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1. 发明申请

US20070224595A1 Nucleic acid molecules and other molecules associated with plants 审中-公开
标题翻译：核酸分子和与植物相关的其他分子
公开(公告)号：US20070224595A1
公开(公告)日：2007-09-27
申请号：US10626717
申请日：2003-07-25
申请人： Scott Andersen , Joseph Byrum , Robert De La Pena
发明人： Scott Andersen , Joseph Byrum , Robert De La Pena
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07K14/415
摘要： Expressed Sequence Tags (ESTs) isolated from wheat are disclosed. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The disclosed ESTs have utility in the development of new strategies for understanding critical plant developmental and metabolic pathways. The disclosed ESTs have particular utility in isolating genes and promoters, identifying and mapping the genes involved in developmental and metabolic pathways, and determining gene function. Sequence homology analyses using the ESTs provided in the present invention, will result in more efficient gene screening for desirable agronomic traits. An expanding database of these select pieces of the plant genomics puzzle will quickly expand the knowledge necessary for subsequent functional validation, a key limitation in current plant biotechnology efforts.
摘要翻译：公开了从小麦分离的表达序列标签（ESTs）。 EST为靶基因和分离新基因提供了独特的分子工具，用于植物保护和改良。所公开的EST可用于开发用于了解关键植物发育和代谢途径的新策略。所公开的EST在分离基因和启动子方面具有特别的用途，鉴定和绘制参与发育和代谢途径的基因以及确定基因功能。使用本发明提供的EST的序列同源性分析将导致对所需农学性状的更有效的基因筛选。这些植物基因组学难题的这些精选片段的不断扩展的数据库将快速扩展后续功能验证所必需的知识，这是当前植物生物技术努力的关键限制。

2. 发明申请

US20070044171A1 Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement 有权
公开(公告)号：US20070044171A1
公开(公告)日：2007-02-22
申请号：US10703032
申请日：2003-11-06
申请人： David Kovalic , Scott Andersen , Joseph Byrum , Timothy Conner , James Masucci , Yihua Zhou
发明人： David Kovalic , Scott Andersen , Joseph Byrum , Timothy Conner , James Masucci , Yihua Zhou
IPC分类号： C12Q1/68 , C07H21/04 , A01H1/00 , C12N15/82 , C12N5/04 , C07K14/415
CPC分类号： C12N15/8261 , A01G22/00 , C07K14/415 , C12N15/8243 , C12N15/8245 , C12N15/8247 , C12N15/8251 , C12N15/8255 , C12N15/8269 , C12N15/8273 , C12N15/8274 , C12N15/8279 , C12N15/902
摘要： Recombinant polynucleotides and recombinant polypeptides useful for improvement of plants are provided. The disclosed recombinant polynucleotides and recombinant polypeptides find use in production of transgenic plants to produce plants having improved properties.

3. 发明授权

US08809621B2 Yield traits for maize 有权
标题翻译：玉米产量性状
公开(公告)号：US08809621B2
公开(公告)日：2014-08-19
申请号：US12536147
申请日：2009-08-05
申请人： Venkata Krishna Kishore , Libardo Andres Gutierrez Rojas , Zhigang Guo , Joseph Byrum
发明人： Venkata Krishna Kishore , Libardo Andres Gutierrez Rojas , Zhigang Guo , Joseph Byrum
IPC分类号： A01H1/02 , A01H5/10
CPC分类号： A01H1/04 , A01H3/00 , A01H5/10 , C12N15/8261 , C12Q1/6895 , C12Q2600/13
摘要： Methods for introgressing an allele of interest of a locus associated with a yield trait into Zea mays germplasm are provided. In some embodiments, the methods include providing a Zea mays plant that contains an allele of interest of a locus associated with a yield trait, wherein the locus associated with the yield trait is identifiable by PCR amplification of a Zea mays nucleic acid with a pair of oligonucleotides primers as disclosed herein, and introgressing the allele of interest into Zea mays germplasm that lacks the allele. Also provided are methods for identifying Zea mays plants that contain at least one allele associated with improved yield, improved maize plants, elite Zea mays plants, biomass produced from improved Zea mays plants, isolated and purified genetic markers, and compositions that include an amplification primer pair capable of amplifying a Zea mays nucleic acid to generate a Zea mays marker amplicon.
摘要翻译：提供了将与产量性状相关的基因座感兴趣等位基因浸入玉米种质的方法。在一些实施方案中，所述方法包括提供包含与产量性状相关的基因座的目的等位基因的玉米种植体，其中与产量性状相关的基因座可通过具有一对玉米的玉米核酸的PCR扩增来鉴定寡核苷酸引物，并将感兴趣的等位基因渗入缺少等位基因的玉米种质。还提供了用于鉴定含有至少一个与改良产量相关的等位基因的Zea mays植物的方法，改良的玉米植物，精英玉米植物，由改良的Zea mays植物产生的生物，分离和纯化的遗传标记，以及包含扩增引物能够扩增Zea mays核酸以产生Zea mays标记扩增子。

4. 发明申请

US20100204921A1 METHOD FOR SELECTING STATISTICALLY VALIDATED CANDIDATE GENES 有权
标题翻译：选择统计证实候选基因的方法
公开(公告)号：US20100204921A1
公开(公告)日：2010-08-12
申请号：US12367045
申请日：2009-02-06
申请人： Venkata Krishna Kishore , Zhigang Guo , Min Li , Daolong Wang , Libardo Andres Gutierrez Rojas , Joseph Dallas Clarke, V , Joseph Byrum
发明人： Venkata Krishna Kishore , Zhigang Guo , Min Li , Daolong Wang , Libardo Andres Gutierrez Rojas , Joseph Dallas Clarke, V , Joseph Byrum
IPC分类号： G06F19/00
CPC分类号： G06F19/18 , G06F19/24
摘要： Provided herein are methods for evaluating associations between candidate genes and a trait of interest in a population. The methods include a combination of genome-wide association analysis and one or more of nested association mapping (NAM), expression QTL analysis (eQTL), and allele epistastic analysis (AEA). Markers are selected or prioritized if they are shown to be positively-correlated with a trait of interest using GWA and a combination of one or both of NAM and eQTL. Also provided are models for evaluating the association between a candidate marker and a trait in a nested population of organisms. These methods include single marker regression and multiple marker regression models. Markers identified using the methods of the invention can be used in marker assisted breeding and selection, as genetic markers for constructing linkage maps, for gene discovery, for identifying genes contributing to a trait of interest, and for generating transgenic organisms having a desired trait.
摘要翻译：本文提供了评估候选基因与群体中感兴趣的性状之间的关联的方法。这些方法包括全基因组关联分析和嵌套关联定位（NAM），表达QTL分析（eQTL）和等位基因分析（AEA）中的一个或多个的组合。如果使用GWA和NAM和eQTL中的一个或两个的组合显示与感兴趣的特征呈正相关的标记被选择或优先化。还提供了用于评估候选标记与嵌套生物群体中的性状之间的关联的模型。这些方法包括单标记回归和多标记回归模型。使用本发明的方法鉴定的标记物可用于标记辅助育种和选择，作为用于构建连锁图谱，用于基因发现，用于鉴定有助于感兴趣性状的基因以及产生具有所需性状的转基因生物的遗传标记。

5. 发明申请

US20070283459A1 Nucleic acid molecules and other molecules associated with plants 审中-公开
标题翻译：核酸分子和与植物相关的其他分子
公开(公告)号：US20070283459A1
公开(公告)日：2007-12-06
申请号：US11239591
申请日：2005-09-30
申请人： Joseph Byrum , Gregory Heck , Thomas La Rosa
发明人： Joseph Byrum , Gregory Heck , Thomas La Rosa
IPC分类号： A01H5/00 , C07H21/04 , C12N15/82 , C07K14/415
CPC分类号： C07K14/415 , C12N15/8242 , C12N15/8261 , C12Q1/6895 , Y02A40/146
摘要： Expressed Sequence Tags (ESTs) isolated from soybean are disclosed. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The disclosed ESTs have utility in the development of new strategies for understanding critical plant developmental and metabolic pathways. The disclosed ESTs have particular utility in isolating genes and promoters, identifying and mapping the genes involved in developmental and metabolic pathways, and determining gene function. Sequence homology analyses using the ESTs provided in the present invention, will result in more efficient gene screening for desirable agronomic traits. An expanding database of these select pieces of the plant genomics puzzle will quickly expand the knowledge necessary for subsequent functional validation, a key limitation in current plant biotechnology efforts.
摘要翻译：公开了从大豆分离的表达序列标签（ESTs）。 EST为靶基因和分离新基因提供了独特的分子工具，用于植物保护和改良。所公开的EST可用于开发用于了解关键植物发育和代谢途径的新策略。所公开的EST在分离基因和启动子方面具有特别的用途，鉴定和绘制参与发育和代谢途径的基因以及确定基因功能。使用本发明提供的EST的序列同源性分析将导致对所需农学性状的更有效的基因筛选。这些植物基因组学难题的这些精选片段的不断扩展的数据库将快速扩展后续功能验证所必需的知识，这是当前植物生物技术努力的关键限制。

6. 发明申请

US20070083945A1 Nucleic acid molecules and other molecules associated with plants 审中-公开
公开(公告)号：US20070083945A1
公开(公告)日：2007-04-12
申请号：US11497489
申请日：2006-08-02
申请人： Joseph Byrum , Conrad Halling , David Kovalic
发明人： Joseph Byrum , Conrad Halling , David Kovalic
IPC分类号： A01H1/00 , C07K14/415 , C12N15/87 , C07H21/04
CPC分类号： C07K14/415
摘要： The present invention is in the field of plant genetics. More specifically the invention relates to nucleic acid molecules and nucleic acid molecules that contain markers, in particular, single nucleotide polymorphism (SNP) and repetitive element markers. In addition, the present invention provides nucleic acid molecules having regulatory elements or encoding proteins or fragments thereof. The invention also relates to proteins and fragments of proteins so encoded and antibodies capable of binding the proteins. The invention also relates to methods of using the nucleic acid molecules, markers, repetitive elements and fragments of repetitive elements, regulatory elements, proteins and fragments of proteins.

7. 发明申请

US20070016974A1 Nucleic acid molecules and other molecules associated with plants 审中-公开
标题翻译：核酸分子和与植物相关的其他分子
公开(公告)号：US20070016974A1
公开(公告)日：2007-01-18
申请号：US11521349
申请日：2006-09-15
申请人： Joseph Byrum , Yijun Ruan , Kevin Wallick
发明人： Joseph Byrum , Yijun Ruan , Kevin Wallick
IPC分类号： A01H5/00 , C07H21/04 , C12N15/82 , C12N5/04
CPC分类号： C07K14/415
摘要： Expressed Sequence Tags (ESTs) isolated from rice are disclosed. The ESTs provide a unique molecular tool for the targeting and isolation of novel genes for plant protection and improvement. The disclosed ESTs have utility in the development of new strategies for understanding critical plant developmental and metabolic pathways. The disclosed ESTs have particular utility in isolating genes and promoters, identifying and mapping the genes involved in developmental and metabolic pathways, and determining gene function. Sequence homology analyses using the ESTs provided in the present invention, will result in more efficient gene screening for desirable agronomic traits. An expanding database of these select pieces of the plant genomics puzzle will quickly expand the knowledge necessary for subsequent functional validation, a key limitation in current plant biotechnology efforts.
摘要翻译：公开了从稻米分离的表达序列标签（ESTs）。 EST为靶基因和分离新基因提供了独特的分子工具，用于植物保护和改良。所公开的EST可用于开发用于了解关键植物发育和代谢途径的新策略。所公开的EST在分离基因和启动子方面具有特别的用途，鉴定和绘制参与发育和代谢途径的基因以及确定基因功能。使用本发明提供的EST的序列同源性分析将导致对所需农学性状的更有效的基因筛选。这些植物基因组学难题的这些精选片段的不断扩展的数据库将快速扩展后续功能验证所必需的知识，这是当前植物生物技术努力的关键限制。

8. 发明申请

US20050071900A1 Soybean cultivar S030150 有权
标题翻译：大豆品种S030150
公开(公告)号：US20050071900A1
公开(公告)日：2005-03-31
申请号：US10672591
申请日：2003-09-26
申请人： William Eby , Kevin Matson , Joseph Byrum
发明人： William Eby , Kevin Matson , Joseph Byrum
IPC分类号： A01H5/10 , A01H1/00 , A01H4/00 , A01H5/00 , C12N15/82
CPC分类号： A01H5/10
摘要： A novel soybean cultivar, designated S030150, is disclosed. The invention relates to the seeds of soybean cultivar S030150, to the plants of soybean S030150 and to methods for producing a soybean plant produced by crossing the cultivar S030150 with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar S030150 with another soybean cultivar.
摘要翻译：公开了一种名为S030150的新型大豆品种。本发明涉及大豆栽培品种S030150的种子，大豆S030150的植物以及通过将品种S030150与其它大豆品种杂交而产生的大豆植物的方法。本发明还涉及通过将品种S030150与另一种大豆品种杂交而产生的杂交大豆种子和植物。

9. 发明申请

US20110035847A1 YIELD TRAITS FOR MAIZE 有权
公开(公告)号：US20110035847A1
公开(公告)日：2011-02-10
申请号：US12536147
申请日：2009-08-05
申请人： Venkata Krishna Kishore , Libardo Andres Gutierrez Rojas , Zhigang Guo , Joseph Byrum
发明人： Venkata Krishna Kishore , Libardo Andres Gutierrez Rojas , Zhigang Guo , Joseph Byrum
IPC分类号： A01H5/00 , C12N15/82 , C12Q1/68 , C07H21/00 , C12N15/74
CPC分类号： A01H1/04 , A01H3/00 , A01H5/10 , C12N15/8261 , C12Q1/6895 , C12Q2600/13
摘要： Methods for introgressing an allele of interest of a locus associated with a yield trait into Zea mays germplasm are provided. In some embodiments, the methods include providing a Zea mays plant that contains an allele of interest of a locus associated with a yield trait, wherein the locus associated with the yield trait is identifiable by PCR amplification of a Zea mays nucleic acid with a pair of oligonucleotides primers as disclosed herein, and introgressing the allele of interest into Zea mays germplasm that lacks the allele. Also provided are methods for identifying Zea mays plants that contain at least one allele associated with improved yield, improved maize plants, elite Zea mays plants, biomass produced from improved Zea mays plants, isolated and purified genetic markers, and compositions that include an amplification primer pair capable of amplifying a Zea mays nucleic acid to generate a Zea mays marker amplicon.

10. 发明申请

US20090191541A1 Nucleic Acid Molecules and Other Molecules Associated with Plants 审中-公开
标题翻译：核酸分子和其他与植物相关的分子
公开(公告)号：US20090191541A1
公开(公告)日：2009-07-30
申请号：US09552087
申请日：2000-04-21
申请人： Joseph Byrum
发明人： Joseph Byrum
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07K14/415
摘要： The present invention is in the field of plant genetics. More specifically the invention relates to nucleic acid molecules and nucleic acid molecules that contain markers, in particular, single nucleotide polymorphism (SNP) and repetitive element markers. In addition, the present invention provides nucleic acid molecules having regulatory elements or encoding proteins or fragments thereof. The invention also relates to proteins and fragments of proteins so encoded and antibodies capable of binding the proteins. The invention also relates to methods of using the nucleic acid molecules, markers, repetitive elements and fragments of repetitive elements, regulatory elements, proteins and fragments of proteins.
摘要翻译：本发明在植物遗传学领域。更具体地，本发明涉及含有标记，特别是单核苷酸多态性（SNP）和重复元件标记的核酸分子和核酸分子。此外，本发明提供具有调节元件或编码蛋白质或其片段的核酸分子。本发明还涉及如此编码的蛋白质和蛋白质的片段以及能够结合蛋白质的抗体。本发明还涉及使用核酸分子，标记，重复元件和重复元件，调节元件，蛋白质和蛋白质片段的片段的方法。

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