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1. 发明专利

JP2008255119A Naphthyridine which affect il-4 and g-csf 审中-公开
标题翻译：影响IL-4和G-CSF的萘啶
公开(公告)号：JP2008255119A
公开(公告)日：2008-10-23
申请号：JP2008117917
申请日：2008-04-28
申请人： Schering Corp , シェーリングコーポレイションSchering Corporation
发明人： SOLOMON DANIEL M , GRACE MICHAEL J , FINE JAY S , BOBER LORETTA A , SHERLOCK MARGARET H
IPC分类号： C07D241/12 , C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/4965 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08
CPC分类号： C07D471/04
摘要： PROBLEM TO BE SOLVED: To provide a compound, a composition and a method, described in the specification, concerning to naphthyridines affecting on IL-4 and G-CSF. SOLUTION: The compound is an antagonist of IL-4 and is an antagonist useful as a medicine for treating allergy, inflammation, autoimmune diseases and specific B-cell lymphomas. The compound and another compound are also a stimulator for production of granulocyte colony stimulus factor (G-CSF) produced from human peripheral blood mononuclear cell (PBMNC) and monocyte/macrophage. So, since the compounds stimulate neutrophile granulopoiesis, the compounds are useful as a treatment medicine for treating a cancer patient and for treating a bone marrow transplanted patient. And pharmaceutical compositions containing a therapeutically effective amount of the compound or another compound with a pharmaceutically permissible carrier are also provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供说明书中描述的关于影响IL-4和G-CSF的萘啶的化合物，组合物和方法。解决方案：该化合物是IL-4的拮抗剂，并且是用作治疗过敏，炎症，自身免疫疾病和特异性B细胞淋巴瘤的药物的拮抗剂。该化合物和另一种化合物也是用于产生由人外周血单核细胞（PBMNC）和单核细胞/巨噬细胞产生的粒细胞集落刺激因子（G-CSF）的刺激剂。因此，由于化合物刺激嗜中性粒细胞生成，所以这些化合物可用作治疗癌症患者和治疗骨髓移植患者的治疗药物。还提供了含有治疗有效量的化合物或另一种化合物与药学上可允许的载体的药物组合物。版权所有（C）2009，JPO＆INPIT

2. 发明申请

WO9748368A3 NAPHTHYRIDINES WHICH AFFECT IL-4 AND G-CSF 审中-公开
标题翻译：影响IL-4和G-CSF的萘啶类
公开(公告)号：WO9748368A3
公开(公告)日：1998-02-05
申请号：PCT/US9709202
申请日：1997-06-18
申请人： SCHERING CORP
发明人： SOLOMON DANIEL M , GRACE MICHAEL J , FINE JAY S , BOBER LORETTA A , SHERLOCK MARGARET H
IPC分类号： C07D241/12 , A61K31/4375 , A61K31/444 , A61K31/4965 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07D471/04 , A61K
CPC分类号： C07D471/04
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein E, Q, T, U, V, L, Z, X, W, M, Y and Y' are as set forth herein, are described. These compounds are useful as agents in the treatment of allergy, inflammation, autoimmune diseases, B-cell lymphomas, tumors, and the after effects of bone marrow transplantation.
摘要翻译：描述了式（I）化合物或其药学上可接受的盐，其中E，Q，T，U，V，L，Z，X，W，M，Y和Y'如本文所述。这些化合物可用作治疗过敏，炎症，自身免疫性疾病，B细胞淋巴瘤，肿瘤和骨髓移植的后期作用的药剂。

3. 发明申请

WO9208792A3 METHOD FOR INCREASING AND ACTIVATING MONOCYTES AND NEUTROPHILS AND FOR INDUCING MATURATION OF MYELOID CELLS WITH INTERLEUKIN-5 审中-公开
标题翻译：用于增加和活化单核细胞和中性粒细胞并诱导MYLEOID细胞成熟的方法
公开(公告)号：WO9208792A3
公开(公告)日：1992-07-23
申请号：PCT/US9108264
申请日：1991-11-14
申请人： SCHERING CORP
发明人： BOBER LORETTA A , GRACE MICHAEL J , CHOU CHUAN-CHU
IPC分类号： A61K38/00 , A61P7/00 , C07K14/54 , C12N15/09 , C12N15/24 , A61K37/02
CPC分类号： C07K14/5409 , A61K38/00
摘要： Methods for increasing and activating monocytes and neutrophils and for inducing the maturation of myeloïd cells in mammals by adminestering IL-5 are disclosed. A method for making IL-5 is also disclosed.

4. 发明专利

SG44544A1 Method for purifying interleukin-4 未知
公开(公告)号：SG44544A1
公开(公告)日：1997-12-19
申请号：SG1996002001
申请日：1990-07-26
申请人： SCHERING CORP
发明人： BONNEM ERIC M , SULLIVAN LEE , GRACE MICHAEL J , BOBER LORETTA , TANG JOHN CHU-TAY , NAVEH DAVID , NAGABHUSHAN TATTANAHALLI , RAMAN JAY R
IPC分类号： C12N5/00 , A61K38/00 , A61P7/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07K20060101 , C07K1/16 , C07K14/00 , C07K14/52 , C07K14/53 , C07K14/535 , C07K14/54 , C07K14/545 , C07K14/55 , C12N15/09 , C12N15/24 , C12P21/00 , C12P21/02 , C12R1/91 , C07K , C12P , C12N , C12R
摘要： A method is provided for purifying interleukin-4 which involves the successive steps of chromatography on a metal chelating agarose gel, chromatography on a cation exchanger, concentration on a stirred cell membrane and size exclusion chromatography.

5. 发明专利

CA2096329A1 METHOD FOR INCREASING AND ACTIVATING MONOCYTES AND NEUTROPHILS AND FOR INDUCING MATURATION OF MYELOID CELLS WITH INTERLEUKIN-5 未知
公开(公告)号：CA2096329A1
公开(公告)日：1992-05-17
申请号：CA2096329
申请日：1991-11-14
申请人： SCHERING CORP
发明人： BOBER LORETTA A , GRACE MICHAEL J , CHOU CHUAN-CHU
IPC分类号： A61K38/00 , A61P7/00 , C07K14/54 , C12N15/09 , C12N15/24 , A61K38/20
摘要： 2096329 9208792 PCTABS00013 Methods for increasing and activating monocytes and neutrophils and for inducing the maturation of myeloïd cells in mammals by adminestering IL-5 are disclosed. A method for making IL-5 is also disclosed.

6. 发明专利

HU9801223A2 METHOD FOR ENHANCING THE ANTIBODY RESPONSE TO SPECIFIC ANTIGENS WITH INTERLEUKIN-10 未知
公开(公告)号：HU9801223A2
公开(公告)日：1998-08-28
申请号：HU9801223
申请日：1996-03-21
申请人： SCHERING CORP
发明人： FINE JAY S , GRACE MICHAEL J
IPC分类号： A61K38/00 , A61K39/09 , A61K39/39 , A61P31/04 , C12N15/24 , A61K38/19 , A61K39/02 , C07K14/54
摘要： A method for enhancing the immune response of a mammal to a vaccine comprising administering to such a mammal an effective amount of IL-10 in conjunction with the vaccine. A pharmaceutical composition comprised of an effective amount of IL-10, a natural, synthetic or recombinant antigen and a pharmaceutcally acceptable carrier.

7. 发明专利

AU3567397A Naphthyridines which affect il-4 and g-csf 未知
公开(公告)号：AU3567397A
公开(公告)日：1998-01-07
申请号：AU3567397
申请日：1997-06-18
申请人： SCHERING CORP
发明人： SOLOMON DANIEL M , GRACE MICHAEL J , FINE JAY S , BOBER LORETTA A , SHERLOCK MARGARET H
IPC分类号： C07D241/12 , A61K31/4375 , A61K31/444 , A61K31/4965 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07D471/04 , A61K31/00

8. 发明专利

AU5189096A Method for enhancing the antibody response to specific antig ens with interleukin-10 未知
公开(公告)号：AU5189096A
公开(公告)日：1996-10-16
申请号：AU5189096
申请日：1996-03-21
申请人： SCHERING CORP
发明人： GRACE MICHAEL J , FINE JAY S
IPC分类号： A61K38/00 , A61K39/09 , A61K39/39 , A61P31/04 , C12N15/24 , A61K38/19 , A61K39/02 , C07K14/54
摘要： A method for enhancing the immune response of a mammal to a vaccine comprising administering to such a mammal an effective amount of IL-10 in conjunction with the vaccine. A pharmaceutical composition comprised of an effective amount of IL-10, a natural, synthetic or recombinant antigen and a pharmaceutcally acceptable carrier.

9. 发明专利

NO920021L 未知
公开(公告)号：NO920021L
公开(公告)日：1993-07-05
申请号：NO920021
申请日：1992-01-02
申请人： SCHERING CORP
发明人： BOBER LORETTA A , GRACE MICHAEL J , CHOU CHUAN-CHU
IPC分类号： C12N5/00 , C12N5/02 , C12N5/10 , C12N15/24

10. 发明专利

CA2258752C NAPHTHYRIDINES WHICH AFFECT IL-4 AND G-CSF 未知
公开(公告)号：CA2258752C
公开(公告)日：2006-08-15
申请号：CA2258752
申请日：1997-06-18
申请人： SCHERING CORP
发明人： SHERLOCK MARGARET H , BOBER LORETTA A , SOLOMON DANIEL M , GRACE MICHAEL J , FINE JAY S
IPC分类号： C07D241/12 , C07D471/04 , A61K31/4375 , A61K31/44 , A61K31/444 , A61K31/47 , A61K31/495 , A61K31/4965 , A61K31/53 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07D241/24 , C07D401/04
摘要： Compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein E, Q, T, U, V, L, Z, X, W, M, Y and Y' are as set forth herein, are described. These compounds are useful as agents in the treatment of allergy, inflammation, autoimmune diseases, B-cell lymphomas, tumors, and the after effects of bone marrow transplantation.

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