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2. 发明专利

DE102008053242A1 未知
公开(公告)号：DE102008053242A1
公开(公告)日：2010-05-06
申请号：DE102008053242
申请日：2008-10-25
申请人： SALTIGO GMBH
发明人： KREIS MICHAEL , BECKMANN EDITH
IPC分类号： C07D213/02
摘要： Preparation of optionally substituted heteroaryl-aryl ethers (I), comprises reacting an aryloxy compound (II) with substituted heteroaryl ether (III). Preparation of optionally substituted heteroaryl-aryl ethers of formula (ARYL-O-HETEROARYL) (I), comprises reacting an aryloxy compound of formula (ARYL-O ->Kat +>) (II) with a substituted heteroaryl ether of formula (HETEROARYL-Y1) (III). ARYL : 6-20C-aryl (optionally substituted with alkyl (preferably methyl), alkoxy (preferably methoxy), aryl, haloalkyl, haloalkoxy (preferably trifluoromethoxy), haloalkylthio, alkenyl, alkoxycarbonyl, alkoxycarbonylamino, dialkylamino, arylalkyl, halo, haloalkyl, 5-6 membered heteroaryl and/or 3-7 membered saturated or partially unsaturated heterocycle); HETEROARYL : pyrazinyl, pyridyl (preferably 4-pyridyl), pyrimidinyl or pyridazinyl (all optionally substituted with alkyl (preferably methyl), alkenyl, alkoxy (preferably methoxy), alkoxycarbonyl, alkoxycarbonylamino, dialkylamino, aryl, arylalkyl, halo, haloalkyl, haloalkylene, haloalkoxy (preferably trifluoromethoxy), haloalkylthio, 5-6 membered heteroaryl, 3-7 membered saturated or partially unsaturated heterocycle); Kat +>any singly charged cation or a 1/n-equivalent of an n-valent cation; and Y1 : halo or pseudohalo. ACTIVITY : Antidepressant. MECHANISM OF ACTION : None given.

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