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    • 2. 发明申请
    • EVALUATING EFFECTS OF EXPOSURE CONDITIONS ON DRUG SAMPLES OVER TIME
    • 暴露条件对药物样品的影响评估时间
    • WO2004078131A2
    • 2004-09-16
    • PCT/US2004/006327
    • 2004-03-01
    • SYMYX TECHNOLOGIES, INC.CARLSON, Eric, D.DESROSIERS, Peter, J.SONG, Li
    • CARLSON, Eric, D.DESROSIERS, Peter, J.SONG, Li
    • A61K
    • G01N33/15B01J2219/00599B01J2219/00686B01J2219/00702B01J2219/00756C40B60/12
    • The present invention relates to the field of research for drug formulations. More particularly, this invention is directed toward an apparatus and method of performing parallel synthesis and screening of multiple drug compositions for stability and compatibility when exposed to various conditions over time, including various environmental and/or chemical conditions. In one aspect, the invention includes a method of testing for effects of a condition on a drug sample. The method includes providing an array of drug samples, simultaneously exposing a first plurality of the drug samples in the array to a first controlled condition for a period of time within an exposure period, and evaluating a plurality of the exposed drug samples at a first time and a second time using a non-destructive test in order to determine whether the condition has an affect on one or more of the drug samples over time. At least a portion of the exposure period between said first and second time, and the non-destructive test is the same each time.
    • 本发明涉及药物制剂的研究领域。 更具体地,本发明涉及当暴露于包括各种环境和/或化学条件在内的各种条件时,在多种药物组合物中进行平行合成和筛选以确保稳定性和相容性的装置和方法。 一方面,本发明包括测试病症对药物样品的影响的方法。 该方法包括提供药物样品阵列,同时将阵列内的第一组多个药物样品暴露于暴露期内的一段时间内的第一受控状态,以及第一次评估多个暴露的药物样品 并且第二次使用非破坏性测试来确定条件是否随着时间对一种或多种药物样品产生影响。 所述第一次和第二次之间的曝光期间的至少一部分与无损检测每次相同。