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1. 发明授权

US08658587B2 Container with a collapsible receptacle and a disinfectant composition 有权
公开(公告)号：US08658587B2
公开(公告)日：2014-02-25
申请号：US13024652
申请日：2011-02-10
申请人： Sabine Behrends , Henning Reinstorff , Andreas Dettmann
发明人： Sabine Behrends , Henning Reinstorff , Andreas Dettmann
IPC分类号： C11D1/66 , C11D3/26 , C11D3/24 , C11D3/43
CPC分类号： B65D35/00 , A01N43/40 , A61L2/18 , A61L2202/15 , A01N2300/00 , A01N25/30 , A01N31/02 , A01N33/12 , A01N47/44
摘要： A container has: a) a collapsible receptacle, the wall of which is designed flexibly such that the internal volume of the receptacle is adapted to the volume of a liquid contained therein, and which has an outlet with an outlet valve; and b) in the receptacle a disinfectant composition in the form of a solution with a content of aliphatic alcohol of at most 20% by weight. It is possible that the disinfectant composition is not contaminated with spores or other germs also after the container has been opened, even upon repeated discharge from the container.

2. 发明授权

US08815912B2 Wound and mucosa antiseptic based on bispyridiniumalkanes 有权
标题翻译：基于双吡啶基烷烃的伤口和粘膜防腐剂
公开(公告)号：US08815912B2
公开(公告)日：2014-08-26
申请号：US12904424
申请日：2010-10-14
申请人： Boris Baur , Sabine Behrends , Jörg Siebert , Andreas Dettmann , Mona Golombiewski
发明人： Boris Baur , Sabine Behrends , Jörg Siebert , Andreas Dettmann , Mona Golombiewski
IPC分类号： A01N43/40 , A61K31/44 , A61K9/00 , A61K9/08 , A61K47/10
CPC分类号： A61K9/0014 , A61K9/08 , A61K31/44 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/183
摘要： The invention relates to an antimicrobially effective composition which comprises a) 0.001 to 1% by weight of bispyridiniumalkane, b) humectant and c) water. The composition has an osmolality of from 230 to 350 mOsmol/kg and is free from surfactant. It is used as wound and mucosa antiseptic.
摘要翻译：本发明涉及一种抗微生物有效的组合物，其包含：a）0.001至1重量％的双吡啶烷烃，b）保湿剂和c）水。组合物的重量摩尔渗透压浓度为230至350mOsmol / kg，不含表面活性剂。用作伤口和粘膜消毒剂。

3. 发明授权

US08541454B2 Antiseptic based on bispyridinium alkanes 有权
标题翻译：基于双吡啶烷烃的防腐剂
公开(公告)号：US08541454B2
公开(公告)日：2013-09-24
申请号：US13156635
申请日：2011-06-09
申请人： Sabine Behrends , Andreas Dettmann , Mona Golombiewski , Elke Kassens
发明人： Sabine Behrends , Andreas Dettmann , Mona Golombiewski , Elke Kassens
IPC分类号： A01N43/40 , A61K31/4425
CPC分类号： A61K9/0014 , A01N43/40 , A61K31/4425 , A61K47/10 , A01N2300/00 , A01N25/12
摘要： An antimicrobially effective composition includes a) at least 0.15% by weight of bispyridinium alkane, b) at least 3.5% by weight of humectant and c) water. Upon dilution with water, the composition produces a solution with an osmolality of from 230 to 350 mOsmol/kg and is free from surfactant. It is used as an antiseptic and is suitable for use in a method for the disinfection of injured or uninjured skin of a human being or animal, preference being given to use in the case of newborns, in particular those born prematurely.
摘要翻译：抗微生物组合物包括a）至少0.15重量％的双吡啶烷烃，b）至少3.5重量％的湿润剂和c）水。用水稀释后，组合物产生的重量摩尔渗透压浓度为230至350mOsmol / kg，不含表面活性剂。它用作防腐剂，并且适用于消毒人或动物的受伤或未受伤皮肤的方法，优选在新生儿的情况下使用，特别是过早出生的那些。

4. 发明授权

US07846947B2 Use of octenidine dihydrochloride in semisolid preparations 有权
标题翻译：在半固体制剂中使用二氢氯辛烷
公开(公告)号：US07846947B2
公开(公告)日：2010-12-07
申请号：US12066832
申请日：2006-09-12
申请人： Jorg Siebert , Mona Golombiewski , Rita Blankenburg , Peter Goroncy-Bermes , Andreas Dettmann , Sabine Behrends
发明人： Jorg Siebert , Mona Golombiewski , Rita Blankenburg , Peter Goroncy-Bermes , Andreas Dettmann , Sabine Behrends
IPC分类号： A61K31/444 , A61P17/02 , A61P17/00 , A61P17/10 , A01N25/04
CPC分类号： A61K9/0014 , A61K9/0031 , A61K9/0034 , A61K31/4409 , A61K47/10 , A61K47/38 , A61K47/44 , Y10S514/944 , Y10S514/967
摘要： The invention relates to the use of octenidine dihydrochloride for manufacturing a semisolid pharmaceutical composition for the treatment of wounds, atopic dermatitides, infected eczemas, dermatomycoses, vaginal infections, acne, herpes and/or for controlling multidrug-resistant pathogens, where the composition comprises from 0.005 to 5% by weight octenidine dihydrochloride, and a corresponding composition.
摘要翻译：本发明涉及用于制备用于治疗伤口，特应性皮肤病，感染的湿疹，皮肤真菌病，阴道感染，痤疮，疱疹和/或用于控制多药耐药病原体的半固体药物组合物的用途，其中组合物包含 0.005〜5重量％的辛烯二酸二盐酸盐，以及相应的组成。

5. 发明申请

US20110003857A1 STABILIZED, ANTIMICROBIALLY EFFECTIVE COMPOSITION WITH A CONTENT OF BISPYRIDINIUM ALKANE 有权
标题翻译：具稳定性，具有双嘧丝巴碱含量的抗微生物有效成分
公开(公告)号：US20110003857A1
公开(公告)日：2011-01-06
申请号：US12919523
申请日：2009-02-18
申请人： Wolfgang Beilfuss , Andreas Dettmann , Sabine Behrends , Mona Golombiewski , Thomas Spuida , Elke Kassens
发明人： Wolfgang Beilfuss , Andreas Dettmann , Sabine Behrends , Mona Golombiewski , Thomas Spuida , Elke Kassens
IPC分类号： A61K31/444 , A61P31/04
CPC分类号： A61K31/4425 , A01N43/40 , A61K8/4926 , A61Q11/00 , A61Q17/005 , A01N25/22 , A01N25/30 , A01N2300/00
摘要： An aqueous-based composition which includes a) at least one bispyridinium alkane (for example octenidine) and b) at least one stabilizer selected from antioxidants, complexing agents, reducing agents, UV filters and photoprotective agents, in particular α-tocopherol, and BHT. The composition can also include c) one or more auxiliaries selected from, for example, nonionic surfactants, ethers, solvents and polymers, in particular fatty alcohol alkoxylates and alkoxylated fatty acid monoglycerides. The presence of the stabilizer reduces or prevents the appearance of decomposition products of bispyridinium alkanes and, in the case of the presence of auxiliaries, of decomposition products of the auxiliaries, such as ethers and peroxides.
摘要翻译：一种水基组合物，其包含a）至少一种双吡啶烷烃（例如，辛烯尼酸）和b）至少一种稳定剂，其选自抗氧化剂，络合剂，还原剂，UV过滤剂和光保护剂，特别是α-生育酚和BHT 。组合物还可以包括c）一种或多种选自例如非离子表面活性剂，醚，溶剂和聚合物，特别是脂肪醇烷氧基化物和烷氧基化脂肪酸单甘油酯的助剂。稳定剂的存在降低或防止双吡啶烷烃的分解产物的出现，以及在助剂的存在的情况下，助剂如醚和过氧化物的分解产物的出现。

6. 发明授权

US06376547B1 Tuberculocidal disinfectant 失效
标题翻译：结核消毒剂
公开(公告)号：US06376547B1
公开(公告)日：2002-04-23
申请号：US09231632
申请日：1999-01-15
申请人： Sabine Behrends , Andreas Dettmann , Michael Mohr
发明人： Sabine Behrends , Andreas Dettmann , Michael Mohr
IPC分类号： A61K3100
CPC分类号： A01N37/44 , A01N47/44 , A01N33/12 , A01N39/00 , A01N25/30 , A01N2300/00
摘要： The invention relates to the use of an N,N′-substituted glycine or of an N,N′-substituted derivative of glycine (a) of the general formula I in which R1 is hydrogen or a straight-chain or branched, saturated or unsaturated alkyl, alkaryl or aralkyl radical having 1 to 30 C atoms, which can optionally contain heteroatoms such as O, S and N, R2 is a straight-chain or branched, saturated or unsaturated alkyl, alkaryl or aralkyl radical having 1 to 30 C atoms containing at least one primary, secondary or tertiary amino group and X is OH, OR3, NH2, NHR4, NR4R5 or O−M+, where R3, R4 and R5 are straight-chain or branched, saturated or unsaturated alkyl, alkaryl or aralkyl radicals which can be identical to or different from one another, and M is a metal cation, as active compound in a tuberculocidal disinfectant.
摘要翻译：本发明涉及使用N，N'-取代的甘氨酸或N，N-取代的甘氨酸衍生物（a），其通式为Iin，其中R 1为氢或直链或支链，饱和或不饱和的具有1至30个C原子的烷基，烷芳基或芳烷基，其可以任选地含有杂原子如O，S和N，R 2是具有1至30个C原子的直链或支链，饱和或不饱和的烷基，烷芳基或芳烷基含有至少一个伯，仲或叔氨基，X是OH，OR 3，NH 2，NHR 4，NR 4 R 5或O-M +，其中R 3，R 4和R 5是直链或支链，饱和或不饱和的烷基，烷芳基或芳烷基其可以相同或不同，M是金属阳离子，作为结核消毒剂中的活性化合物。

7. 发明授权

US08609697B2 Stabilized, antimicrobially effective composition with a content of bispyridinium alkane 有权
标题翻译：具有双吡啶烷烃含量的稳定的抗微生物组合物
公开(公告)号：US08609697B2
公开(公告)日：2013-12-17
申请号：US12919523
申请日：2009-02-18
申请人： Wolfgang Beilfuss , Andreas Dettmann , Sabine Behrends , Mona Golombiewski , Thomas Spuida , Elke Kassens
发明人： Wolfgang Beilfuss , Andreas Dettmann , Sabine Behrends , Mona Golombiewski , Thomas Spuida , Elke Kassens
IPC分类号： A01N43/40 , A61K31/4425
CPC分类号： A61K31/4425 , A01N43/40 , A61K8/4926 , A61Q11/00 , A61Q17/005 , A01N25/22 , A01N25/30 , A01N2300/00
摘要： An aqueous-based composition which includes a) at least one bispyridinium alkane (for example octenidine) and b) at least one stabilizer selected from antioxidants, complexing agents, reducing agents, UV filters and photoprotective agents, in particular α-tocopherol, and BHT. The composition can also include c) one or more auxiliaries selected from, for example, nonionic surfactants, ethers, solvents and polymers, in particular fatty alcohol alkoxylates and alkoxylated fatty acid monoglycerides. The presence of the stabilizer reduces or prevents the appearance of decomposition products of bispyridinium alkanes and, in the case of the presence of auxiliaries, of decomposition products of the auxiliaries, such as ethers and peroxides.
摘要翻译：一种水基组合物，其包含a）至少一种双吡啶烷烃（例如，辛烯尼酸）和b）至少一种选自抗氧化剂，络合剂，还原剂，UV过滤剂和光保护剂，特别是α-生育酚和BHT的稳定剂。组合物还可以包括c）一种或多种选自例如非离子表面活性剂，醚，溶剂和聚合物，特别是脂肪醇烷氧基化物和烷氧基化脂肪酸单甘油酯的助剂。稳定剂的存在降低或防止双吡啶烷烃的分解产物的出现，以及在助剂的存在的情况下，助剂如醚和过氧化物的分解产物的出现。

8. 发明授权

US08404261B2 Antimicrobially active composition having a content of bispyridium alkane (octenidine dihydrochloride) 有权
标题翻译：具有双吡啶烷烃含量（辛烯氢化二辛酸盐）的抗微生物活性组合物
公开(公告)号：US08404261B2
公开(公告)日：2013-03-26
申请号：US12447024
申请日：2007-10-23
申请人： Sabine Behrends , Boris Baur , Thomas Spuida , Andreas Dettmann
发明人： Sabine Behrends , Boris Baur , Thomas Spuida , Andreas Dettmann
IPC分类号： A01N25/00 , A01N25/34
CPC分类号： A61Q11/00 , A61K8/34 , A61K8/345 , A61K8/922 , A61K31/444
摘要： A description is given according to the invention of a composition on an aqueous basis which comprises a) 0.001 to 10% by weight bispyridinium alkane, b) 0.1 to 30% by weight nonionic surfactant, c) 0 to 40% by weight aromatic alcohol and d) 0.01 to 10% by weight polyol selected from alkanediols and alkanetriols. The compositions, as mouthwash solutions, are more active than current commercial products and are distinguished by a pleasant taste and low tendency to foaming.
摘要翻译：根据本发明的水性组合物的描述，其包含a）0.001至10重量％的双吡啶烷烃，b）0.1至30重量％的非离子表面活性剂，c）0至40重量％的芳族醇和 d）选自烷二醇和烷三醇的0.01至10重量％的多元醇。作为漱口液的组合物比当前的商品更具有活性，并且具有令人愉悦的味道和低起泡性的特征。

9. 发明申请

US20110092543A1 Wound And Mucosa Antiseptic Based on Bispyridiniumalkanes 有权
标题翻译：基于双歧杆菌烷烃的伤口和粘膜防腐剂
公开(公告)号：US20110092543A1
公开(公告)日：2011-04-21
申请号：US12904424
申请日：2010-10-14
申请人： Boris Baur , Sabine Behrends , Jörg Siebert , Andreas Dettmann , Mona Golombiewski
发明人： Boris Baur , Sabine Behrends , Jörg Siebert , Andreas Dettmann , Mona Golombiewski
IPC分类号： A61K31/444 , A61P31/00 , A61P31/02
CPC分类号： A61K9/0014 , A61K9/08 , A61K31/44 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/183
摘要： The invention relates to an antimicrobially effective composition which comprises a) 0.001 to 1% by weight of bispyridiniumalkane, b) humectant and c) water. The composition has an osmolality of from 230 to 350 mOsmol/kg and is free from surfactant. It is used as wound and mucosa antiseptic.
摘要翻译：本发明涉及一种抗微生物有效的组合物，其包含：a）0.001至1重量％的双吡啶烷烃，b）保湿剂和c）水。组合物的重量摩尔渗透压浓度为230至350mOsmol / kg，不含表面活性剂。用作伤口和粘膜消毒剂。

10. 发明申请

US20110076242A1 Antimicrobially Active Composition Having A Content Of Bispyridium Alkane (Octenidine Dihydrochloride) 有权
标题翻译：具有双嘧啶烷烷的含量的抗微生物活性组合物（二氢化茚二酮盐酸盐）
公开(公告)号：US20110076242A1
公开(公告)日：2011-03-31
申请号：US12447024
申请日：2007-10-23
申请人： Sabine Behrends , Boris Baur , Thomas Spuida , Andreas Dettmann , Joachim Thiede
发明人： Sabine Behrends , Boris Baur , Thomas Spuida , Andreas Dettmann , Joachim Thiede
IPC分类号： A61K8/49 , A01N43/40 , A61Q11/00 , A01P1/00
CPC分类号： A61Q11/00 , A61K8/34 , A61K8/345 , A61K8/922 , A61K31/444
摘要： A description is given according to the invention of a composition on an aqueous basis which comprises a) 0.001 to 10% by weight bispyridinium alkane, b) 0.1 to 30% by weight nonionic surfactant, c) 0 to 40% by weight aromatic alcohol and d) 0.01 to 10% by weight polyol selected from alkanediols and alkanetriols. The compositions, as mouthwash solutions, are more active than current commercial products and are distinguished by a pleasant taste and low tendency to foaming.
摘要翻译：根据本发明的水性组合物的描述，其包含a）0.001至10重量％的双吡啶烷烃，b）0.1至30重量％的非离子表面活性剂，c）0至40重量％的芳族醇和 d）选自烷二醇和烷三醇的0.01至10重量％的多元醇。作为漱口液的组合物比当前的商品更具有活性，并且具有令人愉悦的味道和低起泡性的特征。

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