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1. 发明专利

CA2587590A1 PYRIMIDINE COMPOUNDS AND USES THEREOF 未知
公开(公告)号：CA2587590A1
公开(公告)日：2006-06-08
申请号：CA2587590
申请日：2005-11-18
申请人： SYNTA PHARMACEUTICALS CORP
发明人： LU RONGZHEN , WADA YUMIKO , HSIA ALBERT Y
IPC分类号： A61K31/5377
摘要： This invention features pyrimidine compounds of formula (I): Rt is aryl, or heteroaryl; each of R2 and R4, independently, is halogen, nitro, cyano, isothionitro, SRc, or ORc; or R2 and R4, taken together, is carbonyl; R3 is Rc, alkenyl, alkynyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl. The featured compounds inhibit the production of IL-12, IL-23 and IL-27 and are useful for treating disorders associated with IL-12, IL-23 and IL-27 overproduction or misregulation, such as inflammatory and immune disorders,

2. 发明专利

AU2005310143A1 Pyrimidine compounds and uses thereof 未知
公开(公告)号：AU2005310143A1
公开(公告)日：2006-06-08
申请号：AU2005310143
申请日：2005-11-18
申请人： SYNTA PHARMACEUTICALS CORP
发明人： HSIA ALBERT Y , LU RONGZHEN , WADA YUMIKO
IPC分类号： A61K31/5377
摘要： This invention features pyrimidine compounds of formula (I): Rt is aryl, or heteroaryl; each of R2 and R4, independently, is halogen, nitro, cyano, isothionitro, SRc, or ORc; or R2 and R4, taken together, is carbonyl; R3 is Rc, alkenyl, alkynyl, ORc, OC(O)Rc, SO2Rc, S(O)Rc, S(O2)NRcRd, NRcRd, NRcCORd, NRcC(O)ORd, NRcC(O)NRcRd, NRcSO2Rd, CORc, C(O)ORc, or C(O)NRcRd; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is O, S, S(O), S(O2), or NRc; Y is a covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which each of Ra and Rb, independently, is H, alkyl, aryl, heteroaryl; and each of Rc and Rd, independently, is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl. The featured compounds inhibit the production of IL-12, IL-23 and IL-27 and are useful for treating disorders associated with IL-12, IL-23 and IL-27 overproduction or misregulation, such as inflammatory and immune disorders,

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