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1. 发明授权

US07763649B2 Carotenoid analogs or derivatives for controlling connexin 43 expression 有权
标题翻译：用于控制连接蛋白43表达的类胡萝卜素类似物或衍生物
公开(公告)号：US07763649B2
公开(公告)日：2010-07-27
申请号：US10793686
申请日：2004-03-04
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A61K31/34 , A61K31/35 , A61K31/335
CPC分类号： C07D207/16 , C07C403/24 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method of controlling (e.g., influencing or affecting) connexin 43 expression in a subject may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. In some embodiments, controlling connexin 43 expression in a subject may effectively treat cardiac arrhythmia and/or cancerous and pre-cancerous cells in a subject. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include an acyclic alkene including at least one substituent and/or a cyclic ring including at least one substituent. In some embodiments, a carotenoid analog or derivative may include at least one substituent.
摘要翻译：在受试者中控制（例如影响或影响）连接蛋白43表达的方法可包括向受试者施用有效量的药学上可接受的制剂。在一些实施方案中，控制受试者中连接蛋白43的表达可以有效地治疗受试者的心律失常和/或癌前和癌前细胞。药学上可接受的制剂可以包括类胡萝卜素的合成类似物或衍生物。受试者可以单独给予类胡萝卜素类似物或衍生物，或与另一种类胡萝卜素类似物或衍生物或共抗氧化剂制剂一起施用。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的无环烯烃和/或包含至少一个取代基的环状环。在一些实施方案中，类胡萝卜素类似物或衍生物可包括至少一个取代基。

2. 发明授权

US07345091B2 Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease 有权
标题翻译：类胡萝卜素醚类似物或衍生物用于抑制和改善疾病
公开(公告)号：US07345091B2
公开(公告)日：2008-03-18
申请号：US10793671
申请日：2004-03-04
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A61K31/341 , A61K31/351
CPC分类号： C07D207/16 , C07C403/24 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The analog or derivative is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. In some embodiments, the invention may include a chemical compound including an at least partially water soluble carotenoid analog or derivative. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. The substituent may be coupled to the cyclic ring with an ether functionality.
摘要翻译：用于抑制和/或改善与受试者相关的疾病的发生的方法，其中受试者单独或与另一种组合施用类胡萝卜素类似物或衍生物，受试者中的活性氧，活性氮物质，自由基和/或非自由基类胡萝卜素类似物或衍生物，或共抗氧化剂制剂。施用类似物或衍生物，使得受试者可能因此减少与活性氧，活性氮物质，自由基和/或非自由基相关的疾病的风险。在一些实施方案中，本发明可以包括包含至少部分水溶性类胡萝卜素类似物或衍生物的化合物。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的环状环。取代基可以用醚官能团连接到环上。

3. 发明授权

US07320997B2 Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease 有权
标题翻译：药物组合物，包括用于抑制和改善疾病的类胡萝卜素酯类似物或衍生物
公开(公告)号：US07320997B2
公开(公告)日：2008-01-22
申请号：US10793692
申请日：2004-03-04
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A61K31/341
CPC分类号： C07D207/16 , C07C403/24 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The analog or derivative is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. In some embodiments, the invention may include a pharmaceutical composition including a carotenoid analog or derivative. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality. The pharmaceutical composition may be adapted to be administered to a human subject.
摘要翻译：用于抑制和/或改善与受试者相关的疾病的发生的方法，其中受试者单独或与另一种组合施用类胡萝卜素类似物或衍生物，受试者中的活性氧，活性氮物质，自由基和/或非自由基类胡萝卜素类似物或衍生物，或共抗氧化剂制剂。施用类似物或衍生物，使得受试者可能因此减少与活性氧，活性氮物质，自由基和/或非自由基相关的疾病的风险。在一些实施方案中，本发明可以包括包含类胡萝卜素类似物或衍生物的药物组合物。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的环状环。取代基可以用酯官能团偶联到环上。药物组合物可以适于施用于人受试者。

4. 发明授权

US07145025B2 Structural carotenoid analogs for the inhibition and amelioration of disease 有权
标题翻译：结构类胡萝卜素类似物用于抑制和改善疾病
公开(公告)号：US07145025B2
公开(公告)日：2006-12-05
申请号：US10629538
申请日：2003-07-29
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A61K31/341
CPC分类号： C07C403/24 , C07D207/16 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury, liver disease, cancer, cardiac arrhythmia and/or sudden cardiac death, and/or any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In one embodiment, a water-soluble and/or water-dispersible astaxanthin analog is particularly effective. This invention further includes pharmaceutical compositions comprising structural carotenoid analogs either alone or in combination.
摘要翻译：用于抑制和/或改善与受试者相关的疾病的发生的方法，其中受试者单独或与另一种类胡萝卜素组合施用类胡萝卜素结构类似物，受试者中的活性氧，活性氮物质，自由基和/或非自由基类似物或辅助抗氧化剂制剂。给予类似物或模拟组合，使得受试者可能因此减少与活性氧，活性氮物质，自由基和/或非自由基相关的疾病的风险。类似物或类似物组合可以施用于受试者以抑制和/或改善缺血再灌注损伤，肝脏疾病，癌症，心律失常和/或心脏猝死，和/或涉及产生活性氧的任何疾病，活性氮物质，自由基和/或非自由基。在一个实施方案中，水溶性和/或水分散性虾青素类似物是特别有效的。本发明还包括单独或组合包含结构类胡萝卜素类似物的药物组合物。

5. 发明授权

US07723327B2 Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease 有权
标题翻译：类胡萝卜素类似物或衍生物用于抑制和改善肝脏疾病
公开(公告)号：US07723327B2
公开(公告)日：2010-05-25
申请号：US10793660
申请日：2004-03-04
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A61K31/34 , A61K31/40 , A61K31/53
CPC分类号： C07D207/16 , C07C403/24 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method of treating liver disease in a subject may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. In some embodiments, a cyclic ring of a carotenoid analog or derivative may include at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality.
摘要翻译：在受试者中治疗肝脏疾病的方法可包括向受试者施用有效量的药学上可接受的制剂。药学上可接受的制剂可以包括类胡萝卜素的合成类似物或衍生物。受试者可以单独给予类胡萝卜素类似物或衍生物，或与另一种类胡萝卜素类似物或衍生物或共抗氧化剂制剂一起施用。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的环状环。在一些实施方案中，类胡萝卜素类似物或衍生物的环状环可包括至少一个取代基。取代基可以用酯官能团偶联到环上。

6. 发明授权

US07592449B2 Structural carotenoid analogs for the inhibition and amelioration of disease 有权
标题翻译：结构类胡萝卜素类似物用于抑制和改善疾病
公开(公告)号：US07592449B2
公开(公告)日：2009-09-22
申请号：US11357897
申请日：2006-02-17
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： C07D233/12 , C07D265/30 , C07D473/00
CPC分类号： C07C403/24 , C07D207/16 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid structural analog, either alone or in combination with another carotenoid analog, or co-antioxidant formulation. The analog or analog combination is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of ischemia-reperfusion injury. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of liver disease. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cancer. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of cardiac arrhythmia and/or sudden cardiac death. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In one embodiment, a water-soluble and/or water-dispersible astaxanthin analog is particularly effective. This invention further includes pharmaceutical compositions comprising structural carotenoid analogs either alone or in combination.
摘要翻译：用于抑制和/或改善与受试者相关的疾病的发生的方法，其中受试者单独或与另一种类胡萝卜素组合施用类胡萝卜素结构类似物，受试者中的活性氧，活性氮物质，自由基和/或非自由基类似物或辅助抗氧化剂制剂。给予类似物或模拟组合，使得受试者可能因此减少与活性氧，活性氮物质，自由基和/或非自由基相关的疾病的风险。模拟或模拟组合可以施用于受试者以抑制和/或改善缺血再灌注损伤。可以将受试者的类似物或类似物组合施用于肝脏疾病的抑制和/或改善。类似物或类似物组合可以施用于受试者以抑制和/或改善癌症。模拟或模拟组合可以施用于受试者以抑制和/或改善心律失常和/或心脏猝死。类似物或模拟组合可以施用于受试者以抑制和/或改善涉及产生活性氧，活性氮物质，自由基和/或非自由基的任何疾病。在一个实施方案中，水溶性和/或水分散性虾青素类似物是特别有效的。本发明还包括单独或组合包含结构类胡萝卜素类似物的药物组合物。

7. 发明授权

US07521584B2 Carotenoid analogs or derivatives for the inhibition and amelioration of disease 有权
标题翻译：用于抑制和改善疾病的类胡萝卜素类似物或衍生物
公开(公告)号：US07521584B2
公开(公告)日：2009-04-21
申请号：US10793670
申请日：2004-03-04
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： C07C403/24
CPC分类号： C07D265/30 , C07C403/24 , C07D207/16 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The analog or derivative is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include a chemical compound including an analog or derivative of a carotenoid. The carotenoid analog or derivative may be synthetic. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include an acyclic alkene including at least one substituent and/or a cyclic ring including at least one substituent. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
摘要翻译：用于抑制和/或改善与受试者相关的疾病的发生的方法，其中受试者单独或与另一种组合施用类胡萝卜素类似物或衍生物，受试者中的活性氧，活性氮物质，自由基和/或非自由基类胡萝卜素类似物或衍生物，或共抗氧化剂制剂。施用类似物或衍生物，使得受试者可能因此减少与活性氧，活性氮物质，自由基和/或非自由基相关的疾病的风险。类似物或模拟组合可以施用于受试者以抑制和/或改善涉及产生活性氧，活性氮物质，自由基和/或非自由基的任何疾病。在一些实施方案中，本发明可以包括包含类胡萝卜素的类似物或衍生物的化合物。类胡萝卜素类似物或衍生物可以是合成的。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的无环烯烃和/或包含至少一个取代基的环状环。在一些实施方案中，类胡萝卜素类似物或衍生物可包括至少一个取代基。取代基可以增强类胡萝卜素类似物或衍生物的溶解度，使得类胡萝卜素类似物或衍生物至少部分地溶解在水中。

8. 发明授权

US07375133B2 Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease 有权
标题翻译：包括类胡萝卜素醚类似物或用于抑制和改善疾病的衍生物的药物组合物
公开(公告)号：US07375133B2
公开(公告)日：2008-05-20
申请号：US10793680
申请日：2004-03-04
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A61K31/341 , A61K31/351
CPC分类号： C07D207/16 , C07C403/24 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method for inhibiting and/or ameliorating the occurrence of diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals in a subject whereby a subject is administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The analog or derivative is administered such that the subject's risk of experiencing diseases associated with reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals may be thereby reduced. The analog or analog combination may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include a pharmaceutical composition including a carotenoid analog or derivative. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. In some embodiments, a cyclic ring of a carotenoid analog or derivative may include at least one substituent. The substituent may be coupled to the cyclic ring with an ether functionality. In some embodiments, a pharmaceutical composition may include a biologically inactive carrier. The pharmaceutical composition may be adapted to be administered to a human subject.
摘要翻译：用于抑制和/或改善与受试者相关的疾病的发生的方法，其中受试者单独或与另一种组合施用类胡萝卜素类似物或衍生物，受试者中的活性氧，活性氮物质，自由基和/或非自由基类胡萝卜素类似物或衍生物，或共抗氧化剂制剂。施用类似物或衍生物，使得受试者可能因此减少与活性氧，活性氮物质，自由基和/或非自由基相关的疾病的风险。类似物或模拟组合可以施用于受试者以抑制和/或改善涉及产生活性氧，活性氮物质，自由基和/或非自由基的任何疾病。在一些实施方案中，本发明可以包括包含类胡萝卜素类似物或衍生物的药物组合物。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的环状环。在一些实施方案中，类胡萝卜素类似物或衍生物的环状环可包括至少一个取代基。取代基可以用醚官能团连接到环上。在一些实施方案中，药物组合物可包括生物活性载体。药物组合物可以适于施用于人受试者。

9. 发明授权

US07317008B2 Carotenoid ester analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury 有权
标题翻译：类胡萝卜素类似物或衍生物用于抑制和改善缺血再灌注损伤
公开(公告)号：US07317008B2
公开(公告)日：2008-01-08
申请号：US10793703
申请日：2004-03-04
申请人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
发明人： Samuel Fournier Lockwood , Sean O'Malley , David G. Watumull , Laura M. Hix , Henry Jackson , Geoff Nadolski
IPC分类号： A61K31/34 , A61K31/40 , A61K31/53
CPC分类号： C07C403/24 , C07D207/16 , C07D265/30 , C07D307/58 , C07F9/117 , C07H13/04
摘要： A method of treating ischemic reperfusion injury in a subject. The method may include administering to the subject an effective amount of a pharmaceutically acceptable formulation. The pharmaceutically acceptable formulation may include a synthetic analog or derivative of a carotenoid. The subject may be administered a carotenoid analog or derivative, either alone or in combination with another carotenoid analog or derivative, or co-antioxidant formulation. The carotenoid analog may include a conjugated polyene with between 7 to 14 double bonds. The conjugated polyene may include a cyclic ring including at least one substituent. In some embodiments, a cyclic ring of a carotenoid analog or derivative may include at least one substituent. The substituent may be coupled to the cyclic ring with an ester functionality.
摘要翻译：治疗受试者缺血再灌注损伤的方法。该方法可以包括向受试者施用有效量的药学上可接受的制剂。药学上可接受的制剂可以包括类胡萝卜素的合成类似物或衍生物。受试者可以单独给予类胡萝卜素类似物或衍生物，或与另一种类胡萝卜素类似物或衍生物或共抗氧化剂制剂一起施用。类胡萝卜素类似物可以包括具有7至14个双键的共轭多烯。共轭多烯可以包括包含至少一个取代基的环状环。在一些实施方案中，类胡萝卜素类似物或衍生物的环状环可包括至少一个取代基。取代基可以用酯官能团偶联到环上。

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