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1. 发明申请

US20130071547A1 LOW CALORIC FAT REPLACERS 审中-公开
标题翻译：低卡路里脂肪替代品
公开(公告)号：US20130071547A1
公开(公告)日：2013-03-21
申请号：US13514207
申请日：2010-12-06
申请人： Sami Damak , Nicolas Godinot , Johannes Le Coutre , Nathalie Martin , Maria Eugenia Barcos
发明人： Sami Damak , Nicolas Godinot , Johannes Le Coutre , Nathalie Martin , Maria Eugenia Barcos
IPC分类号： A23L1/29
CPC分类号： A23L27/204 , A23L27/20 , A23L27/205 , A23L27/2056 , A23L33/10 , A23L33/30 , A23V2002/00 , A61K31/00 , A61K31/194 , A61K31/4439 , A23V2200/124 , A23V2200/3324 , A23V2200/332
摘要： The present invention relates in general to field of food and drinks. In particular, in relates to formulations that mimic the taste of fat but that are lower in calories. One embodiment of the present invention relates to the use of at least one non-fat agonist of GPR40 for imparting a fatty taste to a food product.
摘要翻译：本发明一般涉及食品和饮料领域。特别地，涉及模拟脂肪味道但热量较低的配方。本发明的一个实施方案涉及GPR40的至少一种非脂肪激动剂用于赋予食品的脂肪味。

2. 发明申请

US20130130972A1 ARTIFICIAL SWEETNERS AND PERFORMANCE 审中-公开
标题翻译：人为因素和性能
公开(公告)号：US20130130972A1
公开(公告)日：2013-05-23
申请号：US13634948
申请日：2011-03-14
申请人： Johannes Le Coutre , Peter Van Bladeren , Sami Damak , Trent Stellingwerff
发明人： Johannes Le Coutre , Peter Van Bladeren , Sami Damak , Trent Stellingwerff
IPC分类号： A23L1/30 , A61K38/05
CPC分类号： A23L5/00 , A23L2/60 , A23L7/00 , A23L7/126 , A23L27/30 , A23L29/30 , A23L33/10 , A23L33/125 , A23L33/15 , A23L33/175 , A23V2002/00 , A61K38/05 , A23V2200/33 , A23V2250/24 , A23V2250/61 , A23V2250/606
摘要： The present invention relates to the field of nutritional compositions. In particular, the present invention relates to a nutritional composition comprising sugar substitutes and to their use, e.g., to increase exogenous carbohydrate oxidation, which has been shown to increase performance, for example the performance of athletes.
摘要翻译：本发明涉及营养组合物领域。特别地，本发明涉及包含糖代用品的营养组合物，并且涉及它们用于增加外源性碳水化合物氧化的用途，这已显示增加性能，例如运动员的表现。

3. 发明申请

US20080299270A1 Fat Taste Receptors and Their Methods of Use 审中-公开
标题翻译：脂肪滋养受体及其使用方法
公开(公告)号：US20080299270A1
公开(公告)日：2008-12-04
申请号：US11996935
申请日：2006-07-10
申请人： Sami Damak , Johannes Le-Coutre , Carole Bezencon , Cristina Cartoni
发明人： Sami Damak , Johannes Le-Coutre , Carole Bezencon , Cristina Cartoni
IPC分类号： G01N33/02 , C07K14/705 , C12N5/06 , G01N33/68 , C12Q1/00
CPC分类号： C07K14/705 , A23L35/00 , A23V2200/14 , C07K14/723 , G01N33/566
摘要： Fat taste receptors and methods for using the receptors to screen compounds that mimic fat taste are disclosed. The receptors can include G-protein coupled receptor proteins, such as GPR40 or GPR120. New methods for preparing foods are also disclosed that involve testing compounds in the assay system and then incorporating into foods the identified nonfat compounds that have the taste of fat.
摘要翻译：公开了脂肪味觉受体和使用受体筛选模拟脂肪味道的化合物的方法。受体可以包括G蛋白偶联受体蛋白，如GPR40或GPR120。还公开了用于制备食物的新方法，其涉及在测定系统中测试化合物，然后将所鉴定的具有脂肪味道的脱脂化合物掺入到食品中。

4. 发明申请

US20140024674A1 TRPM5 INHIBITORS SUPPORT BODY WEIGHT REDUCTION WITHOUT REDUCING FOOD INTAKE 审中-公开
标题翻译： TRPM5抑制剂支持体重减轻而不减少食物摄取
公开(公告)号：US20140024674A1
公开(公告)日：2014-01-23
申请号：US14008824
申请日：2012-03-29
申请人： Sami Damak , Philippe Cettour-Rose , Johannes Le Coutre
发明人： Sami Damak , Philippe Cettour-Rose , Johannes Le Coutre
IPC分类号： A61K31/49 , A23L1/30
CPC分类号： A61K31/49 , A23L33/10 , A23L33/105 , A23L33/30 , A23V2002/00 , A23V2200/332
摘要： The present invention relates to the field of weight management and the prevention and/or treatment of metabolic disorders. In particular, the present invention provides a composition comprising at least one Trpm5 inhibitor which is effective in the treatment of prevention of metabolic disorders or risk factors thereof, such as overweightness or obesity, without having to reduce food intake below metabolic needs.
摘要翻译：本发明涉及体重管理领域以及代谢紊乱的预防和/或治疗。特别地，本发明提供了包含至少一种Trpm5抑制剂的组合物，其可有效地预防代谢紊乱或其风险因素，例如超重或肥胖，而不必降低低于代谢需要的食物摄取。

5. 发明授权

US07803982B2 T1R3 transgenic animals, cells and related methods 失效
标题翻译： T1R3转基因动物，细胞和相关方法
公开(公告)号：US07803982B2
公开(公告)日：2010-09-28
申请号：US10892632
申请日：2004-07-15
申请人： Robert Margolskee , Minqing Rong , Sami Damak
发明人： Robert Margolskee , Minqing Rong , Sami Damak
IPC分类号： A01K67/027 , A01K67/00 , G01N33/00 , C12Q3/00 , A01N1/00 , C12N5/07
CPC分类号： C07K14/723 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the discovery, identification and characterization of a receptor protein, referred to herein as T1R3, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses transgenic animals and cells that do not express functional T1R3 protein, particularly knock-out animals and cells, and transgenic animals and cells that express a non-native T1R3 protein. Experimental model systems based on these animals and cells can be used to study T1R3-mediated taste transduction and responses of the components of the T1R3 signal transduction pathway to various tastants, furthering our understanding of the molecular biology and biochemistry of taste. Such model systems would also be useful for screening for novel tastants and taste modulators, such as enhancers of desirable flavors, and blockers of undesirable flavors.
摘要翻译：本发明涉及受体蛋白的发现，鉴定和鉴定，本文称为T1R3，其在味觉受体细胞中表达并与苦味和甜味的感觉相关。本发明包括不表达功能性T1R3蛋白，特别是敲除动物和细胞的转基因动物和细胞，以及表达非天然T1R3蛋白的转基因动物和细胞。基于这些动物和细胞的实验模型系统可用于研究T1R3介导的味觉转导和T1R3信号转导通路的成分对各种滋味的反应，进一步促进了对分子生物学和味觉生物学的认识。这种模型系统还可用于筛选新颖的滋味剂和味觉调节剂，例如所需香料的增强剂和不期望的香料的阻滞剂。

6. 发明申请

US20050177886A1 T1R3 transgenic animals, cells and related methods 失效
标题翻译： T1R3转基因动物，细胞和相关方法
公开(公告)号：US20050177886A1
公开(公告)日：2005-08-11
申请号：US10892632
申请日：2004-07-15
申请人： Robert Margolskee , Minqing Rong , Sami Damak
发明人： Robert Margolskee , Minqing Rong , Sami Damak
IPC分类号： A61K38/00 , C07K14/72 , A01K67/027 , C12N5/06
CPC分类号： C07K14/723 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the discovery, identification and characterization of a receptor protein, referred to herein as T1R3, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses transgenic animals and cells that do not express functional T1R3 protein, particularly knock-out animals and cells, and transgenic animals and cells that express a non-native T1R3 protein. Experimental model systems based on these animals and cells can be used to study T1R3-mediated taste transduction and responses of the components of the T1R3 signal transduction pathway to various tastants, furthering our understanding of the molecular biology and biochemistry of taste. Such model systems would also be useful for screening for novel tastants and taste modulators, such as enhancers of desirable flavors, and blockers of undesirable flavors.
摘要翻译：本发明涉及受体蛋白的发现，鉴定和鉴定，本文称为T1R3，其在味觉受体细胞中表达并与苦味和甜味的感觉相关。本发明包括不表达功能性T1R3蛋白，特别是敲除动物和细胞的转基因动物和细胞，以及表达非天然T1R3蛋白的转基因动物和细胞。基于这些动物和细胞的实验模型系统可用于研究T1R3介导的味觉转导和T1R3信号转导通路的成分对各种滋味的反应，进一步促进了对分子生物学和味觉生物学的认识。这种模型系统还可用于筛选新颖的滋味剂和味觉调节剂，例如所需香料的增强剂和不期望的香料的阻滞剂。

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