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1. 发明申请

WO2017143355A2 A DIRECT SCREW-DRIVEN CELL/BIOLOGICS FABRICATION HEAD FOR THE ASSEMBLY OF 3D TISSUE CONSTRUCTS 审中-公开
标题翻译：一种用于3D组织构建的直接螺杆驱动的细胞/生物学制造头
公开(公告)号：WO2017143355A2
公开(公告)日：2017-08-24
申请号：PCT/US2017/021265
申请日：2017-03-08
申请人： SUNP BIOTECH, LLC , SUN, Wei , HAMID, Qudus
发明人： SUN, Wei , HAMID, Qudus
IPC分类号： C12N5/07
CPC分类号： C12N5/0062 , C12N2533/74
摘要： Tissue generation have advanced tremendously in recent decades. Precision motion systems present a unique opportunity to establish new platforms to fabrication living tissue constructs. The key of successfully building a functional tissue construct, is having the right tool. In order to assemble cells into a functional array, the fabrication head must sustain cell life and have full control of the fluid/bio-suspension being printed. This article presents a direct screw-driven cell/biologics deposition fabrication head for the assembly of three-dimensional tissue constructs. This fabrication head is designed to be 100% biocompatible, sustain cell life, and has full control of mass flow rate with interchangeable nozzles.
摘要翻译：近几十年来，组织生成已经取得了巨大的进步。精密运动系统为建立制造活组织结构的新平台提供了独特的机会。成功构建功能性组织结构的关键是拥有正确的工具。为了将细胞组装成功能性阵列，制造头必须维持细胞寿命并且完全控制正在印刷的流体/生物悬浮液。本文介绍了一种用于组装三维组织结构的直接螺杆驱动的细胞/生物制剂沉积制造头。这种制造头设计为100％生物相容性，可维持细胞寿命，并可通过可互换喷嘴完全控制质量流量。

2. 发明申请

WO2017143355A3 A DIRECT SCREW-DRIVEN CELL/BIOLOGICS FABRICATION HEAD FOR THE ASSEMBLY OF 3D TISSUE CONSTRUCTS 审中-公开
标题翻译：一种用于3D组织构建的直接螺杆驱动的细胞/生物学制造头
公开(公告)号：WO2017143355A3
公开(公告)日：2017-08-24
申请号：PCT/US2017/021265
申请日：2017-03-08
申请人： SUNP BIOTECH, LLC , SUN, Wei , HAMID, Qudus
发明人： SUN, Wei , HAMID, Qudus
IPC分类号： B29C47/00 , B29C47/38 , D01F1/00 , D01F1/02 , D01F1/10 , D01F8/00
摘要： The invention provides a method of producing a cell laden filament. The method includes applying force with the use of a threaded screw drive shaft to extrude a bioactive filament. The bioactive filament may be used in order to establish new platforms for fabrication of living tissue constructs.
摘要翻译：本发明提供了生产细胞负载丝的方法。该方法包括使用螺纹螺杆驱动轴施加力以挤出生物活性细丝。生物活性细丝可以用于建立制造活组织结构的新平台。

3. 发明申请

WO2017143357A1 LOW TEMPERATURE MODULE FOR A 3D BIOLOGICAL PRINTER DEPOSITION SYSTEM AND BUILD PLATFORM 审中-公开
标题翻译：一种三维生物打印机沉积系统和构建平台的低温模块
公开(公告)号：WO2017143357A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/021271
申请日：2017-03-08
申请人： SUNP BIOTECH, LLC
发明人： SUN, Wei , HAMID, Qudus
IPC分类号： A61F2/02 , A61F2/04 , A61F2/06 , A61L27/40 , A61L27/54 , B29C64/10
CPC分类号： B29C64/106 , B29C64/209 , B29C64/364 , B33Y10/00 , B33Y30/00 , C12M33/00 , C12N5/0062
摘要： This article presents a low temperature module for a biological printer's deposition system and build platform. This module is designed to be adaptive and integrative to a current biological printer while providing the ability to maintain a "cold" environment within the fabrication head. A "cold" environment is defined as changing and maintaining the temperature within the printer's fabrication system of at least one degrees Celsius (1 degree C) below ambient temperature.
摘要翻译：本文为生物印刷机的沉积系统和构建平台提供了一个低温模块。该模块被设计成适应当前的生物打印机并与之集成，同时提供保持“冷” 制造头内的环境。 “冷” 环境被定义为改变并维持打印机制造系统内的温度至少比环境温度低1摄氏度（1摄氏度）。

4. 发明申请

WO2017143356A1 HIGH TEMPERATURE MODULE FOR A 3D BIOLOGICAL PRINTER DEPOSITION SYSTEM 审中-公开
标题翻译：一种3D生物打印机沉积系统的高温模块
公开(公告)号：WO2017143356A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/021270
申请日：2017-03-08
申请人： SUNP BIOTECH, LLC
发明人： SUN, Wei , HAMID, Qudus
IPC分类号： A61F2/02 , A61F2/04 , A61F2/06 , A61L27/40 , A61L27/54 , B29C64/10
CPC分类号： B29C64/295 , B33Y30/00 , B33Y40/00
摘要： This present invention provides a high temperature module for a 3D biologies printer's deposition system. This module is designed to be adaptive and integrative to current biological printers while providing the ability to maintain a "hot" environment within the fabrication head. A "hot" environment is defined as changing and maintain the temperature within the printer's fabrication system of at least one degrees Celsius (1 degree C) above ambient temperature.
摘要翻译：本发明提供了用于3D生物打印机沉积系统的高温模块。该模块被设计成适应当前的生物打印机并与之集成，同时提供保持“热” 制造头内的环境。 “热” 环境被定义为改变并保持打印机制造系统内的温度比环境温度高至少1摄氏度（1摄氏度）。

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