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1. 发明专利

AU6334901A Radiation therapy device having controllable radiation emission 未知
公开(公告)号：AU6334901A
公开(公告)日：2001-12-03
申请号：AU6334901
申请日：2001-05-21
申请人： SYNTHEON LLC
发明人： SLATER CHARLES R , JAHRMARKT SCOTT L , SMITH SCOTT T , SMITH KEVIN W
IPC分类号： A61M36/12 , A61N5/10 , A61N5/00
摘要： An implantable radiation therapy device includes a biocompatible radiotranslucent outer capsule containing a radiation shielding element and a radioactive isotope at least partially shielded by the shielding element. When the device is at or below body temperature, radiation is prevented or limited from being transmitted through the outer capsule by the shielding element. When non-ambient energy is applied to the device, the shielding element and radioactive isotope are reconfigured such that an increased level of radiation is transmitted through the outer capsule and emitted by the device.

2. 发明专利

AU1818500A Implantable brachytherapy device having at least partial deactivation capability 未知
公开(公告)号：AU1818500A
公开(公告)日：2000-06-19
申请号：AU1818500
申请日：1999-11-12
申请人： SYNTHEON LLC
发明人： SLATER CHARLES R , JAHRMARKT SCOTT L , SMITH SCOTT T , SMITH KEVIN W
IPC分类号： A61M36/12 , A61N5/10 , A61N5/00
摘要： An implantable brachytherapy device includes a biocompatible outer capsule containing a radiation shielding element and a radioactive isotope between the shielding element and the wall of the outer capsule. When the device is at body temperature, radiation is emitted by the isotope through the wall of the outer capsule. When a predetermined amount of energy is applied to the device, the shielding element is adapted to at least partially surround the isotope, and thereby at least partially prevent the transmission of radiation through the outer capsule.

3. 发明专利

AU1196400A Improved radioactive therapeutic seeds and methods of making the same 未知
公开(公告)号：AU1196400A
公开(公告)日：2000-03-06
申请号：AU1196400
申请日：1999-08-12
申请人： SYNTHEON LLC
发明人： SLATER CHARLES R , JAHRMARKT SCOTT L , SMITH SCOTT T
IPC分类号： A61M36/00 , A61M36/12 , A61N5/10 , A61N5/00
摘要： Radioactive therapeutic seeds include a substantially cylindrical capsule containing a radioactive isotope and, preferably, a radiopaque marker. According to one embodiment, the capsule is made of titanium or stainless steel, the isotope is deposited on the surface of a hollow cylinder and a titanium or stainless steel tube is disposed inside the hollow cylinder. The capsule is sealed by swaging the end of the capsule against the inner tube and welding the swaged end and tube. The inner tube facilitates swaging and protects the contents of the capsule from the heat of welding. In alternate embodiments, a radiopaque marker is disposed inside the inner tube or the cylinder bearing the radioisotope is radiopaque. According to other embodiments, a gripping stem is installed on one or both ends of a capsule, a capsule is made of very thin material with rotary swaged ends welded shut and a supporting structure inside the capsule, a meltable isotope mixture is used to coat the interior of a capsule, a capsule is assembled from two halves which are placed over an interior tube and the halves are butt welded, a capsule is made of a borosilicate or elemental silicon glass tube with ends melted to seal the capsule. Bioabsorbable spacers are provided for use with seeds having gripping/linking stems so that seeds are linked together.

4. 发明申请

WO0009211A9 IMPROVED RADIOACTIVE THERAPEUTIC SEEDS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：改进的放射性治疗种子及其制备方法
公开(公告)号：WO0009211A9
公开(公告)日：2000-08-03
申请号：PCT/US9918384
申请日：1999-08-12
申请人： SYNTHEON LLC , SLATER CHARLES R , JAHRMARKT SCOTT L , SMITH SCOTT T
发明人： SLATER CHARLES R , JAHRMARKT SCOTT L , SMITH SCOTT T
IPC分类号： A61M36/00 , A61M36/12 , A61N5/10 , A61N5/00
CPC分类号： A61N5/1027 , A61N2005/1005 , A61N2005/1023 , A61N2005/1024
摘要： Radioactive therapeutic seeds (10) include a substantially cylindrical capsule (12) containing a radioactive isotope (16), and preferably, a radiopaque marker (18). According to one embodiment, the capsule (12) is made of titanium or stainless steel. The isotope (16) is deposited on the surface of a hollow cylinder (14). A titanium or stainless steel tube (20) is disposed inside the hollow cylinder (14). The capsule (12) is sealed by swaging the end of the capsule (12) against the inner tube (20), welding the swaged end and tube. The inner tube (20) facilitates swaging and protects the contents of the capsule (12) from the heat of welding.
摘要翻译：放射性治疗种子（10）包括含有放射性同位素（16），优选不透射线标记（18）的基本上圆柱形的胶囊（12）。根据一个实施例，胶囊（12）由钛或不锈钢制成。同位素（16）沉积在中空圆柱体（14）的表面上。钛或不锈钢管（20）设置在中空圆筒（14）内。胶囊（12）通过将胶囊（12）的端部压靠内管（20）而被密封，焊接模压的端部和管。内管（20）便于型锻并且保护胶囊（12）的内容物免受焊接热量的影响。

5. 发明专利

CA2352581A1 IMPLANTABLE BRACHYTHERAPY DEVICE HAVING AT LEAST PARTIAL DEACTIVATION CAPABILITY 未知
公开(公告)号：CA2352581A1
公开(公告)日：2000-06-08
申请号：CA2352581
申请日：1999-11-12
申请人： SYNTHEON LLC
发明人： SLATER CHARLES R , JAHRMARKT SCOTT L , SMITH SCOTT T , SMITH KEVIN W
IPC分类号： A61M36/12 , A61N5/10 , A61N5/00
摘要： An implantable brachy-therapy device (10) includes a bio-compatible outer capsule (14) containing a radiation shielding element (30), and radioactive isotope (26) between the shielding element, and the wall of the outer capsul e. When the device is at body temperature, radiation is emitted by the isotope through the wall of the outer capsule. When a predetermined amount of energy is applied to the device, the shielding element is adapted to at least partially surround the isotope, and thereby at least partially prevent the transmission of radiation through the outer capsule.

6. 发明专利

AU5773999A Radioactive seed and method of making 未知
公开(公告)号：AU5773999A
公开(公告)日：2000-03-06
申请号：AU5773999
申请日：1999-08-12
申请人： SYNTHEON LLC
发明人： SLATER CHARLES R , JAHRMARKT SCOTT L , SMITH SCOTT T
IPC分类号： A61M36/12 , A61N5/10 , A61N5/00

7. 发明专利

AU5558499A Radioactive therapeutic seeds 未知
公开(公告)号：AU5558499A
公开(公告)日：2000-03-06
申请号：AU5558499
申请日：1999-08-12
申请人： SYNTHEON LLC
发明人： SLATER CHARLES R , JAHRMARKT SCOTT L , SMITH SCOTT T
IPC分类号： A61M36/12 , A61N5/10 , A61M36/00 , A61N5/00
摘要： Radioactive therapeutic seeds include a two part seed capsule, a radioactive isotope, and, preferably, a radiopaque marker. According to the invention, the seed capsule has an outer part, and an inner part which fits into the outer part and which carries the radioactive isotope. The capsule is sealed by welding the end(s) of the inner part to the end(s) of the outer part. According to one embodiment, the outer part of the seed capsule is a cylinder with one open end and one closed end. The inner part of the seed capsule has a reduced diameter portion which carries the isotope and a larger diameter portion which mates with the open end of the cylinder. According to another embodiment, the outer part of the seed capsule is a cylinder with two open ends. The inner part has a reduced diameter portion which carries the isotope and two larger diameter portions which mate with the open ends of the cylinder. According to some embodiments of the invention, the isotope is carried on a radiopaque structure which is mounted on the reduced diameter portion of the inner part of the seed capsule. According to another embodiment, the inner part of the seed capsule is a hollow member. According to another embodiment, the inner part of the seed capsule is made of radiopaque material.

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