专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120009266A1 COMPOSITION COMPRISING OCAPERIDONE 审中-公开
标题翻译：包含OCAPERIDONE的组合物
公开(公告)号：US20120009266A1
公开(公告)日：2012-01-12
申请号：US13238577
申请日：2011-09-21
申请人： Satish KHANNA , Cesare Mondadori , Stefano Biondi , Arnold Demailly , Jean-Laurent Paparin
发明人： Satish KHANNA , Cesare Mondadori , Stefano Biondi , Arnold Demailly , Jean-Laurent Paparin
IPC分类号： A61K31/519 , A61K9/14 , A61P25/22 , A61P25/24 , A61P25/18 , A61P25/00
CPC分类号： A61K31/519 , A61K9/0004 , A61K9/2054 , A61K9/209
摘要： The present invention relates to a composition comprising ocaperidone as an active substance and an effective amount of water-soluble polymers to increase solubility of ocaperidone. The present invention further relates to a therapeutic system for ocaperidone with a compartment for the drug formulation comprising said composition, and to a process for the preparation thereof as well as to the therapeutic use of said composition as antipsychotic drug. The present invention also relates to the solubilisation of ocaperidone in an aqueous medium with the aid of water soluble swellable polymers.
摘要翻译：本发明涉及一种组合物，其包含作为活性物质的阿替哌酮和有效量的水溶性聚合物，以增加眼科医师的溶解度。本发明还涉及一种用于包含所述组合物的药物制剂的隔室的奥美酮治疗系统，以及其制备方法以及所述组合物作为抗精神病药物的治疗用途。本发明还涉及在水溶性可溶胀聚合物的帮助下，将水凝胶溶解在水性介质中。

2. 发明申请

US20080103159A1 Composition Comprising Ocaperidone 审中-公开
标题翻译：组合物包含Ocaperidone
公开(公告)号：US20080103159A1
公开(公告)日：2008-05-01
申请号：US11884296
申请日：2006-02-15
申请人： Satish Khanna , Cesare Mondadori , Stefano Biondi , Arnold Demailly , Jean-Laurent Paparin
发明人： Satish Khanna , Cesare Mondadori , Stefano Biondi , Arnold Demailly , Jean-Laurent Paparin
IPC分类号： A61K31/495 , A61P25/18
CPC分类号： A61K31/519 , A61K9/0004 , A61K9/2054 , A61K9/209
摘要： The present invention relates to a composition comprising ocaperidone as an active substance and an effective amount of water-soluble polymers to increase solubility of ocaperidone. The present invention further relates to a therapeutic system for ocaperidone with a compartment for the drug formulation comprising said composition, and to a process for the preparation thereof as well as to the therapeutic use of said composition as antipsychotic drug. The present invention also relates to the solubilisation of ocaperidone in an aqueous medium with the aid of water soluble swellable polymers.
摘要翻译：本发明涉及一种组合物，其包含作为活性物质的阿替哌酮和有效量的水溶性聚合物，以增加眼科医师的溶解度。本发明还涉及一种用于包含所述组合物的药物制剂的隔室的奥美酮治疗系统，以及其制备方法以及所述组合物作为抗精神病药物的治疗用途。本发明还涉及在水溶性可溶胀聚合物的帮助下，将水凝胶溶解在水性介质中。

3. 发明申请

US20080200479A1 Ocaperidone Salts and Pharmaceutical Compositions Containing the Same 审中-公开
标题翻译：奥卡吡胺盐及含有其的药物组合物
公开(公告)号：US20080200479A1
公开(公告)日：2008-08-21
申请号：US11816631
申请日：2006-02-24
申请人： Stefano Biondi , Arnold Demailly , Cesare Mondadori , Jean-Laurent Paparin
发明人： Stefano Biondi , Arnold Demailly , Cesare Mondadori , Jean-Laurent Paparin
IPC分类号： A61K31/5025 , C07D235/00 , A61P25/18
CPC分类号： C07D471/04
摘要： The invention relates to new salts of ocaperidone and uses thereof, particularly in the pharmaceutical industry. The invention discloses specific salts of ocaperidone having increased water solubilities, as well as therapeutic methods by administering said salts, in particular for treating various diseases of the central or peripheral nervous system, especially central nervous system. It further deals with pharmaceutical compositions comprising said salts and methods for preparing the same.
摘要翻译：本发明涉及α-磷脂酰胺的新盐及其用途，特别是在制药工业中。本发明公开了具有增加的水溶性的奥美酮特异性盐，以及通过施用所述盐，特别是用于治疗中枢或周围神经系统，特别是中枢神经系统的各种疾病的治疗方法。它还涉及包含所述盐的药物组合物及其制备方法。

4. 发明申请

US20070123519A1 Benzo-1,4-diazepin-2-one derivatives as phosphodiesterase pde2 inhibitors, preparation and therapeutic use thereof 失效
标题翻译：苯并-1,4-二氮杂-2-酮衍生物作为磷酸二酯酶pde2抑制剂，其制备和治疗用途
公开(公告)号：US20070123519A1
公开(公告)日：2007-05-31
申请号：US10582131
申请日：2004-12-23
申请人： Mustapha Abarghaz , Stefano Biondi , Jerome Duranton , Emmanuelle Limanton , Cesare Mondadori , Patrick Wagner
发明人： Mustapha Abarghaz , Stefano Biondi , Jerome Duranton , Emmanuelle Limanton , Cesare Mondadori , Patrick Wagner
IPC分类号： A61K31/5513 , C07D243/14
CPC分类号： C07D405/04 , C07D243/24
摘要： The invention relates to compounds having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in particular for treating various diseases of the central or peripheral nervous system. It further deals with pharmaceutical compositions comprising said compounds and methods for preparing said compounds.
摘要翻译：本发明涉及具有PDE2抑制活性的化合物，以及通过施用所述化合物，特别是用于治疗中枢或周围神经系统的各种疾病的治疗方法。它还涉及包含所述化合物的药物组合物和制备所述化合物的方法。

5. 发明授权

US07410963B2 Benzo-1,4-diazepin-2-one derivatives as phosphodiesterase PDE2 inhibitors, preparation and therapeutic use thereof 失效
标题翻译：苯并-1,4-二氮杂-2-酮衍生物作为磷酸二酯酶PDE2抑制剂，其制备和治疗用途
公开(公告)号：US07410963B2
公开(公告)日：2008-08-12
申请号：US10582131
申请日：2004-12-23
申请人： Mustapha Abarghaz , Stefano Biondi , Jérôme Duranton , Emmanuelle Limanton , Cesare Mondadori , Patrick Wagner
发明人： Mustapha Abarghaz , Stefano Biondi , Jérôme Duranton , Emmanuelle Limanton , Cesare Mondadori , Patrick Wagner
IPC分类号： C07D243/24 , C07D413/04 , A61K31/5513
CPC分类号： C07D405/04 , C07D243/24
摘要： The invention relates to compounds having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in particular for treating various diseases of the central or peripheral nervous system. It further deals with pharmaceutical compositions comprising said compounds and methods for preparing said compounds.
摘要翻译：本发明涉及具有PDE2抑制活性的化合物，以及通过施用所述化合物，特别是用于治疗中枢或周围神经系统的各种疾病的治疗方法。它还涉及包含所述化合物的药物组合物和制备所述化合物的方法。

6. 发明申请

US20100093697A1 Substituted Imidazopyridine Derivatives As Melanocortin-4 Receptor Antagonists 失效
标题翻译：取代的咪唑并吡啶衍生物作为黑皮质素-4受体拮抗剂
公开(公告)号：US20100093697A1
公开(公告)日：2010-04-15
申请号：US12530676
申请日：2008-03-28
申请人： Günther Metz , Holger Deppe , Ulrich Abel , Achim Feurer , Inge Ott , Sonja Nordhoff , Michael Soeberdt , Barbara Hoffmann-Enger , Philipp Weyermann , Hervé Siendt , Christian Rummey , Miroslav Terinek , Marco Henneböhle , Holger Herzner , Cesare Mondadori
发明人： Günther Metz , Holger Deppe , Ulrich Abel , Achim Feurer , Inge Ott , Sonja Nordhoff , Michael Soeberdt , Barbara Hoffmann-Enger , Philipp Weyermann , Hervé Siendt , Christian Rummey , Miroslav Terinek , Marco Henneböhle , Holger Herzner , Cesare Mondadori
IPC分类号： A61K31/551 , C07D471/04 , A61K31/437 , A61K31/497
CPC分类号： C07D471/04 , C07D519/00
摘要： The present invention relates to substituted imidazopyridine derivatives as melanocortin-4 receptor (MC-4R) modulators, in particular as melanocortin-4 receptor antagonists. The antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, amytrophic lateral sclerosis (ALS), anxiety and depression.
摘要翻译：本发明涉及作为黑皮质素-4受体（MC-4R）调节剂的取代的咪唑并吡啶衍生物，特别是黑皮质素-4受体拮抗剂。拮抗剂可用于治疗疾病和疾病，例如癌症恶病质，肌肉消瘦，厌食，肌萎缩性侧索硬化（ALS），焦虑和抑郁。

7. 发明授权

US06939879B2 Use of R (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol for the treatment of substance induced insomnia 有权
标题翻译：使用R（+） - α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇处理物质诱导失眠
公开(公告)号：US06939879B2
公开(公告)日：2005-09-06
申请号：US10609751
申请日：2003-06-30
申请人： Cesare Mondadori , Stephen M. Sorensen , Janice M. Hitchcock
发明人： Cesare Mondadori , Stephen M. Sorensen , Janice M. Hitchcock
IPC分类号： A61K31/445
CPC分类号： A61K31/445
摘要： A method of providing symptomatic relief from sleep induced insomnia in a patient comprising administering an effective amount of R-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol or a pharmaceutically acceptable salt thereof to a patient in need of such treatment.
摘要翻译：一种从睡眠中提供症状缓解诱发的失眠症的方法，包括给予有效量的R - （+） - α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4- 哌啶甲醇或其药学上可接受的盐给需要这种治疗的患者。

8. 发明授权

US06613779B2 Use of R(+) -&agr;-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piper idinemethanol for the treatment of sleep disorders 有权
标题翻译： R（+）-α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇用于治疗睡眠障碍
公开(公告)号：US06613779B2
公开(公告)日：2003-09-02
申请号：US09886424
申请日：2001-06-21
申请人： Cesare Mondadori , Stephen Sorensen , Janice M. Hitchcock
发明人： Cesare Mondadori , Stephen Sorensen , Janice M. Hitchcock
IPC分类号： A61K31445
CPC分类号： A61K31/445 , Y10S514/923
摘要： A method of treating a patient for a Sleep Disorder comprising administering an effective amount of R-(+)-&agr;-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol or a pharmaceutically acceptable salt thereof to a patient in need of such treatment.
摘要翻译：一种治疗患者睡眠障碍的方法，包括给予有效量的R - （+） - α-（2,3-二甲氧基苯基）-1- [2-（4-氟苯基）乙基] -4-哌啶甲醇或其药学上可接受的盐给需要这种治疗的患者。

9. 发明申请

US20060128695A1 Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses 审中-公开
标题翻译：环核苷酸磷酸二酯酶抑制剂，制备及用途
公开(公告)号：US20060128695A1
公开(公告)日：2006-06-15
申请号：US10533157
申请日：2003-10-30
申请人： Jean-Jacques Bourguignon , Claire Lugnier , Mustapha Abarghaz , Yan Lagouge , Patrick Wagner , Cesare Mondadori , Jean-Paul Macher , Dominique Schultz , Pierre Raboisson
发明人： Jean-Jacques Bourguignon , Claire Lugnier , Mustapha Abarghaz , Yan Lagouge , Patrick Wagner , Cesare Mondadori , Jean-Paul Macher , Dominique Schultz , Pierre Raboisson
IPC分类号： A61K31/5513 , C07D403/02 , C07D243/12
CPC分类号： C07D401/04 , A61K31/5513 , A61K31/5517 , C07D243/20 , C07D243/22 , C07D243/24 , C07D405/04 , C07D417/10 , C07D487/04
摘要： The invention concerns the use of PDE2 inhibitors for treating disorders of the central and peripheral nervous system, a method for therapeutic treatment by administering to an animal said inhibitors. More specifically, the invention concerns novel benzodiazepinone derivatives and their uses in therapeutics more particularly for treating pathologies involving activity of a cyclic nucleotide phosphodiesterase type 2. The invention also concerns methods for preparing same and novel synthesis intermediates.
摘要翻译：本发明涉及PDE2抑制剂用于治疗中枢和周围神经系统疾病的方法，一种通过向动物施用所述抑制剂进行治疗性治疗的方法。更具体地，本发明涉及新的苯并二氮杂酮衍生物及其在治疗学中的用途，更具体地涉及治疗涉及2型环核苷酸磷酸二酯酶活性的病理学。本发明还涉及制备其和合成中间体的方法。

10. 发明授权

US4431641A Pharmaceutical compositions having antiepileptic and antineuralgic action 失效
标题翻译：具有抗癫痫和抗神经功能作用的药物组合物
公开(公告)号：US4431641A
公开(公告)日：1984-02-14
申请号：US310197
申请日：1981-10-09
申请人： Cesare Mondadori , Markus Schmutz
发明人： Cesare Mondadori , Markus Schmutz
IPC分类号： A61K31/55 , A61P25/04 , A61P25/08 , A61K31/33 , A61K31/40 , A61K31/44 , A61K31/475
CPC分类号： A61K31/55
摘要： The present invention relates to novel pharmaceutical compositions having antiepileptic and antineuraglic action and containing (a) at least one anticonvulsive compound of the general formula I ##STR1## wherein X.sub.1 is hydrogen, halogen having an atomic number up to 35, or is cyano, and X.sub.2 and Y together are an additional bond, or X.sub.1 and X.sub.2 together are the oxo radical, or X.sub.1 is hydroxy, X.sub.2 is hydrogen and Y is also hydrogen, and (b) at least one nootropic compound of the vincamine type which has the general formula II ##STR2## wherein Z.sub.1 is lower alkoxycarbonyl, Z.sub.2 is hydroxy and Z.sub.3 is hydrogen, or Z.sub.2 and Z.sub.3 together are an additional bond, or one of Z.sub.1 and Z.sub.2 is hydroxy and the other is hydrogen and Z.sub.3 is also hydrogen, in particular vincamine (DCI rec.), in which Z.sub.1 is methoxycarbonyl, Z.sub.2 is hydroxy and Z.sub.3 is hydrogen, and also e.g., vinpocetin (DCI rec.), in which Z.sub.1 is ethoxycarbonyl and Z.sub.2 and Z.sub.3 together form an additional bond, as well as vincanol (DCI prop.), in which one of Z.sub.1 and Z.sub.2 is hydroxy and the other is hydrogen and Z.sub.3 is hydrogen, and the acid addition salts thereof, or at least one nootropic derivative of 2-pyrrolidinone, e.g. 2-oxo-1-pyrrolidineaetamide (piracetam) or one of its nootropic derivatives. The compounds of the general formula II e.g. vincamine, as well as the nootropic derivatives of 2-pyrrolidinone, e.g. piracetam, have in themselves virtually no anticonvulsive activity but potentiate the action of the compounds of the general formula I, e.g. carbamazepine.
摘要翻译：本发明涉及具有抗癫痫和抗神经功能作用的新型药物组合物，并且含有（a）至少一种通式I的抗惊厥药物（I），其中X 1是氢，原子序数高达35的卤素或是氰基，X2和Y一起是另外的键，或者X 1和X 2一起是氧代基，或者X 1是羟基，X 2是氢，Y也是氢，和（b）至少一种长春胺类的特配化合物，具有通式II其中Z 1为低级烷氧基羰基，Z 2为羟基，Z 3为氢，Z 2和Z 3为一个附加键，或者Z 1和Z 2中的一个为羟基，另一个为氢和Z 3 也是氢，特别是长春胺（DCI rec。），其中Z1是甲氧基羰基，Z2是羟基，Z3是氢，以及例如长春西林（DCI rec。），其中Z1是乙氧基羰基，Z2和Z3一起形成额外的粘合剂，以及长春辛醇（DCI prop。），其中一种的Z 1和Z 2是羟基，另一个是氢，Z 3是氢，及其酸加成盐，或2-吡咯烷酮的至少一种向异性衍生物。 2-吡咯烷酮（吡拉西坦）或其引诱性衍生物之一。通式II的化合物例如长春胺，以及2-吡咯烷酮的引诱衍生物，例如。吡拉西坦本身几乎没有抗惊厥活性，但增强了通式I化合物的作用，例如，卡马西平。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式