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1. 发明申请

WO2008037488A1 A METHOD FOR ENHANCING PLANT TOLERANCE 审中-公开
标题翻译：一种增强植物耐性的方法
公开(公告)号：WO2008037488A1
公开(公告)日：2008-04-03
申请号：PCT/EP2007/008462
申请日：2007-09-28
申请人： SYNGENTA PARTICIPATIONS AG , SCHADE, Michael , HOFER, Dieter , GRIMM, Christoph , PEDRONI, Domingos , ARAMAKI, Paulo , KRUPKOVA, Eva , SCHMÜLLING, Thomas , COBB, Andy
发明人： SCHADE, Michael , HOFER, Dieter , GRIMM, Christoph , PEDRONI, Domingos , ARAMAKI, Paulo , KRUPKOVA, Eva , SCHMÜLLING, Thomas , COBB, Andy
IPC分类号： A01N51/00 , A01N47/40 , A01N43/40 , A01P21/00
CPC分类号： A01N51/00 , A01N43/40 , A01N47/40
摘要： A method of increasing functional protein activity in a plant comprising applying to the plant, part of the plant, the plant propagation material thereof and/or a surrounding area thereof an effective amount of one or more neonicotinoid compounds selected from thianicotinyl compounds and tetrahydrofuranyl compounds.
摘要翻译：一种提高植物功能蛋白活性的方法，包括向植物，部分植物，植物繁殖材料和/或其周围区域施用有效量的一种或多种选自噻嗪基化合物和四氢呋喃基化合物的新烟碱类化合物。

2. 发明申请

WO2008000511A3 PEKTIN METHYLTRANSFERASES AND THEIR APPLICATIONS 审中-公开
公开(公告)号：WO2008000511A3
公开(公告)日：2008-01-03
申请号：PCT/EP2007/005794
申请日：2007-06-29
申请人： FREIE UNIVERSITÄT BERLIN , SCHMÜLLING, Thomas , KRUPKOVA, Eva
发明人： SCHMÜLLING, Thomas , KRUPKOVA, Eva
IPC分类号： C12N15/82 , C12N9/10 , C12N15/54 , A01H5/00
摘要： The invention relates to transgenic plants with reduced or enhanced pectin methyltransferases activity, methods for producing such plants and to their use as well as methods of producing modified pections and to compositions comprising such modified pectins.

3. 发明申请

WO2008037431A1 TRANSCRIPTIONAL REPRESSORS OF CYTOKININ SIGNALING AND THEIR USE 审中-公开
标题翻译：细胞因子信号转导代谢及其使用
公开(公告)号：WO2008037431A1
公开(公告)日：2008-04-03
申请号：PCT/EP2007/008331
申请日：2007-09-25
申请人： FREIE UNIVERSITÄT BERLIN , SCHMÜLLING, Thomas , HEYL, Alexander , RAMIREDDY, Eswar
发明人： SCHMÜLLING, Thomas , HEYL, Alexander , RAMIREDDY, Eswar
IPC分类号： C12N15/82 , C12N15/62 , C07K14/415
CPC分类号： C12N15/8261 , C07K14/415 , C07K2319/80 , C12N15/62 , C12N15/79 , C12N15/8201 , C12N15/8241 , C12N15/8295 , Y02A40/146
摘要： The invention relates to fusion proteins capable of acting as transcriptional repressors of cytokinin signaling, to polynucleotides encoding these fusion proteins, to vectors and cells comprising these polynucleotides, and to transgenic plants and parts thereof comprising these polynucleotides, vectors, and cells. The invention further relates to a process for making these transgenic plants and to the use of these transgenic plants for producing seeds of enhanced size, with enhanced seed filling, with reduced seed loss and/or with more rapid germination, and/or for producing a live root system with increased root mass, root length and/or root branching. The invention also relates to a method for enhancing the seed size, for enhancing seed filling, for reducing seed loss, and/or for reducing germination time and/or reproduction time, and/or for enhancing the root mass, root length and/or root branching of a plant and to seeds obtainable by the methods of the present invention.
摘要翻译：本发明涉及能够作为细胞分裂素信号转录抑制子的融合蛋白，编码这些融合蛋白的多核苷酸，包含这些多核苷酸的载体和细胞，以及包含这些多核苷酸，载体和细胞的转基因植物及其部分。本发明进一步涉及一种制备这些转基因植物的方法，以及这些转基因植物用于生产增强大小的种子，具有增强的种子填充，减少的种子损失和/或更迅速的发芽和/或用于产生活根系具有增加的根质量，根长度和/或根分枝。本发明还涉及一种用于增强种子大小，用于增强种子填充，减少种子损失和/或减少萌发时间和/或繁殖时间和/或增强根质量，根长度和/或植物的根分枝和通过本发明的方法可获得的种子。

4. 发明申请

WO2012084715A1 DISRUPTION OF AHP6 GENE LEADS TO PLANTS WITH IMPROVED SEED YIELD 审中-公开
标题翻译：将AHP6基因引导到具有改良种子产量的植物上
公开(公告)号：WO2012084715A1
公开(公告)日：2012-06-28
申请号：PCT/EP2011/073058
申请日：2011-12-16
申请人： SCHMÜLLING, Thomas , WERNER, Tomás
发明人： SCHMÜLLING, Thomas , WERNER, Tomás
IPC分类号： C12N15/82 , C07K14/415 , A01H5/00
CPC分类号： C12N15/8261 , C07K14/415 , C12N15/8295 , Y02A40/146
摘要： The present invention is directed to a method for increasing seed yield in a plant, the method comprising disruption of endogenous AHP6 gene in cells of the plant, wherein said disruption inhibits expression and/or activity of a product of said endogenous AHP6 gene compared to a corresponding control plant lacking such a disruption.
摘要翻译：本发明涉及一种用于提高植物中种子产量的方法，所述方法包括破坏植物细胞中的内源性AHP6基因，其中所述破坏抑制所述内源性AHP6基因的产物的表达和/或活性与相应的对照厂缺乏这样的破坏。

5. 发明申请

WO2011004003A1 DISRUPTION OF CKX3 AND AT LEAST ONE OTHER CKX GENE IN A PLANT OR PLANT CELL LEADS TO IMPROVED TRAITS 审中-公开
标题翻译： CKX3和至少一个其他CKX基因在植物或植物细胞中的突变改善了TRAITS
公开(公告)号：WO2011004003A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059880
申请日：2010-07-09
申请人： SCHMÜLLING, Thomas , BARTRINA Y MANNS, Isabel , WERNER, Tomás
发明人： SCHMÜLLING, Thomas , BARTRINA Y MANNS, Isabel , WERNER, Tomás
IPC分类号： C12N15/82
CPC分类号： C12N15/8295 , C12N9/0026 , C12N9/0032
摘要： The present invention is directed to isolated plant cells and transgenic plants comprising a disruption in at least a CKX3 gene and in one further gene encoding for a cytokininoxidase/dehydrogenase and being different from CKX3 well as to methods of producing such transgenic plants and to methods of increasing seed yield in a plant and/or plant height.
摘要翻译：本发明涉及分离的植物细胞和转基因植物，其包含至少CKX3基因的破坏和编码细胞分裂素酶/脱氢酶的一个另外的基因，并且与CKX3不同，以及产生这种转基因植物的方法以及方法在植物和/或植物高度增加种子产量。

6. 发明申请

WO2016075059A1 DISRUPTION OF ROCK1 GENE LEADS TO PLANTS WITH IMPROVED TRAITS 审中-公开
标题翻译：将ROCK1基因引导到具有改良条件的植物上
公开(公告)号：WO2016075059A1
公开(公告)日：2016-05-19
申请号：PCT/EP2015/076008
申请日：2015-11-09
申请人： SCHMÜLLING, Thomas , NIEMANN, Michael , TOMÀS, Werner
发明人： SCHMÜLLING, Thomas , NIEMANN, Michael , TOMÀS, Werner
IPC分类号： C12N15/82 , C07K14/415 , A01H5/00
CPC分类号： C12N15/8241 , C07K14/415 , C12N15/8295
摘要： The present invention provides a method for improving traits in a plant, like e.g. improving yield-related traits like number of flowers, number of siliques, seed yield, stem growth in a plant, the method comprising disruption of endogenous ROCK1 gene in a plant cell, wherein said disruption inhibits expression and/or activity of a product of said endogenous ROCK1 gene compared to a corresponding control plant cell lacking such a disruption.
摘要翻译：本发明提供了一种改善植物性状的方法，例如，提高产量相关性状，如花数，长角果数，种子产量，植物茎干生长，包括破坏植物细胞内源性ROCK1基因的方法，其中所述破坏抑制所述植物细胞的产物的表达和/或活性内源性ROCK1基因与相应的对照植物细胞相比，缺乏这种破坏。

7. 发明申请

WO2011004005A1 ROCK2 AND ROCK3, TWO NEW GAIN-OF-FUNCTION VARIANTS OF THE CYTOKININ RECEPTORS AHK2 AND AHK3 审中-公开
标题翻译： ROCK2和ROCK3，细胞因子受体AHK2和AHK3的两个新的增益函数变量
公开(公告)号：WO2011004005A1
公开(公告)日：2011-01-13
申请号：PCT/EP2010/059885
申请日：2010-07-09
申请人： FREIE UNIVERSITÄT BERLIN , SCHMÜLLING, Thomas , WERNER, Tomás , BARTRINA Y MANNS, Isabel , BRAUN, Helen
发明人： SCHMÜLLING, Thomas , WERNER, Tomás , BARTRINA Y MANNS, Isabel , BRAUN, Helen
IPC分类号： C07K14/415 , C12N15/82
CPC分类号： C07K14/415 , C12N15/8261 , C12N15/8295 , Y02A40/146
摘要： The present invention relates to two new gain of function variants of the cytokinin receptor proteins AHK2 and AHK3, namely rock2 and rock3, to transgenic organisms comprising at least one of said new gain-of-function cytokinin receptor variants and to a method for the manufacturing of a transgenic plant comprising at least one of the new gain-of-function variants.
摘要翻译：本发明涉及细胞分裂素受体蛋白质AHK2和AHK3的功能变体的两种新增益，即Rock2和rock3，其包含至少一种所述新的功能性增益细胞分裂素受体变体的转基因生物，以及制造方法的转基因植物，其包含新增益功能变体中的至少一种。

8. 发明申请

WO2007137810A1 CYTOKININ RECEPTOR VARIANTS AND THEIR USE 审中-公开
标题翻译：细胞因子受体变异体及其用途
公开(公告)号：WO2007137810A1
公开(公告)日：2007-12-06
申请号：PCT/EP2007/004729
申请日：2007-05-29
申请人： FREIE UNIVERSITÄT BERLIN , SCHMÜLLING, Thomas , HEYL, Alexander , RIEFLER, Michael , PILS, Birgit
发明人： SCHMÜLLING, Thomas , HEYL, Alexander , RIEFLER, Michael , PILS, Birgit
IPC分类号： C12N15/82 , A01H5/00 , C07K14/415 , C12N5/10
CPC分类号： C12N15/8262 , C07K14/415 , C12N15/8241 , C12N15/8267
摘要： The invention relates to cytokinin receptor protein variants exhibiting a reduced binding to cytokinin, to polynucleotides encoding these cytokinin receptor protein variants, to vectors and cells comprising these polynucleotides, and to transgenic plants comprising these polynucleotides, vectors, and cells. The invention further relates to a process for making these transgenic plants and to the use of these transgenic plants for producing seeds of enhanced size, with enhanced seed filling, with reduced seed loss and/or with more rapid germination, and/or a live root system with increased root mass, root length and/or root branching. The invention also relates to a method for enhancing the seed size, seed filling, with reduced seed loss and/or with more rapid germination and/or the root mass, the root length and/or root branching of a plant and to seeds obtainable by the methods of the present invention.
摘要翻译：本发明涉及对细胞分裂素结合降低的细胞分裂素受体蛋白质变体，编码这些细胞分裂素受体蛋白质变体的多核苷酸，包含这些多核苷酸的载体和细胞，以及包含这些多核苷酸，载体和细胞的转基因植物。本发明还涉及一种制备这些转基因植物的方法，以及这些转基因植物用于生产增强大小的种子，具有增强的种子填充，减少的种子损失和/或更迅速的发芽和/或活根系统具有增加的根质量，根长度和/或根分枝。本发明还涉及一种用于增强种子大小，种子填充，减少种子损失和/或具有更快的萌发和/或根质量，植物的根长度和/或根分枝以及种子可获得的种子的方法本发明的方法。

9. 发明申请

WO2007003317A3 TRANSGENIC PLANT WITH TISSUE-SELECTIVELY REDUCED CYTOKININ-RECEPTOR ACTIVITY 审中-公开
公开(公告)号：WO2007003317A3
公开(公告)日：2007-01-11
申请号：PCT/EP2006/006245
申请日：2006-06-22
申请人： FREIE UNIVERSITÄT BERLIN , RIEFLER, Michael , SCHMÜLLING, Thomas
发明人： RIEFLER, Michael , SCHMÜLLING, Thomas
IPC分类号： C12N15/82 , A01H5/00
摘要： The invention relates to a transgenic plant, wherein the activity of AHK2-and/or AHK3- DNA, RNA and/or protein is selectively suppressed or reduced in a specific target tissue of the plant, and wherein the activity of AHK2- and AHK3- DNA, RNA and protein is essentially unaltered in at least one tissue not being target tissue, to methods of making such plants, to methods of making seeds of enhanced size and/or plants with enhanced root branching, and uses of such plants.

10. 发明申请

WO2004098608A1 PYRAZOLO [4, 3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS OF USE 审中-公开
标题翻译：吡咯并[4,3-D]吡啶，其制备方法和使用方法
公开(公告)号：WO2004098608A1
公开(公告)日：2004-11-18
申请号：PCT/EP2004/004855
申请日：2004-05-06
申请人： ÚSTAV EXPERIMENTALNI BOTANIKY AKADEMIE VED CESKE REPUBLIKY , MORAVCOVÁ, Daniela , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, René , BINAROVÁ, Pavla , MLEJNEK, Petr , VOJTESEK, Borek , ULDRIJAN, Stjepan , SCHMÜLLING, Thomas , STRNAD, Miroslav
发明人： MORAVCOVÁ, Daniela , HAVLICEK, Libor , KRYSTOF, Vladimir , LENOBEL, René , BINAROVÁ, Pavla , MLEJNEK, Petr , VOJTESEK, Borek , ULDRIJAN, Stjepan , SCHMÜLLING, Thomas , STRNAD, Miroslav
IPC分类号： A61K31/505
CPC分类号： C07D487/04
摘要： The invention relates to 3-, 7-disubstituted pyrazolo[4,3-d]pyrimidines represented by the general formula I (I), and pharmaceutically acceptable salts thereof, wherein R3 is selected from the group consisting of alkyl, cycloalkyl, , cycloalkyl alkyl, cycloheteroalkyl alkyl, cycloheteroalkyl, aryl, heterocycle, heteroaryl, arylalkyl, heteroarylalkyl, and heteroalkyl, wherein each of the groups may optionally be substituted, R7 is selected from the group consisting of halogen, hydroxyl, hydroxylamino, amino, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, unsubstituted or substituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroarylakyl, substituted or unsubstituted cycloalkyl alkyl, substituted or unsubstituted cycloheteroalkyl alkyl; R7'-X- wherein X is an -NH-, -N(alkyl)-, -0- or -S- moiety and R7' is selected from the group consisting of H, alkyl, cycloalkyl, aryl, alkylcycloalkyl, arylalkyl, heterocycle, heterocyclealkyl, substituted alkyl, substituted cycloalkyl, substituted aryl, substituted arylalkyl, substituted heterocycle, substituted heteroaryl, substituted heteroarylalkyl, substituted heteroalkyl, substituted cycloalkyl alkyl and substituted cycloheteroalkyl alkyl, wherein the groups are preferably substituted by more than one halogen, hydroxyl, amino, mercapto, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, alkyl, alkoxy, and substituted alkyl group.
摘要翻译：本发明涉及由通式I（I）表示的3-，7-二取代的吡唑并[4,3-d]嘧啶及其药学上可接受的盐，其中R 3选自烷基，环烷基，环烷基烷基，环杂烷基烷基，环杂烷基，芳基，杂环，杂芳基，芳基烷基，杂芳基烷基和杂烷基，其中每个基团可任选被取代，R 7选自卤素，羟基，羟基氨基，氨基，羧基，氰基，取代或未取代的芳烷基，取代或未取代的杂烷基，取代或未取代的杂芳基烷基，取代或未取代的环烷基烷基，取代或未取代的环杂烷基烷基;取代或未取代的芳基烷基，其中X是-NH-，-N（烷基） - ， - O-或-S-部分，并且R 7'选自H，烷基，环烷基，芳基，烷基环烷基，芳基烷基，杂环，杂环烷基，取代的烷基，取代的环烷基，取代的芳基，取代的芳基烷基，取代的杂环，取代的杂芳基，取代的杂芳基烷基，取代的杂烷基，取代的环烷基烷基和取代的环杂烷基烷基，其中基团优选被多于一个的卤素，羟基，氨基，巯基，羧基，氰基，硝基，酰胺基，磺基，氨基磺酰氨基，氨基氨基，烷基，烷氧基和取代的烷基。

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