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1. 发明申请

WO2003057707A1 2-O-( -D-GLUCOPYRANOSYL)ASCORBIC ACID, PROCESS FOR ITS PRODUCTION, AND FOODS AND COSMETICS CONTAINING COMPOSITIONS COMPRISING IT 审中-公开
标题翻译： 2-O-（-D-GLUCOPYRANOSYL）抗坏血酸，其生产方法，以及包含组合物的食品和化妆品
公开(公告)号：WO2003057707A1
公开(公告)日：2003-07-17
申请号：PCT/JP2002/013857
申请日：2002-12-27
申请人： SUNTORY LIMITED , MAEDA, Mitsuru , NAKAO, Masahiro , FUKAMI, Harukazu
发明人： MAEDA, Mitsuru , NAKAO, Masahiro , FUKAMI, Harukazu
IPC分类号： C07H17/04
CPC分类号： A61K8/676 , A23L33/105 , A23L33/15 , A23V2002/00 , A61K8/602 , A61K31/375 , A61K2800/52 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C07H1/08 , C07H17/04 , C12P19/60 , A23V2250/708
摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(α-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O-(β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(β-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.
摘要翻译：本发明提供了一种新颖的抗坏血酸衍生物作为维生素C，与常规已知的2-O-（β-谷氨酰-D-吡喃葡萄糖基）抗坏血酸相比，体内的体内稳定性和身体寿命延长。从宁夏枸杞子和/或枸杞子植物提取含有新化合物2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸的组合物。可以使用β-葡萄糖基转移酶酶促合成包含2-O-（β-谷氨酰-D-吡喃葡萄糖基）抗坏血酸的组合物。可以从这样的组合物制备纯2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸。或者，可通过化学合成制备2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸。与对应的D-糖基吡喃糖基衍生物相比，2-O-（＆bgr-D-吡喃葡萄糖基）抗坏血酸产生更高的稳定性和摄取维生素C的寿命，因此非常适合作为维生素C用于化妆品和食品。

2. 发明申请

WO2006019186A1 SKIN CARE PRODUCTS, AS WELL AS FOODS AND BEVERAGES CONTAINING 6-O-PUFA ASCORBIC ESTERS 审中-公开
标题翻译：皮肤护理产品，如含有6-O-PUFA抗坏血酸的食品和饮料
公开(公告)号：WO2006019186A1
公开(公告)日：2006-02-23
申请号：PCT/JP2005/015383
申请日：2005-08-18
申请人： SUNTORY LIMITED , FUKAMI, Harukazu , KAWASHIMA, Hiroshi , ONO, Yoshiko
发明人： FUKAMI, Harukazu , KAWASHIMA, Hiroshi , ONO, Yoshiko
IPC分类号： A61K8/67
CPC分类号： A61K8/676 , A23L33/12 , A23L33/15 , A61Q5/00 , A61Q17/04 , A61Q19/00
摘要： Skin care products which contain as a vitamin C component 6-O-PUFA ascorbates represented by general formula (I): RCO-A (I)where RCO- is an acyl group derived from a polyunsaturated fatty acid, and A is a residue of ascorbic acid that binds by -O- derived from the hydroxyl group in ascorbic acid. The products show improved transfer of ascorbic acid to tissues or cells, allow the functions of ascorbic acid to be exhibited efficiently, and also have the potential to show the functions of PUFAs. Also provided are foods and beverages that contain 6-O-PUFA ascorbates represented by general formula (I).
摘要翻译：含有通式（I）表示的维生素C成分6-O-PUFA抗坏血酸盐的护肤品：RCO-A（I），其中RCO-为衍生自多不饱和脂肪酸的酰基，A为在抗坏血酸中与由羟基衍生的-O-结合的抗坏血酸。产品显示改善抗坏血酸转移至组织或细胞，使抗坏血酸的功能得到有效展现，并具有显示PUFA功能的潜力。还提供含有由通式（I）表示的6-O-PUFA抗坏血酸盐的食品和饮料。

3. 发明申请

WO2004085582A2 LIPID-IMPROVING AGENT AND COMPOSITION CONTAINING LIPID-IMPROVIMG AGENT 审中-公开
标题翻译：含有脂质改进剂的脂质改进剂和组合物
公开(公告)号：WO2004085582A2
公开(公告)日：2004-10-07
申请号：PCT/JP2004/004282
申请日：2004-03-26
申请人： SUNTORY LIMITED , AKIMOTO, Kengo , FUKAMI, Harukazu , GODA, Toshinao
发明人： AKIMOTO, Kengo , FUKAMI, Harukazu , GODA, Toshinao
IPC分类号： C11C3/00
CPC分类号： C12P7/6472 , A23D9/00 , A23L33/115 , A23V2002/00 , A61K31/231 , A61K31/232 , C11C3/08 , A23V2250/5112 , A23V2250/1862
摘要： A lipid-improving agent containing a triglyceride(s) where a poly-unsaturated fatty acid is bonded to 2-position of a triglyceride(s).
摘要翻译：含有甘油三酯的脂质改良剂，其中多不饱和脂肪酸与甘油三酯的2位结合。

4. 发明公开

EP1790733A1 SCREENING METHOD AND SCREENING APPARATUS USING MICRO-CHAMBER ARRAY 有权
标题翻译：筛选 - VERFAHREN屏幕 - VORRICHTUNG UNTER VERWENDUNG EINES MIKROKAMMER-ARRAYS
公开(公告)号：EP1790733A1
公开(公告)日：2007-05-30
申请号：EP05780915.4
申请日：2005-08-24
申请人： SUNTORY LIMITED
发明人： UEDA, Mitsuyoshi , NAKAO, Masahiro , ASAMI, Maki , OCHIAI, Misa , FUKAMI, Harukazu
IPC分类号： C12Q1/02 , C12Q1/34 , C12M1/34
CPC分类号： C12Q1/34 , C12Q1/04
摘要： A method and apparatus for screening a microorganism or protein having a useful function by using a micro-chamber array.
Using the screening method and screening apparatus in accordance with the present invention, a target protein having an enzymatic activity or a microorganism producing such a protein is screened from a sample serving as a screening object by using a base plate having a plurality of micro-chambers arranged in the form of an array. With this method and apparatus, a protein having an enzymatic activity or a microorganism producing such a protein that is present in a micro-chamber is detected by detecting a fluorescence produced by an enzyme reaction of the protein having an enzymatic activity and a fluorescence substrate.
摘要翻译：用于通过使用微室阵列筛选具有有用功能的微生物或蛋白质的方法和装置。使用根据本发明的筛选方法和筛选装置，通过使用具有多个微室的基板，从作为筛选对象的样品筛选具有酶活性的靶蛋白或产生这种蛋白质的微生物以阵列的形式排列。使用该方法和装置，通过检测由具有酶活性的蛋白质和荧光底物的酶反应产生的荧光来检测具有酶活性的蛋白质或产生存在于微室中的蛋白质的微生物。

5. 发明公开

EP1598413A1 PROCESS FOR PRODUCING POWDERED COMPOSITIONS CONTAINING HIGHLY UNSATURATED FATTY ACID ESTERS OF ASCORBIC ACID AND POWDERED COMPOSITIONS CONTAINING THE ESTERS 有权
标题翻译：用于生产抗坏血酸高不饱和脂肪酸酯的含粉末组合物及含酯的粉末组合物
公开(公告)号：EP1598413A1
公开(公告)日：2005-11-23
申请号：EP04715515.5
申请日：2004-02-27
申请人： SUNTORY LIMITED
发明人： FUKAMI, Harukazu
IPC分类号： C11B15/00 , C11C3/00
CPC分类号： C11C3/04 , A23D9/05
摘要： The invention provides a process for powdering highly unsaturated fatty acid esters of ascorbic acid which are pasty and problematic in physical properties by a simple and easy means; highly unsaturated fatty acid esters of ascorbic acid which are improved in stability by powdering; and compositions containing the powdered highly unsaturated fatty acid esters of ascorbic acid. Specifically, a process for powdering a highly unsaturated fatty acid ester of ascorbic acid as represented by the general formula (I): RCO - A [wherein RCO- is acyl derived from a highly unsaturated fatty acid; and A is an ascorbic acid residue bonded through an -O- linkage resulting from an hydroxyl group of ascorbic acid], characterized by mixing a highly unsaturated fatty acid ester of ascorbic acid as represented by the general formula (I) with an aqueous solution of a water-soluble filler to form an emulsion and dehydrating and drying the emulsion by a spray drying method.
摘要翻译：本发明提供了粉末化的抗坏血酸哪些是糊状并通过简单且容易的手段物理性质有问题的高度不饱和脂肪酸酯的方法; 的抗坏血酸其在稳定性通过粉化提高高度不饱和脂肪酸酯; 和COMPOSITIONS CONTAINING抗坏血酸的粉末高度不饱和脂肪酸酯。具体而言，对于由通式（I）所表示的粉化抗坏血酸的高度不饱和脂肪酸酯的方法：RCO - 甲a其中RCO-是从高度不饱和脂肪酸衍生的酰基; 且A是通过键键合的抗坏血酸残基-O从羟基抗坏血酸acidÜ的，由通式（I）所表示与的wässrige溶液混合抗坏血酸高度不饱和脂肪酸酯为特征的所得水溶性填料，以形成乳液和脱水，并通过喷雾干燥法干燥该乳液。

6. 发明公开

EP1192950A1 PREVENTIVE OR THERAPEUTIC DRUGS FOR DERMATITISES CONTAINING CHYMASE INHIBITORS AS THE ACTIVE INGREDIENT 有权
标题翻译：与糜蛋白酶抑制剂的有效手段药物治疗皮炎皮肤反应相
公开(公告)号：EP1192950A1
公开(公告)日：2002-04-03
申请号：EP01906226.4
申请日：2001-02-22
申请人： SUNTORY LIMITED
发明人： FUKAMI, Harukazu , TOMIMORI, Yoshiaki , FUKUDA, Yoshiaki , WATANABE, Naohiro
IPC分类号： A61K45/00 , A61K31/517 , A61K31/536 , A61P43/00 , A61P17/00 , A61P17/04
CPC分类号： C07D239/96 , A61K31/00 , A61K31/517
摘要： A medicament safe and free from side effects, for the prevention or treatment of dermatitis exhibiting a biphasic inflammation reaction or dermatitis induced by repeated exposure to an antigen, which suppresses the progress of the condition and improves the quality of life of the patient, which medicament treats dermatitis exhibiting a biphasic inflammation reaction or dermatitis induced by repeated exposure to an antigen by including a quiazoline derivative having the formula (I) or (II) or its pharmaceutically acceptable salt as an effective ingredient:
摘要翻译：一种药物安全且无副作用，对皮炎的参展通过在抗原反复暴露于诱导双相炎症反应或皮炎其抑制病症的进展，并提高患者的生活，这药物的质量的预防或治疗治疗皮炎由包含具有通式（I）或（II）或其药学上可接受的盐作为有效成分的quiazoline衍生物参展诱导重复暴露于抗原的两相炎症反应或皮炎：

7. 发明公开

EP1114035A1 QUINAZOLINE DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF 有权
标题翻译：喹唑啉衍生物及其治疗用途
公开(公告)号：EP1114035A1
公开(公告)日：2001-07-11
申请号：EP99938565.1
申请日：1999-08-20
申请人： SUNTORY LIMITED
发明人： FUKAMI, Harukazu , ITO, Akiko , IMAJO, Seiichi
IPC分类号： C07D239/96 , C07D403/12 , C07D413/12 , A61K31/505 , A61P9/10 , A61P11/06 , A61P37/08
CPC分类号： C07D401/12 , C07C311/60 , C07D239/96 , C07D413/12
摘要： A quinazoline derivative having formula (I), or a pharmaceutically acceptable salt thereof, which has a chymase inhibitory activity and suppresses the exacerbation of vascular permeability induced by chymase and useful as a medicament, and a pharmaceutical composition containing the same as an essential ingredient.

8. 发明公开

EP1778179A1 SKIN CARE PRODUCTS, AS WELL AS FOODS AND BEVERAGES CONTAINING 6-O-PUFA ASCORBIC ESTERS 有权
标题翻译：含有防止皮肤损伤的UV辐射曝光期间6-O-PUFA抗坏血酸护肤品
公开(公告)号：EP1778179A1
公开(公告)日：2007-05-02
申请号：EP05774814.7
申请日：2005-08-18
申请人： SUNTORY LIMITED
发明人： FUKAMI, Harukazu , KAWASHIMA, Hiroshi , ONO, Yoshiko
IPC分类号： A61K8/67 , A23L1/30
CPC分类号： A61K8/676 , A23L33/12 , A23L33/15 , A61Q5/00 , A61Q17/04 , A61Q19/00
摘要： Skin care products which contain as a vitamin C component 6-O-PUFA ascorbates represented by general formula (I): RCO-A (I)where RCO- is an acyl group derived from a polyunsaturated fatty acid, and A is a residue of ascorbic acid that binds by -O- derived from the hydroxyl group in ascorbic acid. The products show improved transfer of ascorbic acid to tissues or cells, allow the functions of ascorbic acid to be exhibited efficiently, and also have the potential to show the functions of PUFAs. Also provided are foods and beverages that contain 6-O-PUFA ascorbates represented by general formula (I).

9. 发明公开

EP1174151A1 PREVENTIVE OR THERAPEUTIC DRUGS FOR VARIOUS EOSINOPHILIA-RELATED DISEASES CONTAINING CHYMASE INHIBITORS AS THE ACTIVE INGREDIENT 有权
标题翻译：按用途分的抑制剂作为活性成分糜酶嗜酸细胞治疗
公开(公告)号：EP1174151A1
公开(公告)日：2002-01-23
申请号：EP01906225.6
申请日：2001-02-22
申请人： SUNTORY LIMITED
发明人： FUKAMI, Harukazu , WATANABE, Naohiro
IPC分类号： A61K45/00 , A61K31/517 , A61K31/536 , A61P43/00 , A61P37/08 , A61P11/06 , A61P27/16 , A61P27/14 , A61P17/04
CPC分类号： C07D239/96 , A61K31/00 , A61K31/517 , A61K31/536
摘要： A medicament for the prevention or treatment of diseases involving an increase of eosinophils having a chymase inhibitor, as its effective ingredient, which is a safe medicament for the prevention or treatment of diseases accompanied with an increase in eosinophils, which suppresses the progress of the condition, prevents progress of complications, and improves the quality of life of the patient, wherein a quinazoline derivative having the formula (I):
or a pharmaceutically acceptable salt thereof is included.
摘要翻译：一种用于预防或治疗的疾病涉及提高具有糜酶抑制剂嗜酸性粒细胞，作为其有效成分，所有这些是为了与伴随的疾病的预防或治疗一种安全的药物，以增加嗜酸性粒细胞，这抑制病症的进展的药物，防止并发症的进展，提高了患者的生活质量，worin具有式（I）的喹唑啉衍生物：可药用盐或它们是included.v

10. 发明公开

EP0795548A1 QUINAZOLINE DERIVATIVES AND USE THEREOF 失效
标题翻译：中华人民共和国威尼斯人民共和国
公开(公告)号：EP0795548A1
公开(公告)日：1997-09-17
申请号：EP96932039.9
申请日：1996-09-27
申请人： SUNTORY LIMITED
发明人： FUKAMI, Harukazu , ITO, Akiko , NIWATA, Shinjiro , KAKUTANI, Saki , SUMIDA, Motoo , KISO, Yoshinobu
IPC分类号： C07D239/96 , A61K31/505
CPC分类号： C07D401/06 , C07D239/96 , C07D401/12 , C07D401/14 , C07D403/12 , C07F9/65128
摘要： A chymase inhibitor containing as its effective ingredient a quinazoline derivative, or a pharmaceutically acceptable salt thereof, having the formula (1):
and a pharmaceutical preparation for the prevention of cardiac and circulatory system diseases derived from abnormal exacerbation of Ang II production containing the same as its effective ingredient.
摘要翻译：含有具有式（1）的喹唑啉衍生物或其药学上可接受的盐作为其有效成分的食糜酶抑制剂：＆lt; CHEM＆gt;和用于预防源自Ang II产生异常恶化的心脏和循环系统疾病的药物制剂含有与其有效成分相同的物质。

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