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1. 发明授权

US09714408B2 Cell culture method 有权
公开(公告)号：US09714408B2
公开(公告)日：2017-07-25
申请号：US12450480
申请日：2008-04-24
申请人： Satoshi Tanaka , Yoichi Ishizaki , Ryo Suenaga , Yoriko Tokita , Masahito Kogure
发明人： Satoshi Tanaka , Yoichi Ishizaki , Ryo Suenaga , Yoriko Tokita , Masahito Kogure
IPC分类号： C12N5/02 , C12M1/34 , C12M1/00 , C12M1/06 , C12M1/26
CPC分类号： C12M41/32 , C12M23/14 , C12M23/26 , C12M27/02 , C12M29/26 , C12M33/18 , C12M41/26 , C12M41/44
摘要： In a cell culture in a sealed cell culture container, gradual deterioration of culture environment is prevented. A cell culture method in which cell culture is conducted by adding a fresh culture medium to a culture container in which cells and a culture medium are enclosed, which includes the steps ofadjusting the pH of said culture medium to be added to be higher than the pH which is optimum for culture of the cells, and/or adjusting the partial pressure of dissolved carbon dioxide of the culture medium to be added to be lower than the pressure which is optimum for culture of the cells, and/or adjusting the partial pressure of dissolved oxygen of the culture medium to be added to be higher than the pressure which is optimum for culture of the cells; and mixing the adjusted culture medium and the culture medium in said culture-container to adjust at least any of the pH, the partial pressure of dissolved carbon dioxide and the partial pressure of dissolved oxygen to be optimum for culture of said cells, thereby to culture the cells in the culture container.

2. 发明申请

US20100075406A1 CELL CULTURE APPARATUS, CELL CULTURE SYSTEM AND CELL CULTURE METHOD 有权
标题翻译：细胞培养装置，细胞培养系统和细胞培养方法
公开(公告)号：US20100075406A1
公开(公告)日：2010-03-25
申请号：US12450481
申请日：2008-04-25
申请人： Satoshi Tanaka , Yoichi Ishizaki , Ryo Suenaga , Yoriko Tokita , Masahito Kogure
发明人： Satoshi Tanaka , Yoichi Ishizaki , Ryo Suenaga , Yoriko Tokita , Masahito Kogure
IPC分类号： C12M1/34 , C12M1/00
CPC分类号： C12M23/34 , C12M23/14 , C12M27/02 , C12M29/00 , C12M33/18
摘要： By maintaining the cell density during culture at an appropriate level and eliminating the procedure of transferring cells from a container to another container when a large amount of cells are cultured, damage on cells can be reduced, risk of contamination can be lowered, labor saving can be attained and automation can be attained.A cell culture apparatus including: a culture container 11 formed of a soft packing material and having an enclosure part 11-1 in which a culture medium and/or cells being cultured are enclosed is placed; a container table 12 on which the culture container 11 is placed; a roller 13 which is placed on the upper surface of the culture container 11 and divides the enclosure part 11-1 into two or more chambers; and a driving means 15 which relatively moves the roller 13 or the culture container 11, thereby to change the volume of the culture part 11-11 in the enclosure part 11-1 in which a culture medium or cells being cultured are enclosed.
摘要翻译：通过在培养期间维持细胞密度达到适当的水平，并且消除了当培养大量细胞时将细胞从容器转移到另一容器的过程，可以降低细胞损伤，降低污染的风险，节省劳力实现并实现自动化。一种细胞培养装置，其特征在于，包括：由软性包装材料形成的培养容器11，具有包封培养基和/或培养细胞的封闭部11-1; 容器台12，其上放置有培养容器11; 辊13，其放置在培养容器11的上表面上并将外壳部分11-1分成两个或更多个腔室; 以及驱动装置15，其使辊13或培养容器11相对移动，从而改变包封培养基或培养细胞的包封部11-1中的培养部11-11的体积。

3. 发明授权

US09441193B2 Cell culture apparatus, cell culture system and cell culture method 有权
标题翻译：细胞培养装置，细胞培养系统和细胞培养方法
公开(公告)号：US09441193B2
公开(公告)日：2016-09-13
申请号：US12450481
申请日：2008-04-25
申请人： Satoshi Tanaka , Yoichi Ishizaki , Ryo Suenaga , Yoriko Tokita , Masahito Kogure
发明人： Satoshi Tanaka , Yoichi Ishizaki , Ryo Suenaga , Yoriko Tokita , Masahito Kogure
IPC分类号： C12M1/34 , C12M1/00 , C12M1/06 , C12M1/26
CPC分类号： C12M23/34 , C12M23/14 , C12M27/02 , C12M29/00 , C12M33/18
摘要： By maintaining the cell density during culture at an appropriate level and eliminating the procedure of transferring cells from a container to another container when a large amount of cells are cultured, damage on cells can be reduced, risk of contamination can be lowered, labor saving can be attained and automation can be attained.A cell culture apparatus including: a culture container 11 formed of a soft packing material and having an enclosure part 11-1 in which a culture medium and/or cells being cultured are enclosed is placed; a container table 12 on which the culture container 11 is placed; a roller 13 which is placed on the upper surface of the culture container 11 and divides the enclosure part 11-1 into two or more chambers; and a driving means 15 which relatively moves the roller 13 or the culture container 11, thereby to change the volume of the culture part 11-11 in the enclosure part 11-1 in which a culture medium or cells being cultured are enclosed.
摘要翻译：一种细胞培养装置，其特征在于，包括：由软性包装材料形成的培养容器11，具有包封培养基和/或培养细胞的封闭部11-1; 容器台12，其上放置有培养容器11; 辊13，其放置在培养容器11的上表面上并将外壳部分11-1分成两个或更多个腔室; 以及驱动装置15，其使辊13或培养容器11相对移动，从而改变包封培养基或培养细胞的包封部11-1中的培养部11-11的体积。

4. 发明申请

US20100062530A1 CELL CULTURE METHOD, CELL CULTURE SYSTEM AND CULTURE MEDIUM ADJUSTEMENT APPARATUS 有权
标题翻译：细胞培养方法，细胞培养系统和培养中等调节剂
公开(公告)号：US20100062530A1
公开(公告)日：2010-03-11
申请号：US12450480
申请日：2008-04-24
申请人： Satoshi Tanaka , Yoichi Ishizaki , Ryo Suenaga , Yoriko Tokita , Masahito Kogure
发明人： Satoshi Tanaka , Yoichi Ishizaki , Ryo Suenaga , Yoriko Tokita , Masahito Kogure
IPC分类号： C12N5/02 , C12M1/00
CPC分类号： C12M41/32 , C12M23/14 , C12M23/26 , C12M27/02 , C12M29/26 , C12M33/18 , C12M41/26 , C12M41/44
摘要： In a cell culture in a sealed cell culture container, gradual deterioration of culture environment is prevented. A cell culture method in which cell culture is conducted by adding a fresh culture medium to a culture container in which cells and a culture medium are enclosed, which includes the steps ofadjusting the pH of said culture medium to be added to be higher than the pH which is optimum for culture of the cells, and/or adjusting the partial pressure of dissolved carbon dioxide of the culture medium to be added to be lower than the pressure which is optimum for culture of the cells, and/or adjusting the partial pressure of dissolved oxygen of the culture medium to be added to be higher than the pressure which is optimum for culture of the cells; and mixing the adjusted culture medium and the culture medium in said culture container to adjust at least any of the pH, the partial pressure of dissolved carbon dioxide and the partial pressure of dissolved oxygen to be optimum for culture of said cells, thereby to culture the cells in the culture container.
摘要翻译：在密闭的细胞培养容器中的细胞培养物中，防止了培养环境的逐渐恶化。一种细胞培养方法，其中通过向封闭细胞和培养基的培养容器中加入新鲜培养基进行细胞培养，其包括将待加入的培养基的pH调节至高于调节细胞培养最适宜的pH值，和/或将待添加的培养基溶解二氧化碳的分压调整至低于细胞培养最佳的压力，和/或调节分压的待添加培养基的溶解氧高于培养细胞的最佳压力; 并将调节后的培养基和培养液混合，调节pH，溶解二氧化碳的分压和溶解氧的分压中的至少任意一种，使其培养成最适于培养所述细胞，细胞在培养容器中。

5. 发明申请

US20050196567A1 Heat-resistant resin container and method of producing the same 有权
标题翻译：耐热性树脂容器及其制造方法
公开(公告)号：US20050196567A1
公开(公告)日：2005-09-08
申请号：US11071444
申请日：2005-03-04
申请人： Tsutomu Iwasaki , Masahito Kogure , Hisao Iwamoto , Ryo Suenaga
发明人： Tsutomu Iwasaki , Masahito Kogure , Hisao Iwamoto , Ryo Suenaga
IPC分类号： B32B1/08
CPC分类号： B32B7/12 , B32B27/08 , B32B27/306 , B32B27/325 , B32B27/34 , B32B27/36 , B32B2250/24 , B32B2250/40 , B32B2272/00 , B32B2307/306 , B32B2307/412 , B32B2307/558 , B32B2307/7244 , B32B2307/738 , B32B2439/00 , Y10T428/1352
摘要： A container with a flange having excellent heat resistance and impact resistance in the lower part of the barrel portion and having excellent transparency in the wall despite the container is formed by molding an amorphous polyester sheet, and a method of producing the same.
摘要翻译：具有凸缘的容器在筒部的下部具有优异的耐热性和耐冲击性，并且尽管容器通过模制无定形聚酯片而形成，但是壁的透明性优异，并且其制造方法。

6. 发明授权

US07655179B2 Heat-resistant resin container and method of producing the same 有权
标题翻译：耐热性树脂容器及其制造方法
公开(公告)号：US07655179B2
公开(公告)日：2010-02-02
申请号：US11071444
申请日：2005-03-04
申请人： Tsutomu Iwasaki , Masahito Kogure , Hisao Iwamoto , Ryo Suenaga
发明人： Tsutomu Iwasaki , Masahito Kogure , Hisao Iwamoto , Ryo Suenaga
IPC分类号： B29D29/00
CPC分类号： B32B7/12 , B32B27/08 , B32B27/306 , B32B27/325 , B32B27/34 , B32B27/36 , B32B2250/24 , B32B2250/40 , B32B2272/00 , B32B2307/306 , B32B2307/412 , B32B2307/558 , B32B2307/7244 , B32B2307/738 , B32B2439/00 , Y10T428/1352
摘要： A container with a flange having excellent heat resistance and impact resistance in the lower part of the barrel portion and having excellent transparency in the wall despite the container is formed by molding an amorphous polyester sheet, and a method of producing the same.
摘要翻译：具有凸缘的容器在筒部的下部具有优异的耐热性和耐冲击性，并且尽管容器通过模制无定形聚酯片而形成，但是壁的透明性优异，并且其制造方法。

7. 发明授权

US07582249B2 Method of manufacturing thermoplastic resin container 有权
标题翻译：制造热塑性树脂容器的方法
公开(公告)号：US07582249B2
公开(公告)日：2009-09-01
申请号：US10521594
申请日：2003-07-16
申请人： Tsutomu Iwasaki , Masahito Kogure , Hideo Kawasaki , Yasushi Hatano
发明人： Tsutomu Iwasaki , Masahito Kogure , Hideo Kawasaki , Yasushi Hatano
IPC分类号： B29C51/10
CPC分类号： B29C51/08 , B29C49/04 , B29C51/04 , B29C51/262 , B29C2791/006 , B29C2791/007 , B29L2031/7132
摘要： In a method for manufacturing a thermoplastic resin vessel, in which a cup-shaped vessel is thermally formed from a thermoplastic resin sheet by a plug, the method including the steps of: pre-forming a portion of the thermoplastic resin sheet corresponding to an orifice portion or a flange portion of the cup-shaped vessel; and clamping the pre-formed portion of the thermoplastic resin sheet to accomplish the forming. According to the manufacturing method, thickening of a vessel bottom part and warpage of the flange portion can be improved.
摘要翻译：在热塑性树脂容器的制造方法中，由热塑性树脂片通过塞子热形成杯形容器的方法包括以下步骤：预先形成对应于孔口的热塑性树脂片材的一部分杯形容器的部分或凸缘部分; 并夹紧热塑性树脂片材的预成型部分以完成成型。根据制造方法，可以提高容器底部的增厚和凸缘部的翘曲。

8. 发明申请

US20070082151A1 Polyester container, method for manufacturing the same, and method for sealing polyester container 有权
标题翻译：聚酯容器，其制造方法以及聚酯容器密封方法
公开(公告)号：US20070082151A1
公开(公告)日：2007-04-12
申请号：US10577371
申请日：2004-11-04
申请人： Yasushi Hatano , Tsutomu Iwasaki , Masahito Kogure , Hideo Kawasaki , Hisao Iwamoto
发明人： Yasushi Hatano , Tsutomu Iwasaki , Masahito Kogure , Hideo Kawasaki , Hisao Iwamoto
IPC分类号： B32B27/08
CPC分类号： B65D77/2024 , B29C51/04 , B29C65/02 , B29C65/08 , B29C65/10 , B29C65/1412 , B29C65/1422 , B29C66/112 , B29C66/114 , B29C66/131 , B29C66/24221 , B29C66/30223 , B29C66/342 , B29C66/53461 , B29C66/71 , B29C66/72328 , B29C66/72341 , B29C66/8322 , B29C66/849 , B29C2791/006 , B29C2791/007 , B29K2067/00 , B29K2995/0053 , B29L2031/7132 , Y10T428/13 , Y10T428/1352 , Y10T428/1379 , Y10T428/1397 , B29C65/00
摘要： A polyester container furnished with a flange part having mechanical strength, transparency, and heat resistance through orientational crystallization, which polyester container exhibits low-temperature heat sealability, is provided by forming a projecting portion at an upper surface of the crystallized flange part, the projecting portion at at least a heat-sealing-face constituting region rendered amorphous or of low crystallinity. Further, in order to suppress the unevenness of the strength of sealing with a cover member and stably attain the high sealability, the projecting portion is deformed at the time of heat sealing with the cover member so as to form a resin piece protruding toward the interior of the container while being substantially appressed against the upper surface of an opening rim part. The formed resin piece couples with a sealant layer of the cover member.
摘要翻译：通过在结晶化凸缘部分的上表面处形成突出部分，提供通过定向结晶具有机械强度，透明度和耐热性的聚酯容器，该聚酯容器具有低温热封性，至少在热封面构成区域呈现无定形或低结晶度的部分。此外，为了抑制由盖构件的密封强度的不均匀性并且稳定地获得高密封性，突起部在与盖构件的热封时变形，从而形成向内部突出的树脂片同时基本上压在开口边缘部分的上表面上。所形成的树脂片与盖构件的密封层相连。

9. 发明申请

US20050079306A1 Oxygen-absorbing resin composition and packaging container, packaging material, cap or liner material having oxygen absorbability 审中-公开
标题翻译：具有吸氧性的吸氧树脂组合物和包装容器，包装材料，帽或衬垫材料
公开(公告)号：US20050079306A1
公开(公告)日：2005-04-14
申请号：US10958368
申请日：2004-10-06
申请人： Masayasu Koyama , Masahito Kogure , Yasuhiro Oda , Yoshitsugu Maruhashi , Toshio Goryoda , Shogo Mukuno
发明人： Masayasu Koyama , Masahito Kogure , Yasuhiro Oda , Yoshitsugu Maruhashi , Toshio Goryoda , Shogo Mukuno
IPC分类号： A23L3/3436 , B32B27/08 , B65D81/26 , B65D1/00
CPC分类号： B32B27/08 , A23L3/3436 , B32B7/12 , B32B15/20 , B32B27/32 , B32B2553/00 , B65D81/267 , Y10T428/1352
摘要： A thermoplastic resin composition containing an oxygen-absorbing agent, wherein a resin matrix of the thermoplastic resin composition is substantially non-compatible and is composed of a blend of thermoplastic resins or elastomers, and the non-compatible thermoplastic resins and elastomers are present as a non-uniformly distributed structure in the resin matrix. The packaging container or cap of this invention suppresses the lowering of flavor retention incident to the dissolving out of the oxygen absorbing agent or its oxidation product even after retorting sterization. The preservability of the contents and flavor retention can be achieved for a long period of time. According to a preferred embodiment, the oxygen absorbing speed can be increased. After storage for a long time, or after heat sterilization, a rugged state does not occur. There can be formed the oxygen-absorbing resin composition and the packaging container having excellent outer appearance.
摘要翻译：一种含有氧吸收剂的热塑性树脂组合物，其中热塑性树脂组合物的树脂基质基本不相容并由热塑性树脂或弹性体的共混物构成，不相容的热塑性树脂和弹性体以在树脂基体中不均匀分布的结构。本发明的包装容器或盖子即使在蒸煮灭菌后也抑制了从氧吸收剂或其氧化产物中溶解出来的香味保留性降低。内容物的保存性和香味保持能够长时间实现。根据优选实施例，可以提高氧吸收速度。长时间贮存后，加热灭菌后，不会发生坚固的状态。可以形成具有优异外观的氧吸收性树脂组合物和包装容器。

10. 发明授权

US08465817B2 Polyester container 有权
标题翻译：聚酯容器
公开(公告)号：US08465817B2
公开(公告)日：2013-06-18
申请号：US10577371
申请日：2004-11-04
申请人： Yasushi Hatano , Tsutomu Iwasaki , Masahito Kogure , Hideo Kawasaki , Hisao Iwamotoi
发明人： Yasushi Hatano , Tsutomu Iwasaki , Masahito Kogure , Hideo Kawasaki , Hisao Iwamotoi
IPC分类号： B32B1/02 , B65D8/04 , B65D90/02 , B65D6/40 , B65D1/40
CPC分类号： B65D77/2024 , B29C51/04 , B29C65/02 , B29C65/08 , B29C65/10 , B29C65/1412 , B29C65/1422 , B29C66/112 , B29C66/114 , B29C66/131 , B29C66/24221 , B29C66/30223 , B29C66/342 , B29C66/53461 , B29C66/71 , B29C66/72328 , B29C66/72341 , B29C66/8322 , B29C66/849 , B29C2791/006 , B29C2791/007 , B29K2067/00 , B29K2995/0053 , B29L2031/7132 , Y10T428/13 , Y10T428/1352 , Y10T428/1379 , Y10T428/1397 , B29C65/00
摘要： A polyester container furnished with a flange part having mechanical strength, transparency, and heat resistance through orientational crystallization, which polyester container exhibits low-temperature heat sealability, is provided by forming a projecting portion at an upper surface of the crystallized flange part, the projecting portion at at least a heat-sealing-face constituting region rendered amorphous or of low crystallinity. Further, in order to suppress the unevenness of the strength of sealing with a cover member and stably attain the high sealability, the projecting portion is deformed at the time of heat sealing with the cover member so as to form a resin piece protruding toward the interior of the container while being substantially appressed against the upper surface of an opening rim part. The formed resin piece couples with a sealant layer of the cover member.
摘要翻译：通过在结晶化凸缘部分的上表面处形成突出部分，提供通过定向结晶具有机械强度，透明度和耐热性的聚酯容器，该聚酯容器具有低温热封性，至少在热封面构成区域呈现无定形或低结晶度的部分。此外，为了抑制由盖构件的密封强度的不均匀性并且稳定地获得高密封性，突起部在与盖构件的热封时变形，从而形成向内部突出的树脂片同时基本上压在开口边缘部分的上表面上。所形成的树脂片与盖构件的密封层相连。

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