant materials such as PMMA under pressures up to about 4000 psi. The system includes an applicator with a first column having an implant material introduction section adapted to provide for effective loading of the implant material and a second column housing a piston. The introduction section has a larger size than that of a vessel section or bore in which the requisite pressure seal between the piston and bore wall is formed. The first column may include an introduction section flared open to an included larger funnel-like opening or a separate funnel may be used that interfaces with the introduction section to facilitate the introduction of implant material. Handles on the first and second columns to be turned relative to each other to advance the columns toward each other may be provided for manual actuation of the applicator to drive implant material through a cannula and deliver implant material to a desired site.
摘要翻译：这涉及用于精确地加载和控制向患者输送可流动材料的改进的递送系统。特别地，该系统可以用于在高达约4000psi的压力下注入硬组织植入材料，例如PMMA。该系统包括具有第一柱的施用器，该第一柱具有适于提供植入材料的有效载荷的植入材料引入部分和容纳活塞的第二柱。引入部分具有比形成活塞和孔壁之间所需的压力密封的容器部分或孔的尺寸更大的尺寸。第一列可以包括向包括的更大的漏斗状开口敞开的引入部分，或者可以使用与引入部分接合的单独的漏斗以便于植入材料的引入。第一和第二列之间的手柄相对于彼此转动以使列彼此前进可以被提供用于手动致动施加器以通过套管驱动植入材料并将植入材料递送到期望的位置。

2. 发明授权

US6019776A Precision depth guided instruments for use in vertebroplasty 失效
标题翻译：用于椎体成形术的精密深度导向仪器
公开(公告)号：US6019776A
公开(公告)日：2000-02-01
申请号：US950382
申请日：1997-10-14
申请人： Howard Preissman , Mary E. Jensen , Jacques E. Dion
发明人： Howard Preissman , Mary E. Jensen , Jacques E. Dion
IPC分类号： A61B17/34 , A61B17/88 , A61B19/00
CPC分类号： A61B17/8811 , A61B17/3472 , A61B17/3494 , A61B17/3403 , A61B17/3496 , A61B2090/061 , A61B2090/062
摘要： Precision depth guided instruments are provided for use in performing percutaneous implantation of hard tissue implant materials. A depth guided stylet include a point adapted for piercing hard tissue, self-tapping threads for self-tapping into hard tissue, and, optionally, a second set of threads for meshing with threads within a overfitting cannula. The stylet may include an elongated rod having a first section having a first diameter, and a second section having a second diameter larger than the first diameter. A cannula for use with a depth guided stylet includes an elongated tube having first and second open ends adapted for a depth guided stylet to pass therethrough. The cannula may include threads along at least a portion of an interior circumference of the elongated tube, which are adapted to mate with threads on an exterior circumference of the depth guided stylet. Alternatively, a set of intersecting grooves may be included in the handle of the cannula to mate with a protrusion on the handle of the stylet. A method of using the instruments is also disclosed, as is a kit which includes the instruments and which is used to open a pathway into hard tissue.
摘要翻译：提供精密深度导向仪器，用于进行硬组织植入材料的经皮植入。深度导向探针包括适于刺穿硬组织的点，用于自攻入硬组织的自攻螺纹，以及可选地用于与过拟合插管内的螺纹啮合的第二组螺纹。探针可以包括具有第一直径的第一部分的细长杆和具有大于第一直径的第二直径的第二部分。与深度导向的探针一起使用的插管包括细长管，其具有适于深度引导的探针通过的第一和第二开口端。套管可以包括沿着细长管的内圆周的至少一部分的螺纹，其适于与深度导向探针的外周上的螺纹配合。或者，一组交叉的凹槽可以包括在套管的手柄中以与探针的手柄上的突起配合。还公开了使用这些器械的方法，以及包括器械并用于将通路打开到硬组织中的试剂盒。

3. 发明授权

US06309420B1 Enhanced visibility materials for implantation in hard tissue 失效
标题翻译：增强植入硬组织的可见性材料
公开(公告)号：US06309420B1
公开(公告)日：2001-10-30
申请号：US08950256
申请日：1997-10-14
申请人： Howard Preissman
发明人： Howard Preissman
IPC分类号： A61F228
CPC分类号： A61B17/7095 , A61F2/28 , A61F2/30965 , A61F2/44 , A61F2/4601 , A61F2002/3008 , A61F2250/0098 , A61F2310/00293 , A61F2310/00329 , A61F2310/00353 , A61L24/001 , A61L27/50
摘要： An enhanced visibility composition for implantation from a remote source, so that the composition can be readily observed under fluoroscopy or other imaging techniques. The composition include a biocompatible matrix, such as a hard tissue implant material for example, and radiopaque particles mixed in the matrix. The radiopaque particles have a particle size between about 120&mgr; and 2200&mgr;, more preferably about 350&mgr; and 2200&mgr;, even more preferably between about 450&mgr; and 1600&mgr;, and most preferably between about 570&mgr; and 1150&mgr;. Preferably the hard tissue implant and the radiopaque particles are formed or prepared in a slurry. Optionally, the enhanced visibility composition may further include additional radiopaque particles or contrast particles mixed in with the composition, which have a particle size between about 120&mgr; and 350&mgr;, preferably between about 120&mgr; and 250&mgr;.
摘要翻译：用于从远程源植入的增强的可见性组合物，使得可以在荧光透视或其他成像技术下容易地观察组合物。组合物包括生物相容性基质，例如硬组织植入材料，以及混合在基质中的不透射线颗粒。不透射线的颗粒具有约120μm至2200μm之间的粒径，更优选约350μm和2200μm，甚至更优选约450μm至1600μm，最优选约570μm至1150μm。优选地，硬组织植入物和不透射线的颗粒在浆液中形成或制备。任选地，增强的可见性组合物可进一步包括与组合物混合的附加的不透射线颗粒或造影剂颗粒，其具有约120μm至350μm之间，优选约120μm至250μm的粒度。

4. 发明授权

US06231615B1 Enhanced visibility materials for implantation in hard tissue 有权
标题翻译：增强植入硬组织的可见性材料
公开(公告)号：US06231615B1
公开(公告)日：2001-05-15
申请号：US09420093
申请日：1999-10-18
申请人： Howard Preissman
发明人： Howard Preissman
IPC分类号： A61F244
CPC分类号： A61B17/7095 , A61F2/28 , A61F2/30965 , A61F2/44 , A61F2/4601 , A61F2002/3008 , A61F2250/0098 , A61F2310/00293 , A61F2310/00329 , A61F2310/00353 , A61L24/001 , A61L27/50
摘要： An enhanced visibility composition for implantation from a remote source, so that the composition can be readily observed under fluoroscopy or other imaging techniques. The compositions include a biocompatible matrix, such as a hard tissue implant material for example, and radiopaque particles mixed in the matrix. The radiopaque particles have a particle size between about 120&mgr; and 2200&mgr;, more preferably about 350&mgr; and 2200&mgr;, even more preferably between about 450&mgr; and 1600&mgr;, and most preferably between about 570&mgr;0 and 1150&mgr;. Preferably the hard tissue implant and the radiopaque particles are formed or prepared in a slurry. Optionally, the enhanced visibility composition may further include additional radiopaque particles or contrast particles mixed in with the composition, which have a particle size between about 120&mgr; and 350&mgr;, preferably between about 120&mgr; and 250&mgr;.
摘要翻译：用于从远程源植入的增强的可见性组合物，使得可以在荧光透视或其他成像技术下容易地观察组合物。组合物包括生物相容性基质，例如硬组织植入材料和混入基质中的不透射线颗粒。不透射线的颗粒具有约120μm至2200μm之间的粒径，更优选约350μm和2200μm，甚至更优选约450μm至1600μm，最优选约570μm至1150μm。优选地，硬组织植入物和不透射线的颗粒在浆液中形成或制备。任选地，增强的可见性组合物可进一步包括与组合物混合的附加的不透射线颗粒或造影剂颗粒，其具有约120μm至350μm之间，优选约120μm至250μm的粒度。

5. 发明授权

US6033411A Precision depth guided instruments for use in vertebroplasty 失效
标题翻译：用于椎体成形术的精密深度导向仪器
公开(公告)号：US6033411A
公开(公告)日：2000-03-07
申请号：US949839
申请日：1997-10-14
申请人： Howard Preissman
发明人： Howard Preissman
IPC分类号： A61B17/34 , A61B17/88 , A61B19/00 , A61B17/58
CPC分类号： A61B17/8819 , A61B17/3472 , A61B17/3494 , A61B17/3403 , A61B17/3496 , A61B2090/061 , A61B2090/062
摘要： Precision depth guided instruments are provided for use in performing percutaneous implantation of hard tissue implant materials. A depth guided stylet include a point adapted for piercing hard tissue, and preferably, self-tapping threads for self-tapping into hard tissue. The stylet may include an elongated rod having a first section having a first diameter, and a second section having a second diameter larger than the first diameter. A cannula for use with a depth guided stylet includes an elongated tube having first and second open ends adapted for a depth guided stylet to pass therethrough. The cannula may include a pawl passing through the elongated tube for ratcheting against a rack of gear teeth provided on the stylet. Alternatively, a camming mechanism may be pivotal arranged on the stylet. Upon pivoting the camming mechanism, the cam surface provides a driving force against the cannula to drive the cannula along the stylet. A method of using the instruments is also disclosed, as is a kit which includes the instruments and which is used to open a pathway into hard tissue.
摘要翻译：提供精密深度导向仪器，用于进行硬组织植入材料的经皮植入。深度导向探针包括适于刺穿硬组织的点，并且优选地，自攻螺纹用于自攻入硬组织。探针可以包括具有第一直径的第一部分的细长杆和具有大于第一直径的第二直径的第二部分。与深度导向的探针一起使用的插管包括细长管，其具有适于深度引导的探针通过的第一和第二开口端。套管可以包括通过细长管的爪，用于棘爪抵靠设在探针上的齿轮齿。或者，凸轮机构可以枢转地布置在探针上。在枢转凸轮机构时，凸轮表面提供抵抗套管的驱动力以沿着探针引导插管。还公开了使用这些器械的方法，以及包括器械并用于将通路打开到硬组织中的试剂盒。

6. 发明授权

US07510579B2 Enhanced visibility materials for implantation in hard tissue 有权
标题翻译：增强植入硬组织的可见性材料
公开(公告)号：US07510579B2
公开(公告)日：2009-03-31
申请号：US09828539
申请日：2001-04-05
申请人： Howard Preissman
发明人： Howard Preissman
IPC分类号： A61F2/02 , A61F2/04
CPC分类号： A61B17/7095 , A61F2/28 , A61F2/30965 , A61F2/44 , A61F2/4601 , A61F2002/3008 , A61F2250/0098 , A61F2310/00293 , A61F2310/00329 , A61F2310/00353 , A61L24/001 , A61L27/50
摘要： An enhanced visibility composition for implantation from a remote source, so that the composition can be readily observed under fluoroscopy or other imaging techniques is disclosed. The compositions include a biocompatible matrix, such as a hard tissue implant material for example, and radiopaque particles mixed in the matrix. The radiopaque particles have a particle size between about 120μ and 2200μ, more preferably bout 350μ and 2200μ, even more preferably between about 450μ and 1600μ, and most preferably between about 570μ and 1150μ. Preferably the hard tissue implant and the radiopaque particles are formed or prepared in a slurry. Optionally, the enhanced visibility composition may further include additional radiopaque particles or contrast particles mixed in with the composition, which have a particle size between about 120μ and 350μ, preferably between about 120μ and 250μ.
摘要翻译：提供了用于从远程源植入的增强的可见性组合物，使得可以在荧光透视或其它成像技术下容易地观察组合物。组合物包括生物相容性基质，例如硬组织植入材料和混入基质中的不透射线颗粒。不透射线的颗粒的粒径为约120μm至2200μm，更优选为350μm和2200μm，甚至更优选为约450μm至1600μm，最优选为约570μm至1150μm。优选地，硬组织植入物和不透射线的颗粒在浆液中形成或制备。任选地，增强的可见性组合物可进一步包括与组合物混合的附加的不透射线颗粒或造影剂颗粒，其具有约120μm至350μm之间，优选约120μm至250μm的粒度。

7. 发明申请

US20070191964A1 Enhanced visibility materials for implantation in hard tissue 审中-公开
标题翻译：增强植入硬组织的可见性材料
公开(公告)号：US20070191964A1
公开(公告)日：2007-08-16
申请号：US11246967
申请日：2005-10-07
申请人： Howard Preissman
发明人： Howard Preissman
IPC分类号： A61F2/28 , A61B6/12
CPC分类号： A61L24/001 , A61B17/7095 , A61F2/28 , A61F2/30965 , A61F2/44 , A61F2/4601 , A61F2002/3008 , A61F2250/0098 , A61F2310/00293 , A61F2310/00329 , A61F2310/00353 , A61L27/50
摘要： An enhanced visibility composition for implantation from a remote source, so that the composition can be readily observed under fluoroscopy or other imaging techniques is disclosed. The compositions include a biocompatible matrix, such as a hard tissue implant material for example, and radiopaque tracer particles mixed in the matrix. The radiopaque tracer particles have a particle size between about 120μ and 2200μ, more preferably about 350μ and 2200μ, even more preferably between about 450μ and 1600μ, and most preferably between about 570μ and 1150μ. Preferably the hard tissue implant and the radiopaque tracer particles are formed or prepared in a slurry. Optionally, the enhanced visibility composition may further include additional radiopaque contrast particles mixed in with the composition, which have a particle size between about 120μ and 350μ, preferably between about 120μ and 250μ.
摘要翻译：提供了用于从远程源植入的增强的可见性组合物，使得可以在荧光透视或其它成像技术下容易地观察组合物。组合物包括生物相容性基质，例如硬组织植入材料，以及混合在基质中的不透射线示踪剂颗粒。不透射线的示踪剂颗粒具有约120μm至2200μm之间的粒径，更优选约350μm和2200μm，甚至更优选约450μm至1600μm，最优选约570μm至1150μm。优选地，硬组织植入物和不透射线的示踪剂颗粒在浆液中形成或制备。任选地，增强的可见性组合物还可以包括与组合物混合的附加的不透射线造影剂颗粒，其具有在约120μm至350μm之间，优选约120μm和250μm之间的粒度。

8. 发明授权

US07048743B2 Methods for delivering tissue implant material with a high pressure applicator 有权
标题翻译：用高压施加器输送组织植入材料的方法
公开(公告)号：US07048743B2
公开(公告)日：2006-05-23
申请号：US10310354
申请日：2002-12-04
申请人： Scott H. Miller , Howard Preissman
发明人： Scott H. Miller , Howard Preissman
IPC分类号： A61B17/60
CPC分类号： A61B17/8822
摘要： This relates to an improved delivery system for accurately loading and controlling the delivery of flowable material to a patient. Particularly, the system may be used in the injection of hard tissue implant materials such as PMMA under pressures up to about 4000 psi. The system includes an applicator with a first column having an implant material introduction section adapted to provide for effective loading of the implant material and a second column housing a piston. The introduction section has a larger size than that of a vessel section or bore in which the requisite pressure seal between the piston and bore wall is formed. The first column may include an introduction section flared open to an included larger funnel-like opening or a separate funnel may be used that interfaces with the introduction section to facilitate the introduction of implant material. Handles on the first and second columns to be turned relative to each other to advance the columns toward each other may be provided for manual actuation of the applicator to drive implant material through a cannula and deliver implant material to a desired site.
摘要翻译：这涉及用于精确地加载和控制向患者输送可流动材料的改进的递送系统。特别地，该系统可以用于在高达约4000psi的压力下注入硬组织植入材料，例如PMMA。该系统包括具有第一柱的施用器，该第一柱具有适于提供植入材料的有效载荷的植入材料引入部分和容纳活塞的第二柱。引入部分具有比形成活塞和孔壁之间所需的压力密封的容器部分或孔的尺寸更大的尺寸。第一列可以包括向包括的更大的漏斗状开口敞开的引入部分，或者可以使用与引入部分接合的单独的漏斗以便于植入材料的引入。第一和第二列之间的手柄相对于彼此转动以使列彼此前进可以被提供用于手动致动施加器以通过套管驱动植入材料并将植入材料递送到期望的位置。

9. 发明授权

US06348055B1 Non-compliant system for delivery of implant material 有权
标题翻译：用于输送植入材料的不符合标准的系统
公开(公告)号：US06348055B1
公开(公告)日：2002-02-19
申请号：US09688721
申请日：2000-10-16
申请人： Howard Preissman
发明人： Howard Preissman
IPC分类号： A61F504
CPC分类号： A61B17/8816 , A61B17/00491 , A61B17/3468 , A61B2017/00261 , A61F2/44 , A61F2/441 , A61F2/4601 , A61F2/4611 , A61F2002/4623 , A61F2002/4624 , A61F2002/4627 , A61F2002/4635 , A61F2002/4677
摘要： A substantially non-compliant conduit for delivery an implant material from a high pressure applicator to an implant delivery device. Also, a high pressure, substantially non-compliant system for delivery of accurate volumes of implant material to the desired site.
摘要翻译：一种用于将植入材料从高压施加器输送到植入物输送装置的基本上不顺应的导管。而且，用于将精确体积的植入材料输送到所需位置的高压，基本上不符合系统。

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