专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008100618A3 CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S 审中-公开
标题翻译：碳氢化合物的联苯四唑 - 吡唑并吡啶调节剂
公开(公告)号：WO2008100618A3
公开(公告)日：2008-10-02
申请号：PCT/US2008002108
申请日：2008-02-15
申请人： SUNESIS PHARMACEUTICALS INC , AMERIKS MICHAEL K , AXE FRANK U , CAI HUI , EDWARDS JAMES P , GLEASON ELIZABETH ANN , GRICE CHERYL A , MEDUNA STEVEN P , TAYS KEVIN L , WICKBOLDT ALVAH T , WIENER JOHN J M
发明人： AMERIKS MICHAEL K , AXE FRANK U , CAI HUI , EDWARDS JAMES P , GLEASON ELIZABETH ANN , GRICE CHERYL A , MEDUNA STEVEN P , TAYS KEVIN L , WICKBOLDT ALVAH T , WIENER JOHN J M
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P35/00 , A61P37/00
CPC分类号： C07D471/04 , C07D519/00
摘要： Carbon- linked tetrahydro-pyrazolo-pyridine compounds of formula (I) are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
摘要翻译：描述了式（I）的碳连接的四氢 - 吡唑并 - 吡啶化合物，其可用作组织蛋白酶S调节剂。这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。

2. 发明申请

WO2008100620A3 BICYCLIC AMINOPROPYL TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S 审中-公开
标题翻译：双螺旋氨基磷酸四氢吡喃 - 吡咯啉吡啶类调节剂
公开(公告)号：WO2008100620A3
公开(公告)日：2008-11-13
申请号：PCT/US2008002110
申请日：2008-02-15
申请人： SUNESIS PHARMACEUTICALS INC , ALLEN DARIN , AMERIKS MICHAEL K , AXE FRANK U , BURDETT MATTHEW , CAI HUI , CHOONG INGRID , EDWARDS JAMES P , LEW WILLARD , MEDUNA STEVEN P
发明人： ALLEN DARIN , AMERIKS MICHAEL K , AXE FRANK U , BURDETT MATTHEW , CAI HUI , CHOONG INGRID , EDWARDS JAMES P , LEW WILLARD , MEDUNA STEVEN P
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/08
CPC分类号： C07D471/04 , C07D519/00
摘要： Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis.
摘要翻译：描述了双环氨基丙基四氢 - 吡唑并吡啶化合物，其可用作组织蛋白酶S调节剂。这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。

3. 发明申请

WO2008100635A8 1- [3- (MONOCYCLIC AMINO) PROPYL] - 4, 5, 6, 7-TETRAHYDRO-1H-PYRAZOLO [4, 3-C] -PYRIDINES AS MODULATORS OF CATHEPSIN S 审中-公开
标题翻译： 1- [3-（单环氨基）丙基] -4,5,6,7-四氢-1H-吡唑并[4,3-C] - 吡啶作为CATHEPSIN S的调节剂
公开(公告)号：WO2008100635A8
公开(公告)日：2008-10-30
申请号：PCT/US2008002165
申请日：2008-02-15
申请人： SUNESIS PHARMACEUTICALS INC , ALLEN DARIN , AMERIKS MICHAEL K , AXE FRANK U , BURDETT MATTHEW , CAI HUI , CHOONG INGRID , EDWARDS JAMES P , LEW WILLARD , MEDUNA STEVEN P
发明人： ALLEN DARIN , AMERIKS MICHAEL K , AXE FRANK U , BURDETT MATTHEW , CAI HUI , CHOONG INGRID , EDWARDS JAMES P , LEW WILLARD , MEDUNA STEVEN P
IPC分类号： C07D471/04 , A61K31/437 , A61P9/10 , A61P17/06 , A61P19/02 , A61P37/00
CPC分类号： C07D471/04
摘要： Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine compounds of formula (I) are described, which are useful as cathepsin S modulators. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by cathepsin S activity, such as psoriasis, pain, multiple sclerosis, atherosclerosis, and rheumatoid arthritis. Formula (I), wherein: R 1 and R 2 taken together with the nitrogen to which they are attached form a monocyclic heterocycloalkyl group; wherein: R 1 and R 2 taken together with the nitrogen to which they are attached form a monocyclic heterocycloalkyl group, optionally containing one additional heteroatom ring member that is O, S, SO 2 , or NR a , and being unsubstituted or substituted with one, two, or three R b substituents; and wherein R 3 -R 8 , R a , R b and n are as defined herein.
摘要翻译：描述了式（I）的单环氨基丙基四氢 - 吡唑并吡啶化合物，其可用作组织蛋白酶S调节剂。这些化合物可用于治疗由组织蛋白酶S活性介导的疾病状态，病症和病症的药物组合物和方法，例如银屑病，疼痛，多发性硬化，动脉粥样硬化和类风湿性关节炎。式（I）其中：R 1和R 2与它们所连接的氮一起形成单环杂环烷基; 其中：R 1和R 2与它们所连接的氮一起形成单环杂环烷基，任选地含有一个另外的杂原子环成员，其为O，S， SO 2，或NR a a，并且是未取代的或被一个，两个或三个R b取代基取代; 并且其中R 3〜R 8，R a，R b和R b如本文所定义。

4. 发明申请

WO2004022537A3 THIENOPYRROLYL AND FURANOPYRROLYL COMPOUNDS AND THEIR USE AS HISTAMINE H4 RECEPTOR LIGANDS 审中-公开
标题翻译：三烯丙基和呋喃亚甲基化合物及其作为组胺类H4受体配体的用途
公开(公告)号：WO2004022537A3
公开(公告)日：2004-05-06
申请号：PCT/US0328017
申请日：2003-09-05
申请人： JANSSEN PHARMACEUTICA NV , CAI HUI , CARRUTHERS NICHOLAS I , DVORAK CURT A , EDWARDS JAMES P , KWOK ANNETTE K
发明人： CAI HUI , CARRUTHERS NICHOLAS I , DVORAK CURT A , EDWARDS JAMES P , KWOK ANNETTE K
IPC分类号： A61P43/00 , C07D491/04 , C07D495/04 , C07D519/00 , A61K31/40
CPC分类号： C07D491/04 , C07D495/04
摘要： Certain thienopyrrolyl and furanopyrrolyl compounds of formula (I):are disclosed as useful to treat or prevent disorders and conditions mediated by the histamine H4 receptor, including allergic rhinitis.
摘要翻译：公开了某些式（I）的噻吩并吡咯基和呋喃并吡咯基化合物：可用于治疗或预防由组胺H 4受体介导的病症和病症，包括过敏性鼻炎。

5. 发明专利

PE01622009A1 TETRAHIDRO-PIRAZOLO-PIRIDINA LIGADA A CARBONO COMO MODULADORES DE CATEPSINA S 未知
公开(公告)号：PE01622009A1
公开(公告)日：2009-03-12
申请号：PE0003342008
申请日：2008-02-15
申请人： SUNESIS PHARMACEUTICALS INC
发明人： AMERIKS MICHAEL K , AXE FRANK U , CAI HUI , EDWARDS JAMES P , GLEASON ELIZABETH ANN , GRICE CHERYL A , MEDUNA STEVEN P , TAYS KEVIN L , WICKBOLDT ALVAH T , WIENER JOHN J M
IPC分类号： A61K31/437 , A61K31/496 , A61K31/53 , A61K31/55 , A61P1/00 , A61P3/00 , A61P11/00 , A61P17/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , C07D471/00 , C07D471/04
CPC分类号： C07D471/04 , C07D519/00
摘要： REFERIDA A UN DERIVADO DE PIRIDINA DE FORMULA (I), DONDE R1 Y R2 TOMADOS JUNTOS CON EL NITROGENO AL CUAL ESTAN ENLAZADOS FORMAN UN GRUPO HETEROCICLOALQUILO MONOCICLICO SATURADO, DONDE CADA GRUPO CONTIENE UN MIEMBRO DEL ANILLO DE HETEROATOMO ADICIONAL QUE ES O, S, NRa, Y CADA GRUPO ESTA OPCIONALMENTE SUSTITUIDO CON Rb; Rb ES ALQUILO C1-C4, OH, CF3, ENTRE OTROS; Ra ES H, ALQUILO C1-C4, FENILO, ENTRE OTROS; R3 ES H, OH, ALQUILO C1-C4, ENTRE OTROS; R4 ES H, ALQUILO C1-C4, CO-FENIL, ENTRE OTROS; R5 ES HALO O CF3; R6 ES H O F; D ES CH=CH-R8, (CH2)2-3-R8, (CH2)3-5-R9, ENTRE OTROS; R8 ES FENILO O UN GRUPO HETEROARILO MONOCICLICO SUSTITUIDO OPCIONALMENTE CON Rk; Rk ES ALQUILO C1-C4, HALO, CN, COOH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-[4-CLORO-3-(1H-INDOL-5-ILETINIL)-FENIL]-5-METANOSULFONIL-1-(3-MOROFOLIN-4-IL-PROPIL)-4,5,6,7-TETRAHIDRO-1H-PIRAZOLO[4,3-c]PIRIDINA, 3-{4-CLORO-3-[2-(1H-INDOL-5-IL)-ETIL]-FENIL}-5-METANOSULFONIL-1-(3-MORFOLIN-4-IL-PROPIL)-4,5,6,7-TETRAHIDRO-1H-PIRAZOLO[4,3-c]PIRIDINA, (4-{2-CLORO-5-[5-METANOSULFONIL-1-(3-MORFOLIN-4-IL-PROPIL)-4,5,6,7-TETRAHIDRO-1H-PIRAZOLO[4,3-c]PIRIDIN-3-IL]-FENILETINIL}-FENIL)-ACETONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE CATEPSINA S Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS INTESTINALES, LUPUS, ASMA, REACCIONES ALERGICAS, TRANSTORNOS DEL SISTEMA INMUNOLOGICO, ENTRE OTROS

6. 发明专利

CL2008000495A1 Compuestos derivados de tetrahidro-pirazolo[4,3-c]piridina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como alergias, inflamacion, dolor, cancer, entreotras. 未知
公开(公告)号：CL2008000495A1
公开(公告)日：2008-11-03
申请号：CL2008000495
申请日：2008-02-15
申请人： SUNESIS PHARMACEUTICALS INC
发明人： CAI HUI , EDWARDS JAMES P , AMERIKUS MICHAEL K , AXE FRANK U , GLEASON ELIZABETH ANN , GRICE CHERYL A , MEDUNA STEVEN P , TAYS KE
IPC分类号： A61K31/4738 , A61P25/04 , A61P35/00 , A61P37/00 , C07D471/04
摘要： Compuestos derivados de tetrahidro-pirazolo[4,3-c]piridina; composición farmacéutica; y uso en el tratamiento de enfermedades, tales como, alergias, inflamación, dolor, cáncer, entre otras.

7. 发明专利

PE20090162A1 TETRAHIDRO-PIRAZOLO-PIRIDINA LIGADA A CARBONO COMO MODULADORES DE CATEPSINA S 未知
公开(公告)号：PE20090162A1
公开(公告)日：2009-03-12
申请号：PE2008000334
申请日：2008-02-15
申请人： SUNESIS PHARMACEUTICALS INC
发明人： AMERIKS MICHAEL K , AXE FRANK U , CAI HUI , EDWARDS JAMES P , GLEASON ELIZABETH ANN , GRICE CHERYL A , MEDUNA STEVEN P , TAYS KEVIN L , WICKBOLDT ALVAH T , WIENER JOHN J M
IPC分类号： A61K31/437 , A61K31/496 , A61K31/53 , A61K31/55 , A61P1/00 , A61P3/00 , A61P11/00 , A61P17/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , C07D471/00 , C07D471/04
摘要： REFERIDA A UN DERIVADO DE PIRIDINA DE FORMULA (I), DONDE R1 Y R2 TOMADOS JUNTOS CON EL NITROGENO AL CUAL ESTAN ENLAZADOS FORMAN UN GRUPO HETEROCICLOALQUILO MONOCICLICO SATURADO, DONDE CADA GRUPO CONTIENE UN MIEMBRO DEL ANILLO DE HETEROATOMO ADICIONAL QUE ES O, S, NRa, Y CADA GRUPO ESTA OPCIONALMENTE SUSTITUIDO CON Rb; Rb ES ALQUILO C1-C4, OH, CF3, ENTRE OTROS; Ra ES H, ALQUILO C1-C4, FENILO, ENTRE OTROS; R3 ES H, OH, ALQUILO C1-C4, ENTRE OTROS; R4 ES H, ALQUILO C1-C4, CO-FENIL, ENTRE OTROS; R5 ES HALO O CF3; R6 ES H O F; D ES CH=CH-R8, (CH2)2-3-R8, (CH2)3-5-R9, ENTRE OTROS; R8 ES FENILO O UN GRUPO HETEROARILO MONOCICLICO SUSTITUIDO OPCIONALMENTE CON Rk; Rk ES ALQUILO C1-C4, HALO, CN, COOH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 3-[4-CLORO-3-(1H-INDOL-5-ILETINIL)-FENIL]-5-METANOSULFONIL-1-(3-MOROFOLIN-4-IL-PROPIL)-4,5,6,7-TETRAHIDRO-1H-PIRAZOLO[4,3-c]PIRIDINA, 3-{4-CLORO-3-[2-(1H-INDOL-5-IL)-ETIL]-FENIL}-5-METANOSULFONIL-1-(3-MORFOLIN-4-IL-PROPIL)-4,5,6,7-TETRAHIDRO-1H-PIRAZOLO[4,3-c]PIRIDINA, (4-{2-CLORO-5-[5-METANOSULFONIL-1-(3-MORFOLIN-4-IL-PROPIL)-4,5,6,7-TETRAHIDRO-1H-PIRAZOLO[4,3-c]PIRIDIN-3-IL]-FENILETINIL}-FENIL)-ACETONITRILO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE CATEPSINA S Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS INTESTINALES, LUPUS, ASMA, REACCIONES ALERGICAS, TRANSTORNOS DEL SISTEMA INMUNOLOGICO, ENTRE OTROS

8. 发明申请

WO2011157185A3 METHOD FOR BUILDING PACKET DATA NETWORK CONNECTION, ACCESSING GATEWAY, USER EQUIPMENT AND SYSTEM 审中-公开
标题翻译：用于构建分组数据网络连接，接入网关，用户设备和系统的方法
公开(公告)号：WO2011157185A3
公开(公告)日：2012-04-26
申请号：PCT/CN2011075345
申请日：2011-06-03
申请人： HUAWEI TECH CO LTD , CAI HUI , GUO YOURUI , YI QI
发明人： CAI HUI , GUO YOURUI , YI QI
IPC分类号： H04W76/02
CPC分类号： H04W76/027 , H04W76/022
摘要： A method for building a Packet Data Network (PDN) connection, an accessing gateway, a user equipment and a system are provided by the embodiments of the present invention. The method includes: in the case of the user equipment succeeding in authentication and authorization and failing to build a PDN connection, maintaining the connection between the user equipment and the accessing gateway, receiving a connection request for building the PDN connection of a target network transmitted by the user equipment (S210); according to the connection request, building the PDN connection of a gateway device of the target network (S220). According to the technical solution as above, while failing to build the PDN connection for the user equipment succeeding in authentication and authorization, the accessing gateway still maintains the connection between the user equipment and the accessing gateway and enables to receive the connection request initiated by the user equipment and then directly build the PDN connection for the user equipment. Thereby, the present invention does not need to repeatedly build the connection to the user equipment and repeatedly perform the authentication and authorization, thus can reduce the burden of the user side and the network side and save the network resources.
摘要翻译：通过本发明的实施例提供了构建分组数据网络（PDN）连接的方法，接入网关，用户设备和系统。该方法包括：在用户设备成功进行认证授权和未能建立PDN连接的情况下，维护用户设备与接入网关之间的连接，接收建立传输的目标网络的PDN连接的连接请求由用户设备（S210）; 根据连接请求，建立目标网络的网关设备的PDN连接（S220）。根据上述技术方案，当成功认证授权的用户设备未建立PDN连接时，接入网关仍然维护用户设备与接入网关之间的连接，并能够接收到由用户设备，然后直接构建用户设备的PDN连接。由此，本发明不需要重复地建立与用户设备的连接并重复执行认证授权，因此可以减轻用户侧和网络侧的负担并节省网络资源。

9. 发明申请

WO2011157123A3 ONLINE CHARGING METHOD, ONLINE CHARGING SYSTEM, POLICY AND CHARGING RULES FUNCTION 审中-公开
标题翻译：在线充电方法，在线充电系统，政策和充电规则功能
公开(公告)号：WO2011157123A3
公开(公告)日：2012-05-03
申请号：PCT/CN2011074969
申请日：2011-05-31
申请人： HUAWEI TECH CO LTD , CAI HUI
发明人： CAI HUI
IPC分类号： H04L12/14
CPC分类号： H04L12/14 , H04L12/1403 , H04L12/1467 , H04M15/00 , H04M15/64 , H04M15/66 , H04W4/24
摘要： Embodiments of the present invention provide an online charging method, online charging system and a policy and charging rules function, which relate to the communication field. The online charging method includes: obtaining information of a total quota needed by services (S201); judging whether a balance of a user account is enough to complete the services according to the information of the total quota needed by the services and the balance of the user account, and generating the judging result (S202); if the judging result is yes, executing quota management and implementing online charging (S203). The online charging system includes: a first total quota obtaining module, a first judging module and an online charging module. The policy and charging rules function includes: a second total quota obtaining module, a balance obtaining module, a second judging module and a rule processing module. The embodiments of the present invention improve the service experience of users.
摘要翻译：本发明的实施例提供了一种在线计费方法，在线计费系统以及涉及通信领域的策略和计费规则功能。在线收费方法包括：获取服务所需的总配额的信息（S201）; 判断用户账号余额是否足以根据业务所需总配额的信息和用户账号的余额来完成业务，并生成判断结果（S202）; 如果判断结果为是，执行配额管理和实施在线收费（S203）。在线计费系统包括：第一总配额获取模块，第一判断模块和在线计费模块。策略和计费规则功能包括：第二总配额获取模块，余额获取模块，第二判断模块和规则处理模块。本发明的实施例改善了用户的服务体验。

10. 发明申请

WO2011157186A3 METHOD FOR BUILDING PACKET DATA NETWORK CONNECTION, ACCESSING GATEWAY, USER EQUIPMENT AND SYSTEM 审中-公开
标题翻译：用于构建分组数据网络连接，接入网关，用户设备和系统的方法
公开(公告)号：WO2011157186A3
公开(公告)日：2012-04-26
申请号：PCT/CN2011075348
申请日：2011-06-03
申请人： HUAWEI TECH CO LTD , CAI HUI , GUO YOURUI , YI QI
发明人： CAI HUI , GUO YOURUI , YI QI
IPC分类号： H04W76/02
CPC分类号： H04W76/027 , H04W76/022
摘要： A method for building a Packet Data Network (PDN) connection, an accessing gateway, a user equipment and a system are provided by the embodiments of the present invention. The method includes: receiving the Internet Key Exchange (IKE) message indicating performing authentication and authorization transmitted by the user equipment to carry out authentication and authorization for the user equipment (S210); in the case of the user equipment succeeding in authentication and authorization and having built the first PDN connection, directly receiving a connection request for building the second PDN connection of a target network transmitted by the user equipment (S220); according to the connection request, building the second PDN connection of a gateway device of the target network (S230). According to the technical solution as above, under IKE protocol, if the user equipment succeeding in authentication and authorization has built the PDN connection, the user equipment can directly transmit the connection request to the accessing gateway for building a new PDN connection. Thereby, the present invention does not need to repeatedly build the connection to the accessing gateway and repeatedly perform the authentication and authorization as related technique, thus can reduce the burden of the network side and the user side and save the system resources.
摘要翻译：通过本发明的实施例提供了构建分组数据网络（PDN）连接的方法，接入网关，用户设备和系统。该方法包括：接收指示执行用户设备发送的认证和授权的Internet密钥交换（IKE）消息，以对用户设备进行认证和授权（S210）; 在用户设备认证授权成功并构建第一PDN连接的情况下，直接接收用于建立用户设备发送的目标网络的第二PDN连接的连接请求（S220）。根据连接请求，构建目标网络的网关装置的第二PDN连接（S230）。根据上述技术方案，在IKE协议下，如果成功进行认证授权的用户设备建立了PDN连接，用户设备可以直接向接入网关发送连接请求，建立新的PDN连接。因此，本发明不需要重复地建立与接入网关的连接，并且重复执行认证授权作为相关技术，从而可以减轻网络侧和用户侧的负担并节省系统资源。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式