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    • 3. 发明申请
    • CATHETER SYSTEMS
    • 导管系统
    • US20120059255A1
    • 2012-03-08
    • US12874788
    • 2010-09-02
    • Saurav PaulTroy T. TeggIsrael A. ByrdRiki ThaoHarry A. PuryearLinda NemecJohn M. Berns
    • Saurav PaulTroy T. TeggIsrael A. ByrdRiki ThaoHarry A. PuryearLinda NemecJohn M. Berns
    • A61N1/30A61B18/14A61B6/00
    • A61N1/327A61B18/14A61B2018/0016
    • Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
    • 导管系统包括用于电穿孔介导治疗的方向敏感的多极尖端电极组件,电穿孔诱导的原发性坏死治疗和电场诱导的凋亡治疗,包括用于产生狭窄的线性损伤以及分布的广泛区域损伤的构造。 用于电穿孔治疗的监测系统包括将电致变色染料递送到组织部位的机制以及光学配置以光学监测治疗进展以及确认疗法后的成功。 光纤温度感测电极导管包括具有腔体的尖端电极,其内表面被浸渍或涂覆有随着温度变化而改变颜色的热变色/热致变色材料。 光纤/检测器装置监测热致变色或热致变色材料,获取光信号并产生指示光信号光谱的输出信号。 分析仪基于检测器输出和预定的频谱对温度校准数据来确定电极温度。
    • 4. 发明授权
    • System for electroporation therapy
    • 电穿孔治疗系统
    • US09289606B2
    • 2016-03-22
    • US12874788
    • 2010-09-02
    • Saurav PaulTroy T. TeggIsrael A. ByrdRiki ThaoHarry A. PuryearLinda NemecJohn M. Berns
    • Saurav PaulTroy T. TeggIsrael A. ByrdRiki ThaoHarry A. PuryearLinda NemecJohn M. Berns
    • A61B18/18A61N1/32A61B18/14A61B18/00
    • A61N1/327A61B18/14A61B2018/0016
    • Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
    • 导管系统包括用于电穿孔介导治疗的方向敏感的多极尖端电极组件,电穿孔诱导的原发性坏死治疗和电场诱导的凋亡治疗,包括用于产生狭窄的线性损伤以及分布的广泛区域损伤的构造。 用于电穿孔治疗的监测系统包括将电致变色染料递送到组织部位的机制以及光学配置以光学监测治疗进展以及确认疗法后的成功。 光纤温度感测电极导管包括具有腔体的尖端电极,其内表面被浸渍或涂覆有随着温度变化而改变颜色的热变色/热致变色材料。 光纤/检测器装置监测热致变色或热致变色材料,获取光信号并产生指示光信号光谱的输出信号。 分析仪基于检测器输出和预定的频谱对温度校准数据来确定电极温度。
    • 5. 发明申请
    • Ablation electrodes with capacitive sensors for resolving magnitude and direction of forces imparted to a distal portion of a cardiac catheter
    • 具有电容传感器的消融电极,用于分辨施加到心脏导管的远端部分的力的大小和方向
    • US20110022045A1
    • 2011-01-27
    • US12893707
    • 2010-09-29
    • Hong CaoRiki ThaoSaurav Paul
    • Hong CaoRiki ThaoSaurav Paul
    • A61B18/14
    • A61B18/1492A61B5/6852A61B5/6885A61B2090/065
    • A catheter assembly for assessing contact between the catheter assembly and tissue is disclosed. In an exemplary embodiment the assembly includes a catheter shaft and a trio of pressure sensitive capacitive members each of whose electrical resistance varies with a pressure vector applied to the catheter assembly. The assembly also includes at least one measurement terminal to permit the measurement of changes in the electrical characteristics of the pressure sensitive capacitive members. The assembly may optionally include a measurement device to measure resistance, impedance and/or other electrical characteristics. The assembly may utilize a reference electrode secured to the patient's tissue, which permits the measurement device to measure changes between the reference electrode and the at least one measurement terminal. Optionally, the assembly may include a conductive outer layer. Also disclosed are sensor assemblies, contact sensor, methods of contact sensing, and methods of manufacturing relating to the use of pressure sensitive capacitors.
    • 公开了一种用于评估导管组件和组织之间的接触的导管组件。 在示例性实施例中,组件包括导管轴和三个压敏电容构件,每个电阻构件的电阻随着施加到导管组件的压力矢量而变化。 组件还包括至少一个测量端子,以允许测量压敏电容构件的电特性的变化。 组件可以可选地包括测量电阻,阻抗和/或其他电特性的测量装置。 组件可以利用固定到患者组织的参考电极,其允许测量装置测量参考电极和至少一个测量终端之间的变化。 可选地,组件可以包括导电外层。 还公开了传感器组件,接触传感器,接触感测方法以及与使用压敏电容器有关的制造方法。
    • 9. 发明授权
    • Anatomical thermal sensing device and method
    • 解剖热感测装置及方法
    • US09220417B2
    • 2015-12-29
    • US13777556
    • 2013-02-26
    • Saurav PaulTodd R. StangenesRiki Thao
    • Saurav PaulTodd R. StangenesRiki Thao
    • A61B5/00A61B5/01A61B5/053
    • A61B18/1402A61B5/01A61B5/015A61B5/053A61B5/6852A61B5/6885A61B2562/0271
    • A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.
    • 利用温度感测来识别或评估解剖体或结构的医疗装置包括细长的管状构件,至少一个电极,热传感器和温度响应评估系统或部件。 至少一个电极可以连接到细长管状构件的远端部分,并且一个或多个电极可以被配置成向解剖体或结构的一部分提供能量或热量。 热传感器可以被配置为测量解剖体或结构部分(例如组织或血液池)的热响应。 温度响应评估系统或组件可以耦合到热传感器。 在实施例中,该装置可以包括可容纳诸如针的工具的内腔和端口开口。 还公开了使用温度感测来识别解剖体或结构的方法。
    • 10. 发明申请
    • ANATOMICAL THERMAL SENSING DEVICE AND METHOD
    • 解剖学感测装置及方法
    • US20100191142A1
    • 2010-07-29
    • US12751946
    • 2010-03-31
    • Saurav PaulTodd StangenesRiki Thao
    • Saurav PaulTodd StangenesRiki Thao
    • A61B5/01
    • A61B18/1402A61B5/01A61B5/015A61B5/053A61B5/6852A61B5/6885A61B2562/0271
    • A medical device utilizing temperature sensing to identify or assess anatomical bodies or structures includes an elongate tubular member, at least one electrode, a thermal sensor, and a temperature response assessment system or component. The at least one electrode may be connected to the distal portion of the elongate tubular member, and the one or more electrode can be configured to provide energy or heat to a portion of an anatomical body or structure. The thermal sensor may be configured to measure the thermal response of the portion of an anatomical body or structure, e.g., tissue or blood pools. The temperature response assessment system or component can be coupled to the thermal sensor. In embodiments, the device may include a lumen and port opening, which may accommodate a tool, such as a needle. Methods for using temperature sensing to identify an anatomical body or structure are also disclosed.
    • 使用温度感测来识别或评估解剖体或结构的医疗装置包括细长的管状构件,至少一个电极,热传感器和温度响应评估系统或部件。 至少一个电极可以连接到细长管状构件的远端部分,并且一个或多个电极可以被配置成向解剖体或结构的一部分提供能量或热量。 热传感器可以被配置为测量解剖体或结构部分(例如组织或血液池)的热响应。 温度响应评估系统或组件可以耦合到热传感器。 在实施例中,该装置可以包括可容纳诸如针的工具的内腔和端口开口。 还公开了使用温度感测来识别解剖体或结构的方法。