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2. 发明公开

EP0289227A1 Substituted imidazolyl-alkyl-piperazine and -diazepine derivatives 失效
标题翻译：取代基咪唑基烷基 - 哌嗪并 - 二氮杂衍生物。
公开(公告)号：EP0289227A1
公开(公告)日：1988-11-02
申请号：EP88303646.9
申请日：1988-04-22
申请人： SYNTEX PHARMACEUTICALS LTD.
发明人： Pascal, Jean-Claude , Lee, Chi-Ho , Alps, Brian J. , Pinhas, Henri , Whiting, Roger L. , Beranger, Serge
IPC分类号： C07D233/64 , C07D403/06 , A61K31/415 , A61K31/435
CPC分类号： C07D233/64 , C07D403/06
摘要： Substituted imidazolyl-alkyl-piperazine and diazepine derivatives of Formula A:
wherein:
R¹ is aryl;
R² is aryl, C₁₋₄ alkyl, or hydrogen;
R³ is C₁₋₄ alkyl, hydroxy, or hydrogen;
R⁴ is aryl;
R⁵ is aryl;
m is two or three;
n is zero, one or two,
provided that when R³ is hydroxy, n is one or two; and
q is zero, one, two, or three;
and the pharmaceutically acceptable salts thereof, are useful for treating mammals having a variety of disease states, such as stroke, epilepsy or epileptic psychotic symptoms, hypertension, angina, migraine, arrhythmia, thrombosis, embolism, acute cardiac failure, irritable bowel syndrome, neurodegenerative diseases such as Alzheimer's or Huntington's chorea, diuresis, ischemia such as focal and global ischemia or cerebrovascular ischemia induced by cocaine abuse, and also for treatment of spinal injuries.
摘要翻译：式A的取代的咪唑烷基 - 哌嗪和二氮杂衍生物：其中：R 1是芳基; R 2是芳基，C 1-4烷基或氢; R 3是C 1-4烷基，羟基或氢; R 4是芳基; R 5是芳基; m是两三个; n为零，一或二，条件是当R 3为羟基时，n为1或2; q为零，一，二或三; 可用于治疗具有多种疾病状态的哺乳动物，如中风，癫痫或癫痫精神病症状，高血压，心绞痛，偏头痛，心律失常，血栓形成，栓塞，急性心力衰竭，肠易激综合征，神经变性诸如阿尔茨海默病或亨廷顿氏舞蹈病等疾病，利尿，局限性局部缺血，可卡因滥用引起的全脑缺血或脑血管缺血，也用于治疗脊髓损伤。

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