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1. 发明专利

AU3071392A DNA ENCODING A GLYCINE TRANSPORTER AND USES THEREOF 未知
公开(公告)号：AU3071392A
公开(公告)日：1993-06-15
申请号：AU3071392
申请日：1992-11-12
申请人： SYNAPTIC PHARMACEUTICAL CORPORATION
发明人： KELLI SMITH , LAURENCE A BORDEN , THERESA BRANCHEK , PAUL R HARTIG , RICHARD L WEINSHANK
IPC分类号： C12N15/00 , A61K38/00 , C07K14/47
摘要： PCT No. PCT/US92/09662 Sec. 371 Date Nov. 10, 1994 Sec. 102(e) Date Nov. 10, 1994 PCT Filed Nov. 12, 1992 PCT Pub. No. WO93/10228 PCT Pub. Date May 27, 1993This invention provides isolated nucleic acid molecules encoding a mammalian glycine transporter, isolated nucleic acid molecules encoding a human glycine transporter, isolated proteins which are mammalian glycine transporter proteins, isolated proteins which are human glycine transporter proteins, vectors comprising isolated nucleic acid molecules encoding a mammalian or a human glycine transporter, mammalian cells comprising such vectors, antibodies directed to a mammalian glycine transporter, antibodies directed to a human glycine transporter, nucleic acid probes useful for detecting nucleic acid encoding mammalian glycine transporter, nucleic acid probes useful for detecting nucleic acid encoding human glycine transporter, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian glycine transporter, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a human glycine transporter, pharmaceutical compounds related to mammalian glycine transporter, pharmaceutical compounds related to human glycine transporter and nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian or human glycine transporter. This invention also provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with mammalian glycine transporter. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with human glycine transporter.

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