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1. 发明授权

US07960142B2 Stabilized polypeptide compositions 有权
标题翻译：稳定的多肽组合物
公开(公告)号：US07960142B2
公开(公告)日：2011-06-14
申请号：US11894025
申请日：2007-08-17
申请人： Scott Glaser , Stephen Demarest , Brian Robert Miller , William B. Snyder , Xiufeng Wu , Norman Wang , Lisa J. Croner , Alexey Alexandrovich Lugovskoy
发明人： Scott Glaser , Stephen Demarest , Brian Robert Miller , William B. Snyder , Xiufeng Wu , Norman Wang , Lisa J. Croner , Alexey Alexandrovich Lugovskoy
IPC分类号： C12P21/08 , C12N15/79 , C12N15/16 , C12N15/13 , C12N15/09 , C07H21/04 , C07K16/28
CPC分类号： G06F19/16 , A61K39/395 , A61K2039/505 , A61K2039/507 , C07K16/00 , C07K16/2851 , C07K16/2878 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2319/30 , G06F19/18 , G06F19/22 , Y02A90/26
摘要： The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules.
摘要翻译：本发明至少部分地基于由稳定的scFv组成或包含稳定化的scFv的稳定的结合分子的开发以及用于制备这种稳定的分子的方法。

2. 发明申请

US20090048122A1 Stabilized polypeptide compositions 有权
标题翻译：稳定的多肽组合物
公开(公告)号：US20090048122A1
公开(公告)日：2009-02-19
申请号：US11894025
申请日：2007-08-17
申请人： Scott Glaser , Stephen Demarest , Brian Robert Miller , William B. Snyder , Xiufeng Wu , Norman Wang , Lisa J. Croner , Alexey Alexandrovich Lugovskoy
发明人： Scott Glaser , Stephen Demarest , Brian Robert Miller , William B. Snyder , Xiufeng Wu , Norman Wang , Lisa J. Croner , Alexey Alexandrovich Lugovskoy
IPC分类号： C40B30/10 , C07K16/18 , C12N15/11 , C12N15/00 , C12N5/06 , C12P21/04 , A61K39/395 , C07K1/00 , C40B50/02
CPC分类号： G06F19/16 , A61K39/395 , A61K2039/505 , A61K2039/507 , C07K16/00 , C07K16/2851 , C07K16/2878 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2319/30 , G06F19/18 , G06F19/22 , Y02A90/26
摘要： The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules.
摘要翻译：本发明至少部分地基于由稳定的scFv组成或包含稳定化的scFv的稳定的结合分子的开发以及用于制备这种稳定的分子的方法。

3. 发明授权

US08892364B2 Stabilized polypeptide compositions 有权
标题翻译：稳定的多肽组合物
公开(公告)号：US08892364B2
公开(公告)日：2014-11-18
申请号：US11894057
申请日：2007-08-17
申请人： Scott Glaser , Stephen Demarest , Brian Robert Miller , William B. Snyder , Xiufeng Wu , Norman Wang , Lisa J. Croner , Alexey Alexandrovich Lugovskoy
发明人： Scott Glaser , Stephen Demarest , Brian Robert Miller , William B. Snyder , Xiufeng Wu , Norman Wang , Lisa J. Croner , Alexey Alexandrovich Lugovskoy
IPC分类号： G06F17/00 , C07K16/00 , C12N5/10 , G06F19/16 , G06F19/22
CPC分类号： G06F19/16 , A61K39/395 , A61K2039/505 , A61K2039/507 , C07K16/00 , C07K16/2851 , C07K16/2878 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2319/30 , G06F19/18 , G06F19/22 , Y02A90/26
摘要： The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules.
摘要翻译：本发明至少部分地基于由稳定的scFv组成或包含稳定化的scFv的稳定的结合分子的开发和用于制备这种稳定的分子的方法。

4. 发明授权

US07951918B2 Stabilized polypeptide compositions 有权
公开(公告)号：US07951918B2
公开(公告)日：2011-05-31
申请号：US11725970
申请日：2007-03-19
申请人： Scott Glaser , Stephen Demarest , Brian Robert Miller , William B. Snyder , Xiufeng Wu , Norman Wang , Lisa J. Croner , Alexey Alexandrovich Lugovskoy
发明人： Scott Glaser , Stephen Demarest , Brian Robert Miller , William B. Snyder , Xiufeng Wu , Norman Wang , Lisa J. Croner , Alexey Alexandrovich Lugovskoy
IPC分类号： C12P21/08 , C07K16/18 , C07K16/28 , A61K39/395
CPC分类号： G06F19/16 , A61K39/395 , A61K2039/505 , A61K2039/507 , C07K16/00 , C07K16/2851 , C07K16/2878 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2319/30 , G06F19/18 , G06F19/22 , Y02A90/26
摘要： The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules.

5. 发明申请

US20110301331A1 Stabilized polypeptide compositions 有权
公开(公告)号：US20110301331A1
公开(公告)日：2011-12-08
申请号：US11894057
申请日：2007-08-17
申请人： Scott Glaser , Stephen Demarest , Brian Robert Miller , William B. Snyder , Xiufeng Wu , Norman Wang , Lisa J. Croner , Alexey Alexandrovich Lugovsky
发明人： Scott Glaser , Stephen Demarest , Brian Robert Miller , William B. Snyder , Xiufeng Wu , Norman Wang , Lisa J. Croner , Alexey Alexandrovich Lugovsky
IPC分类号： C07K16/00 , C12N5/10 , G06F17/10 , C12N1/19 , G06G7/60 , C12N15/13 , C12N1/21
CPC分类号： G06F19/16 , A61K39/395 , A61K2039/505 , A61K2039/507 , C07K16/00 , C07K16/2851 , C07K16/2878 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2319/30 , G06F19/18 , G06F19/22 , Y02A90/26
摘要： The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules.

6. 发明申请

US20080050370A1 Stabilized polypeptide compositions 有权
标题翻译：稳定的多肽组合物
公开(公告)号：US20080050370A1
公开(公告)日：2008-02-28
申请号：US11725970
申请日：2007-03-19
申请人： Scott Glaser , Stephen Demarest , Brian Miller , William Snyder , Xiufeng Wu , Norman Wang , Lisa Croner
发明人： Scott Glaser , Stephen Demarest , Brian Miller , William Snyder , Xiufeng Wu , Norman Wang , Lisa Croner
IPC分类号： A61K39/395 , C07K16/00 , C07K2/00 , C12N15/13 , C12N15/85 , C12N5/10 , C12P21/00 , C40B50/00 , G06G7/48
CPC分类号： G06F19/16 , A61K39/395 , A61K2039/505 , A61K2039/507 , C07K16/00 , C07K16/2851 , C07K16/2878 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2319/30 , G06F19/18 , G06F19/22 , Y02A90/26
摘要： The invention is based, at least in part, on the development of stabilized binding molecules that consist of or comprise a stabilized scFv and methods for making such stabilized molecules.
摘要翻译：本发明至少部分地基于由稳定的scFv组成或包含稳定化的scFv的稳定的结合分子的开发以及用于制备这种稳定的分子的方法。

7. 发明申请

US20060206269A1 One-dimensional QSAR models 审中-公开
标题翻译：一维QSAR模型
公开(公告)号：US20060206269A1
公开(公告)日：2006-09-14
申请号：US11283650
申请日：2005-11-21
申请人： David Diller , Norman Wang , Robert DeLisle , Andrei Anghelescu
发明人： David Diller , Norman Wang , Robert DeLisle , Andrei Anghelescu
IPC分类号： G06F19/00
CPC分类号： C07K1/00 , C07K2299/00 , G16C20/30
摘要： A set of molecules, the members of which have the same type of biological activity, are represented as one-dimensional strings of atoms. The one-dimensional strings of all members of the set are aligned, in order to obtain a multiple alignment profile of a consensus active compound. The one-dimensional multiple alignment profile is used in deriving a one-dimensional QSAR model to identify other compounds likely to have the same biological activity, and also may be used to derive a three-dimensional multiple alignment profile of the molecules in the set.
摘要翻译：一组分子，其成员具有相同类型的生物活性，被表示为一维原子串。将该组的所有成员的一维串排列，以获得共有活性化合物的多重比对分布。一维多重比对分布用于推导一维QSAR模型以鉴定可能具有相同生物活性的其他化合物，并且还可用于导出该组中分子的三维多重比对分布。

8. 发明授权

US08769691B1 Network traffic reduction 有权
标题翻译：网络流量减少
公开(公告)号：US08769691B1
公开(公告)日：2014-07-01
申请号：US13027178
申请日：2011-02-14
申请人： Gary Hsueh , Jeff Kuo , Sam Chang , Shako Ho , Norman Wang
发明人： Gary Hsueh , Jeff Kuo , Sam Chang , Shako Ho , Norman Wang
IPC分类号： G06F7/04 , G08B23/00
CPC分类号： H04L63/1441
摘要： A server access log includes data records each describing a previous query regarding a suspect computer file of a client computer. Each record includes the CRC code for the suspect computer file, the result of the malware analysis performed on the backend server and other attributes and values. The log is analyzed to retrieve relevant attributes and values from each record. Key attributes and values are generated such as region and continuous query. All CRC codes are grouped according to attribute values. Each group is analyzed to determine the network traffic associated with downloading the entire group to all user computers and the network traffic associated with not downloading the group but responding to future malware queries regarding CRC codes in the group. CRC codes are removed from each group if necessary. CRC code-result pairs for each group are downloaded to all user computers as a pre-fetch cache.
摘要翻译：服务器访问日志包括每个描述关于客户端计算机的可疑计算机文件的先前查询的数据记录。每个记录包括可疑计算机文件的CRC代码，对后端服务器执行的恶意软件分析的结果以及其他属性和值。分析日志以从每个记录检索相关属性和值。生成关键属性和值，如区域和连续查询。所有CRC码根据属性值分组。对每个组进行分析，以确定与将整个组下载到所有用户计算机相关联的网络流量以及与未下载组相关的网络流量，但是响应未来关于组中CRC码的恶意软件查询。如果需要，可以从每个组中删除CRC代码。每个组的CRC码 - 结果对作为预取缓存下载到所有用户计算机。

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