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1. 发明申请

US20060217433A1 Sulfonamide derivatives as ppar modulators 失效
标题翻译：磺酰胺衍生物作为ppar调节剂
公开(公告)号：US20060217433A1
公开(公告)日：2006-09-28
申请号：US10542579
申请日：2004-02-10
申请人： Scott Conner , Lynn Gosset , Jonathan Green , Winton Jones , Nathan Mantlo , Donald Matthews , Daniel Mayhugh , Daryl Smith , Jennifer Vance , Xiaodong Wang , Alan Warshawsky , Leonard Winneroski , Yanping Xu , Guoxin Zhu
发明人： Scott Conner , Lynn Gosset , Jonathan Green , Winton Jones , Nathan Mantlo , Donald Matthews , Daniel Mayhugh , Daryl Smith , Jennifer Vance , Xiaodong Wang , Alan Warshawsky , Leonard Winneroski , Yanping Xu , Guoxin Zhu
IPC分类号： A61K31/404 , A61K31/381 , A61K31/343 , A61K31/195 , C07D333/64
CPC分类号： C07D207/08 , A61K31/00 , A61K45/06 , C07C311/13 , C07C311/17 , C07C311/19 , C07C311/29 , C07C317/14 , C07C323/49 , C07C323/52 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/08 , C07D209/48 , C07D213/64 , C07D213/71 , C07D213/74 , C07D215/36 , C07D231/12 , C07D231/18 , C07D263/32 , C07D271/12 , C07D277/36 , C07D307/79 , C07D307/82 , C07D319/18 , C07D333/34 , C07D333/62 , C07D409/04 , C07D409/12 , C07D413/04 , A61K2300/00
摘要： The present invention is directed to a compound of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, which are useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐，溶剂合物，水合物或立体异构体，其可用于治疗或预防由过氧化物酶体增殖物激活受体（PPAR）介导的病症，例如综合征X型 II型糖尿病，高血糖症，高脂血症，肥胖症，凝血病，高血压，动脉硬化以及与X综合症和心血管疾病有关的其他疾病。

2. 发明申请

US20050075378A1 Modulators of peroxisome proliferator activated receptors (ppar) 失效
标题翻译：过氧化物酶体增殖物激活受体调节剂（ppar）
公开(公告)号：US20050075378A1
公开(公告)日：2005-04-07
申请号：US10477405
申请日：2002-05-24
申请人： Lynn Gossett , Jonathan Green , James Henry , Winton Jones , Donald Matthews , Quanrong Shen , Daryl Smith , Jennifer Vance , Alan Warshawsky , Maria Gonzalez-Garcia
发明人： Lynn Gossett , Jonathan Green , James Henry , Winton Jones , Donald Matthews , Quanrong Shen , Daryl Smith , Jennifer Vance , Alan Warshawsky , Maria Gonzalez-Garcia
IPC分类号： C07D233/64 , A61K31/195 , A61K31/27 , A61K31/277 , A61K31/343 , A61K31/381 , A61K31/4035 , A61K31/415 , A61K31/4164 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4402 , A61K31/443 , A61K31/4439 , A61K31/454 , A61K31/455 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P3/02 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P25/00 , A61P43/00 , C07C233/63 , C07C233/84 , C07C233/87 , C07C255/57 , C07C271/22 , C07C271/24 , C07D209/48 , C07D213/81 , C07D231/12 , C07D233/58 , C07D239/28 , C07D263/32 , C07D277/20 , C07D277/24 , C07D277/28 , C07D277/42 , C07D307/79 , C07D333/28 , C07D333/38 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D495/04 , C07D277/18 , C07D263/52
CPC分类号： C07D209/48 , C07C233/63 , C07C233/87 , C07C255/57 , C07C271/22 , C07C271/24 , C07C2601/04 , C07C2601/14 , C07D213/81 , C07D231/12 , C07D239/28 , C07D263/32 , C07D277/28 , C07D277/42 , C07D307/79 , C07D333/28 , C07D401/06 , C07D409/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D495/04
摘要： The present invention is directed to a compound of formula I, and pharmaceutically acceptable salts, solvates, hydrates or stereoisomer thereof, which are useful in treating Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to Syndrome X as well as cardiovascular diseases.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，溶剂化物，水合物或立体异构体，它们可用于治疗综合征X，II型糖尿病，高血糖症，高脂血症，肥胖症，凝血病，高血压，动脉硬化等与综合征X相关的疾病以及心血管疾病。

3. 发明申请

US20070088018A1 Cb1 antagonist compounds 失效
标题翻译： Cb1拮抗剂化合物
公开(公告)号：US20070088018A1
公开(公告)日：2007-04-19
申请号：US10596495
申请日：2004-12-13
申请人： Jennifer Allen , Albert Amegadzie , Kevin Gardinier , George Gregory , Steven Hitchcock , Paul Hoogestraat , Winton Jones , Daryl Smith
发明人： Jennifer Allen , Albert Amegadzie , Kevin Gardinier , George Gregory , Steven Hitchcock , Paul Hoogestraat , Winton Jones , Daryl Smith
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/496 , C07D471/02
CPC分类号： C07D209/10 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/40 , C07D209/42 , C07D209/96 , C07D231/56 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D417/04 , C07D471/04 , C07D471/10 , C07D491/10
摘要： Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.
摘要翻译：公开了结构式（I）的新型化合物。作为大麻素-1（CB1）受体的调节剂，这些化合物可用于治疗，预防和抑制由CB1受体介导的疾病。因此，本发明的化合物可用于治疗，预防和抑制精神病，记忆缺陷，认知障碍，偏头痛，神经病，神经炎症性疾病（例如，多发性硬化症，吉兰巴利综合症和炎性后遗症病毒性脑炎），脑血管意外，头部创伤，焦虑症，压力，癫痫，帕金森病和精神分裂症。这些化合物也可用于治疗药物滥用障碍，特别是鸦片剂，酒精和尼古丁。所述化合物还可用于治疗与过量食物摄入和与其相关的并发症相关的肥胖或进食障碍。

4. 发明申请

US20170280879A1 Ergonomic Support Device for Weight of a User 审中-公开
公开(公告)号：US20170280879A1
公开(公告)日：2017-10-05
申请号：US15626533
申请日：2017-06-19
申请人： Daryl Smith
发明人： Daryl Smith
IPC分类号： A47C16/04 , A47K3/12
CPC分类号： A47C16/04 , A47K3/125
摘要： An ergonomic support device is provided for accommodating the weight of a user and allowing the user to perform various tasks with reduced effort. The support device is adapted for use in connection with various settings, such as bathtubs, and allows the user to work in or around a space while in a supported position.

5. 发明授权

US09681756B2 Ergonomic support device for weight of a user 有权
公开(公告)号：US09681756B2
公开(公告)日：2017-06-20
申请号：US13774972
申请日：2013-02-22
申请人： Daryl Smith
发明人： Daryl Smith
IPC分类号： A47C16/04 , A47C15/00
CPC分类号： A47C16/04 , A47C15/004
摘要： An ergonomic support device is provided for accommodating the weight of a user and allowing the user to perform various tasks with reduced effort. The support device is adapted for use in connection with various settings, such as bathtubs, and allows the user to work in or around a space while in a supported position.

6. 发明授权

US08296048B2 Vehicle information system 有权
标题翻译：车辆信息系统
公开(公告)号：US08296048B2
公开(公告)日：2012-10-23
申请号：US12723231
申请日：2010-03-12
申请人： Chris Henderson , Daryl Smith
发明人： Chris Henderson , Daryl Smith
IPC分类号： G06F19/00 , B60Q1/00 , B60K15/00 , G01F9/00 , G01F9/02 , G01L3/26 , G01M15/00
CPC分类号： G07C5/004 , B60K35/00 , B60K2350/1092 , F02B77/084 , Y02T10/84
摘要： A vehicle information system operating method performs operations comprising determining an operational period, determining a movement period, determining a modification factor, determining a fuel economy value and determining an adjusted fuel economy value. The determining of the operational period determines the operational period during which a vehicle is running. The determining of the movement period determines the movement period during which the vehicle is in motion. The determining of the modification factor determines the modification factor based on respective durations of the operational period and the movement period. The determining of the fuel economy value determines the fuel economy value associated with the operational period. The determining of the adjusted fuel economy value determines the adjusted fuel economy value based on the fuel economy value and the modification factor.
摘要翻译：车辆信息系统操作方法执行包括确定操作时段，确定移动时段，确定修改因子，确定燃料经济性值和确定经调整的燃料经济性的操作。运行期间的确定决定了车辆运行期间的运行时间。运动周期的确定决定了车辆运动期间的运动周期。修改因子的确定基于操作周期和移动周期的相应持续时间来确定修改因子。确定燃油经济性值决定了与运行期间相关的燃油经济性值。调整后的燃料经济性值的确定基于燃料经济性值和修正因子确定经调节的燃料经济性值。

7. 发明申请

US20060189661A1 Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开
公开(公告)号：US20060189661A1
公开(公告)日：2006-08-24
申请号：US11398556
申请日：2006-04-06
申请人： Bradford Wagenen , Thomas Stormann , Scott Moe , Susan Sheehan , Donald McLeod , Daryl Smith , Methvin Isaac , Abdelmalik Slassi , Ian Egle , Louise Edwards , Tomislav Stefanac , Tao Xin , Jalaj Arora , William Michne
发明人： Bradford Wagenen , Thomas Stormann , Scott Moe , Susan Sheehan , Donald McLeod , Daryl Smith , Methvin Isaac , Abdelmalik Slassi , Ian Egle , Louise Edwards , Tomislav Stefanac , Tao Xin , Jalaj Arora , William Michne
IPC分类号： C07D413/04 , A61K31/4439
CPC分类号： C07D213/75 , C07D213/55 , C07D213/78 , C07D213/79 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14
摘要： The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.

8. 发明申请

US20130220735A1 Ergonomic Support Device for Weight of a User 审中-公开
标题翻译：人体工程学支持设备，用于重量用户
公开(公告)号：US20130220735A1
公开(公告)日：2013-08-29
申请号：US13774972
申请日：2013-02-22
申请人： Daryl Smith
发明人： Daryl Smith
IPC分类号： A47C16/04
CPC分类号： A47C16/04 , A47C15/004
摘要： An ergonomic support device is provided for accommodating the weight of a user and allowing the user to perform various tasks with reduced effort. The support device is adapted for use in connection with various settings, such as bathtubs, and allows the user to work in or around a space while in a supported position.
摘要翻译：提供符合人体工程学的支持装置，用于容纳用户的重量，并允许用户以减少的努力执行各种任务。支撑装置适用于诸如浴缸等各种设置的使用，并且允许用户在支撑位置处在空间中或周围工作。

9. 发明申请

US20110224894A1 VEHICLE INFORMATION SYSTEM 有权
标题翻译：车辆信息系统
公开(公告)号：US20110224894A1
公开(公告)日：2011-09-15
申请号：US12723231
申请日：2010-03-12
申请人： Chris Henderson , Daryl Smith
发明人： Chris Henderson , Daryl Smith
IPC分类号： G06F7/00
CPC分类号： G07C5/004 , B60K35/00 , B60K2350/1092 , F02B77/084 , Y02T10/84
摘要： A vehicle information system operating method performs operations comprising determining an operational period, determining a movement period, determining a modification factor, determining a fuel economy value and determining an adjusted fuel economy value. The determining of the operational period determines the operational period during which a vehicle is running. The determining of the movement period determines the movement period during which the vehicle is in motion. The determining of the modification factor determines the modification factor based on respective durations of the operational period and the movement period. The determining of the fuel economy value determines the fuel economy value associated with the operational period. The determining of the adjusted fuel economy value determines the adjusted fuel economy value based on the fuel economy value and the modification factor.
摘要翻译：车辆信息系统操作方法执行包括确定操作时段，确定移动时段，确定修改因子，确定燃料经济性值和确定调整后的燃料经济性的操作。运行期间的确定决定了车辆运行期间的运行时间。运动周期的确定决定了车辆运动期间的运动周期。修改因子的确定基于操作周期和移动周期的相应持续时间来确定修改因子。确定燃油经济性值决定了与运行期间相关的燃油经济性值。调整后的燃料经济性值的确定基于燃料经济性值和修正因子确定经调节的燃料经济性值。

10. 发明授权

US08260534B2 Vehicle occupant information system for determining obtainable travel distances 有权
标题翻译：用于确定可行程距离的车辆乘客信息系统
公开(公告)号：US08260534B2
公开(公告)日：2012-09-04
申请号：US12701638
申请日：2010-02-08
申请人： Chris Henderson , Daryl Smith
发明人： Chris Henderson , Daryl Smith
IPC分类号： G01F9/00
CPC分类号： G01C22/00 , B60W2520/10 , B60W2530/18 , B60W2560/02 , G01C21/3697
摘要： A vehicle occupant information controller includes a fuel volume determining section, a fuel economy determining section, a first distance determining section, a traveled distance determining section and a second distance determining section. The first distance determining section determines a first obtainable travel distance based on a remaining fuel volume from the fuel volume determining section and a fuel consumption rate from the fuel economy determining section. The traveled distance determining section determines a vehicle traveled distance between two locations. The second distance determining section determines a second obtainable travel distance based on a difference between a previous obtainable travel distance value and an adjusted vehicle traveled distance value, with the adjusted vehicle traveled distance value being equal to a product of the vehicle traveled distance and a distance adjustment factor that is selectively adjusted based on a ratio of the second obtainable travel distance to the first obtainable travel distance.
摘要翻译：车辆乘员信息控制器包括燃料量确定部分，燃料经济性确定部分，第一距离确定部分，行驶距离确定部分和第二距离确定部分。第一距离确定部分基于来自燃料量确定部分的剩余燃料量和来自燃料经济性确定部分的燃料消耗率确定第一可获得的行驶距离。行驶距离确定部分确定两个位置之间的车辆行驶距离。第二距离确定部分基于先前获得的行驶距离值和调整车辆行驶距离值之间的差确定第二可获得行驶距离，其中调整车辆行驶距离值等于车辆行驶距离与距离的乘积基于第二获得的行驶距离与第一可获得的行驶距离的比率来选择性地调节的调节因子。

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