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1. 发明申请

US20100144652A1 COMPOSITION COMPRISING A GLYCOLYTIC INHIBITOR AND A RING SYSTEM COMPRISING A SULPHAMATE GROUP FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：包含糖尿病抑制剂和包含用于治疗癌症的磺酰胺类的环系统的组合物
公开(公告)号：US20100144652A1
公开(公告)日：2010-06-10
申请号：US12526398
申请日：2008-02-07
申请人： Sarah Louise Claire Tagg , Paul Alexander Foster , Simon Paul Newman , John Michael Reed , Atul Purohit , Barry Victor Lloyd Potter
发明人： Sarah Louise Claire Tagg , Paul Alexander Foster , Simon Paul Newman , John Michael Reed , Atul Purohit , Barry Victor Lloyd Potter
IPC分类号： A61K31/7004 , A61K31/70 , A61P35/00
CPC分类号： A61K31/33 , A61K31/565 , A61K31/7004 , A61K45/06 , A61K2300/00
摘要： The present invention provides a composition comprising (a) a glycolytic inhibitor (b) a compound comprising a ring system substituted with at least one of a suiphamate group and an alkoxy group; wherein (a) and (b) are different.
摘要翻译：本发明提供一种组合物，其包含（a）糖酵解抑制剂（b）包含被至少一个磺酸酯基和烷氧基取代的环系的化合物; 其中（a）和（b）不同。

2. 发明申请

US20100105764A1 USE 审中-公开
标题翻译：使用
公开(公告)号：US20100105764A1
公开(公告)日：2010-04-29
申请号：US12475910
申请日：2009-06-01
申请人： Michael John Reed , Atul Purohit , Paul Alexander Foster , Simon Paul Newman , Lok Wai Lawrence Woo , Barry Victor Lloyd Potter , Gillian Reed
发明人： Michael John Reed , Atul Purohit , Paul Alexander Foster , Simon Paul Newman , Lok Wai Lawrence Woo , Barry Victor Lloyd Potter , Gillian Reed
IPC分类号： A61K31/366 , A61P35/00
CPC分类号： A61K31/37
摘要： There is provided a method for the manufacture of a medicament for the treatment of cancer comprising a compound capable of inhibiting a steroid sulphatase enzyme (E.C.3.1.6.2), wherein the cancer is of a type, in which the cancer cells overexpress aromatase enzyme.
摘要翻译：提供了一种制备用于治疗癌症的药物的方法，其包括能够抑制类固醇硫酸酯酶的化合物（E.C.3.1.6.2），其中所述癌症是癌细胞过度表达芳香酶的类型。

3. 发明授权

US07893284B2 Oestrogen derivatives as inhibitors of steroid sulphatase 失效
标题翻译：雌激素衍生物作为类固醇硫酸酯酶的抑制剂
公开(公告)号：US07893284B2
公开(公告)日：2011-02-22
申请号：US11233945
申请日：2005-09-23
申请人： Matthew Leese , Atul Purohit , Michael John Reed , Simon Paul Newman , Surinder Kuman Chander , Fabrice Jourdan , Barry Victor Lloyd Potter
发明人： Matthew Leese , Atul Purohit , Michael John Reed , Simon Paul Newman , Surinder Kuman Chander , Fabrice Jourdan , Barry Victor Lloyd Potter
IPC分类号： C07J3/00 , C07J1/00
CPC分类号： C07J43/00 , C07J41/00
摘要： The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of —OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula -L-R3, wherein L is an optional linker group and R3 is selected from groups which are or which comprise one of a nitrite group, an alcohol, an ester, an ether, an amine and an alkene, provided that when R3 is or comprises an alcohol, L is present; and wherein the A ring of the steroidal ring system is substituted at position 2 or 4 with a group R4, wherein R4 is a hydrocarbyl group.
摘要翻译：本发明提供了包含甾族环系统和选自-OH，氨基磺酸盐基团，膦酸盐基团，硫代膦酸盐基团，磺酸盐基团或磺酰胺基团中的任何一个的任选基团R1的化合物; 其中甾族环体系的D环被式-L-R3的基团R 2取代，其中L是任选的连接基团，并且R 3选自亚硝酸根基团，醇，酯，醚，胺和烯烃，条件是当R3是或包含醇时，存在L; 并且其中所述甾族环系统的A环在位置2或4与基团R 4取代，其中R 4是烃基。

4. 发明授权

US08030296B2 Oestrogen-17-sulphamates as inhibitors of steroid sulphatase 有权
标题翻译：雌激素-17-磺酰胺酸盐作为类固醇硫酸酯酶的抑制剂
公开(公告)号：US08030296B2
公开(公告)日：2011-10-04
申请号：US11368367
申请日：2006-03-03
申请人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Hatem Hejaz , Bertrand Leblond , Matthew Paul Leese , Atul Purohit
发明人： Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Hatem Hejaz , Bertrand Leblond , Matthew Paul Leese , Atul Purohit
IPC分类号： A61K31/56 , C07J1/00
CPC分类号： A61K31/565 , A61K31/37
摘要： There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R1 and R2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth. There is also provided a compound of Formula VIII wherein R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
摘要翻译：提供式I的化合物，其中X是环系; R1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; R2是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; 其中当X是甾体结构且R 1和R 2均为氨基磺酸酯基团时，甾体环体系（X）代表雌激素; 并且其中所述化合物能够抑制类固醇硫酸酯酶（STS）活性和/或能够充当细胞循环的调节剂和/或作为凋亡调节剂和/或细胞生长调节剂。还提供了式VIII的化合物，其中R 2是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; 并且其中所述化合物能够抑制类固醇硫酸酯酶（STS）活性和/或能够充当细胞循环的调节剂和/或作为凋亡调节剂和/或细胞生长调节剂。

5. 发明申请

US20090023710A1 Compound 有权
公开(公告)号：US20090023710A1
公开(公告)日：2009-01-22
申请号：US11968436
申请日：2008-01-02
申请人： Nigel Vicker , Joanna Mary Day , Helen Victoria Bailey , Wesley Heaton , Ana Maria Ramos Gonzalez , Christopher Mark Sharland , Michael John Reed , Atul Purohit , Barry Victor Lloyd Potter
发明人： Nigel Vicker , Joanna Mary Day , Helen Victoria Bailey , Wesley Heaton , Ana Maria Ramos Gonzalez , Christopher Mark Sharland , Michael John Reed , Atul Purohit , Barry Victor Lloyd Potter
IPC分类号： A61K31/55 , C07D211/58 , C07C233/22 , A61P35/00 , C07D223/12 , A61K31/167
CPC分类号： C07C237/22 , C07C233/36 , C07D209/20 , C07D211/56 , C07D211/58 , C07D211/62 , C07D211/96 , C07D215/38 , C07D215/44 , C07D223/12 , C07D223/16 , C07D239/42 , C07D401/12 , C07D401/14 , C07D405/06 , C07D409/06 , C07D409/12 , C07D451/04
摘要： There is provided a compound having Formula (I) wherein each of R1, R2, R3, R4, R5, R6 and R7 are independently selected from (a) H, (b) R17, —OC(R17)3, —OCH(R17)2, —OCH2R17, —C(R17)3, —CH(R17)2, or —CH2R17 wherein R17 is a halogen; (c) —CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl; (h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl; (j) hydroxy; (k) alkoxy; (l) aryloxy; (m) —SO2-alkyl; and (n) —N(R11)C(O)R13; wherein the optional substituents of (d) (e) (f) (h) and (i) are selected from the group consisting of: C1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl and heteroaryl; each of rings A and B are selected from five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring; X is an optional group selected from O, S, S═O, S(═O)2, C═O, S(═O)2NR8, C═ONR9, NR10, wherein R8, R9 and R10 are independently selected from H and hydrocarbyl, wherein n and p are independently selected from 0 and 1; Y is (R11)1-3 wherein each R11 is independently selected from NR12, CR13R14, S(═O)2 and C═O, wherein R12, R13 and R14 are independently selected from Hand hydrocarbyl; Z is selected from (i) six or seven membered ring containing carbon and at least one nitrogen, which may be optionally substituted wherein the substituents may together form further ring fused thereto; and (ii) a —R15—NR16— group wherein R15 is an optionally substituted C1-6 alkyl chain and R16 is selected from H and hydrocarbyl; and R3 is selected from Formula (A).

6. 发明授权

US07361677B2 Polycyclic sulphamate compounds suitable for use as inhibitors of aromatase and/or sulphatase 失效
标题翻译：适用于芳香酶和/或硫酸酯酶抑制剂的多环氨基磺酸盐化合物
公开(公告)号：US07361677B2
公开(公告)日：2008-04-22
申请号：US11209186
申请日：2005-08-22
申请人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
发明人： Barry Victor Lloyd Potter , Lok Wai Lawrence Woo , Atul Purohit , Michael John Reed , Oliver Brook Sutcliffe , Christian Bubert
IPC分类号： A61K31/4196 , C07D249/08
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D413/12 , C07D417/12
摘要： There is provided a compound of Formula I wherein each T is independently selected from H, hydrocarbyl, —F—R, and a bond with one of D, E, P or Q, or together with one of P and Q forms a ring; Z is a suitable atom the valency of which is m; D, E and F are each independently of each other an optional linker group, wherein when Z is nitrogen E is other than CH2 and C═O; P, Q and R are independently of each other a ring system; and at least Q comprises a sulphamate group.
摘要翻译：提供式I的化合物，其中每个T独立地选自H，烃基，-F-R和与D，E，P或Q之一的键，或与P和Q中的一个形成环; Z是一个合适的原子，其化合价是m; D，E和F各自独立地为任选的连接基团，其中当Z为氮时，E不是CH 2和C-O; P，Q和R彼此独立地是环系; 并且至少Q包含氨基磺酸酯基团。

7. 发明授权

US07309715B2 Compound 失效
标题翻译：复合
公开(公告)号：US07309715B2
公开(公告)日：2007-12-18
申请号：US10690708
申请日：2003-10-23
申请人： Nigel Vicker , Su Xiangdong , Dharshini Ganeshapillai , Atul Purohit , Michael John Reed , Barry Victor Lloyd Potter
发明人： Nigel Vicker , Su Xiangdong , Dharshini Ganeshapillai , Atul Purohit , Michael John Reed , Barry Victor Lloyd Potter
IPC分类号： A61K31/428 , C07D277/62
CPC分类号： C07D277/64 , C07D209/08 , C07D235/08 , C07D263/56 , C07D277/14 , C07D417/12
摘要： A compound having Formula I wherein one of R1 and R2 is a group of the formula wherein R4 is selected from H and hydrocarbyl, R5 is a hydrocarbyl group and L is an optional linker group, or R1 and R2 together form a ring substituted with the group wherein R3 is H or a substituent, and wherein X is selected from S, O, NR6 and C(R7)(R8), wherein R6 is selected from H and hydrocarbyl groups, wherein each of R7 and R8 are independently selected from H and hydrocarbyl groups.
摘要翻译：具有式I的化合物，其中R 1和R 2中的一个是下式的基团其中R 4选自H和烃基， R 5是烃基，L是任选的连接基团，或者R 1和R 2一起形成被下列基团取代的环，其中， R 3是H或取代基，其中X选自S，O，NR 6和C（R 7）（R 7）其中R 6选自H和烃基，其中R 7和R 8中的每一个是独立地选自H和烃基。

8. 发明授权

US07119081B2 Oestrogen-17-sulphamates as inhibitors of steroid sulphatase 有权
标题翻译：雌激素-17-磺酰胺酸盐作为类固醇硫酸酯酶的抑制剂
公开(公告)号：US07119081B2
公开(公告)日：2006-10-10
申请号：US10367114
申请日：2003-02-14
申请人： Barry Victor Lloyd Potter , Michael John Reed , Bertrand Leblond , Matthew Paul Leese , Atul Purohit
发明人： Barry Victor Lloyd Potter , Michael John Reed , Bertrand Leblond , Matthew Paul Leese , Atul Purohit
IPC分类号： A01N1/00 , A61K31/56 , C07J1/00
CPC分类号： A61K31/565 , A61K31/37
摘要： There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R1 and R2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth. There is also provided a compound of Formula VIII wherein R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
摘要翻译：提供式I的化合物，其中X是环系; R 1是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; R 2是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个; 其中当X是甾体结构且R 1和R 2两者都是氨基磺酸酯基团时，甾体环体系（X）代表雌激素; 并且其中所述化合物能够抑制类固醇硫酸酯酶（STS）活性和/或能够充当细胞循环的调节剂和/或作为凋亡调节剂和/或细胞生长调节剂。还提供式VIII的化合物，其中R 2是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任一个; 并且其中所述化合物能够抑制类固醇硫酸酯酶（STS）活性和/或能够充当细胞循环的调节剂和/或作为凋亡调节剂和/或细胞生长调节剂。

9. 发明授权

US06858597B2 Halogenated sulphamate-, phosphonate-, thiophosphonate-, sulphonate- and sulphonamide- compounds as inhibitors of steroid sulphatase 失效
标题翻译：卤化的氨基磺酸盐，膦酸盐，硫代膦酸盐，磺酸盐和磺酰胺化合物作为类固醇硫酸酯酶的抑制剂
公开(公告)号：US06858597B2
公开(公告)日：2005-02-22
申请号：US10165599
申请日：2002-06-07
申请人： Michael John Reed , Barry Victor Lloyd Potter , Hatem Hejaz , Atul Purohit
发明人： Michael John Reed , Barry Victor Lloyd Potter , Hatem Hejaz , Atul Purohit
IPC分类号： A61K31/566 , A61P1/02 , A61P1/04 , A61P1/14 , A61P3/10 , A61P5/44 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/02 , A61P11/06 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/00 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07J41/00 , C12Q1/34 , A61K31/56 , C07J1/00
CPC分类号： C12Q1/34 , C07J41/00
摘要： A compound is described. The compound has the formula (Ia) as presented in the FIG. 1; wherein: X is a ring having at least 4 atoms in the ring; K is hydrocarbyl group; Rh1 is an optional halo group; Rh2 is an optional halo group; at least one of Rh1 and Rh2 is present; Rs is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group. The compound is capable of inhibiting steroid sulphatase (STS) activity.
摘要翻译：描述化合物。化合物具有如图1所示的式（Ia）。 1; 其中：X是环中具有至少4个原子的环; K为烃基; Rh1是可选的卤素基团; Rh2是可选的卤素基团; 存在Rh1和Rh2中的至少一种; Rs是氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺基中的任何一个。该化合物能够抑制类固醇硫酸酶（STS）活性。

10. 发明授权

US08394825B2 Compound 失效
标题翻译：复合
公开(公告)号：US08394825B2
公开(公告)日：2013-03-12
申请号：US12593560
申请日：2008-03-27
申请人： Matthew Leese , Fabrice Jourdan , Meriel Kimberley , Atul Purohit , Barry Victor Lloyd Potter , Gillian Reed
发明人： Matthew Leese , Fabrice Jourdan , Meriel Kimberley , Atul Purohit , Michael John Reed , Barry Victor Lloyd Potter
IPC分类号： A61K31/47 , A61K31/472 , C07D217/00
CPC分类号： A61K31/40 , A61K31/403 , A61K31/435 , A61K31/47 , A61K31/55
摘要： The present invention involves tetrahydroisoquinoline compounds and their use in the inhibition and/or prevention of tumor growth.
摘要翻译：本发明涉及四氢异喹啉化合物及其在抑制和/或预防肿瘤生长中的用途。

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