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    • 10. 发明申请
    • Process for the enzymatic synthesis of pyroglutamic esters
    • 酶原合成焦谷氨酸酯的方法
    • US20060074259A1
    • 2006-04-06
    • US11240933
    • 2005-09-30
    • Matthias PascalyOliver Thum
    • Matthias PascalyOliver Thum
    • C07C229/00
    • C12P13/14C07D207/28C12P7/6436
    • A process for the preparation of compounds according to the general formula (I), in which R is a hydrocarbon radical of an alcohol, wherein one or more alcohols of the general formula (II) R—OH  (II) in which R is as defined above, are esterified and/or transesterified without using significant amounts of solvents, preferably without solvents, preferably under reduced pressure at temperatures below 100° C. in the presence of enzymes from the class of hydrolases with a compound according to the general formula (III), in which R1 is either hydrogen or a linear or branched alkyl or alkenyl group having 1 to 3 carbon atoms is provided.
    • 一种制备根据通式(I)的化合物的方法,其中R是醇的烃基,其中一种或多种通式(II)的醇<β在线式描述=“In 线性公式“end =”lead“?> R-OH(II)<?in-line-formula description =”在线公式“end =”tail“?>其中R如上定义,被酯化, /或在不使用大量溶剂的情况下,优选不用溶剂,优选在低于100℃的温度下,在来自一类水解酶的酶与根据通式(III)的化合物存在下进行酯交换反应,其中R 提供氢或具有1〜3个碳原子的直链或支链烷基或链烯基。