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    • 8. 发明授权
    • Transdermal patch for nonsteroidal antiinflammatory drug(s)
    • 非甾体抗炎药的透皮贴剂
    • US06455067B1
    • 2002-09-24
    • US09577787
    • 2000-05-24
    • Yang Pyo WooSung Min Cho
    • Yang Pyo WooSung Min Cho
    • A61F1300
    • A61K47/32A61K9/7053A61K9/7061A61K31/192A61K31/196A61K31/5415A61K31/542A61K47/02A61K47/10A61K47/12A61K47/22A61K47/26
    • This invention relates to an external patch for an antiinflammatory drug containing nonsteroidal antiinflammatory drug which is excellent in the dermal absorption and the skin adhesion, has hardly the skin stimulus. The nonsteroidal antiinflammatory drug composition comprised of nonsteroidal antiinflammatory drug, alkylpyrrolidone, hydrophilic polyethyleneglycol and hydrophilic nonionic surfactant was diffused in the water containing base comprised of water soluble polymer material, water soluble vinyl polymer and water insoluble multivalent metallic salt to provide the external patch containing nonsteroidal drug dissolved and diffused in the water containing base in the microemulsion state, which is excellent in the dermal absorption and also good in the skin adhesion, has hardly the skin irritations.
    • 本发明涉及皮肤吸收和皮肤粘附性优异的含有非甾族抗炎药物的抗炎药物的外用贴片,几乎不具有皮肤刺激性。 由非甾体抗炎药物,烷基吡咯烷酮,亲水性聚乙二醇和亲水性非离子表面活性剂组成的非甾体抗炎药物组合物扩散到由水溶性聚合物材料,水溶性乙烯基聚合物和水不溶性多价金属盐组成的含水基质中,以提供含有非甾体化合物 溶解并扩散在微乳状态的含水基质中的药物,其皮肤吸收性优异,皮肤粘合性良好,几乎不发生皮肤刺激。