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1. 发明申请

US20090263792A1 ATOPIC DERMATITIS MARKER AND TECHNIQUE OF USING THE SAME 有权
标题翻译：特征标记和使用它的技术
公开(公告)号：US20090263792A1
公开(公告)日：2009-10-22
申请号：US12090644
申请日：2006-10-19
申请人： Satoshi Miyata , Kaoru Miyazaki , Chie Yasuda , Akihiro Iwamatsu , Zenro Ikezawa , Michiko Aihara , Kayano Moriyama
发明人： Satoshi Miyata , Kaoru Miyazaki , Chie Yasuda , Akihiro Iwamatsu , Zenro Ikezawa , Michiko Aihara , Kayano Moriyama
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/6881 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/202
摘要： It is an object of the present invention to find substances that can be used as disease markers for atopic dermatitis and the present invention provides a method for determining atopic dermatitis, including measurement of the expression of specific proteins and/or their genes in skin cells and/or skin tissues, wherein the specific proteins change their expression with inflammation caused by atopic dermatitis or change their expression according to the degree of predisposition to atopic dermatitis. The present invention also provides a kit for determining the degree of inflammation of atopic dermatitis or risk of developing atopic dermatitis, as well as a method for determining substances effective in the treatment and/or prevention of atopic dermatitis.
摘要翻译：本发明的目的是找到可用作特应性皮炎的疾病标志物的物质，本发明提供了一种确定特应性皮炎的方法，包括测定皮肤细胞中特异性蛋白质和/或其基因的表达， /或皮肤组织，其中特异性蛋白质根据特应性皮炎引起的炎症改变其表达，或根据对特应性皮炎的倾向程度改变其表达。本发明还提供了用于确定特应性皮炎炎症程度或发展特应性皮炎风险的试剂盒，以及用于确定有效治疗和/或预防特应性皮炎的物质的方法。

2. 发明授权

US07820396B2 Method for determining atopic dermatitis using protein marker 有权
标题翻译：使用蛋白质标记物测定特应性皮炎的方法
公开(公告)号：US07820396B2
公开(公告)日：2010-10-26
申请号：US12090644
申请日：2006-10-19
申请人： Satoshi Miyata , Kaoru Miyazaki , Chie Yasuda , Akihiro Iwamatsu , Zenro Ikezawa , Michiko Aihara , Kayano Moriyama
发明人： Satoshi Miyata , Kaoru Miyazaki , Chie Yasuda , Akihiro Iwamatsu , Zenro Ikezawa , Michiko Aihara , Kayano Moriyama
IPC分类号： G01N33/53 , G01N33/567
CPC分类号： G01N33/6881 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/202
摘要： It is an object of the present invention to find substances that can be used as disease markers for atopic dermatitis and the present invention provides a method for determining atopic dermatitis, including measurement of the expression of specific proteins and/or their genes in skin cells and/or skin tissues, wherein the specific proteins change their expression with inflammation caused by atopic dermatitis or change their expression according to the degree of predisposition to atopic dermatitis. The present invention also provides a kit for determining the degree of inflammation of atopic dermatitis or risk of developing atopic dermatitis, as well as a method for determining substances effective in the treatment and/or prevention of atopic dermatitis.
摘要翻译：本发明的目的是找到可用作特应性皮炎的疾病标志物的物质，本发明提供了一种确定特应性皮炎的方法，包括测定皮肤细胞中特异性蛋白质和/或其基因的表达， /或皮肤组织，其中特异性蛋白质根据特应性皮炎引起的炎症改变其表达，或根据对特应性皮炎的倾向程度改变其表达。本发明还提供了用于确定特应性皮炎炎症程度或发展特应性皮炎风险的试剂盒，以及用于确定有效治疗和/或预防特应性皮炎的物质的方法。

3. 发明授权

US07972788B2 Skin aging marker and technique for use thereof 有权
标题翻译：皮肤老化标记及其使用技术
公开(公告)号：US07972788B2
公开(公告)日：2011-07-05
申请号：US12064602
申请日：2006-08-22
申请人： Satoshi Miyata , Kaoru Miyazaki , Chie Yasuda , Akihiro Iwamatsu
发明人： Satoshi Miyata , Kaoru Miyazaki , Chie Yasuda , Akihiro Iwamatsu
IPC分类号： C12Q1/68 , G01N33/53 , C07K1/00 , C07K14/00 , C07K17/00 , A61K38/17 , C08H1/06
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/6881
摘要： It is an object of the present invention to find substances that can be used as skin aging markers, and the present invention provides a method for determining the degree of skin aging, including measurement of expression of secretory proteins and/or intracellular proteins and/or their genes in skin cells and/or skin tissues, wherein the secretory proteins and/or intracellular proteins change their expression with aging of skin. The present invention also provides a kit for determining the degree of skin aging and a method for identifying substances effective in the prevention of skin aging.
摘要翻译：本发明的目的是找到可用作皮肤老化标记的物质，本发明提供了一种测定皮肤老化程度的方法，包括测定分泌蛋白和/或细胞内蛋白质的表达和/或它们在皮肤细胞和/或皮肤组织中的基因，其中分泌蛋白和/或细胞内蛋白质随着皮肤老化而改变其表达。本发明还提供了用于确定皮肤老化程度的试剂盒以及用于鉴定有效预防皮肤老化的物质的方法。

4. 发明申请

US20090305242A1 SKIN AGING MARKER AND TECHNIQUE FOR USE THEREOF 有权
标题翻译：皮肤老化标记及其使用技术
公开(公告)号：US20090305242A1
公开(公告)日：2009-12-10
申请号：US12064602
申请日：2006-08-22
申请人： Satoshi Miyata , Kaoru Miyazaki , Chie Yasuda , Akihiro Iwamatsu
发明人： Satoshi Miyata , Kaoru Miyazaki , Chie Yasuda , Akihiro Iwamatsu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N33/6881
摘要： It is an object of the present invention to find substances that can be used as skin aging markers, and the present invention provides a method for determining the degree of skin aging, including measurement of expression of secretory proteins and/or intracellular proteins and/or their genes in skin cells and/or skin tissues, wherein the secretory proteins and/or intracellular proteins change their expression with aging of skin. The present invention also provides a kit for determining the degree of skin aging and a method for identifying substances effective in the prevention of skin aging.
摘要翻译：本发明的目的是找到可用作皮肤老化标记的物质，本发明提供了一种测定皮肤老化程度的方法，包括测定分泌蛋白和/或细胞内蛋白质的表达和/或它们在皮肤细胞和/或皮肤组织中的基因，其中分泌蛋白和/或细胞内蛋白质随着皮肤老化而改变其表达。本发明还提供了用于确定皮肤老化程度的试剂盒以及用于鉴定有效预防皮肤老化的物质的方法。

5. 发明申请

US20130135859A1 LIGHT IRRADIATOR, IMAGE SCANNER, AND IMAGE FORMING APPARATUS 失效
标题翻译：光照射器，图像扫描仪和图像形成装置
公开(公告)号：US20130135859A1
公开(公告)日：2013-05-30
申请号：US13678936
申请日：2012-11-16
申请人： Tokiko INOUE , Mitsuru Nakajima , Tsuyoshi Fujimoto , Akihiro Iwamatsu , Chihiro Tanaka
发明人： Tokiko INOUE , Mitsuru Nakajima , Tsuyoshi Fujimoto , Akihiro Iwamatsu , Chihiro Tanaka
IPC分类号： F21V8/00
CPC分类号： G02B6/0011 , G03G15/04054 , H04N1/02481 , H04N1/02855 , H04N1/02865 , H04N2201/02435
摘要： A light irradiator including multiple point light sources arranged in a straight line, a light-transmissive light guiding member provided in front of the point light sources in an emission direction of beams of light emitted from the point light sources, the light guiding member guiding the beams of light in a predetermined direction toward a surface to be irradiated; and two or more protrusions protruding toward the point light sources, provided on a light entering surface of the light guiding member and arranged in the same direction as the point light sources. The light guiding member and the point light sources are positioned such that a distance between the protrusions provided to the light guiding member and irradiation surfaces of the point light sources is equal at two positions.
摘要翻译：一种包括以直线排列的多点光源的光照射器，沿点光源发射的光束的发射方向设置在点光源前面的透光导光部件，导光部件引导沿预定方向的光束朝向待照射的表面; 以及设置在导光部件的光入射面上且与点光源相同的方向配置的朝向点光源突出的两个以上的突起。导光构件和点光源被定位成使得提供给导光构件的突起和点光源的照射表面之间的距离在两个位置处相等。

6. 发明授权

US6013499A Rho target protein kinase p160 失效
标题翻译： Rho靶蛋白激酶p160
公开(公告)号：US6013499A
公开(公告)日：2000-01-11
申请号：US685871
申请日：1996-07-24
申请人： Shuh Narumiya , Akihiro Iwamatsu
发明人： Shuh Narumiya , Akihiro Iwamatsu
IPC分类号： G01N33/53 , A61K38/45 , C07H21/04 , C07K14/47 , C12N1/21 , C12N5/00 , C12N5/10 , C12N9/12 , C12N15/09 , C12Q1/48 , C12R1/91 , G01N33/15 , G01N33/50 , G01N33/566 , C07K14/00
CPC分类号： C12N9/1205
摘要： The object of the present invention is to provide a target protein for the activated Rho protein. The present invention is a protein having the activated Rho protein binding activity and protein kinase activity, or derivatives thereof. The molecular weight of the protein is about 160 kDa as measured by SDS-PAGE. The protein kinase activity of the protein is enhanced when it binds to the activated Rho protein.
摘要翻译：本发明的目的是提供活化的Rho蛋白的靶蛋白。本发明是具有活化的Rho蛋白结合活性和蛋白激酶活性的蛋白质或其衍生物。通过SDS-PAGE测量，蛋白质的分子量为约160kDa。当蛋白质与活化的Rho蛋白质结合时，蛋白质的蛋白激酶活性得到增强。

7. 发明授权

US06001590A Promoter and terminator sequences of formate dehydrogenase gene of Candida boidinii 失效
标题翻译：博伊丁假丝酵母的甲酸脱氢酶基因的启动子和终止子序列
公开(公告)号：US06001590A
公开(公告)日：1999-12-14
申请号：US817926
申请日：1997-05-09
申请人： Toshihiro Komeda , Hisako Suda , Yukio Tamai , Akihiro Iwamatsu , Nobuo Kato , Yasuyoshi Sakai
发明人： Toshihiro Komeda , Hisako Suda , Yukio Tamai , Akihiro Iwamatsu , Nobuo Kato , Yasuyoshi Sakai
IPC分类号： C12N1/15 , C12N9/02 , C12N15/81 , C12N15/31 , C12P21/00
CPC分类号： C12N9/0008 , C12N15/815
摘要： A promoter for a formate dehydrogenase gene from Candida boidinii, substantially comprising a 190 bp or more continuous nucleotide sequence selected from the nucleotide sequence of SEQ ID NO:1; a promoter for a formate dehydrogenase gene from Candida boidinii, substantially comprising the nucleotide sequence of SEQ ID NO:1, 48, 49 or 50; a terminator for a formate dehydrogenase gene from Candida boidinii, substantially comprising the nucleotide sequence of SEQ ID NO:2; a gene expression cassette comprising said promoter, a heterologous gene and said terminator; a recombinant expression vector comprising said gene expression cassette; a transformant transformed with said recombinant expression vector; a process for producing an expression product of a heterologous gene, which comprises culturing said transformant and recovering an expression product of a heterologous gene from the culture.
摘要翻译： PCT No.PCT / JP96 / 02597 371日期：1997年5月9日 102（e）日期1997年5月9日PCT提交1996年9月12日PCT公布。公开号WO97 / 10345 日期：1997年3月20日来自布氏念珠菌的甲酸脱氢酶基因的启动子，基本上包含选自SEQ ID NO：1的核苷酸序列的190bp以上的连续核苷酸序列; 来自布氏念珠菌的甲酸脱氢酶基因的启动子，基本上包含SEQ ID NO：1,49,49或50的核苷酸序列; 来自布氏念珠菌的甲酸脱氢酶基因的终止子，基本上包含SEQ ID NO：2的核苷酸序列; 包含所述启动子，异源基因和所述终止子的基因表达盒; 包含所述基因表达盒的重组表达载体; 用所述重组表达载体转化的转化体; 用于产生异源基因的表达产物的方法，其包括培养所述转化体并从培养物中回收异源基因的表达产物。

8. 发明授权

US10003711B2 Light irradiation device, image reading device, and image forming apparatus 有权
公开(公告)号：US10003711B2
公开(公告)日：2018-06-19
申请号：US15451561
申请日：2017-03-07
申请人： Akihiro Iwamatsu , Kazushige Kawamura , Takuya Kohda
发明人： Akihiro Iwamatsu , Kazushige Kawamura , Takuya Kohda
IPC分类号： H04N1/04 , H04N1/028
CPC分类号： H04N1/02835 , H04N1/0284 , H04N1/02895 , H04N2201/0081 , H04N2201/02462 , H04N2201/02468 , H04N2201/02485
摘要： A light irradiation device includes a light source, a light guide member, and a holding member. The light guide member includes an incident surface, an exit surface, and a held surface. The incident surface has an elongated shape in a main scanning direction and faces a light emitting surface of the light source. The light guide member includes a securing structure in each of both end portions in the main scanning direction, which are out of a light guide area of the light guide member. The securing structure in one end portion is an engagement lug structure protruding to penetrate into a through-hole of the holding member, including a lug on a leading end, and engaging the holding member. The securing structure on another end portion is a fastening structure having a fastening hole penetrated with a fastening member and being secured to the holding member with the fastening member.

9. 发明授权

US09057809B2 Light irradiation device and image forming apparatus 有权
标题翻译：光照射装置和成像装置
公开(公告)号：US09057809B2
公开(公告)日：2015-06-16
申请号：US14468382
申请日：2014-08-26
申请人： Akihiro Iwamatsu , Tsuyoshi Fujimoto , Tokiko Inoue
发明人： Akihiro Iwamatsu , Tsuyoshi Fujimoto , Tokiko Inoue
IPC分类号： H04N1/04 , F21V8/00 , H04N1/028
CPC分类号： H04N1/0284 , G02B6/0045
摘要： A light irradiation device includes: a light source to output diffused light; and a light guide member to guide the diffused light to an irradiation point. The light guide member includes an incidence surface which the diffused light enters, a first emission surface to emit the entered diffused light, while further diffusing the entered diffused light with a first diffusion characteristic to emit the diffused light at a first diffusion angle, and a second emission surface to emit the entered diffused light, while further diffusing the entered diffused light with a second diffusion characteristics to emit the diffused light at a second diffusion angle. The second diffusion angle provided by the second diffusion characteristic is smaller than the first diffusion angle provided by the first diffusion characteristic.
摘要翻译：光照射装置包括：输出漫射光的光源; 以及导向构件，用于将漫射光引导到照射点。导光构件包括漫射光入射的入射面，发射入射漫射光的第一发射面，同时以第一扩散特性进一步扩散入射的漫射光以以第一扩散角发射漫射光，并且第二发射表面发射输入的漫射光，同时进一步扩散具有第二扩散特性的输入的漫射光以以第二扩散角发射漫射光。由第二扩散特性提供的第二扩散角小于由第一扩散特性提供的第一扩散角。

10. 发明授权

US08848262B2 Optical radiation device, image reader, and image forming device 有权
标题翻译：光辐射装置，图像读取器和图像形成装置
公开(公告)号：US08848262B2
公开(公告)日：2014-09-30
申请号：US13687665
申请日：2012-11-28
申请人： Akihiro Iwamatsu , Tsuyoshi Fujimoto , Mitsuru Nakajima , Tokiko Inoue , Chihiro Tanaka
发明人： Akihiro Iwamatsu , Tsuyoshi Fujimoto , Mitsuru Nakajima , Tokiko Inoue , Chihiro Tanaka
IPC分类号： H04N1/04 , H04N1/03 , H04N1/028
CPC分类号： H04N1/02815 , H04N1/02855 , H04N1/02865 , H04N1/02885 , H04N1/03
摘要： An optical radiation device includes a long light source unit in which light emitting elements are arranged in array, a long substrate on which the light source unit is mounted, a long optical guide to guide the light beams from the light emitting elements to a predetermined plane, and an optical collector to collect the light beams reflected by the predetermined plane. The length of an effective read area from a reading center of the optical collector to one end of the predetermined plane is different from that of an effective read area from the reading center to the other end thereof. The optical guide formed by injection molding includes a gate at one end in a length direction and a surface at the other end to exert total reflection, and is disposed so that the gate is positioned on the a same side as a shorter effective read area.
摘要翻译：一种光辐射装置包括：长光源单元，其中发光元件排列成阵列，其中安装有光源单元的长基板;长光导，用于将来自发光元件的光引导到预定平面以及收集由所述预定平面反射的光束的光收发器。从光收发器的读取中心到预定平面的一端的有效读取区域的长度不同于从读取中心到另一端的有效读取区域的长度。通过注射成型形成的光导包括在长度方向上的一端的栅极和另一端的表面以发挥全反射，并且被设置为使得栅极位于与较短的有效读取区域相同的一侧。

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