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1. 发明授权

US09657341B2 Microfluidic system for nucleic acid analysis 有权
公开(公告)号：US09657341B2
公开(公告)日：2017-05-23
申请号：US14074590
申请日：2013-11-07
申请人： Samsung Electronics Co., Ltd.
发明人： Chin-sung Park , Kak Namkoong , Joon-sub Shim , Won-seok Chung , Kyung-ho Kim , Joon-ho Kim , Won-jong Jung
IPC分类号： C12Q1/68 , B01L3/00 , B01L7/00
CPC分类号： C12Q1/686 , B01L3/5027 , B01L3/527 , B01L7/525 , B01L2200/025 , B01L2200/028 , B01L2200/0684 , B01L2200/10 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , B01L2400/0655 , B01L2400/0683 , B01L2400/086
摘要： A microfluidic system for analyzing nucleic acid, the microfluidic system including a reagent supply device including a sample chamber into which a sample can be injected, one or more reagent chambers for containing one or more reagents for extracting nucleic acid from the sample, and a waste chamber in which the used reagent can be discarded; a binding-lysis chamber in which cells are captured from the sample and lysed to form a cell lysate containing nucleic acid; plurality of particles for cell binding disposed in the binding-lysis chamber; a plurality of rehydration chambers into which the cell lysate formed in the binding-lysis chamber can be distributed and mixed with a nucleic acid amplification reagent to form an amplification reaction mixture; a plurality of amplification chambers in which a nucleic acid amplification reaction is performed on the amplification reaction mixture introduced from the plurality of rehydration chambers; and a flow channel system including an outlet and a plurality of inlets connected to the reagent supply device and forming an integrated fluid flow between the binding-lysis chamber, the rehydration chambers, and the amplification chambers.

2. 发明授权

US09095851B2 Apparatus and method of detecting and controlling fluid in microfluidic device 有权
标题翻译：在微流体装置中检测和控制流体的装置和方法
公开(公告)号：US09095851B2
公开(公告)日：2015-08-04
申请号：US13722057
申请日：2012-12-20
申请人： Samsung Electronics Co., Ltd.
发明人： Won-seok Chung , Kak Namkoong , Chin-sung Park , Kyung-ho Kim , Joon-ho Kim
IPC分类号： G01N21/55 , B01L3/00 , G01N35/00
CPC分类号： B01L3/502746 , G01N35/00069 , G01N35/1095 , Y10T137/0391
摘要： A fluid control apparatus including a detecting unit including a light source for irradiating light toward a microfluidic device, and a photodetector for detecting light reflected from the microfluidic device, a transporting unit for moving the detecting unit; and a determining unit for controlling a transporting operation by the transporting unit, where determining a state of a fluid at a particular position relative to the microfluidic device is based on light reflected from the microfluidic device, and method of using same.
摘要翻译：一种流体控制装置，包括：检测单元，包括用于向微流体装置照射光的光源;以及光检测器，用于检测从微流体装置反射的光;传送单元，用于移动检测单元; 以及用于控制由所述输送单元进行的输送操作的确定单元，其中基于从所述微流体装置反射的光来确定相对于所述微流体装置的特定位置处的流体的状态及其使用方法。

3. 发明申请

US20140356853A1 AUTOMATED NUCLEIC ACID ANALYSIS SYSTEM 审中-公开
标题翻译：自动核酸分析系统
公开(公告)号：US20140356853A1
公开(公告)日：2014-12-04
申请号：US14167583
申请日：2014-01-29
申请人： Samsung Electronics Co., Ltd.
发明人： Won-seok CHUNG , Kak Namkoong , Kyung-ho Kim , Chin-sung Park , Joon-ho Kim , Joon-sub Shim , Won-jong Jung
IPC分类号： C12Q3/00
CPC分类号： C12Q3/00 , C12Q1/686 , C12Q2565/629
摘要： A nucleic acid analysis system comprising a seating area configured to receive a microfluidic cartridge; a pneumatic module configured to supply a pneumatic pressure or a vacuum to the cartridge when mounted on the seating area; a thermal module configured to control temperature in a predetermined portion of the cartridge when mounted on the seating area; an optic module positioned to irradiate light onto the cartridge when mounted on the seating area, and detect light generated or reflected from a sample inside the cartridge when mounted on the seating area; a fluid sensing module that determines whether a fluid in a predetermined portion of a cartridge mounted on the seating area is in a gaseous state or a liquid state; a scanning module that moves the optic module and the fluid sensing module relative to the seating area; and a control module that controls operations of the pneumatic module, the thermal module, the optic module, the fluid sensing module, and the scanning module, and processes and analyzes data received therefrom.
摘要翻译：一种核酸分析系统，包括配置成接收微流控盒的座位区域; 气动模块，其构造成当安装在所述座位区域时向所述盒提供气动压力或真空; 配置为当安装在座位区上时控制盒的预定部分中的温度的热模块; 定位成当安装在就座区上时将光照射到盒上的光学模块，以及当安装在座位区域上时，检测从盒内的样品产生或反射的光; 流体感测模块，其确定安装在所述就座区域上的盒的预定部分中的流体是处于气态还是液态; 扫描模块，其相对于所述座位区域移动所述光学模块和所述流体感测模块; 以及控制模块，其控制气动模块，热模块，光模块，流体感测模块和扫描模块的操作，并处理和分析从其接收的数据。

4. 发明申请

US20140206073A1 MICROFLUIDIC SYSTEM FOR NUCLEIC ACID ANALYSIS 有权
标题翻译：核酸分析微流控系统
公开(公告)号：US20140206073A1
公开(公告)日：2014-07-24
申请号：US14074590
申请日：2013-11-07
申请人： Samsung Electronics Co., Ltd.
发明人： Chin-sung Park , Kak Namkoong , Joon-sub Shim , Won-seok Chung , Kyung-ho Kim , Joon-ho Kim , Won-jong Jung
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , B01L3/5027 , B01L3/527 , B01L7/525 , B01L2200/025 , B01L2200/028 , B01L2200/0684 , B01L2200/10 , B01L2300/0672 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487 , B01L2400/0655 , B01L2400/0683 , B01L2400/086
摘要： A microfluidic system for analyzing nucleic acid, the microfluidic system including a reagent supply device including a sample chamber into which a sample can be injected, one or more reagent chambers for containing one or more reagents for extracting nucleic acid from the sample, and a waste chamber in which the used reagent can be discarded; a binding-lysis chamber in which cells are captured from the sample and lysed to form a cell lysate containing nucleic acid; plurality of particles for cell binding disposed in the binding-lysis chamber; a plurality of rehydration chambers into which the cell lysate formed in the binding-lysis chamber can be distributed and mixed with a nucleic acid amplification reagent to form an amplification reaction mixture; a plurality of amplification chambers in which a nucleic acid amplification reaction is performed on the amplification reaction mixture introduced from the plurality of rehydration chambers; and a flow channel system including an outlet and a plurality of inlets connected to the reagent supply device and forming an integrated fluid flow between the binding-lysis chamber, the rehydration chambers, and the amplification chambers.
摘要翻译：一种用于分析核酸的微流体系统，所述微流体系统包括试剂供应装置，其包括可以注入样品的样品室，用于容纳用于从样品中提取核酸的一种或多种试剂的一个或多个试剂室和废物可以丢弃使用的试剂的室; 结合裂解室，其中细胞从样品中捕获并裂解以形成含有核酸的细胞裂解物; 用于细胞结合的多个颗粒设置在结合裂解室中; 多个再结合室，其中在结合 - 溶解室中形成的细胞裂解物可以与核酸扩增试剂分配并混合以形成扩增反应混合物; 多个扩增室，其中对从多个再水化室引入的扩增反应混合物进行核酸扩增反应; 以及流道系统，其包括连接到试剂供应装置的出口和多个入口，并且在结合 - 溶解室，再水化室和扩增室之间形成一体的流体流。

5. 发明授权

US09637733B2 Reagent supply device for analysis of nucleic acid 有权
公开(公告)号：US09637733B2
公开(公告)日：2017-05-02
申请号：US13917462
申请日：2013-06-13
申请人： Samsung Electronics Co., Ltd.
发明人： Chin-sung Park , Kak Namkoong , Joon-sub Shim , Won-seok Chung , Kyung-ho Kim , Joon-ho Kim , Won-jong Jung
IPC分类号： C12N15/10 , B01L3/00
CPC分类号： C12N15/1017 , B01L3/527 , B01L2300/0851 , B01L2300/0861
摘要： A reagent supply device includes a plurality of chambers which are separated from each other such that different reagents may be injected, the plurality of chambers having bottom surfaces made of a membrane, the membrane comprising a destruction pattern which is formed at a position corresponding to each of the plurality of chambers and breachable by an external impact to discharge the injected reagent from the chamber.

6. 发明授权

US09585197B2 Semiconductor device including asymmetric electrode arrangement 有权
标题翻译：包括不对称电极布置的半导体器件
公开(公告)号：US09585197B2
公开(公告)日：2017-02-28
申请号：US14213030
申请日：2014-03-14
申请人： Samsung Electronics Co., Ltd.
发明人： Chin-sung Park , Won-seok Chung
IPC分类号： H05B3/02 , H05B3/26 , H05B3/14 , H01L23/00
CPC分类号： H05B3/265 , H01L24/06 , H01L24/14 , H01L24/16 , H01L24/17 , H01L24/81 , H01L2224/0401 , H01L2224/061 , H01L2224/0612 , H01L2224/06151 , H01L2224/06155 , H01L2224/06165 , H01L2224/141 , H01L2224/1412 , H01L2224/14151 , H01L2224/14155 , H01L2224/14165 , H01L2224/16225 , H01L2224/16227 , H01L2224/16245 , H01L2224/171 , H01L2224/17104 , H01L2224/1712 , H01L2224/81123 , H01L2224/81125 , H01L2224/81127 , H01L2224/81129 , H01L2224/81192 , H01L2924/15153 , H05B3/143 , H05B2203/002 , H05B2203/003 , H05B2203/013 , H05B2203/016 , H05B2203/037 , H01L2924/00012
摘要： Provided is a semiconductor device including an asymmetric electrode arrangement in which a plurality of electrodes are arranged asymmetrically in a vertical or horizontal direction.
摘要翻译：提供了一种半导体器件，其包括其中多个电极在垂直或水平方向上不对称地布置的不对称电极布置。

7. 发明授权

US09244014B2 Multi-channel fluorescence detecting module and nucleic acid analysis system having the same 有权
标题翻译：多通道荧光检测模块和具有相同功能的核酸分析系统
公开(公告)号：US09244014B2
公开(公告)日：2016-01-26
申请号：US14175554
申请日：2014-02-07
申请人： Samsung Electronics Co., Ltd.
发明人： Kyung-ho Kim , Won-seok Chung , Sung-min Chi , Joon-ho Kim , Kak Namkoong , Chin-sung Park
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N2021/6421 , G01N2201/0612 , G01N2201/062 , G01N2201/103 , G01N2201/1053
摘要： Provided are a multi-channel fluorescence detecting module and a nucleic acid analysis system including the multi-channel fluorescence detecting module. The nucleic acid analysis system includes: a plurality of loaders configured to accommodate a plurality of cartridges respectively, the cartridges comprising microfluidic devices; a transfer module including a linear actuator, the linear actuator including a movable unit configured to move linearly; and a fluorescence detecting module fixed to the movable unit, the fluorescence detecting module being configured to emit excitation light to the cartridges and detect fluorescence emitted from samples on the cartridges. The loaders are arranged in a row in a linearly moving direction of the movable unit.
摘要翻译：提供了多通道荧光检测模块和包括多通道荧光检测模块的核酸分析系统。所述核酸分析系统包括：多个装载器，其分别容纳多个盒，所述盒包括微流体装置; 包括线性致动器的转移模块，所述线性致动器包括构造成线性运动的可移动单元; 以及荧光检测模块，其固定到所述可移动单元，所述荧光检测模块被配置为向所述盒发射激发光并检测从所述盒上的样品发出的荧光。装载机沿可移动单元的线性移动方向排成一列。

8. 发明授权

US09200315B2 Reagent container for amplifying nucleic acid, method of preparing the reagent container, method of storing the reagent, and microfluidic system for nucleic acid analysis 有权
标题翻译：用于扩增核酸的试剂容器，制备试剂容器的方法，储存试剂的方法和用于核酸分析的微流体系统
公开(公告)号：US09200315B2
公开(公告)日：2015-12-01
申请号：US14095784
申请日：2013-12-03
申请人： Samsung Electronics Co. Ltd.
发明人： Sung-ouk Jung , Sung-min Chi , Soo-kwan Lee , Sung-hong Kwon , Joon-ho Kim , Kak Namkoong , Chin-sung Park , Kyu-youn Hwang
IPC分类号： C12Q1/68 , B01L3/00 , B01L7/00
CPC分类号： C12Q1/6806 , B01L3/5027 , B01L3/502707 , B01L3/527 , B01L7/52 , B01L2200/04 , B01L2200/0684 , B01L2200/10 , B01L2200/141 , B01L2200/16 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487
摘要： Provided is a reagent container that can maintain stability of a reagent for a long period of time, a method of preparing the reagent container, a method of storing the reagent, and microfluidic systems for conducting cell binding, lysis, nucleic acid extraction, and amplification.
摘要翻译：本发明提供能够长时间保持试剂稳定性的试剂容器，制备试剂容器的方法，储存试剂的方法以及用于进行细胞结合，裂解，核酸提取和扩增的微流体系统。

9. 发明申请

US20150037876A1 MULTI-CHANNEL FLUORESCENCE DETECTING MODULE AND NUCLEIC ACID ANALYSIS SYSTEM HAVING THE SAME 有权
标题翻译：多通道荧光检测模块及其相应的核酸分析系统
公开(公告)号：US20150037876A1
公开(公告)日：2015-02-05
申请号：US14175554
申请日：2014-02-07
申请人： Samsung Electronics Co., Ltd.
发明人： Kyung-ho Kim , Won-seok Chung , Sung-min Chi , Joon-ho Kim , Kak Namkoong , Chin-sung Park
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N2021/6421 , G01N2201/0612 , G01N2201/062 , G01N2201/103 , G01N2201/1053
摘要： Provided are a multi-channel fluorescence detecting module and a nucleic acid analysis system including the multi-channel fluorescence detecting module. The nucleic acid analysis system includes: a plurality of loaders configured to accommodate a plurality of cartridges respectively, the cartridges comprising microfluidic devices; a transfer module including a linear actuator, the linear actuator including a movable unit configured to move linearly; and a fluorescence detecting module fixed to the movable unit, the fluorescence detecting module being configured to emit excitation light to the cartridges and detect fluorescence emitted from samples on the cartridges. The loaders are arranged in a row in a linearly moving direction of the movable unit.
摘要翻译：提供了多通道荧光检测模块和包括多通道荧光检测模块的核酸分析系统。所述核酸分析系统包括：多个装载器，其分别容纳多个盒，所述盒包括微流体装置; 包括线性致动器的转移模块，所述线性致动器包括构造成线性运动的可移动单元; 以及荧光检测模块，其固定到所述可移动单元，所述荧光检测模块被配置为向所述盒发射激发光并检测从所述盒上的样品发出的荧光。装载机沿可移动单元的线性移动方向排成一列。

10. 发明申请

US20140154688A1 REAGENT CONTAINER FOR AMPLIFYING NUCLEIC ACID, METHOD OF PREPARING THE REAGENT CONTAINER, METHOD OF STORING THE REAGENT, AND MICROFLUIDIC SYSTEM FOR NUCLEIC ACID ANALYSIS 有权
标题翻译：用于放大核酸的试剂容器，制备试剂容器的方法，储存试剂的方法和用于核酸分析的微流控系统
公开(公告)号：US20140154688A1
公开(公告)日：2014-06-05
申请号：US14095784
申请日：2013-12-03
申请人： Samsung Electronics Co. Ltd.
发明人： Sung-ouk JUNG , Sung-min Chi , Soo-kwan Lee , Sung-hong Kwon , Joon-ho Kim , Kak Namkoong , Chin-sung Park , Kyu-youn Hwang
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B01L3/5027 , B01L3/502707 , B01L3/527 , B01L7/52 , B01L2200/04 , B01L2200/0684 , B01L2200/10 , B01L2200/141 , B01L2200/16 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0487
摘要： Provided is a reagent container that can maintain stability of a reagent for a long period of time, a method of preparing the reagent container, a method of storing the reagent, and microfluidic systems for conducting cell binding, lysis, nucleic acid extraction, and amplification.
摘要翻译：本发明提供能够长时间保持试剂稳定性的试剂容器，制备试剂容器的方法，储存试剂的方法以及用于进行细胞结合，裂解，核酸提取和扩增的微流体系统。

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