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1. 发明申请

US20090081180A1 ANTIMICROBIAL POLYMER CONJUGATES 审中-公开
标题翻译：抗微生物聚合物共聚物
公开(公告)号：US20090081180A1
公开(公告)日：2009-03-26
申请号：US12271654
申请日：2008-11-14
申请人： Scott M. Walsh , Anjali G. Shah , James J. Mond , Andrew Lees , Joseph J. Drabick
发明人： Scott M. Walsh , Anjali G. Shah , James J. Mond , Andrew Lees , Joseph J. Drabick
IPC分类号： A61K38/48 , C12N9/52
CPC分类号： A61K47/60 , A61K38/00
摘要： Water-soluble polymer conjugates of antimicrobial agents retaining at least a portion of the antimicrobial activity of the agent, pharmaceutical compositions containing the polymer conjugates, and methods for treating microbial infections with the pharmaceutical compositions.
摘要翻译：保留试剂的至少一部分抗微生物活性的抗微生物剂的水溶性聚合物缀合物，含有聚合物共轭物的药物组合物，以及用药物组合物治疗微生物感染的方法。

2. 发明授权

US07452533B2 Antimicrobial polymer conjugate containing lysostaphin and polyethylene glycol 失效
标题翻译：含有溶葡萄球菌素和聚乙二醇的抗微生物聚合物缀合物
公开(公告)号：US07452533B2
公开(公告)日：2008-11-18
申请号：US10403223
申请日：2003-03-26
申请人： Scott M. Walsh , Anjali G. Shah , James J. Mond , Andrew Lees , Joseph J. Drabick
发明人： Scott M. Walsh , Anjali G. Shah , James J. Mond , Andrew Lees , Joseph J. Drabick
IPC分类号： A61K38/48 , A61K38/51 , C12N11/08
CPC分类号： A61K47/60 , A61K38/00
摘要： Water-soluble polymer conjugates of antimicrobial agents retaining at least a portion of the antimicrobial activity of the agent, pharmaceutical compositions containing the polymer conjugates, and methods for treating microbial infections with the pharmaceutical compositions.
摘要翻译：保留试剂的至少一部分抗微生物活性的抗微生物剂的水溶性聚合物缀合物，含有聚合物共轭物的药物组合物，以及用药物组合物治疗微生物感染的方法。

3. 发明申请

US20100221237A1 ENZYME DISRUPTION OF BACTERIAL BIOFILMS 审中-公开
标题翻译：酶抑制细菌生物素
公开(公告)号：US20100221237A1
公开(公告)日：2010-09-02
申请号：US12538692
申请日：2009-08-10
申请人： John F. Kokai-Kun , Julie Adams Wu , James J. Mond , Scott M. Walsh , Anjali G. Shah , Tatyana I. Chanturiya
发明人： John F. Kokai-Kun , Julie Adams Wu , James J. Mond , Scott M. Walsh , Anjali G. Shah , Tatyana I. Chanturiya
IPC分类号： A61K38/48 , A61P31/04
CPC分类号： A01N63/00 , A61K38/482 , A61L27/54 , A61L29/16 , A61L2300/254 , A61L2300/404 , A61L2300/406 , A61L2300/45 , A61K2300/00
摘要： Methods for treating patients in which damaged tissue or an indwelling prosthetic device or catheter has a bacterial biofilm growing thereon, to at least partially disrupt said biofilm, by administering at least one antibacterial enzyme that is lethal or damaging to the biofilm-forming bacteria in an amount that is effective to at least partially disrupt the biofilm upon contact therewith. Methods for prophylactically treating a patient, and methods for disinfecting or sterilizing a surface ex-vivo to remove a biofilm or prevent biofilm growth are also disclosed, as well as implantable articles susceptible to biofilm growth to which a prophylactic coating of an antibacterial enzyme has been applied.
摘要翻译：用于治疗受损组织或留置假体装置或导管的细菌生物膜生长在其上以至少部分地破坏所述生物膜的患者的方法，通过在生物膜形成细菌中施用至少一种对生物膜形成细菌致死或有害的抗菌酶在与其接触时至少部分地破坏生物膜的量是有效的。还公开了用于预防性治疗患者的方法，以及离体消毒或消毒表面以去除生物膜或防止生物膜生长的方法，以及易受生物膜生长敏感的可植入制品，其中抗菌酶的预防性涂层已被应用。

4. 发明授权

US07572439B2 Enzyme disruption of bacterial biofilms 失效
标题翻译：细菌生物膜的酶破坏
公开(公告)号：US07572439B2
公开(公告)日：2009-08-11
申请号：US10401342
申请日：2003-03-26
申请人： John F. Kokai-Kun , Julie M. Adams , James J. Mond , Scott M. Walsh , Anjali G. Shah , Tanya I. Chanturiya
发明人： John F. Kokai-Kun , Julie M. Adams , James J. Mond , Scott M. Walsh , Anjali G. Shah , Tanya I. Chanturiya
IPC分类号： A61K38/46
CPC分类号： A61L27/54 , A01N63/00 , A61K38/482 , A61L29/16 , A61L2300/254 , A61L2300/404 , A61L2300/406 , A61L2300/45 , A61K2300/00
摘要： Methods for treating patients in which damaged tissue or an indwelling prosthetic device or catheter has a bacterial biofilm growing thereon, to at least partially disrupt said biofilm, by administering at least one antibacterial enzyme that is lethal or damaging to the biofilm-forming bacteria in an amount that is effective to at least partially disrupt the biofilm upon contact therewith. Methods for prophylactically treating a patient, and methods for disinfecting or sterilizing a surface ex-vivo to remove a biofilm or prevent biofilm growth are also disclosed, as well as implantable articles susceptible to biofilm growth to which a prophylactic coating of an antibacterial enzyme has been applied.
摘要翻译：用于治疗受损组织或留置假体装置或导管的细菌生物膜生长在其上以至少部分地破坏所述生物膜的患者的方法，通过在生物膜形成细菌中施用至少一种对生物膜形成细菌致死或有害的抗菌酶在与其接触时至少部分地破坏生物膜的量是有效的。还公开了用于预防性治疗患者的方法，以及离体消毒或消毒表面以去除生物膜或防止生物膜生长的方法，以及易受生物膜生长敏感的可植入制品，其中抗菌酶的预防性涂层已被应用。

5. 发明授权

US08697639B2 Compositions and methods for treating bacteria 失效
标题翻译：用于治疗细菌的组合物和方法
公开(公告)号：US08697639B2
公开(公告)日：2014-04-15
申请号：US12422813
申请日：2009-04-13
申请人： Scott M. Walsh , Mary C. Pittaway , James J. Mond
发明人： Scott M. Walsh , Mary C. Pittaway , James J. Mond
IPC分类号： A61K38/12 , A61K31/351 , A61K38/16
CPC分类号： A61K38/164 , A61K31/351 , A61K31/7036 , A61K38/12 , A61K38/14 , A61K2300/00
摘要： The present invention relates to the field of bacteriology. In particular, the present invention provides compositions (e.g., comprising a lantibiotic and mupirocin or gentamicin) and methods of treating (e.g., killing or inhibiting growth of) bacteria. For example, the present invention provides pharmaceutical compounds (e.g., comprising a lantibiotic and mupirocin or gentamicin) and methods of using the same in research, therapeutic and drug screening applications.
摘要翻译：本发明涉及细菌学领域。特别地，本发明提供组合物（例如，包含羊毛硫素和莫匹罗星或庆大霉素）和治疗（例如杀死或抑制细菌生长）的方法。例如，本发明提供药物化合物（例如，包含羊毛硫抗生素和莫匹罗星或庆大霉素）及其在研究，治疗和药物筛选应用中的应用。

6. 发明授权

US06432679B1 Enhancement of B cell activation and immunoglobulin secretion by co-stimulation of receptors for antigen and EBV Gp350/220 有权
标题翻译：通过共刺激抗原和EBV Gp350 / 220的受体增强B细胞活化和免疫球蛋白分泌
公开(公告)号：US06432679B1
公开(公告)日：2002-08-13
申请号：US09328599
申请日：1999-06-10
申请人： James J. Mond , Andrew Lees
发明人： James J. Mond , Andrew Lees
IPC分类号： C12P2104
CPC分类号： A61K39/39 , A61K39/12 , A61K39/245 , A61K39/385 , A61K2039/51 , A61K2039/53 , A61K2039/55516 , A61K2039/6056 , A61K2039/6075 , C07K14/005 , C07K2319/00 , C12N2710/16222 , C12N2710/16234 , C12N2760/18534
摘要： The present invention provides vaccine adjuvants comprising the Epstein Barr Virus glycoprotein 350/220 or naturally occurring variants thereof, a fusion protein comprising EBV Gp350/220 sequence which binds to the CR2 receptor, or a synthetically-derived fragment of Gp350/220 which retains the ability to bind to the CR2 receptor. The present invention further provides immunostimulatory compositions comprising an EBV Gp350/220 adjuvant sequence that binds the CR2 complex and at least one antigen of interest other than Gp350/220. Co-administration of the adjuvant with an antigen of interest, other than an antigen comprising EBV 350/220 sequence, enhances the immunogenicitiy of the antigen. In a preferred embodiment, the adjuvant is directly or indirectly covalently bound to an antigen of interest to form an immunogenic composition. In a most preferred embodiment of the composition, antibodies are elicited against at least one Gp350/220 epitope and against at least one epitope of the antigen.
摘要翻译：本发明提供包含爱泼斯坦巴尔病毒糖蛋白350/220或其天然存在的变体的疫苗佐剂，包含与CR2受体结合的EBV Gp350 / 220序列的融合蛋白，或Gp350 / 220的合成衍生片段，其保留与CR2受体结合的能力。本发明进一步提供免疫刺激组合物，其包含结合CR2复合物和至少一种感兴趣的除Gp350 / 220之外的至少一种目的抗原的EBV Gp350 / 220佐剂序列。佐剂与感兴趣的抗原（包括EBV 350/220序列的抗原）共同给药增强了抗原的免疫原性。在优选的实施方案中，所述佐剂直接或间接共价结合于感兴趣的抗原以形成免疫原性组合物。在组合物的最优选的实施方案中，针对至少一种Gp350 / 220表位并针对抗原的至少一个表位引发抗体。

7. 发明授权

US5585100A Dual carrier immunogenic construct 失效
公开(公告)号：US5585100A
公开(公告)日：1996-12-17
申请号：US402565
申请日：1995-03-13
申请人： James J. Mond , Andrew Lees
发明人： James J. Mond , Andrew Lees
IPC分类号： G01N33/531 , A61K39/385 , A61K47/48 , A61K49/00 , A61P37/04 , A61K39/02 , A61K39/12 , A61K39/116
CPC分类号： A61K47/4833 , A61K39/385 , A61K47/4823 , A61K47/48261 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , Y10S530/806
摘要： A dual carrier immunogenic construct comprised of at least one primary carrier comprising large molecular weight molecule of greater than a 70 KD molecular weight and at least one secondary carrier comprising a T-dependent antigen conjugated to a primary carrier. The dual carrier immunogenic construct may further comprise moieties such as haptens and antigens. Such immunogenic constructs are suitable for use in the diagnosis, treatment, and prevention of diseases.

8. 发明申请

US20130052204A1 (POLY)-GLYCEROLPHOSPHATE-BASED ANTI-GRAM POSITIVE BACTERIAL VACCINE 审中-公开
标题翻译：（POLY）-GLYCEROLPHOSPHATE-BASED抗菌活性细菌疫苗
公开(公告)号：US20130052204A1
公开(公告)日：2013-02-28
申请号：US13508860
申请日：2010-11-15
申请人： Clifford M. Snapper , Andrew Lees , James J. Mond , David Schwartz
发明人： Clifford M. Snapper , Andrew Lees , James J. Mond , David Schwartz
IPC分类号： A61K39/385 , A61P31/04 , C07F9/09 , C07K17/08 , A61K39/40
CPC分类号： A61K39/085 , A61K2039/55505 , A61K2039/55561 , A61K2039/6037
摘要： Provided are an immunogenic composition comprising polyglycerol phosphate (PGP) and methods for using the composition for treating or preventing staphylococcal infections. The PGP may be conjugated to a T-cell dependent antigen. Also provided are methods for synthesizing PGP and methods for conjugating PGP to a T-cell dependent antigen.
摘要翻译：提供了包含聚甘油磷酸酯（PGP）和使用该组合物治疗或预防葡萄球菌感染的方法的免疫原性组合物。 PGP可以与T细胞依赖性抗原缀合。还提供了用于合成PGP的方法和将PGP与T细胞依赖性抗原缀合的方法。

9. 发明授权

US07250494B2 Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria 失效
标题翻译：革兰氏阳性细菌脂磷壁酸特异的口服单克隆和嵌合抗体
公开(公告)号：US07250494B2
公开(公告)日：2007-07-31
申请号：US10323927
申请日：2002-12-20
申请人： Jeffrey R. Stinson , Richard F. Schuman , James J. Mond , Andrew Lees , Gerald Walter Fischer
发明人： Jeffrey R. Stinson , Richard F. Schuman , James J. Mond , Andrew Lees , Gerald Walter Fischer
IPC分类号： C12P21/08 , C12P21/04 , C07K16/00 , C12N5/06 , A61K39/395 , A61K39/40 , C07H21/04
CPC分类号： C07K16/1267 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/195 , C07K16/1271 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/77 , C07K2319/00
摘要： The present invention encompasses monoclonal antibodies that bind to lipoteichoic acid (LTA) of Gram positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro. The invention also provides antibodies having human sequences (chimeric, humanized and human antibodies). The invention also sets forth the variable regions of three antibodies within the invention and presents the striking homology between them.
摘要翻译：本发明包括与革兰氏阳性细菌的脂磷壁酸（LTA）结合的单克隆抗体。抗体还与全细菌结合，增强体外吞噬细菌和杀死细菌。本发明还提供具有人序列（嵌合，人源化和人抗体）的抗体。本发明还阐述了本发明内三种抗体的可变区，并且它们之间具有引人注目的同源性。

10. 发明授权

US5955079A Dual carrier immunogenic construct 失效
标题翻译：双载体免疫原性构建体
公开(公告)号：US5955079A
公开(公告)日：1999-09-21
申请号：US468359
申请日：1995-06-06
申请人： James J. Mond , Andrew Lees
发明人： James J. Mond , Andrew Lees
IPC分类号： G01N33/531 , A61K39/385 , A61K47/48 , A61K49/00 , A61P37/04
CPC分类号： A61K47/4833 , A61K39/385 , A61K47/4823 , A61K47/48261 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , Y10S530/806
摘要： A dual carrier immunogenic construct comprised of at least one primary carrier comprising large molecular weight molecule of greater than a 70 KD molecular weight and at least one secondary carrier comprising a T-dependent antigen conjugated to a primary carrier. The dual carrier immunogenic construct may further comprise moieties such as haptens and antigens. Such immunogenic constructs are suitable for use in the diagnosis, treatment, and prevention of diseases.
摘要翻译：双载体免疫原性构建体由至少一个主载体组成，其包含大于70KD分子量的大分子量分子和至少一种第二载体，其包含与主载体缀合的T依赖性抗原。双载体免疫原性构建体可以进一步包含部分如半抗原和抗原。这样的免疫原性构建体适用于诊断，治疗和预防疾病。

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