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1. 发明专利

AT236163T 未知
公开(公告)号：AT236163T
公开(公告)日：2003-04-15
申请号：AT92916814
申请日：1992-08-06
申请人： SUNTORY LTD
发明人： MIZUNO AKIRA , MIYA MIKIKO , INOMATA NORIO , TATSUOKA TOSHIO , ISHIHARA TAKAFUMI
IPC分类号： C07D487/04 , A61K31/55 , C07D223/00 , C07D209/00
摘要： A pyrroloazepine compound represented by general formula (I) or (II), a salt thereof, a process for the production thereof, and a remedy for the diseases of circulatory organs containing the same as the active ingredient. In general formula (I) or (II) Z1 represents H when there is a bond represented by the broken line, whereas when there is no such a bond, Z1 represents H and Z2 represents OH, or alternatively Z1 and Z2 are combined together to represent O or NOR1 (wherein R1 represents H, alkyl, aryl or aralkyl); R represents alkyl, cycloalkyl, cyclalkyl-alkyl, aryl or aralkyl; A represents alkylene, alkenylene or alkynylene; and Y represents optionally substituted heterocycle or ( alpha ) wherein R2 and R3 represent each H, alkyl, lower alkoxy, aryloxy-substituted alkyl, aryl or aralkyl.

2. 发明专利

CA2093631A1 PYRROLOAZEPINE DERIVATIVE 未知
公开(公告)号：CA2093631A1
公开(公告)日：1993-02-08
申请号：CA2093631
申请日：1992-08-06
申请人： SUNTORY LTD
发明人： MIZUNO AKIRA , CHO HIDETSURA , MIYA MIKIKO , TATSUOKA TOSHIO , ISHIHARA TAKAFUMI
IPC分类号： C07D487/04 , A61K31/55
摘要： (As modified by the Japanese Patent Office as an International Searching authority in view of the Applicant's comments on the Ab stract prepared by the International Searching Authority) This invention provides a pyrroloazepine derivative represented by the following formula (I): (I) wherein, when the bond indicated by the dashed line is present, Z1 represents H but, when the bond indicated by the dashed line is absent, Z1 represents H and Z2 represents OH or Z1 and Z2 are taken together to form O or a group NOR1, R1 representing H, an alkyl group or the like, R represents H, an alkyl group or the like; A represents an alkylene, alkenylene or alkynylene group with one of Hs being optionally substituted by OH; Y represents a group: or in which R2 and R3 individually represent H, an alkyl group or the like, R4 and R5 individually represent H or an alkyl group; B represents a carbonyl group, a ? sulfonyl group or the like; m stands for 1 or 2; n stands for 0 or 1, and D represents an alkoxy group, an aromatic heterocyclic ring or the like; a salt thereof; a preparation process thereof; and a therapeutic for circulatory diseases, said therapeutic containing as an active ingredient the pyrroloazepine derivative or the salt thereof.

3. 发明专利

AU645441B2 Pyrrolo {2,3-c} azepin-4-one derivatives 未知
公开(公告)号：AU645441B2
公开(公告)日：1994-01-13
申请号：AU2403092
申请日：1992-08-06
申请人： SUNTORY LTD
发明人： MIZUNO AKIRA , MIYA MIKIKO , INOMATA NORIO , TATSUOKA TOSHIO , ISHIHARA TAKAFUMI
IPC分类号： C07D487/04 , A61K31/55
摘要： A pyrroloazepine compound represented by general formula (I) or (II), a salt thereof, a process for the production thereof, and a remedy for the diseases of circulatory organs containing the same as the active ingredient. In general formula (I) or (II) Z1 represents H when there is a bond represented by the broken line, whereas when there is no such a bond, Z1 represents H and Z2 represents OH, or alternatively Z1 and Z2 are combined together to represent O or NOR1 (wherein R1 represents H, alkyl, aryl or aralkyl); R represents alkyl, cycloalkyl, cyclalkyl-alkyl, aryl or aralkyl; A represents alkylene, alkenylene or alkynylene; and Y represents optionally substituted heterocycle or ( alpha ) wherein R2 and R3 represent each H, alkyl, lower alkoxy, aryloxy-substituted alkyl, aryl or aralkyl.

4. 发明专利

CA2093631C PYRROLOAZEPINE DERIVATIVE 未知
公开(公告)号：CA2093631C
公开(公告)日：2003-09-23
申请号：CA2093631
申请日：1992-08-06
申请人： SUNTORY LTD
发明人： ISHIHARA TAKAFUMI , MIZUNO AKIRA , CHO HIDETSURA , MIYA MIKIKO , TATSUOKA TOSHIO
IPC分类号： C07D487/04 , A61K31/55
摘要： This invention provides a pyrroloazepine deriva- tive represented by the following formula (I): (see figure I) wherein, when the bond indicated by the dashed line is present, Z1 represents H but, when the bond indicated by the dashed line is absent, Z1 represents H and Z2 represents OH or Z1 and Z2 are taken together to form O or a group NOR1, R1 representing H, an alkyl group or the like, R represents H, an alkyl group or the like; A represents an alkylene, alkenyl.ene or alkynylene group with one of Hs being optionally substituted by OH: Y represents a group: (see figure II, III) in which R2 and R3 individually represent H, an alkyl group or the like, R4 and R5 individually represent H or an alkyl group; B represents a carbonyl group, a sulfonyl group or the like: m stands for 1 or 2; n stands for 0 or 1; and D represents an alkoxy group, an aromatic heterocyclic ring or the like; a salt thereof; a preparation process thereof; and a therapeutic for circulatory diseases, said therapeutic containing as an active ingredient the pyrroloazepine derivative or the salt thereof.

5. 发明专利

DE69232981D1 未知
公开(公告)号：DE69232981D1
公开(公告)日：2003-05-08
申请号：DE69232981
申请日：1992-08-06
申请人： SUNTORY LTD OSAKA
发明人： MIZUNO AKIRA , MIYA MIKIKO , INOMATA NORIO , TATSUOKA TOSHIO , ISHIHARA TAKAFUMI
IPC分类号： C07D487/04 , A61K31/55
摘要： A pyrroloazepine compound represented by general formula (I) or (II), a salt thereof, a process for the production thereof, and a remedy for the diseases of circulatory organs containing the same as the active ingredient. In general formula (I) or (II) Z1 represents H when there is a bond represented by the broken line, whereas when there is no such a bond, Z1 represents H and Z2 represents OH, or alternatively Z1 and Z2 are combined together to represent O or NOR1 (wherein R1 represents H, alkyl, aryl or aralkyl); R represents alkyl, cycloalkyl, cyclalkyl-alkyl, aryl or aralkyl; A represents alkylene, alkenylene or alkynylene; and Y represents optionally substituted heterocycle or ( alpha ) wherein R2 and R3 represent each H, alkyl, lower alkoxy, aryloxy-substituted alkyl, aryl or aralkyl.

6. 发明专利

DE69232980D1 未知
公开(公告)号：DE69232980D1
公开(公告)日：2003-05-08
申请号：DE69232980
申请日：1992-08-06
申请人： SUNTORY LTD OSAKA
发明人： MIZUNO AKIRA , CHO HIDETSURA , MIYA MIKIKO , TATSUOKA TOSHIO , ISHIHARA TAKAFUMI
IPC分类号： C07D487/04 , A61K31/55
摘要： A pyrroloazepine derivative represented by general formula (I), a salt thereof, a process for the production thereof, and a remedy for the diseases of circulatory organs containing the same as the active ingredient. In formula (I) Z1 represents H when there is a bond represented by the broken line, whereas when there is no such a bond, Z1 represents H and Z2 represents OH, or alternatively Z1 and Z2 are combined together to represent O or NOR1 (wherein R1 represents H, alkyl, etc.); R represents H, alkyl, etc.; A represents alkylene, alkenylene or alkynylene each of which may be substituted with one OH group ; and Y represents ( alpha ) or ( beta ) wherein R2 and R3 represent each H, alkyl, etc.; R4 and R5 represent each H or alkyl; B represents carbonyl, sulfonyl, etc.; m represents 1 or 2; n represents 0 or 1; and D represents alkoxy, aromatic heterocyle, etc.

7. 发明专利

CA2093630C PYRROLOAZEPINE COMPOUND 未知
公开(公告)号：CA2093630C
公开(公告)日：2004-01-06
申请号：CA2093630
申请日：1992-08-06
申请人： SUNTORY LTD
发明人： MIZUNO AKIRA , MIYA MIKIKO , INOMATA NORIO , TATSUOKA TOSHIO , ISHIHARA TAKAFUMI
IPC分类号： C07D487/04 , A61K31/55
摘要： This invention provides a pyrroloazepine compound represented by the following Formula (I) or (II): (see formula I and II) wherein, when the bond indicated by the dashed line is present, Z1 represents H but, when the bond indicated by the dashed line is absent, Z1 represents H and Z2 represents OH or Z1 and Z2 are taken together to form O or a group NOR1, R1 representing H or an alkyl, aryl or aralkyl group; R represents an alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, or aralkyl group; A represents an alkylene, alkenylene or alkynylene group; and Y represents a substituted or unsubstituted heterocyclic group or a group: (see formula III) in which R2 and R3 represent H or an alkyl, a lower- alkoxy- or aryloxy-substituted alkyl, aryl or aralkyl group; a salt thereof; a preparation process thereof and a therapeutic for circulatory diseases, said therapeutic containing as an active ingredient the pyr- roloazepine derivative or the salt thereof.

8. 发明专利

AT236162T 未知
公开(公告)号：AT236162T
公开(公告)日：2003-04-15
申请号：AT92916818
申请日：1992-08-06
申请人： SUNTORY LTD
发明人： MIZUNO AKIRA , CHO HIDETSURA , MIYA MIKIKO , TATSUOKA TOSHIO , ISHIHARA TAKAFUMI
IPC分类号： C07D487/04 , A61K31/55 , C07D223/00 , C07D209/00
摘要： A pyrroloazepine derivative represented by general formula (I), a salt thereof, a process for the production thereof, and a remedy for the diseases of circulatory organs containing the same as the active ingredient. In formula (I) Z1 represents H when there is a bond represented by the broken line, whereas when there is no such a bond, Z1 represents H and Z2 represents OH, or alternatively Z1 and Z2 are combined together to represent O or NOR1 (wherein R1 represents H, alkyl, etc.); R represents H, alkyl, etc.; A represents alkylene, alkenylene or alkynylene each of which may be substituted with one OH group ; and Y represents ( alpha ) or ( beta ) wherein R2 and R3 represent each H, alkyl, etc.; R4 and R5 represent each H or alkyl; B represents carbonyl, sulfonyl, etc.; m represents 1 or 2; n represents 0 or 1; and D represents alkoxy, aromatic heterocyle, etc.

9. 发明专利

AU655841B2 Pyrroloazepine derivative 未知
公开(公告)号：AU655841B2
公开(公告)日：1995-01-12
申请号：AU2403192
申请日：1992-08-06
申请人： SUNTORY LTD
发明人： MIZUNO AKIRA , CHO HIDETSURA , MIYA MIKIKO , TATSUOKA TOSHIO , ISHIHARA TAKAFUMI
IPC分类号： C07D487/04 , A61K31/55
摘要： A pyrroloazepine derivative represented by general formula (I), a salt thereof, a process for the production thereof, and a remedy for the diseases of circulatory organs containing the same as the active ingredient. In formula (I) Z1 represents H when there is a bond represented by the broken line, whereas when there is no such a bond, Z1 represents H and Z2 represents OH, or alternatively Z1 and Z2 are combined together to represent O or NOR1 (wherein R1 represents H, alkyl, etc.); R represents H, alkyl, etc.; A represents alkylene, alkenylene or alkynylene each of which may be substituted with one OH group ; and Y represents ( alpha ) or ( beta ) wherein R2 and R3 represent each H, alkyl, etc.; R4 and R5 represent each H or alkyl; B represents carbonyl, sulfonyl, etc.; m represents 1 or 2; n represents 0 or 1; and D represents alkoxy, aromatic heterocyle, etc.

10. 发明专利

CA2093630A1 PYRROLOAZEPINE COMPOUND 未知
公开(公告)号：CA2093630A1
公开(公告)日：1993-02-08
申请号：CA2093630
申请日：1992-08-06
申请人： SUNTORY LTD
发明人： MIZUNO AKIRA , MIYA MIKIKO , INOMATA NORIO , TATSUOKA TOSHIO , ISHIHARA TAKAFUMI
IPC分类号： C07D487/04 , A61K31/55
摘要： As prepared by the International Searching Authority under the provisions of PCT Rule 38.2(b). This invention provides a pyrroloazepine compound represented by the following formula (I) or (II): (I) (II) wherein, when the bond indicated by the dashed line is present, Z1 represents H but, when the bond indicated by the dashed line is absent, Z1 represents H and Z2 represents OH or Z1 and Z2 are taken together to form O or a group NOR1, R1 representing H or an alkyl, aryl or aralkyl group; R represents an alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, or aralkyl group; A represents an alkylene, alkenylene or alkynylene group; and Y represents a substituted or unsubstituted heterocyclic group or a group: in which R2 and R3 represent H or an alkyl, a loweralkoxy- or aryloxy-substituted alkyl, aryl or aralkyl group; a salt thereof; a preparation process thereof; and a therapeutic for circulatory diseases, said therapeutic containing as an active ingredient the pyrroloazepine derivative or the salt thereof.

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