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1. 发明申请

WO2014135650A1 ANTIMICROBIAL COMPOSITIONS 审中-公开
标题翻译：抗微生物组合物
公开(公告)号：WO2014135650A1
公开(公告)日：2014-09-12
申请号：PCT/EP2014/054378
申请日：2014-03-06
申请人： SYMRISE AG , PESARO, Manuel , HÖLSCHER, Bernd , SCHMAUS, Gerhard , KÖHLER, Anja
发明人： PESARO, Manuel , HÖLSCHER, Bernd , SCHMAUS, Gerhard , KÖHLER, Anja
IPC分类号： A01N35/04 , A01P1/00 , A01N31/02 , A01N31/14 , A61Q15/00 , A61Q19/00 , A61K8/33 , A61K8/35
CPC分类号： A01N35/04 , A01N31/02 , A01N31/14 , A23L3/34635 , A23L33/127 , A23V2002/00 , A61K8/34 , A61K8/345 , A61K8/35 , A61Q15/00 , A61Q17/005 , C11D3/48 , A01N31/04
摘要： Suggested is a antimicrobial agent An antimicrobial composition comprising (a) at least one acetophenone derivative of formula (I) in which R 1 stands for hydrogen or methyl, and R 2 stands for hydrogen, hydroxyl or a - OCH 3 group, or a cosmetically or pharmaceutically acceptable salt thereof, and (b) at least one second antimicrobial agent.
摘要翻译：建议抗菌剂一种抗微生物组合物，其包含（a）至少一种式（I）的苯乙酮衍生物，其中R1代表氢或甲基，R2代表氢，羟基或-OC3C，或化妆品或药学上可接受的其盐，和（b）至少一种第二抗微生物剂。

2. 发明申请

WO2014135666A1 COSMETIC COMPOSITIONS 审中-公开
标题翻译：化妆品组合物
公开(公告)号：WO2014135666A1
公开(公告)日：2014-09-12
申请号：PCT/EP2014/054401
申请日：2014-03-06
申请人： SYMRISE AG , PESARO, Manuel , LANGE, Sabine , SCHMAUS, Gerhard
发明人： PESARO, Manuel , LANGE, Sabine , SCHMAUS, Gerhard
IPC分类号： A61K8/92 , A61K8/35 , A61K8/06 , A61Q19/00
CPC分类号： A61K8/35 , A61K8/062 , A61K8/342 , A61K8/345 , A61K8/37 , A61K8/375 , A61K8/891 , A61K8/922 , A61K2800/49 , A61K2800/52 , A61Q5/02 , A61Q19/00
摘要： Suggested is a cosmetic composition, comprising (a) at least one acetophenone derivative or a cosmetically or pharmaceutically acceptable salt thereof in a working amount of from 0.1 to 0.5 % b.w. – calculated on the total composition, (b) at least one oil body or wax, and/or (c) at least one emulsifier and optionally (d) at least one active principle. The compositions show improved emulsion stability.
摘要翻译：提出了一种化妆品组合物，其包含（a）至少一种苯乙酮衍生物或其化妆品或药学上可接受的盐，其加入量为0.1至0.5％b.w。 - 根据总组合物计算，（b）至少一种油体或蜡，和/或（c）至少一种乳化剂和任选的（d）至少一种活性成分。组合物显示改善的乳液稳定性。

3. 发明申请

WO2014191258A2 ANTIMICROBIAL COMPOSITIONS COMPRISING GLYCERYL ETHERS 审中-公开
标题翻译：包含糖果的抗微生物组合物
公开(公告)号：WO2014191258A2
公开(公告)日：2014-12-04
申请号：PCT/EP2014/060355
申请日：2014-05-20
申请人： SYMRISE AG , PESARO, Manuel , KOCH, Oskar , SCHMAUS, Gerhard , KÖHLER, Antje , GRIEGER, Jessica
发明人： PESARO, Manuel , KOCH, Oskar , SCHMAUS, Gerhard , KÖHLER, Antje , GRIEGER, Jessica
IPC分类号： A01N31/02
CPC分类号： A01N31/04 , A01N31/02 , A23L3/34635 , A23V2002/00 , A61K8/34 , A61K8/345 , A61K2800/524 , A61Q5/006 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q9/02 , A61Q9/04 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q17/005 , A61Q17/04 , A61Q19/002 , A61Q19/004 , A61Q19/005 , A61Q19/007 , A61Q19/08 , A61Q19/10 , C11B9/00 , C11D3/2068 , C11D3/48
摘要： Suggested is an antimicrobial agent comprising at least one glycerylether of formula (I) in which R 1 represents a benzyl, methylbenzyl, phenlethyl, or phenylpropyl radical, or a glycerylether of formula (II) in which R 2 stands for a linear or branched alkyl radical having 2 to 12 carbon atoms, on condition that in case of glycerylethers of of formula (II) two or three of said species are present.
摘要翻译：建议包含至少一种式（I）糖基醚的抗微生物剂，其中R 1表示苄基，甲基苄基，苯基乙基或苯基丙基，或式（II）的糖基醚，其中R 2表示直链或支链烷基， 2至12个碳原子，条件是在式（II）的糖精醚的情况下，存在两种或三种所述物质。

4. 发明申请

WO2016001263A1 FLAVOUR AND FRAGRANCE COMPOSITIONS COMPRISING ACETOPHENONE DERIVATIVES 审中-公开
标题翻译：含有乙炔衍生物的香味和香味组合物
公开(公告)号：WO2016001263A1
公开(公告)日：2016-01-07
申请号：PCT/EP2015/064910
申请日：2015-06-30
申请人： SYMRISE AG , SCHMAUS, Gerhard , LANGE, Sabine , PESARO, Manuel
发明人： SCHMAUS, Gerhard , LANGE, Sabine , PESARO, Manuel
IPC分类号： A61K8/35 , A61Q13/00 , A61L9/01 , C11D7/26 , C11D7/50
CPC分类号： A61K8/35 , A61K2800/262 , A61K2800/49 , A61L9/01 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q15/00 , C11B9/0061 , C11D3/0068 , C11D3/2072 , C11D3/50 , C11D7/264
摘要： Suggested are new flavour and fragrance compositions comprising selected acetophenone derivatives, preferably 2-hydroxyacetophenone, 3-hydroxyacetophenone, or 4- hydroxyacetophenone for dissolving flavours and fragrances, and further especially for dissolving liphilic compounds, which are implemented in these products.
摘要翻译：建议包括选择的苯乙酮衍生物，优选2-羟基苯乙酮，3-羟基苯乙酮或用于溶解香料和香料的4-羟基苯乙酮的新风味和香料组合物，进一步特别是用于溶解在这些产品中实施的亲脂化合物。

5. 发明申请

WO2003011802A1 ISO-β-BISABOLOL ALS DUFT-UND AROMASTOFF 审中-公开
标题翻译： ISO测试没药醇AS香，味材料
公开(公告)号：WO2003011802A1
公开(公告)日：2003-02-13
申请号：PCT/EP2002/007546
申请日：2002-07-06
申请人： DRAGOCO GERBERDING & CO. AG , SCHMAUS, Gerhard , MEIER, Manfred , BRAUN, Norbert, A. , HÖLSCHER, Bernd , PICKENHAGEN, Wilhelm
发明人： SCHMAUS, Gerhard , MEIER, Manfred , BRAUN, Norbert, A. , HÖLSCHER, Bernd , PICKENHAGEN, Wilhelm
IPC分类号： C07C35/18
CPC分类号： C07C35/18 , C07C2601/14
摘要： Beschrieben wird die Verbindung (1S/R)-1-[(1S/R)-1,5-Dimethyl-hex-5-enyl]-4-methyl-cyclohex-3-en-1-ol(Iso-β-Bisabolol) der Formel A, sowie deren einzelne Konfigurationsisomere. Iso-β-Bisabolol besitzt einen sehr stark blumigen, maiglöckchen-artigen und äusserst angenehmen Geruch, so dass bereits geringe Mengen dieser Substanz eine sensorisch wahrnehmbare Modifizierung einer Duftstoff- oder Aroma-(Grund-)Komposition bewirken können.
摘要翻译：本发明公开了化合物（1个S / R）-1 - [（1 S / R）-1,5-二甲基己-5-烯基] -4-甲基 - 环己-3-烯-1-醇（异β - 红没药醇）式A，以及它们各自的构型异构体的。异-β没药醇具有非常强的如花，谷状和非常愉快的气味的百合，因此，即使少量的该物质的香料或风味（接地）感官可察觉的修改可能导致组合物。

6. 发明申请

WO2012143576A2 COMPOUNDS FOR PREVENTING, REDUCING AND/OR ALLEVIATING ITCHY SKIN CONDITION(S) 审中-公开
标题翻译：用于预防，减少和/或消除眼科皮肤病症的化合物（S）
公开(公告)号：WO2012143576A2
公开(公告)日：2012-10-26
申请号：PCT/EP2012/066442
申请日：2012-08-23
申请人： SYMRISE AG , SCHMAUS, Gerhard , KROHN, Michael , SOMBROEK, Dirk , HAUSTEDT, Lars Ole , KLUGE, Grit , KOCH, Oskar , KÖHLER, Antje
发明人： SCHMAUS, Gerhard , KROHN, Michael , SOMBROEK, Dirk , HAUSTEDT, Lars Ole , KLUGE, Grit , KOCH, Oskar , KÖHLER, Antje
IPC分类号： A61K31/12
CPC分类号： A61K31/12 , A23G4/12 , A61K8/35 , A61K9/0014 , A61K9/0063 , A61K9/06 , A61K9/1075 , A61K9/2018 , A61K45/06 , A61K47/00 , A61K2800/10 , A61K2800/75 , A61Q5/00 , A61Q5/002 , A61Q5/004 , A61Q5/006 , A61Q5/02 , A61Q5/04 , A61Q5/10 , A61Q5/12 , A61Q11/00 , A61Q13/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/004 , A61Q19/007 , A61Q19/02 , A61Q19/04 , A61K2300/00
摘要： The present invention primarily relates to the use of one or more specific compounds and/or one or more respective salt(s) thereof for preventing, reducing or alleviating itchy skin condition(s), and/or as PAR-2 antagonist. Furthermore, the present invention relates to compositions (products or, respectively, formulations), in particular for topical administration, preferably cosmetic or pharmaceutical compositions, in particular for preventing, reducing or alleviating one or more itchy skin conditions and/or for providing a PAR-2 antagonistic effect, comprising or consisting of an effect amount of such compound(s) and/or salt(s) and one or more cosmetically and/or pharmaceutically acceptable carriers.
摘要翻译：本发明主要涉及一种或多种特定化合物和/或其一种或多种相应的盐用于预防，减轻或缓解瘙痒的皮肤状况和/或作为PAR-2拮抗剂的用途。此外，本发明涉及组合物（产品或分别为制剂），特别是用于局部施用，优选化妆品或药物组合物，特别是用于预防，减少或减轻一种或多种瘙痒皮肤病症和/或提供PAR -2拮抗作用，其包含或由其作用的一种或多种化合物和/或盐和一种或多种化学和/或药学上可接受的载体组成。

7. 发明申请

WO2008119841A3 COMPOSITIONS COMPRISING BENZYL ALCOHOL DERIVATIVES AND FURTHER ANTIMICROBIAL ACTIVE COMPOUNDS 审中-公开
公开(公告)号：WO2008119841A3
公开(公告)日：2008-10-09
申请号：PCT/EP2008/059037
申请日：2008-07-10
申请人： SYMRISE GMBH & CO. KG , SCHMAUS, Gerhard , PFEIFFER, Antje
发明人： SCHMAUS, Gerhard , PFEIFFER, Antje
IPC分类号： A01N31/02 , A01N31/04 , A01P1/00
摘要： The present invention relates to a composition comprising or consisting of: (a) one, two or more compounds selected from the group consisting of benzyl alcohol derivatives of the formula (I) wherein the substituents R 1 ,R 2 , and R 3 are as defined in claim 1, and (b) one, two or more compounds selected from the group consisting of: (i) branched or unbranched 1,2-alkanediols having 3 to 14 carbon atoms, (ii) benzoic acid (INCI: Benzoic Acid) and its esters and salts, (iii) 4-hydroxybenzoic acid and its esters (INCI: Parabens) and salts, (iv) 2,4-hexadienoic acid (INCI: Sorbic Acid) and its salts, (v) 2-phenoxyethanol (INCI: Phenoxyethanol) (vi) 3-iodo-2-propinyl-butylcarbamate (INCI: lodopropynyl Butylcarbamate), (vii) 3-(4-chlorphenoxy)-1,2-propane-1,2-diol (INCI: Chlorphenesin), (viii) urea (INCI: Urea) and derivatives thereof, in particular 1, 1'-methylen-bis(3-(1-hydroxymethyl-2,4-dioximidazolidin-5-yl))urea (INCI: Imidazolidinyl urea), N-hydroxymethyl-N-(1,3-di(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-N'- hydroxymethylurea (INCI: Diazolidinyl Urea) and N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-urea (INCI: Triclocarban), (ix) 1,3-bis-(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidindione (INCI: DMDM hydantoin), (x) 1,2-propanediol, 3-(2-ethylhexyloxy) (INCI: Octoxy glycerin), (xi) isothiazolinones and mixtures thereof (e.g. a mixture of 5-chloro-2-methyl-3(2H)-isothiazolinone and 2-methyl-3(2H)-isothiazolinone with magnesium chloride and magnesium nitrate; INCI: Methylchloroisothiazolinone and Methylisothiazolinone).

8. 发明申请

WO2008003529A1 USE OF TROPOLONE DERIVATIVES AS ANTIOXIDANTS IN COSMETIC AND/OR TOPICAL PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：在化妆和/或局部药物组合物中使用作为抗氧化剂的TROPOLONE衍生物
公开(公告)号：WO2008003529A1
公开(公告)日：2008-01-10
申请号：PCT/EP2007/053347
申请日：2007-04-05
申请人： SYMRISE GMBH & CO. KG , SCHMAUS, Gerhard , FRANKE, Helge , PILLAI, Ravikumar
发明人： SCHMAUS, Gerhard , FRANKE, Helge , PILLAI, Ravikumar
IPC分类号： A61K8/35 , A61Q19/00
CPC分类号： A61K8/35 , A61K8/0208 , A61K2800/522 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10
摘要： The present invention relates to the use of one or more tropolone derivatives of general formula (I) wherein the substituents R 1 , R 2 , R 3 , R 4 , R 5 independently of one another have the following meaning: H; a linear or branched, saturated or unsaturated, aliphatic carbon chain with up to 30 C-atoms; OH; OR 6 , wherein R 6 is a linear or branched, saturated or unsaturated, aliphatic carbon chain with up to 30 C-atoms; COOH; COOR 7 , wherein R 7 is a linear or branched, saturated or unsaturated, aliphatic carbon chain with up to 30 C-atoms; NO 2 ; NH 2 ; F; CI; Br; or I; as antioxidants in cosmetic and/or topical pharmaceutical compositions.
摘要翻译：本发明涉及一种或多种通式（I）的替洛酮衍生物的用途，其中取代基R 1，R 2，R 3， >，R 4，R 5彼此独立地具有以下含义：H; 具有至多30个C原子的直链或支链饱和或不饱和的脂族碳链; 哦; 其中R 6是具有至多30个C原子的直链或支链饱和或不饱和的脂族碳链; COOH; 其中R 7是具有至多30个C原子的直链或支链饱和或不饱和的脂族碳链; NO _{2 ; NH _{2 ; F; CI; BR; 或我; 作为化妆品和/或局部药物组合物中的抗氧化剂。}}

9. 发明申请

WO2007077258A1 STABILIZED PREPARATIONS COMPRISING PHENOLIC COMPOUNDS AND BENZOPHENONES 审中-公开
标题翻译：包含苯酚化合物和苯并噻唑的稳定化制剂
公开(公告)号：WO2007077258A1
公开(公告)日：2007-07-12
申请号：PCT/EP2007/050123
申请日：2007-01-05
申请人： SYMRISE GMBH & CO. KG , LANGE, Sabine , SCHMAUS, Gerhard , VIELHABER, Gabriele
发明人： LANGE, Sabine , SCHMAUS, Gerhard , VIELHABER, Gabriele
IPC分类号： A61K8/35 , A61K8/34 , A61Q19/02 , A61Q19/08 , A61Q5/08
CPC分类号： A61K8/347 , A61K8/35 , A61K2800/52 , A61K2800/782 , A61Q5/08 , A61Q17/04 , A61Q19/02 , A61Q19/08
摘要： The present invention relates primarily to a cosmetic and/or pharmaceutical preparation comprising of consisting of one or more phenolic compounds of the formula (I) where for formula (I) it is the case that: R 1 , R 2 , R 3 , R 4 and R 5 are independently of one another hydrogen, halogen, an OH group, methyl or a linear or branched alkyl having 2, 3, 4 or 5 C atoms, with 1 , 2 or 3 different radicals from the group R 1 , R 2 , R 3 , R 4 and R 5 simultaneously representing an OH group, R 6 and R 7 are independently of one another hydrogen, methyl or a linear or branched alkyl having 2, 3, 4 or 5 C atoms, is an integer from O to 20 and R 8 is methyl or a linear or branched alkyl having 2 or 3 C atoms, a cycloalkyl having 3, 4, 5, 6 or 7 C atoms or a phenyl and one or more compounds of the formula (II) where for formula (II) it is the case that: R 9 , R 10 , R 11 and R 12 independently of one another are hydrogen, methyl, an OH group or a group -O- R and R 13 is methyl or a linear or branched alkyl having 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, and to uses of compounds of the formula (II) for stabilizing compounds of the formula (I), and also to methods of stabilizing compounds of the formula (I).
摘要翻译：本发明主要涉及一种化妆品和/或药物制剂，其包含一种或多种式（I）的酚类化合物，其中对于式（I），其中：R 1， R 2，R 3，R 4，R 5和R 5彼此独立地为氢，卤素，OH 基团，甲基或具有2,3,4或5个C原子的直链或支链烷基，具有1,2或3个不同基团R 1，R 2， R 3，R 4和R 5同时表示OH基团，R 6和R 5， 7个彼此独立地为氢，甲基或具有2,3,4或5个C原子的直链或支链烷基，为O至20的整数，R 8为甲基或具有2或3个C原子的直链或支链烷基，具有3,4,5,6或7个C原子的环烷基或苯基和一种或多种式（II）化合物，其中对于式（II） R 9，R 9， R 10，R 11和R 12彼此独立地是氢，甲基，OH基团或基团-O-R和R“ 13是甲基或具有2,3,4,5,6,7,8,9或10个C原子的直链或支链烷基，以及式（II）化合物用于稳定化合物式（I）化合物的方法，以及稳定式（I）化合物的方法。

10. 发明申请

WO2006134013A1 MIXTURES COMPRISING ANTHRANILIC ACID AMIDES AND COOLING AGENTS AS COSMETIC AND PHARMACEUTICAL COMPOSITIONS FOR ALLEVIATING ITCHING 审中-公开
标题翻译：包含抗坏血酸和冷却剂的混合物作为化妆品和药物组合物进行化妆
公开(公告)号：WO2006134013A1
公开(公告)日：2006-12-21
申请号：PCT/EP2006/062520
申请日：2006-05-23
申请人： SYMRISE GMBH & CO. KG , VIELHABER, Gabriele , SCHMAUS, Gerhard
发明人： VIELHABER, Gabriele , SCHMAUS, Gerhard
IPC分类号： A61Q15/00 , A61Q9/02 , A61Q19/00 , A61K8/42 , A61K31/196 , A61K8/34 , A61K8/37
CPC分类号： A61K31/196 , A61K8/42 , A61K8/445 , A61K2800/244 , A61K2800/75 , A61Q5/02 , A61Q9/02 , A61Q17/04 , A61Q19/00 , A61Q19/002 , A61Q19/004 , A61Q19/005 , A61Q19/007 , A61Q19/08
摘要： The invention relates to a mixture comprising or consisting of: (a) one or more compounds of Formula (1) where the symbols in the compound or each compound of Formula (1) are defined as follows: m = 0, 1 , 2 or 3, p = 0, 1 or 2, n = 0, 1 or 2, where, when n = 1 or 2, R 1 and R 2 in pairs are each H or together are another chemical bond, where, when m = 1 , 2 or 3, each X independently of the others is OH, Oalkyl or Oacyl, and where, when p = 1 or 2, each Y independently of the others is OH, Oalkyl or Oacyl, and R 3 = H or alkyl, R 3 = H also representing the corresponding cosmetically or pharmaceutically acceptable salts and solvates; and (b) one or more cooling agents.
摘要翻译：本发明涉及包含或由以下组成的混合物：（a）一种或多种式（1）化合物，其中化合物或式（1）的每种化合物中的符号定义如下：m = 0,1,2或 3，p = 0,1或2，n = 0,1或2，其中当n = 1或2时，成对地分别为R 1和R 2， H或一起是另一种化学键，其中当m = 1,2或3时，每个X独立地为OH，O烷基或Oacyl，并且其中当p = 1或2时，每个Y独立地为OH ，O烷基或Oacyl，R 3 = H或烷基，R 3 = H，也代表相应的美容或药学上可接受的盐和溶剂化物; 和（b）一种或多种冷却剂。

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