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1. 发明申请

US20100160467A1 ORGANIC-INORGANIC HYBRID SCAFFOLDS WITH SURFACE-IMMOBILIZED NANO-HYDROXYAPATITE AND PREPARATION METHOD THEREOF 有权
标题翻译：表面活性纳米羟基化合物的有机无机混合物及其制备方法
公开(公告)号：US20100160467A1
公开(公告)日：2010-06-24
申请号：US12635615
申请日：2009-12-10
申请人： Sang Cheon Lee , Jeong Ho Chang , Jin Hyung Lee , Kyung Ja Kim , Sung Eun Kim , Ho Chan Hwang , Ke-Won Kang , Seog-Jin Seo , Jin-Young Kim
发明人： Sang Cheon Lee , Jeong Ho Chang , Jin Hyung Lee , Kyung Ja Kim , Sung Eun Kim , Ho Chan Hwang , Ke-Won Kang , Seog-Jin Seo , Jin-Young Kim
IPC分类号： C08J9/00 , C08G63/91 , C08B37/04 , C08B37/08 , C08G63/08 , C08G63/06 , C08G64/00 , C08B37/02 , C08B37/00 , C07K14/78 , C08G79/02
CPC分类号： A61L27/46
摘要： Provided are an organic-inorganic hybrid scaffold with surface-immobilized nano-hydroxyapatite, and a method for the fabrication thereof. The scaffold is fabricated by reacting an acid group present on a surface of nano-hydroxyapatite with a primary amine present on a surface of a polymer support in the presence of EDC (1-ethyl-3-dimethylaminopropyl carbodiimide) to immobilize nano-hydroxyapatite onto the surface of the polymer support. The surface of nano-hydroxyapatite is previously grafted with poly(ethylene glycol methacrylate phosphate) (PolyEGMP) having phosphonic acid functionality or with a polymer having carboxylic acid functionality.
摘要翻译：提供具有表面固定的纳米羟基磷灰石的有机 - 无机杂化支架及其制造方法。在EDC（1-乙基-3-二甲基氨基丙基碳二亚胺）存在下，将存在于纳米羟基磷灰石的表面上的酸基与存在于聚合物载体表面上的伯胺反应，使纳米羟基磷灰石固定在聚合物载体的表面。预先用具有膦酸官能度的聚（乙二醇甲基丙烯酸酯磷酸酯）（PolyEGMP）或具有羧酸官能团的聚合物接枝纳米羟基磷灰石的表面。

2. 发明授权

US08691882B2 Organic-inorganic hybrid scaffolds with surface-immobilized nano-hydroxyapatite and preparation method thereof 有权
标题翻译：具有表面固定化纳米羟基磷灰石的有机 - 无机杂化支架及其制备方法
公开(公告)号：US08691882B2
公开(公告)日：2014-04-08
申请号：US12635615
申请日：2009-12-10
申请人： Sang Cheon Lee , Jeong Ho Chang , Jin Hyung Lee , Kyung Ja Kim , Sung Eun Kim , Ho Chan Hwang , Ke-Won Kang , Seog-Jin Seo , Jin-Young Kim
发明人： Sang Cheon Lee , Jeong Ho Chang , Jin Hyung Lee , Kyung Ja Kim , Sung Eun Kim , Ho Chan Hwang , Ke-Won Kang , Seog-Jin Seo , Jin-Young Kim
IPC分类号： C07K14/78 , C08J9/00 , C08G63/06
CPC分类号： A61L27/46
摘要： Provided are an organic-inorganic hybrid scaffold with surface-immobilized nano-hydroxyapatite, and a method for the fabrication thereof. The scaffold is fabricated by reacting an acid group present on a surface of nano-hydroxyapatite with a primary amine present on a surface of a polymer support in the presence of EDC (1-ethyl-3-dimethylaminopropyl carbodiimide) to immobilize nano-hydroxyapatite onto the surface of the polymer support. The surface of nano-hydroxyapatite is previously grafted with poly(ethylene glycol methacrylate phosphate) (PolyEGMP) having phosphonic acid functionality or with a polymer having carboxylic acid functionality.
摘要翻译：提供具有表面固定的纳米羟基磷灰石的有机 - 无机杂化支架及其制造方法。在EDC（1-乙基-3-二甲基氨基丙基碳二亚胺）存在下，将存在于纳米羟基磷灰石的表面上的酸基与存在于聚合物载体表面上的伯胺反应，使纳米羟基磷灰石固定在聚合物载体的表面。预先用具有膦酸官能度的聚（乙二醇甲基丙烯酸酯磷酸酯）（PolyEGMP）或具有羧酸官能团的聚合物接枝纳米羟基磷灰石的表面。

3. 发明申请

US20100304139A1 METHOD OF PREPARING HIGHLY ORDERED MESOPOROUS SILICA NANOPARTICLES USING THE ADDITION OF TRANSITION METAL SALTS 有权
标题翻译：使用过渡金属盐的添加制备高阶MESOPOROUS二氧化硅纳米粒子的方法
公开(公告)号：US20100304139A1
公开(公告)日：2010-12-02
申请号：US12627381
申请日：2009-11-30
申请人： Jeong-Ho Chang , Jin Hyung Lee , Hye Sun Lee
发明人： Jeong-Ho Chang , Jin Hyung Lee , Hye Sun Lee
IPC分类号： C01B33/12
CPC分类号： C01B37/02 , C01B37/005
摘要： Disclosed is a method of preparing mesoporous silica nanoparticles using hydrothermal synthesis, including adding a transition metal when reacting a surfactant and a silica precursor. The mesoporous silica nanoparticles are high functional particles able to be used as an adsorbent, a sensor, a membrane, a catalyst and a catalyst support, thanks to their large surface area and nano-sized pores. The mesoporous silica nanoparticles are functionally advantageous in terms of increased material diffusion rate and reactivity, easy recycling after use as a catalyst and slow inactivation, compared to conventional mesoporous silica, and are prepared through a very simple process among methods of controlling the particle size of mesoporous silica to a nano size.
摘要翻译：公开了一种使用水热合成制备介孔二氧化硅纳米颗粒的方法，包括在使表面活性剂与二氧化硅前体反应时加入过渡金属。介孔二氧化硅纳米颗粒是能够用作吸附剂，传感器，膜，催化剂和催化剂载体的高功能颗粒，由于其大的表面积和纳米尺寸的孔。介孔二氧化硅纳米粒子在增加材料扩散速率和反应活性方面在功能上是有利的，与传统的介孔二氧化硅相比，在使用后作为催化剂容易再循环并且缓慢失活，并且通过控制颗粒尺寸的方法之间的非常简单的方法制备介孔二氧化硅为纳米尺寸。

4. 发明授权

US09044526B2 Medical product containing active component of propolis or grapefruit seed extract and manufacturing method thereof 有权
标题翻译：含有蜂胶或葡萄柚种子提取物活性成分的医药产品及其制造方法
公开(公告)号：US09044526B2
公开(公告)日：2015-06-02
申请号：US13348751
申请日：2012-01-12
申请人： Jeong Ho Chang , Hye Sun Lee , Jin Hyung Lee
发明人： Jeong Ho Chang , Hye Sun Lee , Jin Hyung Lee
IPC分类号： A61K9/70 , A61K31/216 , A61K31/353 , A61K36/752 , A61P29/00 , A61P31/04 , A61L15/46 , A61L15/40 , C07D311/30
CPC分类号： A61L15/46 , A61K31/216 , A61K31/353 , A61K36/752 , A61L15/40 , A61L2300/30 , A61L2300/404 , C07D311/30
摘要： A medical product containing either an active ingredient of propolis which is a natural antibiotic or a grapefruit seed extract, and a manufacturing method thereof are provided. The medical product is impregnated with a solution of CAPE (caffeic acid phenethyl ester) or pinocembrin, which is an active ingredient of propolis having antibacterial effects, to increase the antibacterial activity of the medical product due to antibacterial compounds contained in the active component, or the medical product is impregnated with a solution of a grapefruit seed extract such that the extract can exhibit antibacterial activity in the medical product.
摘要翻译：提供含有天然抗生素或葡萄柚种子提取物的蜂胶活性成分的医药品及其制造方法。用作为具有抗菌作用的蜂胶的活性成分的CAPE（咖啡酸苯乙酯）或皮诺布林溶液浸渍医疗用品，由于活性成分中含有的抗菌化合物，增加医药产品的抗菌活性，或用葡萄柚种子提取物的溶液浸渍医用产品，使得提取物可以在医疗产品中表现出抗菌活性。

5. 发明授权

US08518361B2 Method of preparing highly ordered mesoporous silica nanoparticles using the addition of transition metal salts 有权
标题翻译：使用过渡金属盐加入高度有序的介孔二氧化硅纳米粒子的方法
公开(公告)号：US08518361B2
公开(公告)日：2013-08-27
申请号：US12627381
申请日：2009-11-30
申请人： Jeong-Ho Chang , Jin Hyung Lee , Hye Sun Lee
发明人： Jeong-Ho Chang , Jin Hyung Lee , Hye Sun Lee
IPC分类号： C01B33/12
CPC分类号： C01B37/02 , C01B37/005
摘要： Disclosed is a method of preparing mesoporous silica nanoparticles using hydrothermal synthesis, including adding a transition metal when reacting a surfactant and a silica precursor. The mesoporous silica nanoparticles are high functional particles able to be used as an adsorbent, a sensor, a membrane, a catalyst and a catalyst support, thanks to their large surface area and nano-sized pores. The mesoporous silica nanoparticles are functionally advantageous in terms of increased material diffusion rate and reactivity, easy recycling after use as a catalyst and slow inactivation, compared to conventional mesoporous silica, and are prepared through a very simple process among methods of controlling the particle size of mesoporous silica to a nano size.
摘要翻译：公开了一种使用水热合成制备介孔二氧化硅纳米颗粒的方法，包括在使表面活性剂与二氧化硅前体反应时加入过渡金属。介孔二氧化硅纳米颗粒是能够用作吸附剂，传感器，膜，催化剂和催化剂载体的高功能颗粒，由于其大的表面积和纳米尺寸的孔。介孔二氧化硅纳米粒子在增加材料扩散速率和反应活性方面在功能上是有利的，与传统的介孔二氧化硅相比，在使用后作为催化剂容易再循环并且缓慢失活，并且通过控制颗粒尺寸的方法之间的非常简单的方法制备介孔二氧化硅为纳米尺寸。

6. 发明授权

US08481092B2 Antimicrobial suture for medical use with grapefruit extract, and manufacturing method thereof 失效
标题翻译：用于葡萄柚提取物的医疗用抗微生物缝线及其制造方法
公开(公告)号：US08481092B2
公开(公告)日：2013-07-09
申请号：US12914352
申请日：2010-10-28
申请人： Jeong Ho Chang , Hye Sun Lee , Jin Hyung Lee
发明人： Jeong Ho Chang , Hye Sun Lee , Jin Hyung Lee
IPC分类号： A61K36/752 , A61K36/00
CPC分类号： A61K36/752 , A61L17/005 , A61L17/06 , A61L2300/30 , A61L2300/404 , C08L67/04
摘要： A method of manufacturing a medical antimicrobial suture having a grapefruit extract which is a grapefruit seed extract including naringin, ascorbic acid or citral is provided. The method includes preparing grapefruit extract solution with a concentration of 500 to 2000 ppm by mixing the grapefruit extract with methanol solvent; and impregnating a biodegradable monofilament suture with the grapefruit extract solution for more than 360 minutes. The grapefruit extract is continuously released in a body for 70 hours after the antimicrobial suture is inserted into the body.
摘要翻译：提供了具有葡萄柚提取物的医用抗微生物缝合线的方法，该提取物是包含柚皮苷，抗坏血酸或柠檬醛的葡萄柚种子提取物。该方法包括通过将葡萄柚提取物与甲醇溶剂混合来制备浓度为500至2000ppm的葡萄柚提取物溶液; 并用葡萄柚提取液浸渍可生物降解的单丝缝合超过360分钟。在将抗菌缝线插入体内后，葡萄柚提取物在体内连续释放70小时。

7. 发明申请

US20080261579A1 MOBILE COMMUNICATION TERMINAL AND METHOD OF CONTROLLING VOLUME THEREOF 有权
标题翻译：移动通信终端及其控制方法
公开(公告)号：US20080261579A1
公开(公告)日：2008-10-23
申请号：US12030770
申请日：2008-02-13
申请人： Jin Sun SHIM , Su Yeon Hwang , Jin Hyung Lee
发明人： Jin Sun SHIM , Su Yeon Hwang , Jin Hyung Lee
IPC分类号： H04M3/00
CPC分类号： H04M1/6016
摘要： A mobile communication terminal and method of controlling a volume thereof are disclosed, by which the volume of the mobile communication terminal can be controlled in case of entering a specific mode while a manner mode is set. The present invention includes entering a specific mode for outputting an audio signal while a manner mode is set, selecting a presence or non-presence of an output of the audio signal, and terminating the specific mode, wherein the manner mode is maintained in case of terminating the specific mode.
摘要翻译：公开了一种移动通信终端及其体积的控制方法，通过该移动通信终端可以在设置方式模式时进入特定模式的情况下控制移动通信终端的音量。本发明包括在设置方式模式时输入音频信号的特定模式，选择音频信号的输出的存在或不存在，以及终止特定模式，其中，在终止具体模式。

8. 发明授权

US06806708B1 Multi-coil reconstruction of MRI signals using linear phase multiplied data with separate demodulators for each coil 有权
标题翻译：使用线性相位相乘数据对MRI信号进行多线圈重建，每个线圈采用单独的解调器
公开(公告)号：US06806708B1
公开(公告)日：2004-10-19
申请号：US10464296
申请日：2003-06-17
申请人： Jin Hyung Lee , John M. Pauly , Dwight G. Nishimura
发明人： Jin Hyung Lee , John M. Pauly , Dwight G. Nishimura
IPC分类号： G01V300
CPC分类号： G01R33/5611
摘要： Imaging time using PILS is reduced by using multiple coils with localized sensitivities with each coil having a separate demodulation channel thereby permitting parallel signal processing and image reconstruction. Images from the multiple coils are then combined to form an image with a larger field of view (FOV).
摘要翻译：使用PILS的成像时间通过使用具有局部灵敏度的多个线圈来减少，每个线圈具有单独的解调信道，从而允许并行信号处理和图像重建。然后将来自多个线圈的图像组合以形成具有较大视场（FOV）的图像。

9. 发明申请

US20220359060A1 JOINT DYNAMIC CAUSAL MODELING AND BIOPHYSICS MODELING TO ENABLE MULTI-SCALE BRAIN NETWORK FUNCTION MODELING 有权
公开(公告)号：US20220359060A1
公开(公告)日：2022-11-10
申请号：US17765259
申请日：2020-09-30
申请人： Jin Hyung LEE , Qin LIU , Onur Cezmi MUTLU , The Board of Trustees of the Leland Stanford Junior University
发明人： Jin Hyung Lee , Qin Liu , Onur Cezmi Mutlu
IPC分类号： G16H30/20 , A61B5/377 , A61B5/00
摘要： Methods, systems, and devices, including computer programs encoded on a computer storage medium are provided for combined dynamic causal modeling and biophysics modeling of brain function. In particular, the disclosed methods of modeling brain function can be used to integrate brain function measurements by two or more methods, such as functional neuroimaging and electrophysiology. Sequential model fitting is used to improve modeling accuracy to generate a more comprehensive model of brain neuronal circuitry.

10. 发明授权

US08423049B2 Mobile communication terminal and method of controlling volume thereof 有权
标题翻译：移动通信终端及其体积的控制方法
公开(公告)号：US08423049B2
公开(公告)日：2013-04-16
申请号：US12030770
申请日：2008-02-13
申请人： Jin Sun Shim , Su Yeon Hwang , Jin Hyung Lee
发明人： Jin Sun Shim , Su Yeon Hwang , Jin Hyung Lee
IPC分类号： H04W24/00 , H04M3/42
CPC分类号： H04M1/6016
摘要： A mobile communication terminal and method of controlling a volume thereof are disclosed, by which the volume of the mobile communication terminal can be controlled in case of entering a specific mode while a manner mode is set. The present invention includes entering a specific mode for outputting an audio signal while a manner mode is set, selecting a presence or non-presence of an output of the audio signal, and terminating the specific mode, wherein the manner mode is maintained in case of terminating the specific mode.
摘要翻译：公开了一种移动通信终端及其体积的控制方法，通过该移动通信终端可以在设置方式模式时进入特定模式的情况下控制移动通信终端的音量。本发明包括在设置方式模式时输入音频信号的特定模式，选择音频信号的输出的存在或不存在，以及终止特定模式，其中，在终止具体模式。

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