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1. 发明专利

JP2013063933A Human neuraminidase inhibitor or chemical chaperone composition 审中-公开
标题翻译：人神经酰胺酶抑制剂或化学药剂组合物
公开(公告)号：JP2013063933A
公开(公告)日：2013-04-11
申请号：JP2011204020
申请日：2011-09-20
申请人： Saitama Univ , 国立大学法人埼玉大学 , Koji Ito , 孝司伊藤
发明人： MATSUOKA KOJI , SUZUKI KAORI , ITO KOJI
IPC分类号： A61K31/7028 , A61P25/00 , A61P43/00 , C07H23/00
摘要： PROBLEM TO BE SOLVED: To provide a hNEU2 inhibitor or a composition showing a chemical chaperone effect on hNEU2.SOLUTION: The human neuraminidase (hNEU2) inhibitor includes: a thiosialooligosaccharide binding dendrimer compound represented by formula (I), a pharmaceutically acceptable salt thereof, or a hydrate of them, and a pharmaceutically acceptable carrier. In the formula: Eand Eare any one of carbon, silicon, and germanium and may be same or different mutually; Rand Rare same of different hydrocarbon groups; R, Rand Rare same or different hydrocarbon chains which may include oxygen, nitrogen and/or a carbonyl group; Ys are thiosialooligosaccharide residue or other substituents and at least one of Ys is a thiosialooligosaccharide residue; l is an integer of 0-2; m is an integer of 0-2; and k is a number of 0 or 1, and 3-m is 1 when k is 0.
摘要翻译：要解决的问题：提供hNEU2抑制剂或对hNEU2显示化学伴侣效应的组合物。人神经氨酸酶（hNEU2）抑制剂包括：由式（I）表示的硫代低聚糖结合树枝状大分子化合物，其药学上可接受的盐或它们的水合物和药学上可接受的载体。在公式中：E 1 和E 2 是碳，硅和锗中的任何一种，并且可以相同或不同 ; R 1 和R 2 与不同的烃基相同; R 3 ，R 4 和R 5 是相同或不同的烃链其可以包括氧，氮和/或羰基; Ys是低聚低聚糖残基或其它取代基，Ys中的至少一个是硫代低聚糖残基; l是0-2的整数; m是0-2的整数; k为0或1的数，当k为0时，3-m为1。版权所有：（C）2013，JPO＆INPIT

2. 发明专利

JP2009292789A Method for producing sialic acid derivative and its use as influenza virus inhibitor 有权
标题翻译：生产水杨酸衍生物的方法及其用作流感病毒抑制剂
公开(公告)号：JP2009292789A
公开(公告)日：2009-12-17
申请号：JP2008150046
申请日：2008-06-09
申请人： Chube Univ , Saitama Univ , 国立大学法人埼玉大学 , 学校法人中部大学
发明人： SUZUKI KAORI , SAKAMOTO JUNICHI , MATSUOKA KOJI , TERUNUMA HIROAKI , HATANO TAKESHI , SUZUKI YASUO
IPC分类号： C07H7/02 , A61K31/7012 , A61K31/7028 , A61P31/12 , C07H15/14
摘要： PROBLEM TO BE SOLVED: To provide a compound effectively inhibiting intrusion of an influenza virus (especially type A virus) into a cell and/or release of the virus from an infected cell.
SOLUTION: Provided are a sialic acid derivative compound expressed by general formula (I) (in the formula, R
1 is a 2-12C alkyl group, alkenyl group containing a double bond or alkynyl group containing a triple bond wherein all groups may contain 1-2 amide bonds; R
2 is a carboxy group, a hydroxy group or a 1-15C alkyl group, alkenyl group or alkynyl group bonded through a sulfide group; and R
3 is a case exchanged with R
2 and is a hydroxy group, or a 1-15C alkyl group, alkenyl group, alkynyl group or a carboxy group bonded through a sulfide group), its pharmacologically permissible salt or hydrate; and an antiviral agent containing the compound or its pharmacologically permissible salt or hydrate as an active component.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供有效地抑制流感病毒（特别是A型病毒）侵入细胞和/或从感染细胞释放病毒的化合物。解决方案：提供由通式（I）表示的唾液酸衍生物化合物（在该式中，R SB 1是/或SB 2是2-12个C烷基，含有双键或炔基的烯基含有三键，其中所有基团可以含有1-2个酰胺键; R SB 2是通过硫化物基团键合的羧基，羟基或1-15C烷基，烯基或炔基 ; R SB 3与R SB 2交换的情况是羟基或1-15C烷基，烯基，炔基或羧基，其通过硫化物组），其药理学上允许的盐或水合物; 和含有该化合物或其药理学允许的盐或水合物作为活性成分的抗病毒剂。版权所有（C）2010，JPO＆INPIT

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