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1. 发明公开

EP2625185A4 ANTI-INFLAMMATORY MACROLIDES 审中-公开
标题翻译：抗炎大环内酯类
公开(公告)号：EP2625185A4
公开(公告)日：2014-03-26
申请号：EP11833216
申请日：2011-10-10
申请人： SYNOVO GMBH , BURNET MICHAEL
发明人： BURNET MICHAEL , GUSE JAN-HINRICH , BAEUERLEIN CHRISTIANE , EGGERS MARY
IPC分类号： C07H17/08 , A61K31/7048 , A61P29/00 , C07D413/12
CPC分类号： C07H17/08

2. 发明申请

WO2012051126A3 ANTI-INFLAMMATORY MACROLIDES 审中-公开
标题翻译：抗炎药物
公开(公告)号：WO2012051126A3
公开(公告)日：2012-08-16
申请号：PCT/US2011055657
申请日：2011-10-10
申请人： SYNOVO GMBH , BURNET MICHAEL , GUSE JAN-HINRICH , BAEUERLEIN CHRISTIANE , EGGERS MARY
发明人： BURNET MICHAEL , GUSE JAN-HINRICH , BAEUERLEIN CHRISTIANE , EGGERS MARY
IPC分类号： C07H17/08 , A61K31/7048 , A61P29/00 , C07D413/12
CPC分类号： C07H17/08
摘要： The invention provides novel compounds and compositions and methods for making and using the compounds and compositions.
摘要翻译：本发明提供了用于制备和使用化合物和组合物的新型化合物及其组合物和方法。

3. 发明申请

WO2005027828A3 CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE, FORMULATION AND PHARMACEUTICAL APPLICATIONS THEREOF 审中-公开
标题翻译：生物活性化合物的结合，其制备和使用方法，制剂和药物应用
公开(公告)号：WO2005027828A3
公开(公告)日：2005-07-28
申请号：PCT/US2004026485
申请日：2004-08-16
申请人： SYNOVO GMBH , GUTKE HANS-JURGEN , FLOHR CHRISTIAN , BECK ALBERT , MARGUTTI SIMONA , EGGERS MARY , GUSE JAN-HINRICH , KHOBZAOUI MOUSSA , BURNET MICHAEL
发明人： GUTKE HANS-JURGEN , FLOHR CHRISTIAN , BECK ALBERT , MARGUTTI SIMONA , EGGERS MARY , GUSE JAN-HINRICH , KHOBZAOUI MOUSSA , BURNET MICHAEL
IPC分类号： A01N43/04 , A61K20060101 , A61K47/48 , A61K49/00 , C07G11/00 , C07H15/00 , C07H17/08
CPC分类号： C07H15/00 , A61K47/54 , A61K47/545 , A61K47/549 , A61K49/0004 , C07H17/08
摘要： This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.
摘要翻译：本发明的特征在于下式的化合物：T - （ - LC）m，T是转运载体，L是分子量高达240道尔顿的键或连接体，C是非抗生素治疗剂，m 是1,2,3,4,5,6,7或8，其中转运载体具有至少2的免疫选择性比，转运载体通过键或连接体与非抗生素治疗剂共价结合，化合物的免疫选择比至少为2。

4. 发明申请

WO2011100769A3 KINASE MODULATORS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的激酶调节剂
公开(公告)号：WO2011100769A3
公开(公告)日：2011-12-01
申请号：PCT/US2011024947
申请日：2011-02-15
申请人： SYNOVO GMBH , BURNET MICHAEL , GUSE JAN-HINRICH , BAUERLEIN CHRISTIANE , HAHN ULRIKE
发明人： BURNET MICHAEL , GUSE JAN-HINRICH , BAUERLEIN CHRISTIANE , HAHN ULRIKE
IPC分类号： A61K31/4439 , A61K31/4427 , A61P35/00
CPC分类号： C07D231/38 , A61K31/415 , A61K31/4439 , A61K31/519 , A61K45/06 , A61K47/481 , A61K47/55 , C07D401/04 , C07D405/14 , C07D417/04 , C07D471/04 , C07H13/02 , A61K2300/00
摘要： A method of treating cancer in which a compound that inhibits the expression, production or release of IL-IO by immune cells is combined with a compound that stimulates the production of IL- 12 when given in combination with, or in the presence of TNFa. Said method is effective when provided in addition to standard therapies, notably chemotherapy using cytotoxic drugs and other forms of immune therapy including therapeutic vaccines.
摘要翻译：一种治疗癌症的方法，其中当与TNFα组合或存在时，将抑制免疫细胞的IL-10表达，产生或释放的化合物与刺激IL-12产生的化合物组合。所述方法除了提供标准疗法外，特别是使用细胞毒性药物和其它形式的免疫治疗包括治疗性疫苗的化学疗法是有效的。

5. 发明专利

IL262004D0 Detecting microbial infections in wounds 未知
公开(公告)号：IL262004D0
公开(公告)日：2018-10-31
申请号：IL26200418
申请日：2018-09-27
申请人： SYNOVO GMBH , CONVATEC TECHNOLOGIES INC , BURNET MICHAEL , QUALIZYME DIAGNOSTICS GMBH AND CO KG , BOWLER PHILIP , WROE SARAH , STEVEN JADE , METCALF DANIEL GARY , PARSONS DAVID , BALLAMY LUCY , HEINZLE ANDREA , SIGL EVA , LUSCHNIG DANIEL , GAMERITH CLEMENS
发明人： BURNET MICHAEL , BOWLER PHILIP , WROE SARAH , STEVEN JADE , METCALF DANIEL GARY , PARSONS DAVID , BALLAMY LUCY , HEINZLE ANDREA , SIGL EVA , LUSCHNIG DANIEL , GAMERITH CLEMENS
IPC分类号： A61F20060101
摘要： Provided herein are microbial infection indicator devices, including dressing with indicators, standalone indicator inserts or disks that can be freely placed at a wound site or dressing, and applications thereof for displaying a visible or detectable signal to a user upon detection of an analyte or biomarker indicative of an infection, such as a color change.

6. 发明专利

CA2814333A1 ANTI-INFLAMMATORY MACROLIDES 未知
公开(公告)号：CA2814333A1
公开(公告)日：2012-04-19
申请号：CA2814333
申请日：2011-10-10
申请人： SYNOVO GMBH , BURNET MICHAEL
发明人： GUSE JAN-HINRICH , BAEUERLEIN CHRISTIANE , EGGERS MARY , BURNET MICHAEL
IPC分类号： C07H17/08 , A61K31/7048 , A61P29/00 , C07D413/12
摘要： The invention provides novel compounds and compositions and methods for making and using the compounds and compositions.

7. 发明公开

EP2482802A4 NOVEL PESTICIDE FORMULATIONS 审中-公开
标题翻译：新型农药制剂
公开(公告)号：EP2482802A4
公开(公告)日：2013-08-07
申请号：EP10820940
申请日：2010-09-29
申请人： BURNET MICHAEL , GUSE JAN-HINRICH , REISSER MARTIN
发明人： BURNET MICHAEL , GUSE JAN-HINRICH , REISSER MARTIN
IPC分类号： A61K9/14 , A01N25/10 , A01N25/26
CPC分类号： A01N25/10 , A01N37/34 , A01N37/40 , A01N39/04 , A01N41/10 , A01N43/50 , A01N43/54 , A01N43/653 , A01N43/70 , A01N47/36 , A01N47/40 , A01N51/00 , A01N57/20
摘要： Bioactive substances are imbedded or mixed into functionalized matrices to form homogenous water-insoluble solid complexes with desirable field properties such as reduced leaching in soil, improved leaf retention, selective unloading to roots and convenient packaging and application. Bioactive substances of this disclosure include pharmaceutical agents and pesticides including herbicides, insecticides, bacteriocides, rodenticides, nematicide and fungicides. The matrices comprise a monomeric-, oligomeric- or (co)polymeric backbone which may be derivatized with chemical groups exhibiting ionic (amines, carboxyls), hydrophobic, and ligandbinding interactions to form the matrix of the formulation. The various matrices may be mixed with additives or modifiers, grafted, or fused to obtain optimal properties. The formulations may be applied as granules, suspensions, emulsions in sprays, foams, or coats for seeds and fertilizers. Alternatively they may be melted and sprayed as concentrates. The formulations may be applied to foliage, soil, irrigation water, construction materials, seeding materials, grains, and buildings.

8. 发明专利

IL262024D0 Detecting microbial infection in wounds 未知
公开(公告)号：IL262024D0
公开(公告)日：2018-10-31
申请号：IL26202418
申请日：2018-09-28
申请人： BURNET MICHAEL , QUALIZYME DIAGNOSTICS GMBH AND CO KG , HEINZLE ANDREA , SIGL EVA , LUSCHNIG DANIEL , UNIV OF NATURAL RESOURCES AND LIFE SCIENCES VIENNA , ACIB GMBH , GAMERICH CLEMENS , TEGL GREGOR , GUEBITZ GEOEG
发明人： BURNET MICHAEL , HEINZLE ANDREA , SIGL EVA , LUSCHNIG DANIEL , GAMERICH CLEMENS , TEGL GREGOR , GUEBITZ GEOEG
IPC分类号： G01N20060101
摘要： The disclosed technology relates to chemical entities for the detection of wounds, e.g., chronic wounds or infected wounds, including compositions, substrates, kits, dressing materials, and articles, and systems containing such compounds. The disclosed technology further relates to methods of using these compositions, kits and systems in diagnostic assays, and in the diagnosis and/or detection of chronic or infected wounds based on enzymatic action on specific moieties and/or reaction sites. The disclosed technology additionally relates to detection of pathogenic, e.g., bacterial and/or viral substances, such as enzymes and substrates, at the wound situs. Additional disclosure relates to methods of characterizing wounds based on expression of a plurality of markers and using such information to treat, manage, and follow-up patients suffering from chronic or infected wounds.

9. 发明专利

AR047077A1 FORMULACIONES DE PESTICIDA QUE CONTIENEN BIOPOLIMEROS SUSTITUIDOS Y POLIMEROS ORGANICOS PARA MEJORAR LA ACTIVIDAD RESIDUAL, EL TAMANO DE GOTA, LA ADHERENCIA Y LA RESISTENCIA A LA LLUVIA SOBRE LAS HOJAS Y REDUCCION EN EL LAVADO DEL SUELO 未知
公开(公告)号：AR047077A1
公开(公告)日：2006-01-04
申请号：ARP040104948
申请日：2004-12-29
申请人： GRESSEL JONATHAN BEN , BURNET MICHAEL
发明人： GRESSEL JONATHAN BEN , BURNET MICHAEL
IPC分类号： A01N25/10 , A01N25/24 , A01N25/12 , A01N25/16
摘要： Los polímeros funcionalizados se mezclan con los pesticidas para formar complejos semi-estables que tienen propiedades beneficiosas para el campo: lavado reducido en el suelo, una retencion mejorada sobre hojas (resistencia a la lluvia), descarga selectiva en raíces y un envasado y aplicacion convenientes. Los pesticidas con los que se pueden formar complejos incluyen a los herbicidas, insecticidas (incluso los compuestos para controlar artropodos que no son insectos y nemátodos), bactericidas, rodenticidas y funguicidas. Los polímeros con los que se pueden formar complejos incluyen a los derivados de carbohidratos, amidas, iminas, alcanos, vinilos, estirenos y glicoles. Los polímeros pueden estar funcionalizados con grupos químicos que exhiben interacciones ionicas (aminas y carboxilos), hidrofobicas, formacion de complejos (por ejemplo, quelantes de metal) e interacciones de enlace de ligando. Los diversos polímeros funcionalizados pueden ser mixtos, injertados o fusionados para obtener propiedades optimas. Las formulaciones de polímero/pesticida se pueden aplicar como gránulos, suspensiones o soluciones en pulverizadores, como espumas o como recubrimientos para semillas y fertilizantes. Las formulaciones se pueden aplicar al follaje, al suelo, al agua para irrigacion, materiales para construccion (plásticos, madera), materiales para siembra, granos y construcciones edilicias.

10. 发明专利

AU2010301135A1 Novel pesticide formulations 未知
公开(公告)号：AU2010301135A1
公开(公告)日：2012-04-12
申请号：AU2010301135
申请日：2010-09-29
申请人： BURNET MICHAEL , GUSE JAN HINRICH , REISSER MARTIN
发明人： BURNET MICHAEL , GUSE JAN-HINRICH , REISSER MARTIN
IPC分类号： A61K9/14 , A01N25/26
摘要： Bioactive substances are imbedded or mixed into functionalized matrices to form homogenous water-insoluble solid complexes with desirable field properties such as reduced leaching in soil, improved leaf retention, selective unloading to roots and convenient packaging and application. Bioactive substances of this disclosure include pharmaceutical agents and pesticides including herbicides, insecticides, bacteriocides, rodenticides, nematicide and fungicides. The matrices comprise a monomeric-, oligomeric- or (co)polymeric backbone which may be derivatized with chemical groups exhibiting ionic (amines, carboxyls), hydrophobic, and ligandbinding interactions to form the matrix of the formulation. The various matrices may be mixed with additives or modifiers, grafted, or fused to obtain optimal properties. The formulations may be applied as granules, suspensions, emulsions in sprays, foams, or coats for seeds and fertilizers. Alternatively they may be melted and sprayed as concentrates. The formulations may be applied to foliage, soil, irrigation water, construction materials, seeding materials, grains, and buildings.

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