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1. 发明授权

US06464720B2 Radially expandable stent 有权
标题翻译：径向扩张支架
公开(公告)号：US06464720B2
公开(公告)日：2002-10-15
申请号：US09822066
申请日：2001-03-30
申请人： Scott E. Boatman , Kimberly D. Brummett , Thomas A. Osborne
发明人： Scott E. Boatman , Kimberly D. Brummett , Thomas A. Osborne
IPC分类号： A61F206
CPC分类号： A61F2/915 , A61F2/88 , A61F2/91 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/91583 , A61F2230/0054 , A61F2250/0036 , A61F2250/0098 , A61L31/022 , A61L31/18
摘要： A radially expandable stent (10) made from a cannula or sheet of biocompatible material that includes at least one longitudinal segment (14) comprised of a series of laterally interconnected closed cells (13). Each closed cell of a longitudinal segment is defined laterally by a pair of longitudinal struts (15, 16) that are interconnected at each end by a circumferentially adjustable member (19, 20). When the stent is expanded using a balloon (47), the opposing circumferentially adjustable members deform to allow circumferential expansion of the longitudinal segment, while the length of the segment, as defined by the longitudinal struts, is maintained. Self-expanding versions of the stent utilize a nickel-titanium alloy. Adjacent longitudinal segments are joined by flexible interconnection segments (21) that permit the stent to bend laterally. The flexible interconnection segment is comprised of curvilinear struts (22, 23) that form a series of serpentine bends (81) that distribute lateral bending forces. In a preferred embodiment, a short strut interconnects longitudinal segments and an adjacent interconnection segment. Each interconnection strut attaches to the longitudinal segment within a region (27) at the end (17) of a longitudinal strut (15) dividing two adjacent closed cells.
摘要翻译：一种由包括生物相容性材料的套管或片材制成的径向可扩张的支架（10），其包括由一系列横向互连的闭孔（13）构成的至少一个纵向段（14）。纵向段的每个闭合单元由一对纵向支柱（15,16）侧向地限定，所述纵向支柱在每个端部由周向可调节构件（19,20）互连。当使用球囊（47）扩张支架时，相对的周向可调部件变形以允许纵向段的周向膨胀，而由纵向支柱限定的段的长度保持。自扩张型支架采用镍钛合金。相邻的纵向段通过柔性互连段（21）连接，允许支架横向弯曲。柔性互连部分由曲线支柱（22,23）组成，其形成分布横向弯曲力的一系列蛇形弯曲部（81）。在优选实施例中，短支柱将纵向段和相邻互连段互连。每个互连支柱在分开两个相邻闭孔的纵向支柱（15）的端部（17）处的区域（27）内附接到纵向段。

2. 发明授权

US06881209B2 Medical device including unitary, continuous portion of varying durometer 有权
标题翻译：医疗设备包括单位，连续部分变化的硬度
公开(公告)号：US06881209B2
公开(公告)日：2005-04-19
申请号：US09848742
申请日：2001-05-03
申请人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , Thomas A. Osborne , David A. Drewes, Jr. , David R. Lessard , Maggie A. Z. Hupcey
发明人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , Thomas A. Osborne , David A. Drewes, Jr. , David R. Lessard , Maggie A. Z. Hupcey
IPC分类号： A61L29/06 , C08F283/04 , C08G69/48 , A61M25/00 , B29C45/00 , B29C47/00 , B29D9/00
CPC分类号： A61M25/0009 , A61L29/06 , B29C35/08 , B29K2077/00 , B29L2031/7542 , C08F283/04 , C08G69/48 , Y10T29/4998 , C08L77/00 , C08F218/16
摘要： A medical device (110) including a catheter shaft (111) and a unitarily and continuously formed portion (108) having a varying durometer, and optionally including an expandable balloon (18, 118). One or both of the unitarily and continuously formed portion (108) and the balloon (18, 118) are made from an irradiation cross-linked or cross-linkable mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The aromatic molecule can be 1,3,5 triethyl benzene; 1,2,4 triethyl benzene; and 1,3,5 triisopropyl benzene. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide.
摘要翻译：一种医疗装置（110），包括导管轴（111）和具有变化的硬度的整体连续形成部分（108），并且可选地包括可膨胀气囊（18,118）。整体和连续形成的部分（108）和球囊（18,118）中的一个或两个由聚酰胺弹性体和至少一种另外的交联反应物的照射交联或可交联混合物制成。聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。芳族分子可以是1,3,5三乙基苯; 1,2,4三乙苯; 和1,3,5三异丙基苯。交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性在其苄基位点处的氢。交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。

3. 发明授权

US06447540B1 Stent deployment device including splittable sleeve containing the stent 失效
标题翻译：支架展开装置，包括含支架的可拆卸套筒
公开(公告)号：US06447540B1
公开(公告)日：2002-09-10
申请号：US08971113
申请日：1997-11-14
申请人： Arthur B. Fontaine , Susan DosPassos , Brian L. Bates , Scott E. Boatman , Michael C. Hoffa , Thomas A. Osborne
发明人： Arthur B. Fontaine , Susan DosPassos , Brian L. Bates , Scott E. Boatman , Michael C. Hoffa , Thomas A. Osborne
IPC分类号： A61F206
CPC分类号： A61F2/97 , A61F2/95 , A61F2/958 , A61F2002/9511 , A61F2002/9583 , A61M25/0668 , A61M25/10
摘要： A stent deployment device (10) includes a catheter (12), a stent (14) positioned on the catheter (12), and a sleeve (16) carried on the catheter (12). The sleeve (16) has a portion (18) extending fully over and containing the stent (14). The stent deployment device (10) also includes a mechanism (20) for splitting at least the portion (18) of the sleeve (16) extending over the stent (14) and, preferably, for splitting the entire sleeve (16). Splitting of the sleeve portion (18) permits expansion of the stent (14). The mechanism (20) can include an inflatable, nondistending balloon (22) carried on the catheter (12), the stent (14) and the sleeve portion (18) being positioned over the balloon (22). The stent (14) can be self-expanding or can be expanded by the balloon (22) itself. Alternatively, the mechanism (20) can include a bulbous end (24) on the catheter (12). Longitudinal movement of the bulbous catheter end (24) with respect to the sleeve (16) splits at least the sleeve portion (18), permitting expansion of the stent (14). As further alternatives, the mechanism (20) can include a garrote (66) connected to the sleeve or a partial segment (62) of the sleeve (16) folded back alongside the stent (14). The sleeve (16) can be the same length as the catheter (12) or can be shorter than the catheter (12). In the former case, the mechanism (20) can include a pair of graspable wings (56) for splitting the full length of the sleeve (16). It is preferred that at least the portion (18) of the sleeve (16) extending over the stent (14) includes a longitudinally extending structure 46 for ensuring that the sleeve portion (18) will in fact split upon operation of the mechanism (20).
摘要翻译：支架展开装置（10）包括导管（12），定位在导管（12）上的支架（14）和承载在导管（12）上的套筒（16）。套筒（16）具有完全延伸并且容纳支架（14）的部分（18）。支架展开装置（10）还包括一个机构（20），用于至少分开延伸在支架（14）上的套筒（16）的部分（18），并且优选地用于分割整个套筒（16）。套筒部分（18）的分裂允许支架（14）膨胀。机构（20）可以包括承载在导管（12）上的可膨胀的非重排球囊（22），支架（14）和套筒部分（18）定位在球囊（22）上方。支架（14）可以是自膨胀的，或者可以由气囊（22）自身扩张。或者，机构（20）可以包括在导管（12）上的球根端（24）。球根导管端部（24）相对于套筒（16）的纵向移动至少分开套筒部分（18），从而允许支架（14）的膨胀。作为另外的替代方案，机构（20）可以包括连接到套筒的衣壳（66）或套管（16）的沿着支架（14）折回的部分段（62）。套筒（16）可以与导管（12）的长度相同，或者可以比导管（12）短。在前一种情况下，机构（20）可以包括用于分离套筒（16）的全长的一对可抓握翼（56）。优选地，延伸在支架（14）上的套筒（16）的至少部分（18）包括纵向延伸的结构46，用于确保套筒部分（18）实际上将在

4. 发明授权

US07722795B2 Medical device including unitary, continuous portion of varying durometer 有权
标题翻译：医疗设备包括单位，连续部分变化的硬度
公开(公告)号：US07722795B2
公开(公告)日：2010-05-25
申请号：US10813415
申请日：2004-03-30
申请人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , Thomas A. Osborne , David A. Drewes, Jr. , David R. Lessard , Maggie A. Z. Hupcey
发明人： Scott E. Boatman , David G. Burton , Michael C. Hoffa , Thomas A. Osborne , David A. Drewes, Jr. , David R. Lessard , Maggie A. Z. Hupcey
IPC分类号： B29C35/08
CPC分类号： A61M25/0009 , A61L29/06 , B29C35/08 , B29K2077/00 , B29L2031/7542 , C08F283/04 , C08G69/48 , Y10T29/4998 , C08L77/00 , C08F218/16
摘要： A medical device (110) including a catheter shaft (111) and a unitarily and continuously formed portion (108) having a varying durometer, and optionally including an expandable balloon (18, 118). One or both of the unitarily and continuously formed portion (108) and the balloon (18, 118) are made from an irradiation cross-linked or cross-linkable mixture of a polyamide elastomer and at least one additional cross-linking reactant. The polyamide elastomer can be a polyester amide, a polyether ester amide or a polyether amide, and is preferably a nylon block copolymer. The aromatic molecule can be 1,3,5 triethyl benzene; 1,2,4 triethyl benzene; and 1,3,5 triisopropyl benzene. The cross-linking reactant can be: (a) a difunctional material, (b) a trifunctional material, (c) a tetrafunctional material, or (d) an aromatic molecule containing at least two ring substituents, each of the ring substituents having labile hydrogens at a benzylic site therein. The cross-linking reactant can also be diallyl phthalate or meta-phenylene dimaleimide.
摘要翻译：一种医疗装置（110），包括导管轴（111）和具有变化的硬度的整体连续形成部分（108），并且可选地包括可膨胀气囊（18,118）。整体和连续形成的部分（108）和球囊（18,118）中的一个或两个由聚酰胺弹性体和至少一种另外的交联反应物的照射交联或可交联混合物制成。聚酰胺弹性体可以是聚酯酰胺，聚醚酯酰胺或聚醚酰胺，优选为尼龙嵌段共聚物。芳族分子可以是1,3,5三乙基苯; 1,2,4三乙苯; 和1,3,5三异丙基苯。交联反应物可以是：（a）双官能材料，（b）三官能材料，（c）四官能材料，或（d）含有至少两个环取代基的芳族分子，每个环取代基具有不稳定性在其苄基位点处的氢。交联反应物也可以是邻苯二甲酸二烯丙酯或间亚苯基二马来酰亚胺。

5. 发明授权

US09498271B2 Coaxial needle cannula with distal spiral mixer and side ports for fluid injection 有权
标题翻译：同轴针套管与远端螺旋混合器和侧面端口用于注射液体
公开(公告)号：US09498271B2
公开(公告)日：2016-11-22
申请号：US12914167
申请日：2010-10-28
申请人： Thomas A. Osborne , Jeffry S. Melsheimer , Christopher D. Bosel
发明人： Thomas A. Osborne , Jeffry S. Melsheimer , Christopher D. Bosel
IPC分类号： A61B17/88 , A61M5/315 , B01F5/06 , A61M5/19
CPC分类号： A61J1/20 , A61B17/8816 , A61B17/8822 , A61B18/06 , A61B2017/8838 , A61M5/19 , A61M5/31581 , B01F5/0473 , B01F5/0614 , B01F5/0615 , B01F2215/0029
摘要： Disclosed is a multi-lumen mixing device that includes a first and second lumen constructed and arranged to separately pass a first and second reagent to a mixing chamber in the device, where the mixing chamber includes a mixing feature that mixes the first and second reagents. The disclosed multi-lumen mixing device may also include a port in fluid communication with the reaction mixing to permit the product of the combined reagents to be injected into a patent.
摘要翻译：公开了一种多腔混合装置，其包括构造和布置成将第一和第二试剂分开地通过装置中的混合室的第一和第二腔，其中混合室包括混合第一和第二试剂的混合特征。所公开的多腔混合装置还可以包括与反应混合流体连通的端口，以允许将组合试剂的产物注入专利。

6. 发明授权

US08246672B2 Endovascular graft with separately positionable and removable frame units 有权
标题翻译：血管内移植物具有单独定位和可拆卸的框架单元
公开(公告)号：US08246672B2
公开(公告)日：2012-08-21
申请号：US12339596
申请日：2008-12-19
申请人： Thomas A. Osborne
发明人： Thomas A. Osborne
IPC分类号： A61F2/06
CPC分类号： A61F2/013 , A61F2/07 , A61F2/89 , A61F2002/016 , A61F2002/065 , A61F2002/9534 , A61F2220/0058 , A61F2230/005 , A61F2230/0054 , A61F2230/008 , A61F2230/0093
摘要： A device for repairing a vessel body including a plurality distinct and independently positionable, expandable frame units disposed within a tubular graft. The independent frame units are capable of being positioned, repositioned, or removed to conform the tubular graft to the anatomy of the vessel body.
摘要翻译：一种用于修理容器主体的装置，包括设置在管状移植物内的多个不同且可独立定位的可扩展框架单元。独立的框架单元能够定位，重新定位或移除以使管状移植物符合血管体的解剖结构。

7. 发明授权

US08197534B2 Valve device with inflatable chamber 有权
标题翻译：带充气室的阀门装置
公开(公告)号：US08197534B2
公开(公告)日：2012-06-12
申请号：US11394303
申请日：2006-03-30
申请人： Thomas A. Osborne , Jacob A. Flagle , John A. Brumleve
发明人： Thomas A. Osborne , Jacob A. Flagle , John A. Brumleve
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2412 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0026 , A61F2230/0095 , A61F2250/0003 , Y10T29/494
摘要： Prosthetic valve devices for implantation in body vessels are provided. The prosthetic valve device includes at least one flexible member that permits fluid flow in a first direction and substantially prevents fluid flow in a second. The valve device also includes an inflatable chamber at least partially attached to the flexible member. The inflatable chamber is adapted to receive inflating media and is adapted to contact the body vessel. A delivery system is also provided that includes a valve device and a delivery apparatus. The delivery apparatus includes a member adapted for filling the chamber of the valve device with inflating media. A related method of making the valve device is also provided.
摘要翻译：提供用于植入体内血管的假体瓣膜装置。所述人工瓣膜装置包括至少一个柔性构件，其允许流体沿第一方向流动并且基本上防止流体在第二方向流动。阀装置还包括至少部分地附接到柔性构件的可充气室。充气室适于接收充气介质并且适于接触身体容器。还提供了包括阀装置和输送装置的输送系统。输送装置包括适于用充气介质填充阀装置的室的构件。还提供了制造阀装置的相关方法。

8. 发明授权

US08043302B2 Implant retrieval assembly and method for retrieving an implant 有权
标题翻译：植入物检索组件和用于检索植入物的方法
公开(公告)号：US08043302B2
公开(公告)日：2011-10-25
申请号：US11708235
申请日：2007-02-20
申请人： Jeffry S. Melsheimer , Thomas A. Osborne
发明人： Jeffry S. Melsheimer , Thomas A. Osborne
IPC分类号： A61B17/26
CPC分类号： A61B17/221 , A61B17/32056 , A61B17/3468 , A61B2017/0046 , A61B2017/00477 , A61B2017/2919
摘要： An implant retrieval frame for advancement of a retrieval device to snare an implant is disclosed. The frame comprises a first arm and a second arm. The first arm has a first handle end and a first pivot end. The second arm has a second handle end and a second pivot end. The second pivot end is connected to the first pivot end to define a pivot axis about which the first and second arm pivotally move. The frame further comprises a connector to which the retrieval device is attached. The connector is configured to cooperate with the first and second arms to translate pivotal movement of one of the first and second arms to linear movement of the retrieval device relative to the pivot point.
摘要翻译：公开了一种用于推进提取装置以圈套植入物的植入物检索框架。框架包括第一臂和第二臂。第一臂具有第一手柄端和第一枢转端。第二臂具有第二手柄端和第二枢转端。第二枢转端连接到第一枢转端以限定枢转轴线，第一和第二臂枢转运动。该框架还包括一个连接器，拾取装置附接到该连接器。连接器构造成与第一和第二臂配合以将第一和第二臂之一的枢转运动转换成相对于枢转点的线性运动。

9. 发明申请

US20100063577A1 METHOD OF IMPLANTING A PROSTHETIC VALVE 审中-公开
标题翻译：植入预制阀的方法
公开(公告)号：US20100063577A1
公开(公告)日：2010-03-11
申请号：US12621214
申请日：2009-11-18
申请人： Brian C. Case , Thomas A. Osborne , Jacob A. Flagle , Fred T. Parker
发明人： Brian C. Case , Thomas A. Osborne , Jacob A. Flagle , Fred T. Parker
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Methods of implanting a prosthetic valve in a body vessel are provided. A first expandable frame member is delivered to and deployed at a point of treatment in a body vessel. A second expandable frame member is delivered to the point of treatment. The second expandable frame member has an attached graft member that forms a valve adapted to permit fluid flow through the body vessel in a first direction and to substantially prevent fluid flow through the body vessel in a second, opposite direction. After deployment of the first expandable frame member, the second expandable frame member is deployed at the point of treatment such that the second frame member is positioned radially inward of the first frame member within said body vessel to form a prosthetic valve.
摘要翻译：提供了将人造瓣植入人体容器中的方法。第一可膨胀框架构件被输送到身体容器中并在其处处被部署。第二可膨胀框架构件被输送到处理点。第二可膨胀框架构件具有附接的移植构件，其形成适于允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体容器。在展开第一可膨胀框架构件之后，第二可膨胀框架构件在处理点处展开，使得第二框架构件位于所述主体容器内的第一框架构件的径向内侧以形成人造瓣膜。

10. 发明授权

US07628803B2 Implantable vascular device 有权
公开(公告)号：US07628803B2
公开(公告)日：2009-12-08
申请号：US10642372
申请日：2003-08-15
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.

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