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1. 发明申请

US20150283182A1 INJECTABLE ALLOGRAFT PUR COMPOSITE CARRYING rhBMP2 审中-公开
标题翻译：可注射的合成树脂复合材料进行rhBMP2
公开(公告)号：US20150283182A1
公开(公告)日：2015-10-08
申请号：US13280299
申请日：2011-10-24
申请人： Scott A. Guelcher , Jerald E. Dumas , Edna Margarita Prieto , Katarzyna Zienkiewicz
发明人： Scott A. Guelcher , Jerald E. Dumas , Edna Margarita Prieto , Katarzyna Zienkiewicz
IPC分类号： A61K35/32 , A61K47/34 , A61K38/18
CPC分类号： A61K35/32 , A61K38/1875 , A61K47/34 , A61L27/3608 , A61L27/44 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/414 , C08L75/04
摘要： Embodiments of the present inventions comprise composites of bone particles and polyurethane(s), as well as methods of making such composite and uses thereof. Certain embodiments further comprise a growth factor that can be provided in powder form. Growth factors may be bone morphogenic proteins, such as rhBMP-2. A porous composite comprises a plurality of bone particles, polyurethanes with which the bone particles are combined, and at least one growth factor. A composition may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength for most orthopedic applications.
摘要翻译：本发明的实施方案包括骨颗粒和聚氨酯的复合材料，以及制备这种复合材料及其用途的方法。某些实施方案还包括可以以粉末形式提供的生长因子。生长因子可能是骨形态发生蛋白，如rhBMP-2。多孔复合材料包括多个骨颗粒，骨颗粒与其结合的聚氨酯和至少一个生长因子。组合物可以是可模制的和/或可注射的。在植入或注射后，可以将组合物设置成形成提供机械强度并支持细胞生长的多孔复合材料。本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为大多数矫形应用提供机械强度。

2. 发明申请

US20110237704A1 Particle/Polyurethane Composites and Methods thereof 有权
标题翻译：颗粒/聚氨酯复合材料及其方法
公开(公告)号：US20110237704A1
公开(公告)日：2011-09-29
申请号：US13005528
申请日：2011-01-12
申请人： Scott A. Guelcher , Edna Margarita Prieto , Jerald E. Dumas , Katarzyna Jadwiga Zienkiewicz , Jonathan Page , Subhabrata Bhattacharyya
发明人： Scott A. Guelcher , Edna Margarita Prieto , Jerald E. Dumas , Katarzyna Jadwiga Zienkiewicz , Jonathan Page , Subhabrata Bhattacharyya
IPC分类号： A61L27/18 , A61L27/46 , C08G18/83 , C08G18/77
CPC分类号： A61L27/46 , A61L27/446 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/406 , C08L75/04
摘要： The present invention encompasses the finding that certain treatments (e.g., surface modifications) to particulate materials can provide surprising and unexpected benefits and/or features to composites and/or compositions as described herein. In some embodiments, such benefits and/or features may render particular composites and/or compositions particularly useful in a certain therapeutic context (e.g, for repair of tibial plateau, femoral head, craniofacial, or lateral mandibular body defects). The present invention demonstrates that certain composites and/or compositions wherein the particular material is or comprises defatted bone have surprising and beneficial attributes.
摘要翻译：本发明包括对颗粒材料的某些处理（例如，表面改性）可以为本文所述的复合材料和/或组合物提供令人惊奇和意想不到的益处和/或特征的发现。在一些实施方案中，这样的益处和/或特征可以使特定的复合材料和/或组合物在特定的治疗背景下特别有用（例如，用于修复胫骨平台，股骨头，颅面或侧向下颌体缺陷）。本发明证明特定材料是或包含脱脂骨的某些复合物和/或组合物具有令人惊奇和有益的属性。

3. 发明授权

US09950096B2 Particle/polyurethane composites and methods thereof 有权
公开(公告)号：US09950096B2
公开(公告)日：2018-04-24
申请号：US13005528
申请日：2011-01-12
申请人： Scott A. Guelcher , Edna Margarita Prieto , Jerald E. Dumas , Katarzyna Jadwiga Zienkiewicz , Jonathan Page
发明人： Scott A. Guelcher , Edna Margarita Prieto , Jerald E. Dumas , Katarzyna Jadwiga Zienkiewicz , Jonathan Page
IPC分类号： A61L27/46 , A61L27/44 , A61L27/48 , A61L27/54 , A61L27/56
CPC分类号： A61L27/46 , A61L27/446 , A61L27/48 , A61L27/54 , A61L27/56 , A61L2300/406 , C08L75/04
摘要： The present invention encompasses the finding that certain treatments (e.g., surface modifications) to particulate materials can provide surprising and unexpected benefits and/or features to composites and/or compositions as described herein. In some embodiments, such benefits and/or features may render particular composites and/or compositions particularly useful in a certain therapeutic context (e.g, for repair of tibial plateau, femoral head, craniofacial, or lateral mandibular body defects). The present invention demonstrates that certain composites and/or compositions wherein the particular material is or comprises defatted bone have surprising and beneficial attributes.

4. 发明授权

US09333276B2 Bone/polyurethane composites and methods thereof 有权
标题翻译：骨/聚氨酯复合材料及其方法
公开(公告)号：US09333276B2
公开(公告)日：2016-05-10
申请号：US12608850
申请日：2009-10-29
申请人： Scott A. Guelcher , Subhabrata Bhattacharyya , Katarzyna Jadwiga Zienkiewicz , Shaun A. Tanner , Jerald E. Dumas
发明人： Scott A. Guelcher , Subhabrata Bhattacharyya , Katarzyna Jadwiga Zienkiewicz , Shaun A. Tanner , Jerald E. Dumas
IPC分类号： A61L27/44 , A61L27/56
CPC分类号： A61L27/44 , A61L27/56 , C08L75/04
摘要： Present inventions present composites of bone particles and polyurethane(s), as well as methods of making such composite and uses thereof. A porous composite comprises a plurality of bone particles; and polyurethanes with which the bone particles are combined. To prepare a porous composite, a composition comprise a plurality of bone particles, polyurethane precursors including polyisocyanate prepolymers and polyols, water and catalyst. A composition is either naturally moldable and/or injectable, or it can be made moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength for most orthopedic applications.
摘要翻译：本发明提出了骨颗粒和聚氨酯的复合材料，以及制备这种复合材料及其用途的方法。多孔复合材料包括多个骨颗粒; 和与其结合的聚氨酯。为了制备多孔复合材料，组合物包含多个骨颗粒，包括多异氰酸酯预聚物和多元醇的聚氨酯前体，水和催化剂。组合物可以是天然可模塑的和/或可注射的，或者它可以是可模制的和/或可注射的。在植入或注射后，可以将组合物设置成形成提供机械强度并支持细胞生长的多孔复合材料。本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为大多数矫形应用提供机械强度。

5. 发明申请

US20100297082A1 WEIGHT-BEARING POLYURETHANE COMPOSITES AND METHODS THEREOF 审中-公开
标题翻译：重量的聚氨酯组合物及其方法
公开(公告)号：US20100297082A1
公开(公告)日：2010-11-25
申请号：US12783548
申请日：2010-05-19
申请人： Scott A. Guelcher , Jerald E. Dumas , Todd M. Boyce
发明人： Scott A. Guelcher , Jerald E. Dumas , Todd M. Boyce
IPC分类号： A61F2/28 , B29C43/02 , A61P19/00 , A61K48/00 , A61K35/12 , A61K38/18 , A61K38/02 , A61K38/43 , A61K31/195 , A61K47/34
CPC分类号： A61K35/32 , A61F2/28 , A61F2310/00359 , A61K31/00 , A61K31/195 , A61K38/00 , A61L27/3608 , A61L27/44 , B29C43/003 , C08L75/04
摘要： Present inventions present composites of particles and polymers, as well as methods of making such composite and uses thereof. A low or non-porous composite comprises a plurality of bone particles; and polyurethane components with which the bone particles are combined. Provided composites can be prepared in a one-shot process. Alternatively or additionally, composites can be prepared by compression molding under a high pressure. Before or after implantation, provided composites may be set to form a hardened state of composites that provides mechanical strength and supports the in-growth of cells.
摘要翻译：本发明提出了颗粒和聚合物的复合材料，以及制备这种复合材料及其用途的方法。低或非多孔复合材料包括多个骨颗粒; 和与其组合的聚氨酯组分。提供的复合材料可以在一个单一的过程中制备。或者或另外，复合材料可以通过在高压下压塑而制备。在植入之前或之后，提供的复合材料可以被设置成形成复合材料的硬化状态，其提供机械强度并支持细胞的生长。

6. 发明申请

US20100112032A1 Bone/Polyurethane Composites and Methods Thereof 有权
标题翻译：骨/聚氨酯复合材料及其方法
公开(公告)号：US20100112032A1
公开(公告)日：2010-05-06
申请号：US12608850
申请日：2009-10-29
申请人： Scott A. Guelcher , Subhabrata Bhattacharyya , Katarzyna Jadwiga Zienkiewicz , Shaun A. Tanner , Jerald E. Dumas
发明人： Scott A. Guelcher , Subhabrata Bhattacharyya , Katarzyna Jadwiga Zienkiewicz , Shaun A. Tanner , Jerald E. Dumas
IPC分类号： A61K9/00 , A61F2/28 , A61P43/00
CPC分类号： A61L27/44 , A61L27/56 , C08L75/04
摘要： Present inventions present composites of bone particles and polyurethane(s), as well as methods of making such composite and uses thereof. A porous composite comprises a plurality of bone particles; and polyurethanes with which the bone particles are combined. To prepare a porous composite, a composition comprise a plurality of bone particles, polyurethane precursors including polyisocyanate prepolymers and polyols, water and catalyst. A composition is either naturally moldable and/or injectable, or it can be made moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength for most orthopedic applications.
摘要翻译：本发明提出了骨颗粒和聚氨酯的复合材料，以及制备这种复合材料及其用途的方法。多孔复合材料包括多个骨颗粒; 和与其结合的聚氨酯。为了制备多孔复合材料，组合物包含多个骨颗粒，包括多异氰酸酯预聚物和多元醇的聚氨酯前体，水和催化剂。组合物可以是天然可模塑的和/或可注射的，或者它可以是可模制的和/或可注射的。在植入或注射后，可以将组合物设置成形成提供机械强度并支持细胞生长的多孔复合材料。本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为大多数矫形应用提供机械强度。

7. 发明申请

US20100247672A1 POLYURETHANE/BONE COMPOSITIONS AND METHODS 审中-公开
标题翻译：聚氨酯/骨组合物和方法
公开(公告)号：US20100247672A1
公开(公告)日：2010-09-30
申请号：US12676700
申请日：2008-09-05
申请人： Scott A. Guelcher , Jerald Dumas
发明人： Scott A. Guelcher , Jerald Dumas
IPC分类号： A61K35/32 , A61F2/28
CPC分类号： A61L27/3608 , A61F2/2846 , A61F2002/2817 , A61L27/48 , C08L75/04
摘要： A flowable, injectable composite that comprises mineralized allograft bone; and at least one degradable polyurethane that has a quasi-prepolymer and a resin mix, the resin mix having a polyester polyol and a catalyst; wherein the composite has a compression strength of greater than about 10 MPa and a modulus of greater than about 1 GPa.
摘要翻译：可流动的可注射复合材料，包括矿化同种异体移植骨; 和至少一种具有准预聚物和树脂混合物的可降解聚氨酯，所述树脂混合物具有聚酯多元醇和催化剂; 其中所述复合材料具有大于约10MPa的压缩强度和大于约1GPa的模量。

8. 发明申请

US20090163613A1 Polymer polyols with improved properties and a process for their production 审中-公开
标题翻译：具有改进性能的聚合物多元醇及其生产方法
公开(公告)号：US20090163613A1
公开(公告)日：2009-06-25
申请号：US12004801
申请日：2007-12-20
申请人： Scott A. Guelcher , Jiong England , Rick L. Adkins
发明人： Scott A. Guelcher , Jiong England , Rick L. Adkins
IPC分类号： C08G65/00
CPC分类号： C08G18/632 , C08G2101/00
摘要： This invention relates to polymer polyols having a solids content of greater than or equal to 10 to 60% by weight, a mean average particle size of at least 0.6μ, and which contain a specified concentration of blinding particles. This invention also relates to a process for preparing these polymer polyols.
摘要翻译：本发明涉及固体含量大于或等于10至60重量％，平均粒度至少为0.6微米且含有特定浓度的致盲颗粒的聚合物多元醇。本发明还涉及制备这些聚合物多元醇的方法。

9. 发明申请

US20120183622A1 ENCAPSULATED CELLS AND COMPOSITES THEREOF 审中-公开
标题翻译：包封细胞及其复合物
公开(公告)号：US20120183622A1
公开(公告)日：2012-07-19
申请号：US13353257
申请日：2012-01-18
申请人： Scott A. Guelcher , Baek-Hee Lee , Ruijing Guo , Bing Li
发明人： Scott A. Guelcher , Baek-Hee Lee , Ruijing Guo , Bing Li
IPC分类号： A61K35/12 , A61K9/50
CPC分类号： A61K9/0024 , A61K9/5036 , A61K35/00
摘要： Embodiments of the present invention comprise biodegradable composites including a polyurethane component and cells encapsulated in gel beads, as well as methods of making such composite and uses thereof. In certain embodiments the gel beads are alginate beads. The composites may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength, supports the in-growth of cells, and/or delivers cells to particular tissues. Inventive composites have the advantage of being able to fill irregularly shaped implantation sites, deliver cells in a localized and noninvasive manner, and optimize cell proliferation and differentiation of delivered cells.
摘要翻译：本发明的实施方案包括包含聚氨酯组分和包封在凝胶珠中的细胞的生物可降解复合材料，以及制备这种复合材料及其用途的方法。在某些实施方案中，凝胶珠粒是藻酸盐珠粒。复合材料可以是可模塑的和/或可注射的。在植入或注射后，可以将组合物设置成形成提供机械强度的多孔复合材料，支持细胞的生长和/或将细胞递送到特定组织。本发明的复合材料具有能够填充不规则形状的植入位点，以局部和非侵入性方式递送细胞并优化递送细胞的细胞增殖和分化的优点。

10. 发明授权

US07160975B2 Methacrylates as stabilizers for polymer polyols 有权
标题翻译：甲基丙烯酸酯作为聚合物多元醇的稳定剂
公开(公告)号：US07160975B2
公开(公告)日：2007-01-09
申请号：US10909476
申请日：2004-08-02
申请人： Rick L. Adkins , Scott A. Guelcher
发明人： Rick L. Adkins , Scott A. Guelcher
IPC分类号： C08G18/62
CPC分类号： C08G18/635 , C08G18/409 , C08G18/6795
摘要： This invention relates to ethylenically unsaturated macromers which contain reactive unsaturation, and to a process for preparing these ethylenicallly unsaturated macromers which contain reactive unsaturation. The process of preparing these ethylenically unsaturated macromers comprises reacting a monofunctional compound which corresponds to a specific formula with at least one alkylene oxide, in the presence of at least one alkoxylation catalyst. The ethylenically unsaturated macromers correspond to the formula set forth herein. This invention also relates to preformed stabilizers comprising ethylenically unsaturated macromers, to a process for preparing these preformed stabilizers, to polymer polyols comprising these preformed stabilizers, and to a process of preparing these polymer polyols which comprise these preformed stabilizers. Polymer polyols comprising ethylenically unsaturated macromers and a process for their preparation are also described.
摘要翻译：本发明涉及含有反应性不饱和键的烯键式不饱和大分子单体，以及制备这些具有反应性不饱和度的烯属不饱和大单体的方法。制备这些烯属不饱和大分子单体的方法包括在至少一种烷氧基化催化剂的存在下使对应于特定式的单官能化合物与至少一种烯化氧反应。烯键式不饱和大分子单体对应于本文所述的式。本发明还涉及包含烯属不饱和大分子单体的预制稳定剂，制备这些预型稳定剂的方法，包括这些预制稳定剂的聚合物多元醇，以及包含这些预型稳定剂的这些聚合物多元醇的制备方法。还描述了包含烯属不饱和大分子单体的聚合物多元醇及其制备方法。

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