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1. 发明申请

US20090053300A1 MONOCLONAL ANTIBODY, GENE ENCODING THE ANTIBODY, HYBRIDOMA, PHARMACEUTICAL COMPOSITION, AND DIAGNOSTIC REAGENT 审中-公开
标题翻译：单克隆抗体，编码抗体，杂交物，药物组合物和诊断试剂的基因
公开(公告)号：US20090053300A1
公开(公告)日：2009-02-26
申请号：US12279160
申请日：2007-02-23
申请人： Saiko Hosokawa , Yoko Hirakawa , Kazumasa Fukuda , Rieko Nakamura , Yoshiro Saikawa , Masahiko Aoki , Koichiro Kumai
发明人： Saiko Hosokawa , Yoko Hirakawa , Kazumasa Fukuda , Rieko Nakamura , Yoshiro Saikawa , Masahiko Aoki , Koichiro Kumai
IPC分类号： A61K39/395 , C07K16/00 , C12N15/13 , C12N15/85 , A61K39/44 , A61K9/127 , C12N5/10 , C12N5/16
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/73 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57446
摘要： Disclosed is a monoclonal antibody which has a heavy chain variable region containing amino acid sequences depicted in SEQ ID NOs:74, 76 and 78 and a light chain variable region containing amino acid sequences depicted in SEQ ID NOs:80, 82 and 84. The monoclonal antibody can be used as a cancer therapeutic agent which acts selectively on a cancer tissue of non-small lung cancer, pancreatic cancer, gastric cancer or the like.
摘要翻译：公开了具有包含SEQ ID NO：74,76和78所示的氨基酸序列的重链可变区和含有SEQ ID NO：80,82和84所示氨基酸序列的轻链可变区的单克隆抗体。单克隆抗体可以用作非选择性地作用于非小细胞肺癌，胰腺癌，胃癌等癌症组织的癌症治疗剂。

2. 发明授权

US07396915B2 Monoclonal antibody and gene encoding the same, hybridoma, pharmaceutical composition, and diagnostic reagent 失效
标题翻译：单克隆抗体和编码相同的基因，杂交瘤，药物组合物和诊断试剂
公开(公告)号：US07396915B2
公开(公告)日：2008-07-08
申请号：US10546594
申请日：2004-02-27
申请人： Saiko Hosokawa , Masahiko Aoki , Yoko Hirakawa , Seima Itami , Hiroe Umeki , Yoshiro Saikawa , Koichiro Kumai , Kazumasa Fukuda
发明人： Saiko Hosokawa , Masahiko Aoki , Yoko Hirakawa , Seima Itami , Hiroe Umeki , Yoshiro Saikawa , Koichiro Kumai , Kazumasa Fukuda
IPC分类号： C07K16/00
CPC分类号： G01N33/57442 , A61K47/6857 , A61K47/6913 , C07K16/30 , C07K2317/73 , G01N33/57423
摘要： A novel human monoclonal antibody specifically recognizing cancer cells such as non-small cell lung cancer, pancreatic cancer and gastric cancer cells is produced by hybridomas which are obtained by fusing lymphocytes derived from a cancer tissue of a cancer patient with mouse myeloma cells. An anti-cancer drug is obtained by using the antibody alone or anchoring the antibody on the surface of a liposome containing a toxin or an anti-cancer drug encapsulated therein. More specifically, an anti-cancer drug is obtained by using an antibody, in which variable region of its heavy chain comprises the amino acid sequence of SEQ ID NO: 115 and variable region of the light chain comprises the amino acid sequence of SEQ ID NO: 117, alone or anchoring the antibody on the surface of a liposome containing a toxin or an anti-cancer drug encapsulated therein.
摘要翻译：通过将衍生自癌症患者的癌症组织的淋巴细胞与小鼠骨髓瘤细胞融合获得的杂交瘤产生特异性识别癌细胞例如非小细胞肺癌，胰腺癌和胃癌细胞的新型人单克隆抗体。通过单独使用抗体或将抗体锚定在包含毒素或其中的抗癌药物的脂质体的表面上来获得抗癌药物。更具体地，通过使用抗体，其重链的可变区包含SEQ ID NO：115的氨基酸序列并且轻链的可变区包含SEQ ID NO的氨基酸序列：117单独或将抗体锚定在包含其中的毒素或抗癌药物的脂质体的表面上。

3. 发明申请

US20060088538A1 Monoclonal antibody and gene encoding the same, hybridoma, pharmaceutical composition, and diagnostic reagent 失效
标题翻译：单克隆抗体和编码相同的基因，杂交瘤，药物组合物和诊断试剂
公开(公告)号：US20060088538A1
公开(公告)日：2006-04-27
申请号：US10546594
申请日：2004-02-27
申请人： Saiko Hosokawa , Masahiko Aoki , Yoko Hirakawa , Seima Itami , Hiroe Umeki , Yoshiro Saikawa , Koichiro Kumai , Kazumasa Fukuda
发明人： Saiko Hosokawa , Masahiko Aoki , Yoko Hirakawa , Seima Itami , Hiroe Umeki , Yoshiro Saikawa , Koichiro Kumai , Kazumasa Fukuda
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/30
CPC分类号： G01N33/57442 , A61K47/6857 , A61K47/6913 , C07K16/30 , C07K2317/73 , G01N33/57423
摘要： A novel human monoclonal antibody specifically recognizing cancer cells such as non-small cell lung cancer, pancreatic cancer and gastric cancer cells is produced by hybridomas which are obtained by fusing lymphocytes derived from a cancer tissue of a cancer patient with mouse myeloma cells. An anti-cancer drug is obtained by using the antibody alone or anchoring the antibody on the surface of a liposome containing a toxin or an anti-cancer drug encapsulated therein. More specifically, an anti-cancer drug is obtained by using an antibody, in which variable region of its heavy chain comprises the amino acid sequence of SEQ ID NO: 115 and variable region of the light chain comprises the amino acid sequence of SEQ ID NO: 117, alone or anchoring the antibody on the surface of a liposome containing a toxin or an anti-cancer drug encapsulated therein.
摘要翻译：通过将衍生自癌症患者的癌症组织的淋巴细胞与小鼠骨髓瘤细胞融合获得的杂交瘤产生特异性识别癌细胞例如非小细胞肺癌，胰腺癌和胃癌细胞的新型人单克隆抗体。通过单独使用抗体或将抗体锚定在包含毒素或其中的抗癌药物的脂质体的表面上来获得抗癌药物。更具体地，通过使用抗体，其重链的可变区包含SEQ ID NO：115的氨基酸序列并且轻链的可变区包含SEQ ID NO的氨基酸序列：117单独或将抗体锚定在包含其中的毒素或抗癌药物的脂质体的表面上。

4. 发明授权

US4829179A Surface analyzer 失效
标题翻译：表面分析仪
公开(公告)号：US4829179A
公开(公告)日：1989-05-09
申请号：US70252
申请日：1987-07-06
申请人： Masahiko Aoki , Masashi Konishi , Yasuhiro Matsuda , Naoto Okazaki
发明人： Masahiko Aoki , Masashi Konishi , Yasuhiro Matsuda , Naoto Okazaki
IPC分类号： G01N23/20 , G01Q30/04 , G21K1/093 , H01J49/02 , H01J49/14 , H01J49/30
CPC分类号： H01J49/30 , G01N23/20 , G21K1/093 , H01J49/025 , H01J49/142
摘要： A surface analyzer for analyzing physical properties of the surface of a sample by means of PELS (Proton energy loss spectroscopy) in which accelerated ion beams such as proton beams impinge on the sample in the vertical direction to the surface of the sample and ion beams scattered from the sample are decelerated and then detected by an analyzer to analyze the energy loss of the ion beams. The surface analyzer comprises an ion beam source for generating ion beams, deflecting means for deflecting the ion beams from the ion beam source, irradiating the surface of the sample with the ion beams from the ion beam source in the vertical direction to the surface of the sample, and deflecting scattered ion beams from the sample, accelerating and decelerating means for accelerating the ion beams before the ion beams impinge on the sample and decelerating the scattered ion beams, and analyzing means for detecting the scattered beams and analyzing energy loss of the ion beams.
摘要翻译：用于通过PELS（质子能量损失光谱法）分析样品表面的物理性质的表面分析仪，其中质子束等加速离子束在垂直方向上撞击在样品的表面上并且离子束散射从样品减速，然后由分析仪检测，以分析离子束的能量损失。表面分析仪包括用于产生离子束的离子束源，用于偏转来自离子束源的离子束的偏转装置，用垂直方向的离子束源的离子束照射样品的表面采样和偏转来自样品的散射离子束，加速和减速装置，用于在离子束照射在样品上并加速散射的离子束之前加速离子束，以及分析装置，用于检测散射光束并分析离子的能量损失梁。

5. 发明授权

US6160262A Method and apparatus for deflecting charged particles 有权
标题翻译：用于偏转带电粒子的方法和装置
公开(公告)号：US6160262A
公开(公告)日：2000-12-12
申请号：US176110
申请日：1998-10-21
申请人： Masahiko Aoki , Masayasu Tanjyo
发明人： Masahiko Aoki , Masayasu Tanjyo
IPC分类号： C23C14/48 , H01J37/05 , H01J37/317 , H01J49/26 , H01L21/265 , H01J37/30
CPC分类号： H01J49/26 , H01J37/05 , H01J2237/055 , H01J2237/057 , H01J2237/31701
摘要： A large-area ion beam having a one-directionally long section is generated in a magnetically shielded ion source. The ion beam is bent evenly to form a large center angle of about 90 degrees in the direction of the short side by a window/frame type magnet having a large gap and having left and right frames each wound with a plurality of coils. Then, the ion beam is made to pass through a slit plate having a one-directionally long opening so that unnecessary ions are removed. The ion beam is then radiated onto a subject which makes a translational motion in the direction of the short side of the beam.
摘要翻译：在磁屏蔽离子源中产生具有单向长截面的大面积离子束。离子束被均匀地弯曲，以通过具有大间隙的窗/框型磁体在短边方向上形成约90度的大的中心角，并且具有卷绕有多个线圈的左右框架。然后，使离子束通过具有一向长的开口的狭缝板，从而去除不需要的离子。然后将离子束辐射到对象上，该对象在光束的短边方向上进行平移运动。

6. 发明授权

US4866272A Surface analyzer for determining the energy distribution of scattered proton beams 失效
标题翻译：用于确定散射质子束能量分布的表面分析仪
公开(公告)号：US4866272A
公开(公告)日：1989-09-12
申请号：US190070
申请日：1988-05-04
申请人： Masahiko Aoki
发明人： Masahiko Aoki
IPC分类号： G01N23/225 , G01N23/203 , G01Q10/00 , H01J37/252 , H01J49/06 , H01J49/46
CPC分类号： G01N23/203 , H01J49/06 , H01J49/46
摘要： A surface analyzer for analyzing the atomic composition of the surface of sample. An ion source generates a proton beam. A magnet directs the proton beam through an accelerating device toward the sample for collision therewith. Protons that are scattered at an angle of 180.degree. pass through the accelerating device in the reverse direction and are decelerated. The magnet directs the protons as a parallel beam to a position detecting device that indicates the position at which the proton beam strikes and energy loss of the protons can be determined.

7. 发明授权

US07096880B2 Float type steam trap 有权
标题翻译：浮子式疏水阀
公开(公告)号：US07096880B2
公开(公告)日：2006-08-29
申请号：US10616650
申请日：2003-07-09
申请人： Masahiko Aoki , Jiro Sanui
发明人： Masahiko Aoki , Jiro Sanui
IPC分类号： F16T1/24
CPC分类号： F16T1/24 , Y10T137/3068 , Y10T137/7439
摘要： There is provided a float type steam trap having a casing having a float chamber formed with an inflow port and an outflow port. A holder has a flow path communicating with the outflow port. A valve seat on the holder communicates with the outflow port. A float has a float body and a lever with a valve element. One end of the lever is fixed to the float body, and the other end is supported by the holder. The valve element slides with the up-and-down movement of the float body to open and close the valve seat 5.
摘要翻译：提供一种具有带有形成有流入口和流出口的浮动室的壳体的浮动式疏水阀。支架具有与流出口连通的流路。支架上的阀座与流出口连通。浮子具有浮体和具有阀元件的杠杆。杠杆的一端固定在浮体上，另一端由支架支撑。阀体随着浮子体的上下运动而滑动，以打开和关闭阀座5。

8. 发明授权

US06216554B1 Control cable 有权
标题翻译：控制电缆
公开(公告)号：US06216554B1
公开(公告)日：2001-04-17
申请号：US09268885
申请日：1999-03-16
申请人： Hiroshi Kimura , Masahiko Aoki , Kanji Nagayoshi , Kenichi Nishida
发明人： Hiroshi Kimura , Masahiko Aoki , Kanji Nagayoshi , Kenichi Nishida
IPC分类号： F16C126
CPC分类号： F16C1/10 , F16C1/205 , F16C1/26 , Y10T74/20402 , Y10T74/20456
摘要： A control cable with an inner cable having on its outer peripheral surface an inner coating formed of a polyamide synthetic resin while an outer casing having on its inner peripheral surface a liner formed by a mixture of polybutylene terephthalate and a polybutylene decanedicarboxylate copolymer and an elastomer having an epoxy radical containing an olefinic copolymer wherein the elastomer is in a range of 0˜30% by weight of the total resinous composition or mixture of PBT and PBD.
摘要翻译：具有内部电缆的控制电缆在其外周表面上具有由聚酰胺合成树脂形成的内涂层，而外壳在其内周表面上具有由聚对苯二甲酸丁二醇酯和聚丁烯癸二羧酸酯共聚物的混合物形成的衬垫和具有含有烯烃共聚物的环氧基，其中弹性体在总树脂组合物或PBT和PBD的混合物的0〜30重量％的范围内。

9. 发明申请

US20140116189A1 CONTROL CABLE TERMINAL SUPPORTING APPARATUS 审中-公开
标题翻译：控制电缆终端支持设备
公开(公告)号：US20140116189A1
公开(公告)日：2014-05-01
申请号：US14124189
申请日：2012-06-05
申请人： Kazuyoshi Nono , Masahiko Aoki , Yoshikatsu Tsuge , Kazumichi Miyashita
发明人： Kazuyoshi Nono , Masahiko Aoki , Yoshikatsu Tsuge , Kazumichi Miyashita
IPC分类号： F16C1/10
CPC分类号： F16C1/265 , F16C1/108 , F16C2361/65 , Y10T74/2045
摘要： A terminal supporting apparatus 10 supports at least one of two ends of a control cable having an inner cable and an outer cable. The terminal supporting apparatus 10 includes: a hub 12 attached to an end of the outer cable, and having a flange on an outer periphery thereof; a cushion member 14 disposed to surround the outer periphery of the hub, and being in contact with the flange at both a front surface and a rear surface of the flange; and a housing 17 having a housing part that houses the cushion member. When an angle formed between an axis of the housing part and an axis of the hub is varied in a range of 0.0° to 6.0°, a diagonal static spring constant of the cushion member in an axial direction thereof may be in a range of 350 to 600 N/mm.
摘要翻译：终端支持装置10支撑具有内部电缆和外部电缆的控制电缆的两端中的至少一个。终端支持装置10包括：轮毂12，其附接到外部缆线的端部，并且在其外周上具有凸缘; 缓冲构件14，被布置成围绕轮毂的外周并且在凸缘的前表面和后表面处与凸缘接触; 以及具有容纳该缓冲部件的壳体部的壳体17。当在壳体部分的轴线和轮毂的轴线之间形成的角度在0.0°至6.0°的范围内变化时，缓冲构件在其轴向方向上的对角线静态弹簧常数可以在350 至600N / mm。

10. 发明申请

US20050236041A1 Float type steam trap 有权
标题翻译：浮子式疏水阀
公开(公告)号：US20050236041A1
公开(公告)日：2005-10-27
申请号：US10616650
申请日：2003-07-09
申请人： Masahiko Aoki , Jiro Sanui
发明人： Masahiko Aoki , Jiro Sanui
IPC分类号： F16T1/24
CPC分类号： F16T1/24 , Y10T137/3068 , Y10T137/7439
摘要： There is provided a float type steam trap having a casing having a float chamber formed with an inflow port and an outflow port. A holder has a flow path communicating with the outflow port. A valve seat on the holder communicates with the outflow port. A float has a float body and a lever with a valve element. One end of the lever is fixed to the float body, and the other end is supported by the holder. The valve element slides with the up-and-down movement of the float body to open and close the valve seat 5.
摘要翻译：提供一种具有带有形成有流入口和流出口的浮动室的壳体的浮动式疏水阀。支架具有与流出口连通的流路。支架上的阀座与流出口连通。浮子具有浮体和具有阀元件的杠杆。杠杆的一端固定在浮体上，另一端由支架支撑。阀体随着浮子体的上下运动而滑动，以打开和关闭阀座5。

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