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1. 发明申请

US20080050719A1 Gene expression profiles in liver disease 审中-公开
标题翻译：肝脏疾病中的基因表达谱
公开(公告)号：US20080050719A1
公开(公告)日：2008-02-28
申请号：US10499695
申请日：2002-12-20
申请人： Sang Seok Koh , Qing Liu , Hyun-Ho Chung , Weu Zeng , Bogman Lee , Subrahmanyam Yeramilli , Si Young Song
发明人： Sang Seok Koh , Qing Liu , Hyun-Ho Chung , Weu Zeng , Bogman Lee , Subrahmanyam Yeramilli , Si Young Song
IPC分类号： C12Q1/68 , G01N33/574 , A61K38/17 , A61K48/00 , G06F19/00 , C12M1/34
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , Y02A90/26
摘要： The present invention results from the examination of tissue from hepatic carcinomas to identify genes differentially expressed between cancerous liver tissue and diseased but non-cancerous liver tissue. The invention includes diagnostic, screening, drug design and therapeutic methods using these genes, as well as solid supports comprising oligonucleotide arrays that are complementary to or hybridize to the differentially expressed genes.
摘要翻译：本发明是通过检查来自肝癌的组织来鉴定癌肝组织与患病非癌肝组织之间差异表达的基因。本发明包括使用这些基因的诊断，筛选，药物设计和治疗方法，以及包含与差异表达基因互补或杂交的寡核苷酸阵列的固体支持物。

2. 发明授权

US09164105B2 Pancreatic cancer biomarker using the characteristics of pancreatic cancer stem cells, and use thereof 有权
标题翻译：使用胰腺癌干细胞特征的胰腺癌生物标志物及其用途
公开(公告)号：US09164105B2
公开(公告)日：2015-10-20
申请号：US13979615
申请日：2012-01-13
申请人： Si Young Song , Soo Been Park , Sun A Kim
发明人： Si Young Song , Soo Been Park , Sun A Kim
IPC分类号： A61K38/00 , G01N33/68 , G01N33/574 , C12Q1/68 , C12N15/113
CPC分类号： G01N33/6893 , C12N15/113 , C12N2310/14 , C12N2310/531 , C12Q1/6881 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/57438
摘要： The present invention relates to a novel molecular marker for pancreatic cancer stem cells and pancreatic cancer, to a marker detection method, and to a screening method. The present invention is a marker discovered from the cell lines of pancreatic cancer, wherein the marker may detect pancreatic cancer, in particular early pancreatic cancer, through the detection of a pancreatic cancer stem cell marker. In addition, the marker of the present invention may enable an accurate diagnosis and prognosis analysis of pancreatic cancer.
摘要翻译：本发明涉及胰腺癌干细胞和胰腺癌的新型分子标记，标记检测方法和筛选方法。本发明是从胰腺癌细胞系发现的标志物，其中该标志物可通过检测胰腺癌干细胞标记物来检测胰腺癌，特别是早期胰腺癌。此外，本发明的标记物可以实现对胰腺癌的准确诊断和预后分析。

3. 发明申请

US20140039033A1 NOVEL PANCREATIC CANCER BIOMARKER USING THE CHARACTERISTICS OF PANCREATIC CANCER STEM CELLS, AND USE THEREOF 有权
标题翻译：使用胰腺癌干细胞特征的新型胰腺癌生物标志物及其用途
公开(公告)号：US20140039033A1
公开(公告)日：2014-02-06
申请号：US13979615
申请日：2012-01-13
申请人： Si Young Song , Soo Been Park , Sun A. Kim
发明人： Si Young Song , Soo Been Park , Sun A. Kim
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C12N15/113 , C12N2310/14 , C12N2310/531 , C12Q1/6881 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/57438
摘要： The present invention relates to a novel molecular marker for pancreatic cancer stem cells and pancreatic cancer, to a marker detection method, and to a screening method. The present invention is a marker discovered from the cell lines of pancreatic cancer, wherein the marker may detect pancreatic cancer, in particular early pancreatic cancer, through the detection of a pancreatic cancer stem cell marker. In addition, the marker of the present invention may enable an accurate diagnosis and prognosis analysis of pancreatic cancer.
摘要翻译：本发明涉及胰腺癌干细胞和胰腺癌的新型分子标记，标记检测方法和筛选方法。本发明是从胰腺癌细胞系中发现的标志物，其中该标志物可通过检测胰腺癌干细胞标记物来检测胰腺癌，特别是早期胰腺癌。此外，本发明的标记物可以实现对胰腺癌的准确诊断和预后分析。

4. 发明授权

US10023915B2 Method for screening for a cancer treatment agent using the interaction between PAUF and a binding partner thereof 有权
公开(公告)号：US10023915B2
公开(公告)日：2018-07-17
申请号：US14008537
申请日：2011-08-02
申请人： Si Young Song , Sun A Kim , Soo Bin Park
发明人： Si Young Song , Sun A Kim , Soo Bin Park
IPC分类号： C12Q1/68 , G01N33/15 , C12Q1/6886 , G01N33/574 , G01N33/68
摘要： The present invention relates to a method for screening for a cancer treatment agent by contacting a test material with pancreatic adenocarcinoma upregulated factor (PAUF) and GLRX3, SNAPIN, or UBL4A, as a binding partner for PAUF, and then analyzing whether or not the test material inhibits the binding of the PAUF and GLRX3, SNAPIN, or UBL4A serving as a binding partner therefor, thereby determining that the test material is a cancer treatment agent if the binding is inhibited. The invention also relates to a pharmaceutical composition containing the test material as an active ingredient for inhibiting and treating cancer. The pharmaceutical composition of the present invention, which contains, as an active ingredient, an inhibitor for inhibiting PAUF from binding with a binding partner, effectively inhibits PAUF signaling related to the onset of cancer, thus enabling various kinds of cancer (especially pancreatic cancer) to be treated.

5. 发明申请

US20140018304A1 METHOD FOR SCREENING FOR A CANCER TREATMENT AGENT USING THE INTERACTION BETWEEN PAUF AND A BINDING PARTNER THEREOF 有权
标题翻译：用于使用PAUF与其结合合作伙伴之间的相互作用的癌症治疗剂进行筛选的方法
公开(公告)号：US20140018304A1
公开(公告)日：2014-01-16
申请号：US14008537
申请日：2011-08-02
申请人： Si Young Song , Sun A Kim , Soo Bin Park
发明人： Si Young Song , Sun A Kim , Soo Bin Park
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： C12Q1/6886 , G01N33/57438 , G01N33/6893 , G01N2333/4706
摘要： The present invention relates to a method for screening for a cancer treatment agent by contacting a test material with pancreatic adenocarcinoma upregulated factor (PAUF) and GLRX3, SNAPIN, or UBL4A, as a binding partner for PAUF, and then analyzing whether or not the test material inhibits the binding of the PAUF and GLRX3, SNAPIN, or UBL4A serving as a binding partner therefor, thereby determining that the test material is a cancer treatment agent if the binding is inhibited. The invention also relates to a pharmaceutical composition containing the test material as an active ingredient for inhibiting and treating cancer. The pharmaceutical composition of the present invention, which contains, as an active ingredient, an inhibitor for inhibiting PAUF from binding with a binding partner, effectively inhibits PAUF signaling related to the onset of cancer, thus enabling various kinds of cancer (especially pancreatic cancer) to be treated.
摘要翻译：本发明涉及通过使测试材料与胰腺腺癌上调因子（PAUF）和GLRX3，SNAPIN或UBL4A作为PAUF的结合配偶体接触来筛选癌症治疗剂的方法，然后分析是否测试材料抑制作为其结合配偶体的PAUF和GLRX3，SNAPIN或UBL4A的结合，从而确定如果结合被抑制，则测试材料是癌症治疗剂。本发明还涉及含有作为抑制和治疗癌症的活性成分的测试材料的药物组合物。含有抑制PAUF与结合配偶体结合的抑制剂作为活性成分的本发明的药物组合物能够有效抑制与癌症发生有关的PAUF信号传导，从而能够进行各种癌症（尤其是胰腺癌）待处理

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