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1. 发明授权

US09145583B2 Multi-spot metal-capped nanostructure array nucleic acid chip for diagnosis of corneal dystrophy and preparation method thereof 有权
标题翻译：用于诊断角膜营养不良的多点金属封端纳米结构阵列核酸芯片及其制备方法
公开(公告)号：US09145583B2
公开(公告)日：2015-09-29
申请号：US13391167
申请日：2010-08-18
申请人： Sang Yup Lee , So Young Yoo , Do Kyun Kim , Tae Jung Park , Jung Kuk Yun , Gene Lee
发明人： Sang Yup Lee , So Young Yoo , Do Kyun Kim , Tae Jung Park , Jung Kuk Yun , Gene Lee
IPC分类号： C12Q1/68 , C12M1/36 , B82Y30/00
CPC分类号： C12Q1/6837 , B01J2219/00509 , B01J2219/00608 , B01J2219/00612 , B01J2219/00614 , B01J2219/00621 , B01J2219/00637 , B01J2219/00648 , B01J2219/00722 , B82Y30/00 , C12Q1/6883 , C12Q2600/158
摘要： A multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing corneal dystrophy, and more particularly to a multi-spot metal-capped nanostructure array nucleic acid chip capable of employing LSPR (localized surface plasmon resonance) optical properties, a preparation method thereof, and a multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing BIGH3 gene mutations, which can diagnose various corneal dystrophies. The metal-capped nanostructure array nucleic acid chip can be combined with analysis devices, including a light source, a detector, a spectrophotometer and a computer, to provide an LSPR optical property-based optical biosensor, and the use of the multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing BIGH3 gene mutations allows the simultaneous diagnosis of various corneal dystrophies that are genetic ocular diseases.
摘要翻译：一种用于诊断角膜营养不良的多点金属帽纳米结构阵列核酸芯片，更具体地涉及能够使用LSPR（局部表面等离子共振）光学性质的多点金属封端的纳米结构阵列核酸芯片，其制备方法，以及用于诊断BIGH3基因突变的多点金属帽纳米结构阵列核酸芯片，其可以诊断各种角膜营养不良。金属封端的纳米结构阵列核酸芯片可以与包括光源，检测器，分光光度计和计算机的分析装置组合，以提供基于LSPR光学性质的光学生物传感器，并且使用多点金属用于诊断BIGH3基因突变的封闭的纳米结构阵列核酸芯片允许同时诊断作为遗传性眼部疾病的各种角膜营养不良。

2. 发明申请

US20140243222A1 MULTI-SPOT METAL-CAPPED NANOSTRUCTURE ARRAY NUCLEIC ACID CHIP FOR DIAGNOSING OF CORNEAL DYSTROPHY AND PREPARATION METHOD THEREOF PRODUCING SAME 有权
标题翻译：多点金属填充纳米结构阵列核苷酸芯片，用于诊断角膜晶状体及其制备方法
公开(公告)号：US20140243222A1
公开(公告)日：2014-08-28
申请号：US13391167
申请日：2010-08-18
申请人： Sang Yup Lee , So Young Yoo , Do Kyun Kim , Tae Jung Park , Jung Kuk Yun , Gene Lee
发明人： Sang Yup Lee , So Young Yoo , Do Kyun Kim , Tae Jung Park , Jung Kuk Yun , Gene Lee
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , B01J2219/00509 , B01J2219/00608 , B01J2219/00612 , B01J2219/00614 , B01J2219/00621 , B01J2219/00637 , B01J2219/00648 , B01J2219/00722 , B82Y30/00 , C12Q1/6883 , C12Q2600/158
摘要： A multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing corneal dystrophy, and more particularly to a multi-spot metal-capped nanostructure array nucleic acid chip capable of employing LSPR (localized surface plasmon resonance) optical properties, a preparation method thereof, and a multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing BIGH3 gene mutations, which can diagnose various corneal dystrophies. The metal-capped nanostructure array nucleic acid chip can be combined with analysis devices, including a light source, a detector, a spectrophotometer and a computer, to provide an LSPR optical property-based optical biosensor, and the use of the multi-spot metal-capped nanostructure array nucleic acid chip for diagnosing BIGH3 gene mutations allows the simultaneous diagnosis of various corneal dystrophies that are genetic ocular diseases.
摘要翻译：一种用于诊断角膜营养不良的多点金属帽纳米结构阵列核酸芯片，更具体地涉及能够使用LSPR（局部表面等离子共振）光学性质的多点金属封端的纳米结构阵列核酸芯片，其制备方法，以及用于诊断BIGH3基因突变的多点金属帽纳米结构阵列核酸芯片，其可以诊断各种角膜营养不良。金属封端的纳米结构阵列核酸芯片可以与包括光源，检测器，分光光度计和计算机的分析装置组合，以提供基于LSPR光学性质的光学生物传感器，并且使用多点金属用于诊断BIGH3基因突变的封闭的纳米结构阵列核酸芯片允许同时诊断作为遗传性眼部疾病的各种角膜营养不良。

3. 发明授权

US09970051B2 System for diagnosing Avellino corneal dystrophy 有权
公开(公告)号：US09970051B2
公开(公告)日：2018-05-15
申请号：US13876603
申请日：2011-09-30
申请人： Gene Lee , Jung Kuk Yun
发明人： Gene Lee , Jung Kuk Yun
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a system for diagnosing Avellino corneal dystrophy, and more particularly to a system for diagnosing Avellino corneal dystrophy, in which whether a sample is normal or Avellino corneal dystrophy is determined based on the ratio of the input first PCR amplification value and the second PCR amplification value. The system makes it possible to diagnosis Avellino corneal dystrophy in a simpler and accurate manner without being influenced by the doctor's skill. Particularly, the inventive system makes the overall process systematic, and thus provides accurate diagnosis. In addition, the system can also easily administer a number of test subjects.

4. 发明申请

US20120077200A1 PRIMERS FOR DIAGNOSING AVELLINO CORNEAL DYSTROPHY 审中-公开
标题翻译：用于诊断AVELLINO CORNEAL DYSTROPHY的准则
公开(公告)号：US20120077200A1
公开(公告)日：2012-03-29
申请号：US13264784
申请日：2009-12-01
申请人： Gene Lee , Jung Kuk Yun
发明人： Gene Lee , Jung Kuk Yun
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6883 , C12Q1/686 , C12Q2600/112 , C12Q2600/156 , C12Q2561/113
摘要： The present invention relates to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, and more particularly to a real-time PCR primer pair and probe for diagnosing Avellino corneal dystrophy, which can accurately diagnose the presence or absence of a mutation in exon 4 of BIGH3 gene, which is responsible for Avellino corneal dystrophy. The use of the primer pair and probe according to the invention can diagnose Avellino corneal dystrophy in a more rapid and accurate manner than a conventional method that uses a DNA chip or PCR.
摘要翻译：本发明涉及用于诊断Avellino角膜营养不良的实时PCR引物对和探针，更具体地涉及用于诊断Avellino角膜营养不良的实时PCR引物对和探针，其可以准确地诊断突变的存在或不存在在BIGH3基因的外显子4中，其负责Avellino角膜营养不良症。根据本发明的引物对和探针的使用可以比使用DNA芯片或PCR的常规方法更快速和准确地诊断Avellino角膜营养不良症。

5. 发明申请

US20130302811A1 SYSTEM FOR DIAGNOSING AVELLINO CORNEAL DYSTROPHY 有权
标题翻译：用于诊断AVELLINO CORNEAL DYSTROPHY的系统
公开(公告)号：US20130302811A1
公开(公告)日：2013-11-14
申请号：US13876603
申请日：2011-09-30
申请人： Gene Lee , Jung Kuk Yun
发明人： Gene Lee , Jung Kuk Yun
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6883 , C12Q2600/156
摘要： The present invention relates to a system for diagnosing Avellino corneal dystrophy, and more particularly to a system for diagnosing Avellino corneal dystrophy, in which whether a sample is normal or Avellino corneal dystrophy is determined based on the ratio of the input first PCR amplification value and the second PCR amplification value. The system makes it possible to diagnosis Avellino corneal dystrophy in a simpler and accurate manner without being influenced by the doctor's skill. Particularly, the inventive system makes the overall process systematic, and thus provides accurate diagnosis. In addition, the system can also easily administer a number of test subjects.
摘要翻译：本发明涉及Avellino角膜营养不良症诊断系统，更具体地说，涉及一种诊断Avellino角膜营养不良的系统，其中判定样本是正常还是Avellino角膜营养不良是基于输入的第一PCR扩增值和第二个PCR扩增值。该系统可以以更简单准确的方式诊断Avellino角膜营养不良，而不受医生的技能影响。特别地，本发明的系统使整个过程系统化，从而提供准确的诊断。此外，系统还可以轻松管理多个测试对象。

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