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1. 发明申请

US20090124706A1 CONTACT LENS SOLUTION AND METHOD FOR HYDROPHILIZING CONTACT LENS BY USING THE SAME 审中-公开
标题翻译：接触透镜解决方案和使用相同方式对接触镜进行加氢处理
公开(公告)号：US20090124706A1
公开(公告)日：2009-05-14
申请号：US12348935
申请日：2009-01-06
申请人： Satoru MATSUMOTO , Yasuyuki Kato , Naoki Anan , Yumi Anan Executrix , Mitsuaki Goto , Masamichi Iwama
发明人： Satoru MATSUMOTO , Yasuyuki Kato , Naoki Anan , Yumi Anan Executrix , Mitsuaki Goto , Masamichi Iwama
IPC分类号： A61K47/32 , C08L5/00
CPC分类号： C11D3/0078 , A61L12/08 , C11D3/3773
摘要： It is an object of the present invention to provide a contact lens solution that imparts stable hydrophilicity even to a surface of a contact lens having strong water repellency. There was prepared a contact lens solution comprising a copolymer of N-p-vinylbenzyl-D-lactonamide and at least one monomer copolymerizable therewith. The copolymer is present in the solution in an amount of 0.0001 to 5 w/v %.
摘要翻译：本发明的目的是提供即使对具有强斥水性的隐形眼镜的表面也具有稳定亲水性的隐形眼镜溶液。制备了包含N-对乙烯基苄基-D-内酰胺和至少一种可与其共聚的单体的共聚物的隐形眼镜溶液。该溶液中共聚物的存在量为0.0001至5w / v％。

2. 发明申请

US20110129434A1 MOISTURIZING AGENT 审中-公开
标题翻译：滋润剂
公开(公告)号：US20110129434A1
公开(公告)日：2011-06-02
申请号：US12991835
申请日：2009-04-27
申请人： Mitsuaki Goto , Masamichi Iwama , Yumi Anan
发明人： Mitsuaki Goto , Masamichi Iwama , Yumi Anan
IPC分类号： A61K31/74 , A61Q1/00 , C08F12/08
CPC分类号： A61K31/702 , A61K8/8111 , A61K8/8117 , A61K8/8129 , A61Q19/08
摘要： Disclosed is a moisturizing agent comprising a copolymer represented by formula (1). [In formula (1), A represents a substituent containing an oligosaccharide composed of 2 to 6 monosaccharide molecules bound to each other; B represents a group represented by formula (2); m and n represent numbers which meet the following equation m:n=9:1 to 1:9; and Z represents a hydrogen group, a methyl group or an ethyl group.] [In formula (2), X represents a saturated or unsaturated monocyclic or dicyclic ring having 5 to 10 ring-constituting members, or a molecule containing a nitrogen or an oxygen, provided that the ring may contain 1 to 3 atoms independently selected from the group consisting of a nitrogen, a sulfur and an oxygen; n represents a number of 0 or 1; Y represents —NHCO—, —CONH—, —NHCONH—, —NH—, —CO, or an alkyl group having 0 or more carbon atoms; and R represents a linear or branched alkyl, alkenyl or alkynyl having 1 to 20 carbon atoms which, if required, may be substituted by one or two hydroxy, mercapto, amino, cyano, heterocyclyl, heterocyclyloxy, phenyl, benzyl, heteroaryl, phenoxy, benzyloxy or heteroaryloxy groups.]
摘要翻译：公开了包含由式（1）表示的共聚物的保湿剂。 [式（1）中，A表示含有由相互结合的2〜6个单糖分子构成的寡糖的取代基。 B表示式（2）表示的基团。 m和n表示满足以下等式m的数：n = 9：1至1：9; Z表示氢原子，甲基或乙基。] [式（2）中，X表示具有5〜10个环构成成分的饱和或不饱和的单环或双环，或含有氮或氧，条件是环可以含有1-3个独立地选自氮，硫和氧的原子; n表示0或1的数; Y表示-NHCO-，-CONH-，-NHCONH-，-NH-，-CO或具有0个或更多个碳原子的烷基; 并且R表示具有1至20个碳原子的直链或支链烷基，烯基或炔基，如果需要，其可以被一个或两个羟基，巯基，氨基，氰基，杂环基，杂环基氧基，苯基，苄基，杂芳基，苯氧基，苄氧基或杂芳氧基。

3. 发明申请

US20070286847A1 Adoptive Immune Cells For Tumor Vaccines 有权
标题翻译：免疫细胞用于肿瘤疫苗
公开(公告)号：US20070286847A1
公开(公告)日：2007-12-13
申请号：US11579280
申请日：2004-05-11
申请人： Kenichiro Hasumi , Akira Imaizumi , Masamichi Iwama , Mitsuaki Goto
发明人： Kenichiro Hasumi , Akira Imaizumi , Masamichi Iwama , Mitsuaki Goto
IPC分类号： A01N63/00 , C12N5/00 , C12N5/08
CPC分类号： C12N5/0068 , A61K2039/5154 , C12N2533/70
摘要： The present invention provides a method for preparing adoptive immune cells comprising the following steps of a) obtaining mammalian antigen-presenting associated cells; b) culturing the resulting cells in a culture vessel coated with a sugar chain-containing polymer; and c) detaching the cells by shaking the culture vessel without treating the cells with enzyme and without using a cell detaching tool; adoptive immune cells obtained by this preparing method; a culture vessel coated with a sugar chain-containing polymer for use in this preparation method; a kit for preparing an adoptive immune cell vaccine; and a method and a medicine for treating a malignant tumor, type I diabetes, atopic allergic diseases or infections using the adoptive immune cells.
摘要翻译：本发明提供一种制备过继免疫细胞的方法，包括以下步骤：a）获得哺乳动物抗原呈递相关细胞; b）将所得细胞培养在涂有含糖链的聚合物的培养容器中; 和c）通过摇动培养容器而不用酶处理细胞并且不使用细胞分离工具来分离细胞; 通过该制备方法获得的过继免疫细胞; 用该制备方法使用的含糖链聚合物的培养容器; 用于制备过继性免疫细胞疫苗的试剂盒; 以及使用过继免疫细胞治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的方法和药物。

4. 发明申请

US20100092445A1 Adoptive immune cells for tumor vaccines 有权
标题翻译：免疫细胞用于肿瘤疫苗
公开(公告)号：US20100092445A1
公开(公告)日：2010-04-15
申请号：US12653090
申请日：2009-12-08
申请人： Kenichiro Hasumi , Akira Imaizumi , Masamichi Iwama , Mitsuaki Goto
发明人： Kenichiro Hasumi , Akira Imaizumi , Masamichi Iwama , Mitsuaki Goto
IPC分类号： A61K45/00 , C12N5/0786 , A61P35/00 , A61P3/10 , A61P37/08
CPC分类号： C12N5/0068 , A61K2039/5154 , C12N2533/70
摘要： Adoptive immune cells obtained by a method including (a) obtaining mammalian antigen-presenting associated cells; (b) culturing the resulting cells from step (a) in a culture liquid contained in a culture vessel coated with a sugar chain-containing polymer; and (c) detaching the cells from step (b) by shaking the culture vessel without treating the cells with an enzyme and without using a cell detaching tool. A method for treating a malignant tumor, type I diabetes, an atopic allergic disease or an infection, by administering the adoptive immune cells to a patient. A pharmaceutical composition for treating a malignant tumor, type I diabetes, an atopic allergic disease or an infection, including the adoptive immune cells and a pharmaceutically acceptable carrier.
摘要翻译：通过包括（a）获得哺乳动物抗原呈递相关细胞的方法获得的免疫免疫细胞; （b）从包含在含有糖链的聚合物的培养容器中的培养液中培养来自步骤（a）的所得细胞; 和（c）通过摇动培养容器从步骤（b）中分离细胞而不用酶处理细胞，而不使用细胞分离工具。通过向患者施用过继免疫细胞来治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的方法。用于治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的药物组合物，包括过继免疫细胞和药学上可接受的载体。

5. 发明授权

US07655393B2 Adoptive immune cells for tumor vaccines 有权
标题翻译：免疫细胞用于肿瘤疫苗
公开(公告)号：US07655393B2
公开(公告)日：2010-02-02
申请号：US11579280
申请日：2004-05-11
申请人： Kenichiro Hasumi , Akira Imaizumi , Masamichi Iwama , Mitsuaki Goto
发明人： Kenichiro Hasumi , Akira Imaizumi , Masamichi Iwama , Mitsuaki Goto
IPC分类号： A01N1/02
CPC分类号： C12N5/0068 , A61K2039/5154 , C12N2533/70
摘要： The present invention provides a method for preparing adoptive immune cells comprising the following steps of a) obtaining mammalian antigen-presenting associated cells; b) culturing the resulting cells in a culture vessel coated with a sugar chain-containing polymer; and c) detaching the cells by shaking the culture vessel without treating the cells with enzyme and without using a cell detaching tool; adoptive immune cells obtained by this preparing method; a culture vessel coated with a sugar chain-containing polymer for use in this preparation method; a kit for preparing an adoptive immune cell vaccine; and a method and a medicine for treating a malignant tumor, type I diabetes, atopic allergic diseases or infections using the adoptive immune cells.
摘要翻译：本发明提供一种制备过继免疫细胞的方法，包括以下步骤：a）获得哺乳动物抗原呈递相关细胞; b）将所得细胞培养在涂有含糖链的聚合物的培养容器中; 和c）通过摇动培养容器而不用酶处理细胞并且不使用细胞分离工具来分离细胞; 通过该制备方法获得的过继免疫细胞; 用该制备方法使用的含糖链聚合物的培养容器; 用于制备过继性免疫细胞疫苗的试剂盒; 以及使用过继免疫细胞治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的方法和药物。

6. 发明授权

US08075882B2 Adoptive immune cells for tumor vaccines 有权
标题翻译：免疫细胞用于肿瘤疫苗
公开(公告)号：US08075882B2
公开(公告)日：2011-12-13
申请号：US12653090
申请日：2009-12-08
申请人： Kenichiro Hasumi , Akira Imaizumi , Masamichi Iwama , Mitsuaki Goto
发明人： Kenichiro Hasumi , Akira Imaizumi , Masamichi Iwama , Mitsuaki Goto
IPC分类号： A61K35/12 , C12N5/07
CPC分类号： C12N5/0068 , A61K2039/5154 , C12N2533/70
摘要： Adoptive immune cells obtained by a method including (a) obtaining mammalian antigen-presenting associated cells; (b) culturing the resulting cells from step (a) in a culture liquid contained in a culture vessel coated with a sugar chain-containing polymer; and (c) detaching the cells from step (b) by shaking the culture vessel without treating the cells with an enzyme and without using a cell detaching tool. A method for treating a malignant tumor, type I diabetes, an atopic allergic disease or an infection, by administering the adoptive immune cells to a patient. A pharmaceutical composition for treating a malignant tumor, type I diabetes, an atopic allergic disease or an infection, including the adoptive immune cells and a pharmaceutically acceptable carrier.
摘要翻译：通过包括（a）获得哺乳动物抗原呈递相关细胞的方法获得的免疫免疫细胞; （b）从包含在含有糖链的聚合物的培养容器中的培养液中培养来自步骤（a）的所得细胞; 和（c）通过摇动培养容器从步骤（b）中分离细胞而不用酶处理细胞，而不使用细胞分离工具。通过向患者施用过继免疫细胞来治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的方法。用于治疗恶性肿瘤，I型糖尿病，特应性过敏性疾病或感染的药物组合物，包括过继免疫细胞和药学上可接受的载体。

7. 发明授权

US06642050B1 Three-dimensional cell culture material having sugar polymer containing cell recognition sugar chain 失效
标题翻译：具有含有细胞识别糖链的糖聚合物的三维细胞培养物质
公开(公告)号：US06642050B1
公开(公告)日：2003-11-04
申请号：US09787239
申请日：2001-03-16
申请人： Mitsuaki Goto , Toshihiro Akaike , Jun Yang
发明人： Mitsuaki Goto , Toshihiro Akaike , Jun Yang
IPC分类号： C12N506
CPC分类号： C12N5/0068 , C12N5/0671 , C12N2501/11 , C12N2501/33 , C12N2533/70
摘要： A cell culture material comprising a sugar containing polymer in which at least one kind of sugar chain is bonded as a side chain via a spacer molecule is made into a three-dimensional shape whereupon a three-dimensional cell material is prepared. With regard to the sugar containing polymer, a sugar containing polymer having a carboxyl group such as alginic acid, hyaluronic acid, pectic acid or a derivative thereof is preferably used. Sugar chain having a specific recognition to a cell is bonded as a side chain and, therefore, when the cell is incubated using the cell culture material, it is possible to maintain and improve the proliferation, morphology and function of the cells and to retain the cell form in a form of near that in vivo due to a specific interaction between the cell and the sugar chain.
摘要翻译：将包含至少一种糖链作为侧链经由间隔分子结合的含糖聚合物的细胞培养材料制成三维形状，由此制备三维细胞材料。关于含糖聚合物，优选使用具有羧基的含糖聚合物，例如藻酸，透明质酸，果胶酸或其衍生物。具有对细胞的特异性识别的糖链作为侧链键合，因此当使用细胞培养材料温育细胞时，可以维持和改善细胞的增殖，形态和功能，并保持细胞形式由于细胞和糖链之间的特异性相互作用而在体内接近形式。

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