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1. 发明专利

CA2122937A1 HUMAN CHONDROMODULIN-I PROTEIN 未知
公开(公告)号：CA2122937A1
公开(公告)日：1994-11-12
申请号：CA2122937
申请日：1994-05-05
申请人： SUZUKI FUJIO , HIRAKI YUJI , TAKAHASHI KAZUHIRO , SUZUKI JUNKO , KONDO JUN , KOHARA ATSUKO , MORI AKIKO , YAMADA EI
发明人： SUZUKI FUJIO , HIRAKI YUJI , TAKAHASHI KAZUHIRO , SUZUKI JUNKO , KONDO JUN , KOHARA ATSUKO , MORI AKIKO , YAMADA EI
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/51 , C12N5/10 , C12N15/16 , C12P21/02 , A61K38/22 , C07K14/575
摘要： A novel human chondromodulin-I protein having a molecular weight of about 26,000 dalton on SDS-PAGE and capable of stimulating the growth of chondrocytes with or without FGF, promoting the differential potency of said cells, and inhibiting the growth of vascular endothelial cells, a DNA encoding said protein, expression vector containing said DNA, a transformant capable of producing recombinant chondromodulin-I protein, a process for producing chondromodulin-I protein by culturing said transformant and a pharmaceutical composition containing chondromodulin-I protein as an active ingredient.

2. 发明专利

ES2286817T3 PROTEINA CONDROMODULINA-I HUMANA. 未知
公开(公告)号：ES2286817T3
公开(公告)日：2007-12-01
申请号：ES94107364
申请日：1994-05-11
申请人： HIRAKI YUJI
发明人： SUZUKI FUJIO , HIRAKI YUJI , TAKAHASHI KAZUHIRO , SUZUKI JUNKO , KONDO JUN , KOHARA ATSUKO
IPC分类号： C12N15/09 , C12N15/16 , A61K38/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/51 , C12N5/10 , C12P21/02
摘要： Una proteína condromodulina-I humana que comprende una secuencia de aminoácidos que se presenta en SEQ ID NO 2, 3 ó 4 que tiene la capacidad de estimular el crecimiento de condrocitos.

3. 发明专利

DE69434997T2 未知
公开(公告)号：DE69434997T2
公开(公告)日：2008-03-06
申请号：DE69434997
申请日：1994-05-11
申请人： HIRAKI YUJI
发明人： SUZUKI FUJIO , HIRAKI YUJI , TAKAHASHI KAZUHIRO , SUZUKI JUNKO , KONDO JUN , KOHARA ATSUKO , MORI AKIKO , YAMADA EI
IPC分类号： C12N15/09 , C12N15/16 , A61K38/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/51 , C12N5/10 , C12P21/02
摘要： A novel human chondromodulin-I protein having a molecular weight of about 26,000 dalton on SDS-PAGE and capable of stimulating the growth of chondrocytes with or without FGF, promoting the differential potency of said cells, and inhibiting the growth of vascular endothelial cells, a DNA encoding said protein, expression vector containing said DNA, a transformant capable of producing recombinant chondromodulin-I protein, a process for producing chondromodulin-I protein by culturing said transformant and a pharmaceutical composition containing chondromodulin-I protein as an active ingredient.

4. 发明专利

AT366310T 未知
公开(公告)号：AT366310T
公开(公告)日：2007-07-15
申请号：AT94107364
申请日：1994-05-11
申请人： HIRAKI YUJI
发明人： SUZUKI FUJIO , HIRAKI YUJI , TAKAHASHI KAZUHIRO , SUZUKI JUNKO , KONDO JUN , KOHARA ATSUKO , MORI AKIKO , YAMADA EI
IPC分类号： C12N15/09 , C12N15/16 , A61K38/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/51 , C12N5/10 , C12P21/02
摘要： A novel human chondromodulin-I protein having a molecular weight of about 26,000 dalton on SDS-PAGE and capable of stimulating the growth of chondrocytes with or without FGF, promoting the differential potency of said cells, and inhibiting the growth of vascular endothelial cells, a DNA encoding said protein, expression vector containing said DNA, a transformant capable of producing recombinant chondromodulin-I protein, a process for producing chondromodulin-I protein by culturing said transformant and a pharmaceutical composition containing chondromodulin-I protein as an active ingredient.

5. 发明专利

DE69434997D1 未知
公开(公告)号：DE69434997D1
公开(公告)日：2007-08-16
申请号：DE69434997
申请日：1994-05-11
申请人： HIRAKI YUJI
发明人： SUZUKI FUJIO , HIRAKI YUJI , TAKAHASHI KAZUHIRO , SUZUKI JUNKO , KONDO JUN , KOHARA ATSUKO , MORI AKIKO , YAMADA EI
IPC分类号： C12N15/09 , C12N15/16 , A61K38/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/51 , C12N5/10 , C12P21/02
摘要： A novel human chondromodulin-I protein having a molecular weight of about 26,000 dalton on SDS-PAGE and capable of stimulating the growth of chondrocytes with or without FGF, promoting the differential potency of said cells, and inhibiting the growth of vascular endothelial cells, a DNA encoding said protein, expression vector containing said DNA, a transformant capable of producing recombinant chondromodulin-I protein, a process for producing chondromodulin-I protein by culturing said transformant and a pharmaceutical composition containing chondromodulin-I protein as an active ingredient.

6. 发明专利

CA2022752A1 HEPATIC PARENCHYMAL CELL GROWTH FACTOR, GENE ENCODING THE SAME, PROCESS FOR PRODUCING THE FACTOR, AND TRANSFORMANTS PRODUCING THE FACTOR 未知
公开(公告)号：CA2022752A1
公开(公告)日：1991-02-12
申请号：CA2022752
申请日：1990-08-07
申请人： MITSUBISHI CHEM CORP , MIYAZAWA KEIJI , DAIKUHARA YASUSHI , TSUBOUCHI HIROHITO , NAKA DAIJI , TAKAHASHI KAZUHIRO , MATSUI RIE , YOSHIYAMA YOSHIKO , ISHII TAKEHISA
发明人： KITAMURA NAOMI , MIYAZAWA KEIJI , DAIKUHARA YASUSHI , TSUBOUCHI HIROHITO , NAKA DAIJI , TAKAHASHI KAZUHIRO , MATSUI RIE , YOSHIYAMA YOSHIKO , ISHII TAKEHISA
IPC分类号： A61K38/00 , C07K14/475 , C12N15/16
摘要： According to the present invention, there are provided hepatic parenchymal cell growth factor obtained by recombinant DNA technology, a gene coding for the factor, an expression vector capable of expressing the gene, a cell, in particular animal cell, transformed with the expression vector, and a process for producing the hepatic parenchymal cell growth factor.

7. 发明申请

WO2013039260A2 METHOD FOR PURIFYING CHLORINATED HYDROCARBON 审中-公开
标题翻译：纯化氯化烃的方法
公开(公告)号：WO2013039260A2
公开(公告)日：2013-03-21
申请号：PCT/JP2012074131
申请日：2012-09-13
申请人： DAIKIN IND LTD , CHAKI TAKEHIRO , TAKAHASHI KAZUHIRO , YOSHIMI HITOSHI , TANAKA YOSHINORI , IWANAGA YUUSUKE
发明人： CHAKI TAKEHIRO , TAKAHASHI KAZUHIRO , YOSHIMI HITOSHI , TANAKA YOSHINORI , IWANAGA YUUSUKE
IPC分类号： C07C17/38
CPC分类号： C07C17/383 , C07C17/206 , C07C17/25 , C07C17/38 , Y02P20/582 , C07C19/10 , C07C21/18 , C07C19/01
摘要： The present invention provides a method for purifying chlorinated hydrocarbon(s), comprising cooling a mixture containing hydrogen fluoride and at least one chlorinated hydrocarbon selected from the group consisting of 2-chloro-3,3,3-trifluoropropene, 2,3-dichloro-3,3-difluoropropene, 1,2,3-trichloro-1,1-difluoropropane, and 1,1,1,2,3-pentachloropropane to cause liquid-liquid separation of the mixture into an upper liquid phase having a high hydrogen fluoride concentration and a lower liquid phase having a high chlorinated hydrocarbon concentration, and a method for purifying a chlorinated hydrocarbon, comprising subjecting the lower liquid phase obtained by the liquid-liquid separation to a distillation operation. According to the present invention, a chlorinated hydrocarbon can be purified by separating and removing hydrogen fluoride from a chlorinated hydrocarbon-hydrogen fluoride mixture under simple and economically advantageous conditions.
摘要翻译：本发明提供了一种纯化氯化烃的方法，该方法包括冷却含有氟化氢和至少一种选自2-氯-3,3,3-三氟丙烯，2,3-二氯 -3,3-二氟丙烯，1,2,3-三氯-1,1-二氟丙烷和1,1,1,2,3-五氯丙烷，以引起混合物的液 - 液分离成具有高氟化氢浓度以及氯代烃浓度高的下层液相的氯化烃精制方法，以及将通过液液分离得到的下层液相进行蒸馏操作的方法。根据本发明，可以通过在简单和经济上有利的条件下从氯化烃 - 氟化氢混合物中分离和除去氟化氢来纯化氯化烃。

8. 发明申请

WO2010050373A3 PROCESS FOR PREPARING 2,3,3,3-TETRAFLUOROPROPENE 审中-公开
标题翻译：制备2,3,3,3-四氯丙烯的方法
公开(公告)号：WO2010050373A3
公开(公告)日：2010-11-25
申请号：PCT/JP2009067971
申请日：2009-10-13
申请人： DAIKIN IND LTD , NOSE MASATOSHI , TAKAHASHI KAZUHIRO , KOMATSU YUZO , SUGIYAMA AKINARI , SHIBANUMA TAKASHI
发明人： NOSE MASATOSHI , TAKAHASHI KAZUHIRO , KOMATSU YUZO , SUGIYAMA AKINARI , SHIBANUMA TAKASHI
IPC分类号： C07C17/087 , C07C17/25 , C07C17/383 , C07C21/18
CPC分类号： C07C17/25 , C07C17/087 , C07C17/383 , C07C21/18 , Y02P20/582 , C07C21/22
摘要： The present invention provides a process for preparing 2,3,3,3-tetrafluoropropene comprising the steps of: (a) reacting 3,3,3-trifluoropropyne with hydrogen fluoride while heating to obtain a product containing 2,3,3,3-tetrafluoropropene; (b) separating the product obtained in Step (a) into Component A containing 2,3,3,3-tetrafluoropropene and 3,3,3-trifluoropropyne, and Component B containing 1,3,3,3-tetrafluoropropene; (c) separating 2,3,3,3-tetrafluoropropene and 3,3,3-trifluoropropyne contained in Component A obtained in Step (b) into each compound; (d) conducting a dehydrofluorination reaction by heating Component B obtained in Step (b) in the presence of a catalyst; (e) separating the product obtained in Step (d) into Component C containing 2,3,3,3-tetrafluoropropene and 3,3,3-trifluoropropyne, and Component D containing 1,3,3,3-tetrafluoropropene; (f) separating 2,3,3,3-tetrafluoropropene and 3,3,3-trifluoropropyne contained in Component C obtained in Step (e) into each compound; and (g) conducting a dehydrofluorination reaction by heating Component D obtained in Step (e) in the presence of a catalyst. The present invention provides an effective and industrially applicable process for preparing 2,3,3,3-tetrafluoropropene.
摘要翻译：本发明提供一种制备2,3,3,3-四氟丙烯的方法，包括以下步骤：（a）在加热的同时使3,3,3-三氟丙炔与氟化氢反应，得到含有2,3,3,3-四氟丙烯的产物 -tetrafluoropropene; （b）将步骤（a）中获得的产物分离成含有2,3,3,3-四氟丙烯和3,3,3-三氟丙炔的组分A，以及含有1,3,3,3-四氟丙烯的组分B; （c）将步骤（b）中获得的组分A中所含的2,3,3,3-四氟丙烯和3,3,3-三氟丙炔分离成各化合物; （d）通过加热步骤（b）中获得的组分B在催化剂存在下进行脱氟化氢反应; （e）将步骤（d）中获得的产物分离成含有2,3,3,3-四氟丙烯和3,3,3-三氟丙炔的组分C，以及含有1,3,3,3-四氟丙烯的组分D; （f）将步骤（e）中获得的组分C中所含的2,3,3,3-四氟丙烯和3,3,3-三氟丙炔分离成各化合物; 和（g）通过加热在步骤（e）中获得的组分D在催化剂存在下进行脱氟化氢反应。本发明提供了制备2,3,3,3-四氟丙烯的有效和工业上适用的方法。

9. 发明申请

WO2010024366A2 AZEOTROPIC OR AZEOTROPE-LIKE COMPOSITION AND PROCESS FOR PRODUCING 2,3,3,3-TETRAFLUOROPROPENE 审中-公开
标题翻译：共沸或类共沸组合物及生产2,3,3,3-四氟丙烯的方法
公开(公告)号：WO2010024366A2
公开(公告)日：2010-03-04
申请号：PCT/JP2009065023
申请日：2009-08-21
申请人： DAIKIN IND LTD , TAKAHASHI KAZUHIRO
发明人： TAKAHASHI KAZUHIRO
IPC分类号： C07C17/383 , C07C21/18
CPC分类号： C09K5/10 , C07C17/383 , C07C21/18 , C09K2205/24 , C09K2205/32 , C09K2205/40
摘要： The present invention provides a process for producing 2,3,3,3-tetrafluoropropene, comprising distilling a mixture of water and 2,3,3,3-tetrafluoropropene to separate the mixture into a first stream and a second stream, the first stream containing 2,3,3,3-tetrafluoropropene with a water content higher than the original mixture, and the second stream containing 2,3,3,3-tetrafluoropropene with a water content lower than the original mixture; and obtaining 2,3,3,3-tetrafluoropropene with a reduced water content from the second stream. The process of the invention can efficiently remove water from 2,3,3,3-tetrafluoropropene (HFO-1234yf).
摘要翻译：本发明提供了生产2,3,3,3-四氟丙烯的方法，包括蒸馏水和2,3,3,3-四氟丙烯的混合物以将混合物分离成第一物流和第二物流，第一物流含水量高于原始混合物的2,3,3,3-四氟丙烯和含水量低于原始混合物的第二流体含2,3,3,3-四氟丙烯; 并从第二物流获得具有降低的水含量的2,3,3,3-四氟丙烯。本发明的方法可以有效地从2,3,3,3-四氟丙烯（HFO-1234yf）中除去水。

10. 发明申请

WO2009064022A3 PROCESS FOR PRODUCING ( Z) - AND (E) -1, 1, 1, 2, 3-PENTAFLUOROPROPENE 审中-公开
标题翻译：（Z） - 和（E）-1,1,2,3-三氟苯酚的制备方法
公开(公告)号：WO2009064022A3
公开(公告)日：2009-07-09
申请号：PCT/JP2008071063
申请日：2008-11-13
申请人： DAIKIN IND LTD , TAKAHASHI KAZUHIRO
发明人： TAKAHASHI KAZUHIRO
IPC分类号： C07C17/358 , C07C17/383 , C07C21/18
CPC分类号： C07C17/358 , C07B2200/09 , C07C17/25 , C07C17/383 , C07C21/18
摘要： A mixture comprising a Z-isomer and an E-isomer of 1,1,1,2,3-pentafluoropropene (HFC-1225ye) is distilled to separate it into a first stream composed substantially of either one of the Z-isomer and the E-isomer, and a second stream comprising the Z-isomer and the E-isomer; and the second stream is subjected to an isomerization reaction to obtain a third stream having an increased ratio of the one isomer therein from that in the second stream; and then the third stream is reused as at least a part of the above mixture as a raw material. The order of the isomerization reaction and the distillation may be reversed. Thus, either one of the Z-isomer and E-isomer can be efficiently produced.
摘要翻译：将包含1,1,1,2,3-五氟丙烯（HFC-1225ye）的Z-异构体和E-异构体的混合物蒸馏，将其分离成基本上由Z-异构体和 E-异构体和包含Z-异构体和E-异构体的第二物流; 使第二物流进行异构化反应，得到与第二物流中的一种异构体的比率增加的第三物流; 然后将第三流作为原料的上述混合物的至少一部分再利用。异构化反应和蒸馏的顺序可以颠倒。因此，可以有效地制备Z-异构体和E-异构体之一。

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