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1. 发明授权

US07514244B2 Lipid and food compositions containing docosahexaenoic acid and docosapentaenoic acid 失效
标题翻译：含有二十二碳六烯酸和二十二碳五烯酸的脂质和食物组合物
公开(公告)号：US07514244B2
公开(公告)日：2009-04-07
申请号：US10341300
申请日：2003-01-13
申请人： Satohiro Tanaka , Toshiaki Yaguchi , Sakayu Shimizu , Tsutomu Sogo , Shigeaki Fujikawa
发明人： Satohiro Tanaka , Toshiaki Yaguchi , Sakayu Shimizu , Tsutomu Sogo , Shigeaki Fujikawa
IPC分类号： C12P7/64 , A23K1/16
CPC分类号： C12P7/6427 , A23D9/007 , A23K20/158 , A23L33/12 , C11C1/045 , C12P7/6472 , C12R1/645 , C12R1/89
摘要： A process for preparing lipids which contain docosahexaenoic acid (DHA) and/or docosapentaenoic acid (DPA) is disclosed. The process includes the steps of cultivating in a medium a microorganism which belongs to the genus Ulkenia having the ability to produce DHA and/or DPA and recovering the lipids from the culture. The process may further include the step of separating DHA and/or DPA from the lipids.
摘要翻译：公开了一种制备含有二十二碳六烯酸（DHA）和/或二十二碳五烯酸（DPA）的脂质的方法。该方法包括在培养基中培养属于具有产生DHA和/或DPA的能力的乌尔肯尼亚属的微生物并从培养物中回收脂质的步骤。该方法还可以包括从脂质中分离DHA和/或DPA的步骤。

2. 发明授权

US06509178B1 Process for preparing docosahexaenoic acid and docosapentaenoic acid with ulkenia 有权
标题翻译：二十二碳六烯酸和二十二碳五烯酸的制备方法
公开(公告)号：US06509178B1
公开(公告)日：2003-01-21
申请号：US09230212
申请日：1999-05-03
申请人： Satohiro Tanaka , Toshiaki Yaguchi , Sakayu Shimizu , Tsutomu Sogo , Shigeaki Fujikawa
发明人： Satohiro Tanaka , Toshiaki Yaguchi , Sakayu Shimizu , Tsutomu Sogo , Shigeaki Fujikawa
IPC分类号： C12P764
CPC分类号： C12P7/6427 , A23D9/007 , A23K20/158 , A23L33/12 , C11C1/045 , C12P7/6472 , C12R1/645 , C12R1/89
摘要： A process for preparing lipids which contain docosahexaenoic acid (DHA) and/or docosapentaenoic acid (DPA) is disclosed. The process includes the steps of cultivating in a medium a microorganism which belongs to the genus Ulkenia having the ability to produce DHA and/or DPA and recovering the lipids from the culture. The process may further include the step of separating DHA and/or DPA from the lipids.
摘要翻译：公开了一种制备含有二十二碳六烯酸（DHA）和/或二十二碳五烯酸（DPA）的脂质的方法。该方法包括在培养基中培养属于具有产生DHA和/或DPA的能力的乌尔肯尼亚属的微生物并从培养物中回收脂质的步骤。该方法还可以包括从脂质中分离DHA和/或DPA的步骤。

3. 发明申请

US20080269329A1 Process for Production of Microbial Fat/Oil Containing Discretional Amount of Diacylglycerol and Said Fat/Oil 审中-公开
标题翻译：含有二酰基甘油和所述脂肪/油的离散量的微生物脂肪/油的生产方法
公开(公告)号：US20080269329A1
公开(公告)日：2008-10-30
申请号：US11660859
申请日：2005-08-19
申请人： Shigeaki Fujikawa , Eiji Sakuradani , Jun Ogawa , Sakayu Shimizu
发明人： Shigeaki Fujikawa , Eiji Sakuradani , Jun Ogawa , Sakayu Shimizu
IPC分类号： C12P7/64 , A61K31/201 , C07C57/00 , A61K31/202
CPC分类号： A61K8/375 , A23D9/013 , A23K20/158 , A23L33/115 , A23L33/12 , A23V2002/00 , A61K8/67 , A61K8/922 , A61K8/99 , A61Q19/00 , C11B1/10 , C11B3/12 , C12P7/6472 , A23V2250/182 , A23V2250/1882
摘要： In a process for the production of diacylglycerol-containing fat/oil where the ratio of diacylglycerol to the total neutral lipid is more than 20% by weight and a polyunsaturated fatty acid is a constituting fatty acid, a process which is characterized in that a microbe being able to produce said fat/oil is incubated and, if desired, said fat/oil is collected.
摘要翻译：在制备含二酰基甘油的脂肪/油的方法中，其中二酰基甘油与总中性脂质的比例大于20重量％，多不饱和脂肪酸是构成脂肪酸的方法，其特征在于将微生物能够产生所述脂肪/油的温育，如果需要，收集所述脂肪/油。

4. 发明授权

US06746857B2 Media for culturing microorganisms and process for producing unsaturated fatty acids or lipids containing the same 有权
标题翻译：用于培养微生物的培养基和用于生产不饱和脂肪酸或含有它们的脂质的方法
公开(公告)号：US06746857B2
公开(公告)日：2004-06-08
申请号：US09331759
申请日：1999-06-25
申请人： Kenichi Higashiyama , Toshiaki Yaguchi , Kengo Akimoto , Sakayu Shimizu
发明人： Kenichi Higashiyama , Toshiaki Yaguchi , Kengo Akimoto , Sakayu Shimizu
IPC分类号： C12P764
CPC分类号： C12P7/6427 , C12N1/14 , C12P7/6472
摘要： A process for controlling the mycelial morphology of a microorganism belonging to the genus Mortierella during culturing and a process for producing unsaturated fatty acids and a lipid containing them by using a culture medium for culturing a microorganism in which phosphate ions, potassium ions, sodium ions, magnesium ions, and calcium ions in the culture medium are in the range of 5 to 60 mM, 5 to 60 mM, 2 to 50 mM, 0.5 to 9 mM, and 0.5 to 12 mM, respectively, characterized in that the microorganism belonging to the genus Mortierella is cultured in a culture medium containing phosphate ions in the range of 5 to 60 mM, potassium ions in the range of 5 to 60 mM, sodium ions in the range of 2 to 50 mM, magnesium ions in the range of 0.5 to 9 mM, and calcium ions in the range of 0.5 to 12 mM, respectively, to produce unsaturated fatty acids and the lipid containing them, and the culture medium for culturing a microorganism having phosphate ions, potassium ions, sodium ions, magnesium ions, and calcium ions in the range of 5 to 60 mM, 5 to 60 mM, 2 to 50 mM, 0.5 to 9 mM, and 0.5 to 12 mM, respectively.
摘要翻译：用于在培养期间控制属于被孢霉属属的微生物的菌丝体形态的方法以及通过使用培养基培养不饱和脂肪酸和含有它们的脂质的方法来培养微生物的方法，其中磷酸根离子，钾离子，钠离子，培养基中的镁离子和钙离子分别为5〜60mM，5〜60mM，2〜50mM，0.5〜9mM，以及0.5〜12mM的范围，其特征在于，属于将被孢霉属属菌体培养在含有5-60mM磷酸根离子，5-60mM范围钾离子，2-50mM范围内的钠离子，0.5- 至9mM，钙离子分别为0.5-12mM，以产生不饱和脂肪酸和含有它们的脂质，以及用于培养具有磷酸根离子，钾离子，钠离子，镁离子的微生物的培养基 s和钙离子分别在5至60mM，5至60mM，2至50mM，0.5至9mM和0.5至12mM的范围内。

5. 发明授权

US08273562B2 Method for producing 4-hydroxy-L-isoleucine 有权
公开(公告)号：US08273562B2
公开(公告)日：2012-09-25
申请号：US13344110
申请日：2012-01-05
申请人： Tomohiro Kodera , Sergey Vasilievich Smirnov , Natalia Nikolaevna Samsonova , Veronika Aleksandrovna Kotliarova , Natalia Yurievna Rushkevich , Yury Ivanovich Kozlov , Vitaly Grigorievich Paraskevov, legal representative , Sakayu Shimizu , Jun Ogawa , Makoto Hibi
发明人： Tomohiro Kodera , Sergey Vasilievich Smirnov , Natalia Nikolaevna Samsonova , Veronika Aleksandrovna Kotliarova , Natalia Yurievna Rushkevich , Yury Ivanovich Kozlov , Sakayu Shimizu , Jun Ogawa , Makoto Hibi
IPC分类号： C12N9/02 , C12N15/00 , C12N1/20 , C12Q1/68 , C12P21/06 , C12P21/04 , C07H21/04
CPC分类号： C12N9/0069 , C12P13/06
摘要： A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.

6. 发明授权

US07927843B2 Method of preparing 2-deoxyribose 5-phosphate 有权
标题翻译： 2-脱氧核糖5-磷酸的制备方法
公开(公告)号：US07927843B2
公开(公告)日：2011-04-19
申请号：US11878558
申请日：2007-07-25
申请人： Sakayu Shimizu , Jun Ogawa
发明人： Sakayu Shimizu , Jun Ogawa
IPC分类号： C12P19/02
CPC分类号： C12R1/22 , C12N9/88 , C12N9/90 , C12P19/02
摘要： The present invention discloses a method of preparing 2-deoxyribose 5-phosphate by reacting glyceraldehyde 3-phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase but substantially no phosphates or the enzyme derived from the microorganism. The present invention also discloses a method of preparing 2-deoxyribose 5-phosphate by reacting dihydroxyacetone phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase and triose-phosphate isomerase but substantially no phosphates or the enzymes derived from the microorganism.
摘要翻译：本发明公开了一种在含有2-脱氧核糖-5-磷酸醛缩酶但基本上不含磷酸盐的微生物本身存在下使甘油醛-3-磷酸和乙醛反应制备2-脱氧核糖-5-磷酸的方法，微生物。本发明还公开了一种在含有2-脱氧核糖-5-磷酸醛缩酶和丙糖磷酸异构酶但基本上不含磷酸盐的微生物本身存在下使磷酸二羟丙酮和乙醛反应制备2-脱氧核糖-5-磷酸的方法，或者源于微生物的酶。

7. 发明申请

US20080261281A1 Novel Carbonyl Reductase, Gene Thereof and Method of Using the Same 有权
标题翻译：新型羰基还原酶，其基因及其使用方法
公开(公告)号：US20080261281A1
公开(公告)日：2008-10-23
申请号：US11659481
申请日：2005-08-01
申请人： Noriyuki Kizaki , Miho Yano , Masahiro Funaki , Teruaki Takesue , Yoshihiko Yasohara , Souichi Morikawa , Takahisa Nakai , Michihiko Kataoka , Sakayu Shimizu
发明人： Noriyuki Kizaki , Miho Yano , Masahiro Funaki , Teruaki Takesue , Yoshihiko Yasohara , Souichi Morikawa , Takahisa Nakai , Michihiko Kataoka , Sakayu Shimizu
IPC分类号： C12N9/14 , C12N15/52 , C12N1/21 , C12P13/02
CPC分类号： C12P13/02 , C12N9/0006 , C12P41/002
摘要： The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging to the genus Ogataea, a DNA encoding the polypeptide and a transformant that produces the polypeptide. The present invention moreover relates to a method of producing (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol utilizing the polypeptide or the transformant.Using the polypeptide or transformant of the present invention, optically active alcohols such as (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol and the like can be produced efficiently.
摘要翻译：本发明涉及具有不对称还原（3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁酮的活性以产生（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4- 从属于Ogataea的微生物分离的丁氧基羰基氨基-4-苯基-2-丁醇，编码多肽的DNA和产生多肽的转化体。本发明还涉及利用多肽或转化体制备（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁醇的方法。使用本发明的多肽或转化体，可以有效地制备光学活性醇如（2R，3S）-1-氯-3-叔丁氧基羰基氨基-4-苯基-2-丁醇等。

8. 发明申请

US20070298468A1 Method of preparing 2-deoxyribose 5-phosphate 有权
公开(公告)号：US20070298468A1
公开(公告)日：2007-12-27
申请号：US11878558
申请日：2007-07-25
申请人： Sakayu Shimizu , Jun Ogawa
发明人： Sakayu Shimizu , Jun Ogawa
IPC分类号： C12P19/02
CPC分类号： C12R1/22 , C12N9/88 , C12N9/90 , C12P19/02
摘要： The present invention discloses a method of preparing 2-deoxyribose 5-phosphate by reacting glyceraldehyde 3-phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase but substantially no phosphatase or the enzyme derived from the microorganism. The present invention also discloses a method of preparing 2-deoxyribose 5-phosphate by reacting dihydroxyacetone phosphate and acetaldehyde in the presence of either a microorganism itself which contains 2-deoxyribose-5-phosphate aldolase and triose-phosphate isomerase but substantially no phosphatase or the enzymes derived from the microorganism.

9. 发明授权

US06974685B2 High production method of prenyl alcohol using saccharomyces cells 失效
标题翻译：使用酵母细胞制备异戊醇的高生产方法
公开(公告)号：US06974685B2
公开(公告)日：2005-12-13
申请号：US10022434
申请日：2001-12-20
申请人： Masayoshi Muramatsu , Shusei Obata , Sakayu Shimizu
发明人： Masayoshi Muramatsu , Shusei Obata , Sakayu Shimizu
IPC分类号： C12N1/38 , C12P7/04 , C12R1/645 , C12P7/02
CPC分类号： C12N1/38 , C12P7/04
摘要： The present invention provides a high production method of prenyl alcohol, which comprises culturing prenyl alcohol-producing cells in a medium with an increased sugar content in the presence of at least one member selected from the group consisting of a surfactant, a fat or oil, and a terpene to produce and accumulate prenyl alcohol in the cells; allowing the accumulated prenyl alcohol to be secreted from the cells; and then collecting prenyl alcohol. The present invention enables prenyl alcohol to be highly produced in and effectively secreted from prenyl alcohol-producing cells by culturing the cells in a medium with an increased sugar content in the presence of at least one member selected from the group consisting of a surfactant, a fat or oil, and a terpene.
摘要翻译：本发明提供了高产的异戊醇的制备方法，其包括在选自表面活性剂，脂肪或油中的至少一种的存在下，在具有增加的糖含量的培养基中培养异戊醇产生细胞，和萜烯在细胞中产生和积累异戊醇; 允许从细胞中分泌积累的异戊醇; 然后收集异戊醇。本发明通过在选自表面活性剂，表面活性剂，表面活性剂的至少一种的存在下，在具有增加的糖含量的介质中培养细胞，使异戊烯醇高产生并由异戊烯醇产生细胞有效分泌脂肪或油，和萜烯。

10. 发明授权

US06972191B2 Method for production of geranylgeraniol and analogous compounds thereof by microorganisms 失效
标题翻译：通过微生物生产香叶基香叶醇及其类似物的方法
公开(公告)号：US06972191B2
公开(公告)日：2005-12-06
申请号：US10022695
申请日：2001-12-20
申请人： Masayoshi Muramatsu , Shusei Obata , Sakayu Shimizu
发明人： Masayoshi Muramatsu , Shusei Obata , Sakayu Shimizu
IPC分类号： C07C33/02 , C12P7/04 , C12R1/85 , C12P7/02
CPC分类号： C12P7/04
摘要： The present invention provides a method for producing geranylgeraniol and analogous compounds thereof, which comprises culturing yeast cells (ascomycetes and deuteromycetes), bacterial cells, actinomycete cells or filamentous fungus cells, all of which are capable of producing geranylgeraniol and analogous compounds thereof, in a medium to produce and accumulate geranylgeraniol and analogous compounds thereof in the cells and/or in the extracellular environment; and then collecting these compounds. The present invention enables inexpensive mass production of geranylgeraniol and analogous compounds thereof by using microorganisms capable of producing geranylgeraniol, farnesol and/or nerolidol useful as biosynthetic intermediates of terpenes, carotenoids and/or steroids.
摘要翻译：本发明提供了一种生产香叶基香叶醇及其类似化合物的方法，其包括培养酵母细胞（子囊菌和氘核菌素），细菌细胞，放线菌细胞或丝状真菌细胞，所有这些能够产生香叶基香叶醇及其类似物培养基以在细胞和/或细胞外环境中产生和积累香叶基香叶醇及其类似物; 然后收集这些化合物。本发明可以通过使用能够产生香叶基香叶醇，法呢醇和/或橙花叔醇作为萜烯，类胡萝卜素和/或类固醇的生物合成中间体的微生物，从而廉价地批量生产香叶基香叶醇及其类似物。

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