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1. 发明专利

JPS5927862A (p-hydroxyphenyl)(perfluoroalkyl)acetonitrile derivative 失效
标题翻译：（对羟基苯基）（全氟代苄基）乙酸衍生物
公开(公告)号：JPS5927862A
公开(公告)日：1984-02-14
申请号：JP13734282
申请日：1982-08-09
申请人： Sagami Chem Res Center
发明人： UMEMOTO TERUO , MIYANO OSAMU
IPC分类号： C07C69/732 , C07C39/24 , C07C51/00 , C07C59/56 , C07C67/00 , C07C253/00 , C07C255/31 , C07C255/36
摘要： NEW MATERIAL:The compound of formula I (Rf is lower perfluoroalkyl; R is H or tertiary alkyl).
EXAMPLE: 4-(1'-Cyano-2',2',2'-trifluoroethyl)-2,6-di-t-butylphenol.
USE: A synthetic intermediate of p-hydroxyphenyl-α-trifluoromethyl-acetic acid or its ester useful as a modifier of cephalosporin.
PROCESS: The compound of formula I can be prepared by the catalytic hydrogenation of the quinone compound of formula II in the presence of a reduction catalyst (e.g. Pd/C). The reaction is preferably carried out in a solvent (e.g. acetonitrile) at 0W60°C. A compound of formula I wherein R is tert-alkyl can be converted to another compound wherein R is H by reacting with aluminum chloride. The compound of formula II used as a starting material can be obtained by reacting a phenol, etc. with (perfluoroalkyl)aryl iodonium salt, and treating the reaction product with a base in the presence of acetocyanhydrin.
COPYRIGHT: (C)1984,JPO&Japio
摘要翻译：新材料：式Ⅰ化合物（Rf为低级全氟烷基; R为H或叔烷基）。实施例：4-（1'-氰基-2' ，2' ，2'-三氟乙基）-2,6-二叔丁基苯酚。用途：对羟基苯基-α-三氟甲基 - 乙酸或其酯可用作头孢菌素修饰剂的合成中间体。方法：式I化合物可以通过在还原催化剂（例如Pd / C）的存在下催化氢化式II的醌化合物来制备。该反应优选在0-60℃的溶剂（例如乙腈）中进行。其中R是叔烷基的式I化合物可以通过与氯化铝反应转化为其中R为H的另一化合物。用作原料的式II化合物可以通过使苯酚等与（全氟烷基）芳基碘鎓盐反应，并在乙酰甘油存在下用碱处理反应产物来获得。

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